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GABA 500 mg

NOW
4.7
★ ★ ★ ★ ★
(83161 ratings)
GABA 500 mg
Product Image
Score83
The clearly disclosed 500 mg serving is focused and practical, though ordinary oral GABA has inconsistent real-world effects.
How scoring works
Quantity:100 Capsule(s) • (100 servings)
Goals:
Mood Support
Sleep Support
Stress Relief

Score 83

The clearly disclosed 500 mg serving is focused and practical, though ordinary oral GABA has inconsistent real-world effects.
How scoring works

Also available as

1 option
200 servings GABA 500 mg • 200 Capsule(s) • 200 servings $15.07 ($0.07 per serving)
$8.70($0.08 per serving)
Walmart
$ 11.88
iHerb
$ 9.17
Pure Formulas
$ 8.92
Vitacost
$ 9.79
Daily Vita
$ 8.70
Amazon
$ 9.17
iHerb
$ 9.17
Report prices

Analysis

500 mg sits within a practical standalone range for a product aimed at relaxation, stress, or sleep support. Oral GABA targets an inhibitory pathway, but its ability to reach the brain reliably remains uncertain.

Vegetable capsule delivery is simple and provides a fixed serving. A small vitamin B6 amount adds a relevant neurotransmitter cofactor without distracting from the main active.

Very low serving cost and a generous supply support economical regular use. The formula is better suited to situational calming than to broad mood support or circadian sleep timing.

Who is it for
  • Adults seeking a simple calming supplement
  • Users who prefer vegetable capsule delivery
Best for
  • Situational relaxation support
  • A focused single-pathway formula

Pros

  • Clearly disclosed 500 mg amount
  • Includes a small vitamin B6 cofactor
  • One-hundred-serving supply

Cons

  • Ordinary oral GABA has uncertain brain delivery
  • No branded fermented source
  • Does not address circadian timing

Warnings

  • GABA may cause drowsiness; do not drive or operate machinery until its effects are known.
  • Alcohol, sleep medicines, sedating antihistamines, and other sedatives may intensify impaired alertness.
  • GABA may lower blood pressure in some users; monitor for dizziness when using blood-pressure medicine.

Nutrient quality

81 Highest impact

Conventional oral delivery does not overcome the main uncertainty about how much ordinary GABA reaches the brain. well-centered falls within a practical standalone range.

Ingredient transparency

81 Highest impact

GABA and its supporting nutrient have individual amounts. Excipients and daily directions are absent from the supplied data, which leaves some label details uncertain.

Customer satisfaction

71 High impact

The aggregate satisfaction average is strong, though no detailed feedback is supplied. The large volume provides a stable aggregate satisfaction signal.

Value for money

99 Highest impact

A clear, practical amount supports good formula value despite generic sourcing. The serving cost is exceptionally low for the GABA amount.

Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
C Goal FitA- Strength of SupportB- CoverageA+ Formula Quality
Vitamin B6 · 2 mg

GABA at 500 mg may promote relaxation, but oral GABA has uncertain access to the brain and human mood evidence is limited. Vitamin B6 supports neurotransmitter metabolism but the pyridoxine amount is only nutritional.

Both active amounts are clearly disclosed in a focused formula. GABA may cause drowsiness, and its calming effect can add to alcohol, sedatives, or other medicines that impair alertness.

Study evidence
GABA Supportive 12 studies
Vitamin B6 Supportive 19 studies
Sleep Support
Sleep Support
Impact
High effect
C Goal FitA- Strength of SupportC CoverageA Formula Quality

The vegetable capsule provides a practical standalone relaxation dose. It provides 500 mg of clearly disclosed GABA with a small vitamin B6 amount for a defined sleep-related pathway.

Oral GABA has uncertain access to the brain, so sleep-specific effects remain less predictable. Its simple formula leaves efficacy, rather than dose clarity, as the main uncertainty.

Study evidence
GABA Supportive 4 studies
Vitamin B6 Disputed 7 studies
Stress Relief
Stress Relief
Impact
High effect
C Goal FitA Strength of SupportC- CoverageA Formula Quality
GABA · 500 mgVitamin B6 · 2 mg

A 500 mg GABA serving directly targets inhibitory signaling and may promote relaxation for some users. Human evidence is mixed because supplemental GABA does not reliably reach the brain in large amounts.

