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NeuroCalm

Designs for Health
4.8
★ ★ ★ ★ ★
(52 ratings)
Theanine 100 mg
GABA 100 mg
Taurine 300 mg
5-HTP 50 mg
Product Image
Score71
A premium, multi-pathway calming blend supports stress and sleep routines. Modest secondary doses, high cost, and serotonergic interaction risk are the key trade-offs.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Mood Support
Sleep Support
Brain Health
Stress Relief
Cognitive Support

Score 71

A premium, multi-pathway calming blend supports stress and sleep routines. Modest secondary doses, high cost, and serotonergic interaction risk are the key trade-offs.
How scoring works
$64.99($2.16 per serving)
Pure Formulas
$ 64.99
iHerb
$ 64.99
Report prices

Analysis

PharmaGABA and L-theanine each provide 100 mg, complemented by inositol, taurine, chamomile, magnesium, and 5-HTP. Active B6, methylcobalamin, and branded phosphatidylserine improve form quality.

The formula is well suited to relaxation and calm focus, but magnesium, phosphatidylserine, taurine, and 5-HTP are conservative amounts. It offers broader pathway coverage than a simple GABA product without reaching full standalone doses for every ingredient.

Two capsules are convenient, though the serving cost is high. The calming stack can cause drowsiness, and the 5-HTP component requires careful medication screening.

Who is it for
  • Adults seeking a broad calming formula
  • People who value branded GABA and phosphatidylserine
  • Users wanting theanine with active B vitamins
Best for
  • Stress relief
  • Nighttime relaxation
  • Calm-focus support

Pros

  • Uses PharmaGABA
  • Provides 100 mg L-theanine
  • Includes active B6 and methylcobalamin
  • Adds magnesium glycinate and Sharp PS

Cons

  • High serving cost
  • Magnesium amount is modest
  • Phosphatidylserine is lightly dosed
  • More relaxing than productivity focused

Warnings

  • Do not combine 5-HTP with serotonergic medicines such as SSRIs, SNRIs, MAO inhibitors, or tramadol
  • The combined calming ingredients may cause drowsiness
  • Chamomile may trigger reactions in people sensitive to ragweed-family plants
  • The high B12 amount may not be needed by everyone

Nutrient quality

83 Highest impact

PharmaGABA, methylcobalamin, pyridoxal phosphate, glycinate magnesium, and named chamomile markers support form quality. Theanine, GABA, inositol, taurine, and chamomile are useful blend doses, while magnesium and phosphatidylserine are modest.

.

Ingredient transparency

82 Highest impact

Active amounts are stated and no proprietary blend hides a core dose. Missing excipient details and complete use directions leave the supplied label information incomplete.

.

Customer satisfaction

62 Moderate impact

The supplied aggregate satisfaction average provides a broad signal, while the response volume determines how stable it appears. No comment-level evidence is available to assess repeated complaints or confirm intended-use experiences.

.

Value for money

48 Lower impact

Quality, safety trade-offs, or serving economics materially weaken value. Each listed active has a plausible role in the broad calming design.

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Report analysis

Goals

Mood Support
Mood Support
Impact
Highest effect
B+ Goal FitB+ Strength of SupportA- CoverageA- Formula Quality
Vitamin B6 · 2.5 mgVitamin B12 · 1000 mcgMagnesium · 75 mg5-HTP · 50 mg

5-HTP, theanine, branded GABA, P5P, magnesium, and phosphatidylserine address neurotransmitter, stress, and structural pathways. The combination is well aligned with calm mood support, though several ingredients sit at conservative amounts.

Theanine and PharmaGABA reach useful doses, while 5-HTP is a starting amount and magnesium is modest. 5-HTP can interact with antidepressants, tramadol, and other serotonergic medicines by increasing serotonin exposure.

