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GABA 500 mg

NOW
4.7
★ ★ ★ ★ ★
(83013 ratings)
GABA 500 mg
Product Image
Score84
A focused standard GABA product delivering 500 mg in a single capsule. The small B6 addition does not resolve variable response to oral GABA.
How scoring works
Quantity:200 Capsule(s) • (200 servings)
Goals:
Stress Relief
Sleep Support
Mood Support

Score 84

A focused standard GABA product delivering 500 mg in a single capsule. The small B6 addition does not resolve variable response to oral GABA.
How scoring works

Also available as

1 option
100 servings GABA 500 mg • 100 Capsule(s) • 100 servings $8.70 ($0.08 per serving)
$15.07($0.07 per serving)
Vitacost
$ 18.47
iHerb
$ 17.14
Daily Vita
$ 16.20
Amazon
$ 15.07
iHerb
$ 17.14
Report prices

Analysis

The single capsule supplies 500 mg of standard GABA. The formula also has 2 mg of vitamin B6.

The amount falls in a practical standalone range for trying relaxation or bedtime support. Oral GABA response varies, so a clear dose is more useful than assuming the ingredient will affect everyone in the same way.

The main limitation is that the small B6 addition does not resolve variable response to oral GABA. The product fits adults seeking moderate GABA with a small B6 addition, provided sedative stacking and next-day drowsiness are considered.

Who is it for
  • adults seeking moderate GABA with a small B6 addition
  • people seeking focused relaxation support without a multi-herb blend
Best for
  • evening relaxation
  • supporting a calmer bedtime routine

Pros

  • Clearly states 500 mg of GABA
  • Single capsule is easy to use
  • 2 mg of vitamin B6

Cons

  • The small B6 addition does not resolve variable response to oral GABA
  • Oral GABA effects may differ substantially between users
  • Focused formula does not address broader causes of poor sleep or stress

Warnings

  • GABA may cause drowsiness, dizziness, or reduced alertness.
  • Alcohol, sleep medicines, benzodiazepines, antihistamines, or other sedatives may intensify drowsiness when combined with GABA.

Nutrient quality

85 Highest impact

The capsule is practical and vitamin B6 has a defined form, while GABA sourcing is generic. The GABA amount provides substantial standalone depth, and gABA and a relevant neurotransmitter cofactor form a concise calming formula.

.

Ingredient transparency

82 Highest impact

Every listed active has a specific amount and no proprietary blend obscures the formula. Complete intake directions and inactive ingredients are not supplied, leaving part of the label unverified.

.

Customer satisfaction

72 High impact

The supplied aggregate satisfaction level is strong. The extensive feedback volume makes the aggregate dependable.

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Value for money

96 Highest impact

The useful amount and relevant cofactor strongly support the low cost. The serving is exceptionally economical, and the formula compares very well among standard GABA products.

.
Report analysis

Goals

Stress Relief
Stress Relief
Impact
High effect
B- Goal FitB+ Strength of SupportC+ CoverageA Formula Quality
GABA · 500 mgVitamin B6 · 2 mg

A clearly stated GABA amount provides targeted inhibitory-neurotransmitter support, with a small vitamin B6 amount adding a relevant cofactor. Oral GABA has uncertain access to the brain, so the formula’s practical effect may vary.

The capsule supplies a full standalone GABA amount in one unit and avoids a crowded blend. The source is unbranded and the production method is not disclosed, limiting ingredient-quality confidence.

Study evidence
GABA Supportive 6 studies
Vitamin B6 Supportive 10 studies
Sleep Support
Sleep Support
Impact
High effect
D+ Goal FitB+ Strength of SupportC- CoverageA- Formula Quality

A full GABA amount may support relaxation, but oral GABA has limited and uncertain evidence for improving sleep. The small vitamin B6 amount offers cofactor support without making the formula more sleep specific.

The one-capsule serving is transparent and straightforward. It focuses deeply on one calming pathway but does not address circadian timing or overnight maintenance.

Study evidence
GABA Supportive 4 studies
Vitamin B6 Disputed 7 studies
Mood Support
Mood Support
Impact
High effect
D+ Goal FitB+ Strength of SupportC- CoverageA Formula Quality
Vitamin B6 · 2 mg

GABA offers a simple route to relaxation, with vitamin B6 acting as a relevant neurotransmitter cofactor. Direct human evidence for oral GABA mood benefits remains limited.

The substantial amount and clear label provide good depth in one narrow pathway. Five hundred milligrams of GABA may cause drowsiness when combined with alcohol, sleep aids, or other sedatives.

Study evidence
GABA Supportive 12 studies
Vitamin B6 Supportive 19 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 2 mg
GABA
500 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
GABA · 500 mg OverallScore87
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

The clearly disclosed GABA amount sits comfortably within the preferred standalone range. Standard capsule delivery is practical, though the source lacks branded fermentation details. The low serving cost provides excellent value for the active amount.

View ingredientView products
Loading alternative details
74 Performance

Liposomal GABA

Quicksilver Scientific
<p>240 mg GABA with 100 mg L-theanine and phosphatidylcholine broadens the original's single-ingredient approach and may better support relaxation through complementary pathways. The supplied data do not establish how much the liposomal delivery changes absorption, and the serving cost is high.</p>
85 Performance

Pharma GABA 250 mg

Natural Factors Stress-Relax
<p>250 mg fermented branded GABA provides clearer source definition than the original's generic GABA. The branded source improves ingredient definition, although oral GABA effects can vary and drowsiness remains possible.</p>
83 Performance

GABA 500 mg

NOW
<p>500 mg GABA with 2 mg vitamin B6 adds a small relevant vitamin cofactor while retaining the original's GABA amount. Generic sourcing and uncertain oral brain availability limit confidence, and drowsiness remains possible.</p>
84 Budget

GABA

NOW
<p>Lower serving cost and 500 mg GABA make this a more economical option for the same GABA-focused sleep and stress goals. Generic sourcing and uncertain oral brain availability limit confidence, and drowsiness remains possible.</p>
81 Budget

GABA 750 mg

Source Naturals Serene Science
<p>Lower serving cost and 750 mg GABA make this a more economical option for the same GABA-focused sleep and stress goals. Generic sourcing and uncertain oral brain availability limit confidence, while the high amount may increase drowsiness.</p>
83 Budget

GABA 500 mg

Nutricost
<p>Lower serving cost and 500 mg GABA with 2 mg vitamin B6 make this a more economical option for the same GABA-focused sleep and stress goals. Generic sourcing and uncertain oral brain availability limit confidence, and drowsiness remains possible.</p>
83 Value

GABA 750 mg

NOW
<p>750 mg GABA offers a practical formula-and-cost balance, although it is not cheaper than the unusually economical original. Generic sourcing and uncertain oral brain availability limit confidence, while the high amount may increase drowsiness.</p>
83 Value

GABA 500 mg

Swanson
<p>500 mg GABA offers a practical formula-and-cost balance, although it is not cheaper than the unusually economical original. Generic sourcing and uncertain oral brain availability limit confidence, and drowsiness remains possible.</p>
81 Value

GABA Powder

Source Naturals Serene Science
<p>Lower serving cost paired with 750 mg GABA creates a stronger balance of focused calming support and value than the original. Generic sourcing and uncertain oral brain availability limit confidence, while the high amount may increase drowsiness.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  2. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  3. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  4. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  5. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  6. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  7. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  8. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  9. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  10. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  11. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  12. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  13. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  14. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  15. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  16. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  17. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  18. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  19. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  20. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  21. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  22. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA
  23. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forVitamin B6
  24. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  25. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  26. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6