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Vitamin K2 100 mcg

4.8
★ ★ ★ ★ ★
(197 ratings)
Vitamin K 100 mcg
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Score83
A strong-value MK-7 and D3 pairing for everyday calcium handling, with clear doses but no lipid carrier or premium K2 sourcing.
How scoring works
Capsule
Quantity:90 Capsule(s) • (90 servings)
Goals:
Heart Health
General Health
Bone Health
Anti-Aging
Cardiovascular Support

Score 83

A strong-value MK-7 and D3 pairing for everyday calcium handling, with clear doses but no lipid carrier or premium K2 sourcing.
How scoring works
$26.99($0.29 per serving)
iHerb
$ 26.99
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Analysis

MK-7 supports vitamin K-dependent proteins that guide calcium use, while vitamin D3 supports calcium absorption. Both forms and practical maintenance amounts are clearly disclosed.

The pairing is strong for bone and vascular foundations without unnecessary extras. A dry capsule lacks a stated lipid carrier, and the MK-7 source is not identified as branded or all-trans.

The product fits adults seeking a simple D3 and K2 maintenance formula. It remains focused on calcium regulation and does not cover structural minerals, lipids, or cardiac-energy pathways.

Who is it for
  • Adults wanting combined D3 and K2
  • Value-focused bone-support users
  • People seeking a compact maintenance formula
Best for
  • Calcium metabolism
  • Bone-support cofactors
  • Vascular calcium handling

Pros

  • Practical MK-7 amount
  • Vitamin D3 is a logical companion
  • Strong value per serving

Cons

  • Dry capsule has no lipid carrier
  • No branded or all-trans MK-7 claim
  • No calcium or magnesium

Warnings

  • MK-7 can oppose warfarin and related vitamin K antagonist medicines
  • Take with a meal containing fat unless the label says otherwise
  • Account for vitamin D from other supplements to avoid unnecessary duplication

Nutrient quality

94 Highest impact

Menaquinone-7 and cholecalciferol are well-regarded forms, and vitamin K2 is meaningful, while vitamin D3 provides moderate maintenance support. Neither amount appears unnecessarily aggressive, while the focused two-active formula avoids low-value extras.

Ingredient transparency

84 Highest impact

Specific amounts are listed for every supplied active ingredient. No proprietary blend hides active doses, while capsule, softgel, or tablet excipients are not included in the supplied details.

Customer satisfaction

68 High impact

The supplied aggregate satisfaction metric is very strong, and the feedback volume offers some support but is less robust than heavily reviewed alternatives. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money

84 Highest impact

Strong forms and a focused pairing support good value. Each capsule provides useful bone-support nutrients at a moderate cost, while the formula avoids unnecessary extras.

Report analysis

Goals

Heart Health
Impact
Highest effect
A Goal FitA+ Strength of SupportB CoverageA+ Formula Quality
Vitamin K · 100 mcgVitamin D · 10 mcg

MK-7 vitamin K2 at 100 mcg directly supports proteins that guide calcium away from arteries, while vitamin D3 complements calcium handling. Both amounts are clear and the one-capsule design is focused.

The formula does not address lipids, nitric oxide, or cardiac energy, but it provides good depth in its selected pathway. Vitamin K2 can oppose warfarin-type anticoagulants and requires prescriber guidance for users of those medicines.

Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
General Health
Impact
Highest effect
A- Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Vitamin D · 10 mcgVitamin K · 100 mcg

Vitamin K2 and vitamin D3 form a focused pair for calcium handling and skeletal maintenance. Both nutrients are relevant to long-term health, although the formula does not cover many other foundational needs.

MK-7 and cholecalciferol are named directly and supplied at useful maintenance amounts. Vitamin K2 can oppose warfarin-type anticoagulants, so people using those medicines need clinician-guided intake.

Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Bone Health
Impact
Highest effect
A- Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 100 mcgVitamin D · 10 mcg

MK-7 activates proteins involved in binding calcium to bone, while vitamin D3 supports calcium absorption. Both forms are clearly identified and supplied at practical daily amounts.

The focused combination does not provide calcium, magnesium, or protein-matrix material, so it works mainly as a regulatory complement. MK-7 can interfere with warfarin and other vitamin K antagonist medicines, making consistent clinician-guided use important for people taking them.

Study evidence
Vitamin K Supportive 78 studies
Anti-Aging
Impact
Highest effect
B+ Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 100 mcgVitamin D · 10 mcg

Vitamin K2 as MK-7 supports bone mineral placement and vitamin K-dependent proteins involved in vascular flexibility. That calcium-management pathway is relevant to healthy aging, though clinical longevity outcomes are less established than the mechanism.

Vitamin D3 complements K2 by supporting calcium absorption and creates a compact bone-and-vascular pairing. Vitamin K can counteract warfarin and other vitamin K antagonist medicines, so users of those drugs need clinician-guided intake.

Study evidence
Vitamin K Supportive 27 studies
Cardiovascular Support
Impact
Highest effect
A- Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Vitamin K · 100 mcgVitamin D · 10 mcg

The clearly disclosed MK-7 amount directly supports calcium management, and vitamin D3 is a logical partner in the formula. Its focused design is well aligned with vascular integrity, although it does not address lipids, blood flow, or heart-rhythm support.

The dose is well targeted and the active forms are easy to assess, but no lipid carrier, branded source, or all-trans purity assurance is provided. Vitamin K2 can interfere with warfarin-type anticoagulants, so users of those medicines need prescriber guidance before starting or changing the dose.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin D3 (Cholecalciferol)
10 mcg
Vitamin K2 (Menaquinone-7)
100 mcg
Gluten Free Adults 18–50 Dairy Free
Report overview
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

A clearly stated MK-7 amount lands in the preferred daily range and is paired with vitamin D3. The dry capsule lacks stated fat-based delivery support, and the MK-7 source is not branded or guaranteed all-trans. Its low cost per serving makes the focused combination a strong value.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsHeart Health Cardiovascular Support forVitamin K
  2. Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials.
    Vlasschaert C; Goss CJ; Pilkey NG; McKeown S; Holden RM · Nutrients · 2021
    Systematic review9 studies pooledHeart Health forVitamin K
  3. Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.
    Witham MD; Lees JS; White M; Band M; Bell S; Chantler DJ; Ford I; Fulton RL; Kennedy G; Littleford RC; McCrea IV; McGlynn D; Panarelli M; Ralston MR; Rutherford E; Severn A; Thomson N; Traynor JP; Struthers AD; Wetherall K; Mark PB · Journal of the American Society of Nephrology : JASN · 2021
    Randomized trial159 participantsHeart Health forVitamin K
  4. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  5. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  6. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  7. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  8. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  9. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  10. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  11. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  12. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  13. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  14. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  15. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  16. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  17. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  18. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  19. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  20. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  21. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  22. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  23. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  24. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  25. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  26. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  27. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  28. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  29. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  30. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  31. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  32. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  33. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forVitamin D
  34. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K