BioCoenzymated Pyridoxal 5'-Phosphate 50 mg
Natural Factors
BioCoenzymated Pyridoxal 5'-Phosphate 50 mg
4.9
★ ★ ★ ★ ★
(7066 ratings)
Vitamin B6 50 mg
Score 90.0
Natural Factors BioCoenzymated P5P provides the highly bioavailable, active form of Vitamin B6 at an effective 50mg dose, making it excellent for energy, brain, and mood support, backed by strong consumer feedback.
Quantity: 30 Capsule(s)Servings size: 1 Vegetarian Capsule(s) (30 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
General Health
leaderboard Score 90.0
Natural Factors BioCoenzymated P5P provides the highly bioavailable, active form of Vitamin B6 at an effective 50mg dose, making it excellent for energy, brain, and mood support, backed by strong consumer feedback.
insights Analysis
Natural Factors BioCoenzymated Pyridoxal 5'-Phosphate (P5P) offers the active, coenzymated form of Vitamin B6, which is directly usable by the body without requiring liver conversion. This is particularly advantageous for individuals with genetic variations or liver conditions that might impair B6 metabolism, ensuring optimal absorption and utilization. The 50mg dosage is effective for addressing common deficiencies and supporting roles in energy, brain, and mood. With a high volume of positive reviews, it stands as a trusted option, despite being priced higher than standard Pyridoxine HCl supplements.
- Utilizes the active and highly bioavailable Pyridoxal 5'-Phosphate (P5P) form of B6.
- 50mg dosage is potent for therapeutic use and addressing deficiencies.
- High review count indicates strong consumer satisfaction and product reliability.
- Higher price per serving compared to common Pyridoxine HCl alternatives.
- May be a higher dose than necessary for general daily maintenance for some users.
$6.97($0.23 per serving)
 iHerb | $ 6.97 |
bolt Effectiveness for goals
Yes, Vitamin B6 is a widely recognized and often recommended treatment for nausea and vomiting in pregnancy, commonly known as morning sickness. It is considered a first-line pharmacological therapy for mild to moderate symptoms. Pregnant individuals should consult their healthcare provider before taking any supplements.
Vitamin B6, or pyridoxine, is crucial for over 100 enzyme reactions, primarily involved in protein metabolism, red blood cell formation, and nervous system health. It plays a key role in metabolic processes that convert food into energy. Maintaining adequate B6 levels supports overall health and proper bodily functions.
Absolutely, Vitamin B6 is vital for brain development and function, and for maintaining a healthy nervous system. It is involved in the synthesis of several key neurotransmitters, such as serotonin, dopamine, and GABA, which regulate mood, sleep, and cognitive processes. Adequate B6 intake is essential for proper nerve signaling.
Some studies suggest that Vitamin B6 supplementation may help reduce certain PMS symptoms, particularly mood swings, irritability, and breast tenderness. The exact mechanism is not fully understood, but it may involve its role in neurotransmitter synthesis. However, evidence is mixed, and more robust research is needed.
Vitamin B6 is involved in the production of neurotransmitters like serotonin and norepinephrine, which are critical for mood regulation. Some research indicates that B6 supplementation may positively influence mood and reduce symptoms of depression, particularly in individuals with a deficiency. However, it should not replace prescribed treatments for mental health conditions.
schedule Dosage, timing & forms
The Recommended Dietary Allowance (RDA) for adult men and women (19-50 years) is 1.3 mg per day. For those over 50, it is 1.7 mg for men and 1.5 mg for women. These recommendations are for healthy individuals.
Yes, taking excessively high doses of Vitamin B6, particularly from supplements, can be harmful. The most well-known adverse effect is sensory neuropathy, which can cause numbness and tingling in the extremities. This risk increases with doses significantly above the Tolerable Upper Intake Level (UL) of 100 mg/day.
The Tolerable Upper Intake Level (UL) for Vitamin B6 in adults is 100 mg per day. Consuming amounts significantly above this UL, particularly from supplements, can lead to adverse effects like peripheral neuropathy. It is advisable not to exceed this limit without professional guidance.
There is no specific "best" time to take Vitamin B6; it can be taken at any time of day. Consistency in taking the supplement is generally more important than the exact timing. Some individuals may prefer to take it with a meal to avoid potential stomach upset.
Vitamin B6 supplements commonly contain pyridoxine hydrochloride (pyridoxine HCl). The active coenzyme form, pyridoxal 5'-phosphate (P5P), is also available in some supplements. Other forms like pyridoxal and pyridoxamine also exist in food.
health_and_safety Safety & interactions
Long-term intake of high doses, typically exceeding 200 mg per day, can lead to sensory peripheral neuropathy, characterized by numbness, tingling, and pain in the extremities. Other less common side effects might include skin lesions, photosensitivity, and gastrointestinal issues. These effects usually resolve after discontinuing supplementation.
For adults, the tolerable upper intake level (UL) for Vitamin B6 is set at 100 mg per day from supplements and fortified foods. Consuming amounts above this UL regularly increases the risk of adverse effects, primarily neurological damage. This limit is established to prevent potential harm.
The primary and most concerning symptom of Vitamin B6 toxicity, typically from chronic high doses, is sensory peripheral neuropathy. This involves symptoms like numbness, tingling, and burning pain, often starting in the hands and feet. Other less common signs might include skin lesions or gastrointestinal upset.