Study evidence
5-HTP Supportive 9 studies
GABA Supportive 12 studies
Magnesium Supportive 60 studies
Theanine Supportive 12 studies
Sleep Support
Sleep Support
Impact
Highest effect
B+ Goal FitB+ Strength of SupportA- CoverageB+ Formula Quality
Magnesium · 75 mgTheanine · 100 mg

PharmaGABA, L-theanine, chamomile, taurine, inositol, and 5-HTP create broad nervous-system and serotonin-related support. Active vitamin B6 and magnesium glycinate strengthen form quality.

Magnesium is below a typical focused amount, and 5-HTP is only a starting dose. The 5-HTP component should not be combined with serotonergic medicines because excess serotonin can cause a serious reaction.

Study evidence
5-HTP Supportive 1 study
GABA Supportive 4 studies
Magnesium Supportive 23 studies
Taurine Not classified

No linked studies yet.

Theanine Supportive 8 studies
Vitamin B6 Disputed 7 studies
Brain Health
Brain Health
Impact
Highest effect
B Goal FitB+ Strength of SupportB+ CoverageA- Formula Quality
Vitamin B12 · 1000 mcgVitamin B6 · 2.5 mgMagnesium · 75 mg

Theanine, PharmaGABA, phosphatidylserine, active B vitamins, magnesium, and calming botanicals support mental resilience and relaxation. Several branded or active forms strengthen ingredient quality and disclosure.

Phosphatidylserine and magnesium are modest, while the formula focuses more on calming than memory or cognitive speed. The 5-HTP can interact with serotonergic medicines such as SSRIs or MAO inhibitors, and the combined calming ingredients may cause drowsiness.

Study evidence
Magnesium Supportive 86 studies
Theanine Supportive 17 studies
Stress Relief
Stress Relief
Impact
High effect
A- Goal FitB- Strength of SupportB+ CoverageB Formula Quality
Magnesium · 75 mgVitamin B12 · 1000 mcgGABA · 100 mgVitamin B6 · 2.5 mgTheanine · 100 mg

PharmaGABA, theanine, chamomile, magnesium, taurine, phosphatidylserine, and 5-HTP address several relaxation pathways. Branded GABA and phosphatidylserine plus active B vitamins improve form quality.

Magnesium, taurine, and phosphatidylserine are modest, so pathway breadth is greater than dose depth. The 5-HTP should not be combined with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines because excess serotonin can cause a serious reaction.

Study evidence
5-HTP Supportive 18 studies
GABA Supportive 6 studies
Magnesium Supportive 13 studies
Taurine Supportive 5 studies
Theanine Supportive 16 studies
Cognitive Support
Cognitive Support
Impact
High effect
C Goal FitB- Strength of SupportC CoverageB+ Formula Quality
Vitamin B6 · 2.5 mgVitamin B12 · 1000 mcgMagnesium · 75 mgTheanine · 100 mg

L-theanine, phosphatidylserine, taurine, and magnesium may support calm cognitive function. Theanine and phosphatidylserine have relevant evidence, while GABA and 5-HTP are more closely linked to relaxation.

Theanine and several calming actives are meaningfully dosed, but phosphatidylserine is modest. Calm attention, neural membranes, and relaxation are represented without alertness or circulation support.

Study evidence
Magnesium Supportive 24 studies
Theanine Supportive 25 studies
Mental Focus
Mental Focus
Impact
Moderate effect
C- Goal FitB- Strength of SupportC CoverageC Formula Quality
Vitamin B6 · 2.5 mgVitamin B12 · 1000 mcgMagnesium · 75 mgTheanine · 100 mg

L-theanine and phosphatidylserine may support calm attention, while taurine, GABA, inositol, and 5-HTP emphasize relaxation. The formula may suit focus disrupted by tension but is unlikely to improve alertness broadly.

Amounts are transparent and several forms are well identified, including PharmaGABA and Sharp PS. 5-HTP should not be combined with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines because excessive serotonin can cause a serious reaction.

