Product Image

Sleep Regimen 3-in-1

NOW
4.5
★ ★ ★ ★ ★
(1303 ratings)
Theanine 200 mg
Melatonin 3 mg
5-HTP 50 mg
Product Image
Score87
A transparent and well-dosed sleep trio offers strong practical value, provided serotonin-raising medicines are not part of the user's regimen.
How scoring works
Quantity:90 Capsule(s) • (90 servings)
Goals:
Sleep Support
Stress Relief
Mood Support
Brain Health
General Health

Score 87

A transparent and well-dosed sleep trio offers strong practical value, provided serotonin-raising medicines are not part of the user's regimen.
How scoring works
$16.89($0.18 per serving)
Pure Formulas
$ 18.13
Amazon
$ 16.89
Vitacost
$ 19.67
Daily Vita
$ 17.40
iHerb
$ 18.36
Walmart
$ 17.92
Report prices

Analysis

Theanine provides a strong calming foundation, melatonin supports sleep timing, and 5-HTP adds a serotonin-pathway component. Each active reaches a purposeful amount without an oversized ingredient list.

Exact disclosure and a single-capsule serving make the formula easy to evaluate. The main limitation is not transparency but the medication restrictions introduced by 5-HTP.

The product fits adults seeking a focused, economical bedtime combination. It is not appropriate for unsupervised use with antidepressants, monoamine oxidase inhibitors, tramadol, or triptans.

Who is it for
  • Adults seeking a focused sleep capsule
  • People who want strong theanine and moderate 5-HTP
Best for
  • Sleep onset
  • Bedtime relaxation
  • Long-supply use

Pros

  • Purposeful doses of all three actives
  • Fully disclosed formula
  • Long single-capsule supply

Cons

  • 5-HTP limits medication compatibility
  • Melatonin may cause morning grogginess
  • Not designed for occasional dose adjustment

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, monoamine oxidase inhibitors, tramadol, or triptans without clinical guidance
  • Melatonin may cause next-day drowsiness

Nutrient quality

93 Highest impact

All three actives are meaningfully dosed and directly support bedtime use. Unspecified purity and 5-HTP standardization are the main quality gaps.

Ingredient transparency

85 Highest impact

Every listed active amount is disclosed, and no proprietary blend obscures the formula. Complete daily directions and inactive-ingredient details are not available.

Customer satisfaction

69 High impact

The aggregate satisfaction measure is favorable, with response volume determining how much confidence it deserves. Comment-level evidence is absent, so recurring complaints and purpose fit cannot be verified.

Value for money

98 Highest impact

Useful amounts and a focused one-capsule design create excellent value. No active appears to inflate the formula without adding purpose.

Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A Goal FitA Strength of SupportA CoverageA+ Formula Quality
Melatonin · 3 mgTheanine · 200 mg

Melatonin, L-theanine, and 5-HTP create a focused multi-pathway sleep formula. The amounts support circadian timing, mental relaxation, and serotonin-to-melatonin production without obvious token dosing.

Each active is separately disclosed in one capsule, although the 5-HTP extract lacks a stated standardization. Because 5-HTP raises serotonin, people using SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines should avoid combining them unless a clinician specifically approves it.

Study evidence
5-HTP Supportive 1 study
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Stress Relief
Stress Relief
Impact
Highest effect
B+ Goal FitB+ Strength of SupportA- CoverageA- Formula Quality
Theanine · 200 mg

L-theanine, 5-HTP, and melatonin combine relaxation, serotonin support, and sleep timing for stress that disrupts mood or sleep. The formula is targeted and well dosed, though it is intended for nighttime rather than general daytime stress.

Theanine reaches a strong effective amount, while 5-HTP and melatonin use cautious, clearly stated doses. Because 5-HTP raises serotonin, combining it with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising drugs can increase the risk of serotonin toxicity.

Study evidence
5-HTP Supportive 18 studies
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Mood Support
Mood Support
Impact
High effect
B Goal FitB- Strength of SupportB- CoverageA Formula Quality
5-HTP · 50 mg

5-HTP directly supports serotonin production, while L-theanine adds calm-mood support. Melatonin makes the combination more sleep-focused but remains coherent for nighttime use.

Theanine is strongly dosed and 5-HTP provides a cautious amount with clear disclosure. The 5-HTP may cause serotonin excess with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines, while melatonin can add drowsiness.

