Product Image

Tranquil Sleep

Natural Factors Stress-Relax
4.4
★ ★ ★ ★ ★
(2102 ratings)
Theanine 200 mg
Melatonin 3 mg
5-HTP 30 mg
Product Image
Score82
A transparent, well-balanced bedtime trio has strong theanine support, with 5-HTP interactions as the main limitation.
How scoring works
Quantity:90 Softgel(s) • (45 servings)
Goals:
Sleep Support
Stress Relief
Brain Health
Mood Support
Productivity Boost

Score 82

A transparent, well-balanced bedtime trio has strong theanine support, with 5-HTP interactions as the main limitation.
How scoring works

Also available as

1 option
45 servings Melatonin 3 mg, Theanine 200 mg +1 more • 45 Softgel(s) • 22 servings $13.97 ($0.63 per serving)
$26.57($0.59 per serving)
iHerb
$ 26.57
Vitacost
$ 26.57
Amazon
$ 26.57
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Analysis

Suntheanine provides a well-characterized calming base, and melatonin directly targets sleep timing. Griffonia-derived 5-HTP adds a modest serotonin-pathway component without crowding the formula.

The softgel keeps every active amount visible and avoids a proprietary blend. The 5-HTP amount is modest, but it still carries meaningful interactions with serotonin-raising medicines.

The product fits adults seeking combined relaxation and sleep-onset support in a softgel. It is unsuitable for casual use alongside antidepressants, monoamine oxidase inhibitors, tramadol, or triptans.

Who is it for
  • Adults seeking a focused three-active sleep formula
  • People who value branded theanine
Best for
  • Sleep onset
  • Bedtime relaxation
  • Stress-related restlessness

Pros

  • Uses branded Suntheanine
  • All active amounts are disclosed
  • Coherent three-ingredient design

Cons

  • 5-HTP amount is modest
  • Melatonin can cause residual grogginess
  • Not suitable with many serotonin-raising medicines

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, monoamine oxidase inhibitors, tramadol, or triptans without clinical guidance
  • Melatonin may cause next-day drowsiness

Nutrient quality

93 Highest impact

Branded theanine and well-chosen melatonin provide strong core dose quality. Modest 5-HTP adds a complementary pathway without overcrowding the formula.

Ingredient transparency

83 Highest impact

Every listed active amount is disclosed, and no proprietary blend obscures the formula. Complete daily directions and inactive-ingredient details are not available.

Customer satisfaction

70 High impact

The aggregate satisfaction measure is favorable, with response volume determining how much confidence it deserves. Comment-level evidence is absent, so recurring complaints and purpose fit cannot be verified.

Value for money

80 High impact

Branded theanine and a coherent three-active formula support good value. The serving is not inexpensive, but it avoids token padding.

Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A+ Goal FitA+ Strength of SupportA+ CoverageA+ Formula Quality
Melatonin · 3 mgTheanine · 200 mg

Suntheanine at 200 mg and melatonin at 3 mg combine a preferred calming active with direct circadian signaling. Enteric-coated softgels and exact individual amounts support a well-defined bedtime formula.

The 30 mg 5-HTP amount is modest but adds a serotonin-related pathway without overcrowding the blend. 5-HTP can interact with SSRIs, MAO inhibitors, triptans, or other serotonin-raising medicines and increase serotonin-related adverse effects.

Study evidence
5-HTP Supportive 1 study
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Stress Relief
Stress Relief
Impact
Highest effect
B Goal FitB+ Strength of SupportB CoverageA- Formula Quality
Theanine · 200 mg

Branded L-theanine provides a well-dosed calming pathway, while melatonin and 5-HTP add targeted support when stress interferes with sleep. The combination is more suitable for nighttime tension than for maintaining alert daytime resilience.

The enteric-coated softgel clearly discloses each active and uses a recognized L-theanine source. 5-HTP can interact with serotonergic medicines, while melatonin and the combined calming actives may cause drowsiness.

Study evidence
5-HTP Supportive 18 studies
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Brain Health
Brain Health
Impact
High effect
C Goal FitA- Strength of SupportC CoverageA- Formula Quality

A full 200 mg dose of branded L-theanine supports relaxed attention, while 5-HTP and melatonin shift the formula toward sleep. Better sleep may indirectly support cognition, but the blend is not designed for daytime memory or mental performance.