Study evidence
Theanine Supportive 19 studies

Ingredients

IngredientAmount per serving
Vitamin B-6 (Pyridoxal 5-Phosphate)
 2.5 mg
Vitamin B12 (Methylcobalamin)
 1000 mcg
Magnesium (TRAACS Magnesium Glycinate Chelate buffered)
 75 mg
Inositol
400 mg
Taurine
300 mg
German Chamomile (Apigenin)
 200 mg
gamma-Aminobutyric acid (PharmaGABA(TM))
 100 mg
L-Theanine
100 mg
5-HTP
50 mg
Phosphatidylserine (Sharp PS(R) Green)
 50 mg
Gluten Free Adults 18–50
Report overview
Theanine · 100 mg OverallScore82
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

A clearly disclosed 100 mg L-theanine dose falls within the preferred range for relaxation and focus support. The active L-isomer is named, but no branded source or added purity evidence is given. Cost is high for the theanine amount, while meaningful 5-HTP and branded GABA doses add value to the wider formula.

View ingredientView products
GABA (PharmaGABA(TM)) · 100 mg OverallScore78
A Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD- Value

Branded PharmaGABA gives the formula a well-defined premium source at a clearly disclosed 100 mg serving. Standard capsules deliver a broad calming blend with theanine, chamomile, magnesium, taurine, and other supporting compounds. The serving carries a steep cost, while 5-HTP deserves caution for people using serotonergic medicines.

View ingredientView products
Taurine · 300 mg OverallScore44
C- Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value

The formula uses a modest taurine dose as one part of a broader calming blend. Generic taurine lacks free-form, purity-grade, source, and testing details, while the amount is stated only for two capsules. The included 5-HTP should not be combined with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines because excess serotonin can cause a serious reaction.

View ingredientView products
Loading alternative details
78 Performance

Serenelle

Quality Of Life
<p>Sensoril ashwagandha, 200 mg of theanine, PharmaGABA, and lemon balm provide focused stress support, giving it a stronger fit for sleep and stress support. The serving is not among the least expensive options.</p>
83 Performance

GABA Soothe

Jarrow Formulas
<p>Sensoril ashwagandha, theanine, and GABA create a concise calming blend at useful amounts, giving it a stronger fit for sleep and stress support. Combined calming ingredients may add to alcohol, sleep aids, or other sedating medicines.</p>
82 Performance

Tranquil Sleep

Natural Factors Stress-Relax
<p>Branded Suntheanine, physiological melatonin, and a modest Griffonia-derived 5-HTP amount form a defined bedtime blend, giving it a stronger fit for sleep and stress support. The 5-HTP can interact with serotonin-raising medicines.</p>
87 Budget

Sleep Regimen 3-in-1

NOW
<p>Theanine, melatonin, and Griffonia-derived 5-HTP create a concise sleep formula while lowering the recurring cost. The 5-HTP extract lacks standardization and can interact with serotonin-raising medicines.</p>
82 Budget

Theanine Serene

Source Naturals Serene Science
<p>Magnesium, 500 mg of GABA, 450 mg of taurine, 200 mg of theanine, and holy basil provide focused stress support while lowering the recurring cost. The exact chelate and holy-basil standardization are not disclosed.</p>
83 Budget

ZenMind

NutriCology
<p>Two hundred milligrams of branded theanine plus 550 mg of GABA create a focused relaxation formula while lowering the recurring cost. Oral GABA has uncertain brain availability, and the combination may add to sedating medicines or alcohol.</p>
79 Value

Superior Sleep

Doctor's Best
<p>Sensoril ashwagandha, theanine, GABA, melatonin, and 5-HTP provide substantial sleep coverage, creating a useful quality-to-cost trade-off for sleep and stress support. Five milligrams of melatonin may cause grogginess, and 5-HTP can interact with serotonin-raising medicines.</p>
82 Value