Yes, Vitamin B6 can interact with several medications. For instance, it may reduce the effectiveness of levodopa (used for Parkinson's disease) and can interact with anti-seizure medications like phenytoin and phenobarbital. It is important to consult a healthcare provider when combining Vitamin B6 supplements with prescription drugs.
Vitamin B6 is generally considered safe during pregnancy and breastfeeding when taken within recommended dietary allowances. Higher doses might be used under medical supervision for specific conditions like severe morning sickness. Always discuss any supplementation with a healthcare provider to ensure appropriate dosing.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B6 | 50 mg |
Categories
Vitamin B6 95.0
This product stands out within the Vitamin B6 collection due to its use of the superior Pyridoxal 5'-Phosphate (P5P) form, which offers enhanced bioavailability and direct biological activity compared to standard pyridoxine HCl, making it a premium choice for B6 supplementation.
Goals
Energy 95.0
P5P is crucial for metabolic pathways involved in energy production, including converting food into usable energy. Its active form ensures efficient utilization, directly supporting cellular energy levels.
Brain Health 95.0
Vitamin B6, particularly in its active P5P form, is essential for neurotransmitter synthesis (like serotonin, dopamine, GABA) which are vital for cognitive function, memory, and nerve signaling. Its direct bioavailability supports optimal brain chemistry.
Mood Support 95.0
P5P plays a key role in the production of mood-regulating neurotransmitters such as serotonin and norepinephrine. Supplying it in an active form can directly aid in balancing these chemicals, contributing to improved mood and reduced symptoms of depression or anxiety.
Recommended Alternatives
92 Value 
Vitamin B-6 50 mg
Nature's Way
4.8
★★★★★
(1720 ratings)
Provides the same active Pyridoxal 5'-Phosphate (P5P) form at an equivalent 50mg dose, but at a significantly lower price per serving (6 cents vs 23 cents), offering superior value for the active form.
89 Value 
B-6 100 mg
Source Naturals
4.7
★★★★★
(819 ratings)
Offers a potent 100mg dose of Pyridoxine HCl at an extremely low price per serving (5 cents), providing excellent value for those seeking a higher dose of B6 without the premium cost of P5P.
87 Value 
Vitamin B6 100 mg
Natural Factors
4.8
★★★★★
(2404 ratings)
From the same brand, this alternative offers a higher 100mg dose of Pyridoxine HCl for 8 cents per serving, representing good value for a trusted brand's higher potency B6.
88 Performance 
P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength
Swanson
4.8
★★★★★
(1062 ratings)
Offers Pyridoxal 5'-Phosphate (P5P), the same active form of B6, at a slightly lower but still effective 40mg dose, making it a comparable quality alternative for direct absorption.
87 Performance 
B-Complex '100'
Solgar
4.7
★★★★★
(446 ratings)
While its B6 is Pyridoxine HCl, this is a comprehensive B-complex from a highly reputable brand, providing broader synergistic B vitamin support that can be 'better' for holistic B vitamin needs.
86 Performance 
B-100
NOW
4.8
★★★★★
(9362 ratings)
Another highly-rated, comprehensive B-complex from a trusted brand, offering a full spectrum of B vitamins, including 100mg of B6, for more holistic nutritional support than a single B6 product.
85 Budget 
Vitamin B6 50 mg
Solgar
4.7
★★★★★
(2822 ratings)
Offers 50mg of B6 (HCl form) from a reputable brand at a significantly lower price per serving (7 cents vs 23 cents), providing a cost-effective option for basic B6 needs.
90 Budget 
B-6 100 mg
NOW
4.8
★★★★★
(6041 ratings)
Provides a higher 100mg dose of B6 (HCl form) at an exceptionally low price per serving (4 cents), making it one of the most budget-friendly choices for potent B6 supplementation.
88 Budget 
B-6 100 mg
21st Century
4.7
★★★★★
(5959 ratings)
An incredibly affordable option, offering 100mg of B6 (HCl form) for just 4 cents per serving, representing significant savings for those on a tight budget.
92 Value
Vitamin B-6 50 mg
Nature's Way
4.8
★★★★★
(1720 ratings)
Provides the same active Pyridoxal 5'-Phosphate (P5P) form at an equivalent 50mg dose, but at a significantly lower price per serving (6 cents vs 23 cents), offering superior value for the active form.
89 Value
B-6 100 mg
Source Naturals
4.7
★★★★★
(819 ratings)
Offers a potent 100mg dose of Pyridoxine HCl at an extremely low price per serving (5 cents), providing excellent value for those seeking a higher dose of B6 without the premium cost of P5P.
87 Value
Vitamin B6 100 mg
Natural Factors
4.8
★★★★★
(2404 ratings)
From the same brand, this alternative offers a higher 100mg dose of Pyridoxine HCl for 8 cents per serving, representing good value for a trusted brand's higher potency B6.
88 Performance
P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength
Swanson
4.8
★★★★★
(1062 ratings)
Offers Pyridoxal 5'-Phosphate (P5P), the same active form of B6, at a slightly lower but still effective 40mg dose, making it a comparable quality alternative for direct absorption.
87 Performance
B-Complex '100'
Solgar
4.7
★★★★★
(446 ratings)
While its B6 is Pyridoxine HCl, this is a comprehensive B-complex from a highly reputable brand, providing broader synergistic B vitamin support that can be 'better' for holistic B vitamin needs.
86 Performance
B-100
NOW
4.8
★★★★★
(9362 ratings)
Another highly-rated, comprehensive B-complex from a trusted brand, offering a full spectrum of B vitamins, including 100mg of B6, for more holistic nutritional support than a single B6 product.