The dose is clearly disclosed and vitamin B6 provides a small cofactor role without unnecessary complexity. The formula is focused, but it does not include magnesium, an adaptogen, or a second well-supported pathway.

Study evidence
GABA Supportive 6 studies
Vitamin B6 Supportive 10 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 2 mg
GABA
500 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
GABA · 500 mg OverallScore87
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

The 500 mg dose sits in the preferred range for standalone GABA and is clearly disclosed. A vegetable capsule provides practical delivery, although the GABA source is not identified as a branded fermented form. Cost efficiency is especially strong, while the incomplete excipient details leave some purity uncertainty.

View ingredientView products
Loading alternative details
85 Performance

Pharma GABA 250 mg

Natural Factors Stress-Relax
<p>A meaningful amount of fermented branded GABA provides well-defined, focused relaxation support. Compared with the original, the fermented branded source provides clearer source definition; the defined source improves quality confidence, although individual response to oral GABA may still vary.</p>
79 Performance

PharmaGABA Chewables

Designs for Health
<p>Branded fermented GABA and a well-targeted amount provide focused relaxation support. Compared with the original, the fermented branded source provides clearer source definition; the defined source improves quality confidence, although individual response to oral GABA may still vary.</p>
77 Performance

Liposomal GABA

Quicksilver Scientific
<p>Liposomal delivery plus L-theanine creates a technically strong and coherent calming formula. Compared with the original, liposomal delivery and L-theanine provide a broader calming design; the supplied feedback and high serving cost still weaken value confidence.</p>
86 Budget

GABA

NOW
<p>A substantial GABA amount in flexible liquid form provides highly economical relaxation support. The lower serving cost improves value compared with the original; its comparable disclosed amount preserves the same basic intensity, while ordinary oral GABA still has uncertain brain availability.</p>
81 Budget

GABA 750 mg

Source Naturals Serene Science
<p>A clearly disclosed upper-range GABA amount provides focused calming support in a simple formula, but ordinary oral GABA has uncertain access to the brain and human effects vary. The lower serving cost improves value compared with the original; its higher amount may increase drowsiness, while ordinary oral GABA still has uncertain brain availability.</p>
83 Budget

GABA 500 mg

Nutricost
<p>A clearly disclosed well-centered GABA amount provides focused calming support in a simple formula, but ordinary oral GABA has uncertain access to the brain and human effects vary. The lower serving cost improves value compared with the original; its comparable disclosed amount preserves the same basic intensity, while ordinary oral GABA still has uncertain brain availability.</p>
89 Value

GABA Powder

Source Naturals Serene Science
<p>The combination of a flexible 750 mg GABA serving and an economical serving creates better practical value than the original. The larger amount may cause drowsiness, especially alongside alcohol or other sedating products.</p>
88 Value

GABA 500 mg

Swanson
<p>The combination of clearly disclosed 500 mg GABA and an economical serving creates better practical value than the original. Ordinary oral GABA has uncertain access to the brain, so individual effects may vary.</p>
87 Value

GABA 750 mg

NOW
<p>The combination of clearly disclosed 750 mg GABA and an economical serving creates better practical value than the original. The larger amount may cause drowsiness, especially alongside alcohol or other sedating products.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  2. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  3. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  4. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsStress Relief Sleep Support forGABA
  5. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  6. The impact of matching for reproductive status on the comparison of magnetic spectroscopic measurements of glutamate and gamma-aminobutyric acid + in the medial prefrontal cortex of women with major depression.
    Tran KH; Luki J; Hanstock S; Hanstock CC; Seres P; Aitchison K; Shandro T; Le Melledo JM · Journal of affective disorders · 2024
    Case-control study48 participantsMood Support forGABA
  7. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  8. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  9. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  10. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  11. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  12. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  13. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  14. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  15. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  16. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  17. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  18. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  19. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  20. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  21. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  22. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  23. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA
  24. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forVitamin B6
  25. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  26. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  27. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6