Study evidence
5-HTP Supportive 9 studies
Theanine Supportive 12 studies
Brain Health
Brain Health
Impact
High effect
C Goal FitA Strength of SupportB- CoverageB+ Formula Quality

L-theanine may support calm attention, while melatonin and 5-HTP focus the formula on sleep rather than daytime cognition. Each active amount is clearly disclosed.

The combination may indirectly support brain function through rest, but it offers little direct memory or neuroprotective coverage. 5-HTP can interact with serotonergic medicines, and melatonin may add next-day drowsiness.

Study evidence
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
General Health
General Health
Impact
High effect
C- Goal FitB+ Strength of SupportC- CoverageA- Formula Quality

The sleep-focused blend may support a limited part of daily well-being through melatonin, L-theanine, and 5-HTP. Its role is narrower than foundational nutrition because it mainly targets sleep onset and relaxation.

Each active is clearly listed at a meaningful amount, and the formula is logically focused. Melatonin can alter sleep timing, while 5-HTP may interact with serotonin-raising medicines, so this combination needs added care in those situations.

Study evidence
Melatonin Supportive 69 studies
Mental Focus
Mental Focus
Impact
Moderate effect
D+ Goal FitB+ Strength of SupportF CoverageD- Formula Quality
Theanine · 200 mg

L-theanine can support relaxed attention, but melatonin and 5-HTP make the formula primarily sleep-oriented. Those calming ingredients may reduce daytime alertness rather than sustain it.

The L-theanine amount is well chosen and fully disclosed. Melatonin may cause next-day drowsiness, and 5-HTP can raise the risk of excess serotonin with SSRIs, MAO inhibitors, or triptans.

Study evidence
Theanine Supportive 19 studies

Ingredients

IngredientAmount per serving
L-Theanine
200 mg
5-HTP (Griffonia simplicifolia Seed Extract)
 50 mg
Melatonin
3 mg
Gluten Free Adults 18–50 Vegan Dairy Free Women Vegetarian
Report overview
Theanine · 200 mg OverallScore92
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The formula provides a clearly disclosed 200 mg L-Theanine dose within the optimal range. Generic sourcing leaves purity less certain, but the cost per active amount is highly efficient. Added 5-HTP may interact with serotonergic medicines such as SSRIs, while melatonin may add sedation.

View ingredientView products
Melatonin · 3 mg OverallScore64
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value

The 3 mg melatonin dose is physiological and clearly delivered in one capsule. Standard immediate release favors sleep onset rather than all-night maintenance. The multi-ingredient formula has moderate value, but no third-party purity certification is shown.

View ingredientView products
5-HTP (Griffonia simplicifolia Seed Extract) · 50 mg OverallScore61
B- Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyC Value

The moderate 5-HTP amount suits a cautious starting approach, while theanine and melatonin make the blend specifically sleep focused. A vegetable capsule is practical, but the botanical extract lacks a stated standardization and specialized release system. Avoid use with SSRIs or other serotonin-raising drugs, and combining the melatonin blend with alcohol or sedatives may increase drowsiness.

View ingredientView products
Loading alternative details
82 Performance

Tranquil Sleep

Natural Factors Stress-Relax
<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. Branded Suntheanine, physiological melatonin, and Griffonia-derived 5-HTP make a coherent bedtime blend in an enteric-coated softgel. The modest 5-HTP amount is secondary, and it can interact with SSRIs, SNRIs, MAO inhibitors, triptans, or other serotonin-raising medicines.</p>
79 Performance

Superior Sleep

Doctor's Best
<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. Ashwagandha, theanine, GABA, melatonin, and 5-HTP are all supplied at meaningful amounts for sleep support. The 5 mg melatonin dose may cause morning grogginess, and 5-HTP can raise serotonin-related risk with SSRIs, SNRIs, MAO inhibitors, or tramadol.</p>
77 Performance

Lights Out Sleep

ALLMAX
<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. A varied sleep blend provides useful valerian, GABA, melatonin, and active vitamin B6. Theanine and several herbs are modest, while extract standardization remains incomplete.</p>
85 Budget