Theanine is well dosed and clearly sourced, while the 30 mg 5-HTP amount is a small supporting dose. 5-HTP can add to serotonin-raising medicines, and melatonin may cause next-day drowsiness in sensitive users.

Study evidence
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
Mood Support
Mood Support
Impact
High effect
C- Goal FitB Strength of SupportC CoverageA- Formula Quality
5-HTP · 30 mg

Branded L-theanine provides a well-supported calming dose, while low-dose 5-HTP adds limited serotonin-precursor support. Melatonin shifts the formula toward sleep rather than broad mood stability.

The combination is coherent for bedtime but may cause drowsiness. Users should not combine its 5-HTP with SSRIs, MAO inhibitors, or other serotonin-raising drugs because serotonin excess can be dangerous.

Study evidence
5-HTP Supportive 9 studies
Theanine Supportive 12 studies
Productivity Boost
Productivity Boost
Impact
High effect
C Goal FitA- Strength of SupportC CoverageC Formula Quality
Theanine · 200 mg

L-theanine may support calm attention, while melatonin and 5-HTP mainly shift the blend toward nighttime relaxation. The combination may indirectly aid next-day function when poor sleep is the main barrier but is not suited to active work periods.

All three active amounts are clearly disclosed, and branded L-theanine adds useful quality information. Melatonin may cause drowsiness, while 5-HTP can interact with serotonergic antidepressants and increase serotonin-related adverse effects.

Study evidence
Theanine Supportive 5 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
D Goal FitB+ Strength of SupportD+ CoverageD Formula Quality
Theanine · 200 mg

Branded L-theanine supports relaxation, but melatonin and 5-HTP shift the formula toward sleep rather than daytime cognitive performance. The combination may indirectly support cognition through better sleep when sleep quality is a limiting factor.

The enteric-coated softgel clearly discloses meaningful amounts of all three actives. Melatonin may cause next-day drowsiness, and 5-HTP may interact with serotonergic antidepressants by raising serotonin excessively.

Study evidence
Theanine Supportive 25 studies
Mental Focus
Mental Focus
Impact
Moderate effect
D+ Goal FitA Strength of SupportF CoverageF Formula Quality
Theanine · 200 mg

Branded L-theanine is well dosed for calm attention, but the formula is built for sleep rather than daytime focus. Melatonin and 5-HTP can cause drowsiness that works against sustained alertness.

The exact active amounts and branded theanine source are strengths. People using serotonergic medicines should avoid combining them casually with 5-HTP, and the melatonin amount may leave sensitive users groggy the next day.

Study evidence
Theanine Supportive 19 studies

Ingredients

IngredientAmount per serving
Suntheanine L-Theanine
200 mg
5-HTP (Griffonia simplicifolia)
 30 mg
Melatonin
3 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Theanine · 200 mg OverallScore96
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Suntheanine supplies a branded, high-purity L-theanine source at a preferred dose. Melatonin and 5-HTP make the blend more sleep-oriented and may increase nighttime drowsiness rather than support daytime focus. Cost per active amount is competitive for the branded form.

View ingredientView products
Melatonin · 3 mg OverallScore54
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD Value

The softgel is designed mainly for sleep onset and has no supplied independent purity certification. The melatonin amount is within the physiological range. The high serving cost is only partly offset by its formulation features.

View ingredientView products
5-HTP (Griffonia simplicifolia) · 30 mg OverallScore52
B+ Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyF Value

The enteric-coated softgel may improve comfort, and Griffonia simplicifolia is clearly named as the botanical source. The low 5-HTP amount is paired with L-theanine and melatonin, making it a broader sleep blend rather than a concentrated 5-HTP option. The supplied label details lack a specific serotonin-medication warning, while the 5-HTP content offers poor value.