Theanine Serene

Source Naturals
<p>Magnesium, 500 mg of GABA, 450 mg of taurine, 200 mg of theanine, and holy basil provide broad calming support, creating a useful quality-to-cost trade-off for sleep and stress support. The exact magnesium chelate and botanical standardization are not disclosed.</p>
79 Value

Relax Magnesium Powder Berry

youtheory
<p>Magnesium citrate with 100 mg each of theanine and GABA provides concise physical relaxation support, creating a useful quality-to-cost trade-off for sleep and stress support. Magnesium citrate may loosen stools, and serving guidance is incomplete.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  2. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsStress Relief Sleep Support forGABA
  3. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA Mood Support Stress Relief forTheanine
  4. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  5. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsStress Relief Mental Focus forTheanine
  6. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsStress Relief Sleep Support forTheanine
  7. Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
    Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
    Randomized trial120 participantsStress Relief forTheanine
  8. Correlations between dietary taurine intake and life stress in Korean college students.
    Sung MJ; Chang KJ · Advances in experimental medicine and biology · 2009
    Observational studyStress Relief forTaurine
  9. Profiling inflammatory and oxidative stress biomarkers following taurine supplementation: a systematic review and dose-response meta-analysis of controlled trials.
    Faghfouri AH; Seyyed Shoura SM; Fathollahi P; Shadbad MA; Papi S; Ostadrahimi A; Faghfuri E · European journal of clinical nutrition · 2022
    Meta-analysisStress Relief forTaurine
  10. Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial.
    Moludi J; Qaisar SA; Kadhim MM; Ahmadi Y; Davari M · Nutrition & metabolism · 2022
    Randomized trial120 participantsStress Relief forTaurine
  11. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledMental Focus Brain Health Cognitive Support forTheanine
  12. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsMental Focus Cognitive Support forTheanine
  13. Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
    Mátyus RO; Szikora Z; Bodó D; Vargáné Szabó B; Csupor É; Csupor D; Tóth B · Journal of clinical medicine · 2025
    Meta-analysis148 participants5 studies pooledMental Focus forTheanine
  14. A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood.
    Dodd FL; Kennedy DO; Riby LM; Haskell-Ramsay CF · Psychopharmacology · 2016
    Randomized trial24 participantsMental Focus forTheanine
  15. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  16. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  17. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  18. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  19. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  20. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  21. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  22. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  23. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus forTheanine
  24. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.
    Doyle LW; Crowther CA; Middleton P; Marret S; Rouse D · The Cochrane database of systematic reviews · 2009
    Meta-analysis6,145 participants5 studies pooledCognitive Support forMagnesium
  25. Effects of magnesium valproate adjuvant therapy on patients with dementia: A systematic review and meta-analysis.
    Zhang C; Sun L; Sun H · Medicine · 2022
    Meta-analysis1,899 participants22 studies pooledCognitive Support forMagnesium
  26. Effects of magnesium supplementation on serum brain-derived neurotrophic factor levels and cognitive function in patients undergoing fluoxetine therapy for depression.
    Noor NJ; Syamsuddin S; Liaury K; Tawali S; Idris I; Azis I; Lisal ST · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsCognitive Support forMagnesium
  27. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsCognitive Support forMagnesium
  28. Could intraoperative magnesium sulphate protect against postoperative cognitive dysfunction?
    Hassan WF; Tawfik MH; Nabil TM; Abd Elkareem RM · Minerva anestesiologica · 2021
    Randomized trial80 participantsCognitive Support forMagnesium
  29. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  30. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  31. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  32. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  33. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  34. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  35. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  36. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  37. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  38. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  39. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  40. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  41. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  42. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  43. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  44. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  45. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  46. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  47. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  48. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  49. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  50. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  51. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  52. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  53. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  54. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  55. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
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    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
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    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
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    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
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    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
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    García-García C; Baik I · Nutrition research and practice · 2022
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    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
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    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
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    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
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