3 a.m. Melatonin Fast Dissolve Lavender Vanilla

Natrol
<p>The lower serving cost makes this a more economical alternative. Fast-dissolve melatonin and a modest L-theanine amount create a simple, economical option for sleep onset. The formula offers little depth beyond those two actives, and melatonin can cause next-day drowsiness in sensitive users.</p>
65 Budget

Sleep+ Calm Strawberry

Natrol Kids
<p>No strictly cheaper eligible choice remained, so this is one of the closest low-cost alternatives. A low melatonin amount suits a cautious children’s bedtime formula, but theanine and the hidden botanical blend contribute little at their small amounts. Caregivers should follow the age-specific label because the serving may vary, and use should remain limited to bedtime because melatonin causes drowsiness.</p>
62 Budget

Triple Action Sleep

Solgar
<p>No strictly cheaper eligible choice remained, so this is one of the closest low-cost alternatives. A substantial theanine amount and staged tablet design support a clear sleep purpose. Very high melatonin raises the chance of morning grogginess, while an undisclosed herbal blend prevents full safety and dose assessment.</p>
64 Value

Sleep + Calm Strawberry

Natrol
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. L-theanine and melatonin create a direct sleep-onset gummy at an economical serving cost. The melatonin amount is less conservative, and the opaque botanical blend prevents ingredient-specific safety review while morning grogginess remains possible.</p>
72 Value

Sleep Blackberry Zen

OLLY
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. Melatonin and L-theanine provide practical sleep-onset support in a convenient gummy. Small botanical additions and immediate-release delivery add little depth beyond the core actives.</p>
69 Value

Sleep Support

Bluebonnet Targeted Choice
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. Theanine, valerian, tart cherry, passionflower, 5-HTP, and chamomile form a coherent but lightly dosed sleep blend. Botanical standards and tart-cherry melatonin yield are incomplete, while 5-HTP can dangerously add to serotonergic medicines and the combined formula may cause drowsiness.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  2. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  3. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  4. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  5. Current Evidence on Common Dietary Supplements for Sleep Quality.
    Esquivel MK; Ghosn B · American journal of lifestyle medicine · 2025
    Narrative reviewSleep Support forTheanine
  6. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  7. Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
    Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
    Randomized trial120 participantsStress Relief forTheanine
  8. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  9. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  10. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  11. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  12. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  13. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  14. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  15. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  16. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  17. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  18. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  19. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  20. Melatonin for preventing and treating jet lag.
    Herxheimer A; Petrie KJ · The Cochrane database of systematic reviews · 2001
    Systematic review10 studies pooledGeneral Health forMelatonin
  21. Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life.
    Schroder CM; Malow BA; Maras A; Melmed RD; Findling RL; Breddy J; Nir T; Shahmoon S; Zisapel N; Gringras P · Journal of autism and developmental disorders · 2019
    Randomized trial125 participantsGeneral Health forMelatonin
  22. Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
    Fatemeh G; Sajjad M; Niloufar R; Neda S; Leila S; Khadijeh M · Journal of neurology · 2022
    Meta-analysis23 studies pooledGeneral Health forMelatonin
  23. Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses.
    Choi K; Lee YJ; Park S; Je NK; Suh HS · Sleep medicine reviews · 2022
    Meta-analysis24 studies pooledGeneral Health forMelatonin
  24. Effectiveness of melatonin for the treatment of nocturia: a randomized controlled trial.
    Leerasiri P; Pariyaeksut P; Hengrasmee P; Asumpinwong C · International urogynecology journal · 2023
    Randomized trial60 participantsGeneral Health forMelatonin
  25. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  26. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  27. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  28. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  29. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  30. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  31. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  32. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  33. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  34. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  35. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine
  36. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  37. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  38. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  39. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsProductivity Boost forTheanine
  40. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  41. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  42. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  43. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  44. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  45. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  46. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support forTheanine
  47. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  48. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  49. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  50. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  51. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  52. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
    Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
    Randomized trial202 participantsStress Relief forMelatonin
  53. Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
    Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
    Randomized trial90 participantsStress Relief forMelatonin
  54. Melatonin for pre- and postoperative anxiety in adults.
    Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
    Meta-analysis774 participants12 studies pooledStress Relief forMelatonin
  55. Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
    Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
    Meta-analysis441 participants5 studies pooledStress Relief forMelatonin
  56. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
    Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
    Randomized trial88 participantsStress Relief forMelatonin