View ingredientView products
Loading alternative details
82 Performance

Tranquil Sleep

Natural Factors Stress-Relax
<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. Branded Suntheanine, physiological melatonin, and Griffonia-derived 5-HTP create a well-defined sleep formula in an enteric-coated softgel. The modest 5-HTP amount is secondary and can interact with serotonin-raising medicines.</p>
77 Performance

Lights Out Sleep

ALLMAX
<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. A varied sleep blend provides useful valerian, GABA, melatonin, and active vitamin B6. Theanine and several herbs are modest, while extract standardization remains incomplete.</p>
76 Performance

Genius Sleep Aid

The Genius Brand
<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. Low-dose melatonin, theanine, glycine, inositol, and rutaecarpine form a thoughtful sleep blend with conservative circadian support. Glycine is below common focused amounts, rutaecarpine evidence is limited, and the premium serving cost weakens value.</p>
87 Budget

Sleep Regimen 3-in-1

NOW
<p>The lower serving cost makes this a more economical alternative. Melatonin, L-theanine, and Griffonia-derived 5-HTP create a focused, fully disclosed sleep formula with excellent serving value. The 5-HTP extract lacks standardization and can interact with SSRIs, SNRIs, MAO inhibitors, triptans, or other serotonin-raising medicines.</p>
85 Budget

3 a.m. Melatonin Fast Dissolve Lavender Vanilla

Natrol
<p>The lower serving cost makes this a more economical alternative. Fast-dissolve melatonin and a modest L-theanine amount create a simple, economical option for sleep onset. The formula offers little depth beyond those two actives, and melatonin can cause next-day drowsiness in sensitive users.</p>
79 Budget

Superior Sleep

Doctor's Best
<p>The lower serving cost makes this a more economical alternative. Ashwagandha, theanine, GABA, melatonin, and 5-HTP are all supplied at meaningful amounts for sleep support. The 5 mg melatonin dose may cause morning grogginess, and 5-HTP can raise serotonin-related risk with SSRIs, SNRIs, MAO inhibitors, or tramadol.</p>
65 Value

Sleep+ Calm Strawberry

Natrol Kids
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. A low melatonin amount suits a cautious children’s bedtime formula, but theanine and the hidden botanical blend contribute little at their small amounts. Caregivers should follow the age-specific label because the serving may vary, and use should remain limited to bedtime because melatonin causes drowsiness.</p>
64 Value

Sleep + Calm Strawberry

Natrol
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. L-theanine and melatonin create a direct sleep-onset gummy at an economical serving cost. The melatonin amount is less conservative, and the opaque botanical blend prevents ingredient-specific safety review while morning grogginess remains possible.</p>
62 Value

Triple Action Sleep

Solgar
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. A substantial theanine amount and staged tablet design support a clear sleep purpose. Very high melatonin raises the chance of morning grogginess, while an undisclosed herbal blend prevents full safety and dose assessment.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  2. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  3. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  4. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  5. Current Evidence on Common Dietary Supplements for Sleep Quality.
    Esquivel MK; Ghosn B · American journal of lifestyle medicine · 2025
    Narrative reviewSleep Support forTheanine
  6. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  7. Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
    Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
    Randomized trial120 participantsStress Relief forTheanine
  8. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledMental Focus Brain Health Cognitive Support forTheanine
  9. Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
    Mátyus RO; Szikora Z; Bodó D; Vargáné Szabó B; Csupor É; Csupor D; Tóth B · Journal of clinical medicine · 2025
    Meta-analysis148 participants5 studies pooledMental Focus forTheanine
  10. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsMental Focus Productivity Boost forTheanine
  11. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  12. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  13. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  14. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  15. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  16. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  17. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  18. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  19. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  20. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  21. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  22. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  23. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  24. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  25. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  26. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  27. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  28. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  29. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  30. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  31. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  32. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine
  33. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  34. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  35. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  36. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  37. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  38. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  39. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  40. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  41. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  42. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support forTheanine
  43. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  44. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  45. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  46. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  47. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  48. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
    Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
    Randomized trial202 participantsStress Relief forMelatonin
  49. Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
    Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
    Randomized trial90 participantsStress Relief forMelatonin
  50. Melatonin for pre- and postoperative anxiety in adults.
    Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
    Meta-analysis774 participants12 studies pooledStress Relief forMelatonin
  51. Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
    Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
    Meta-analysis441 participants5 studies pooledStress Relief forMelatonin
  52. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
    Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
    Randomized trial88 participantsStress Relief forMelatonin