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Superior Sleep

Doctor's Best
4.3
★ ★ ★ ★ ★
(457 ratings)
Theanine 200 mg
Ashwagandha 250 mg
5-HTP 200 mg
GABA 100 mg
Melatonin 5 mg
Product Image
Score79
A strongly dosed, transparent sleep blend with useful ingredients but significant serotonergic and sedation cautions.
How scoring works
Quantity:60 Veggie Cap(s) • (30 servings)
Goals:
Stress Relief
Sleep Support
Mood Support
Brain Health
Weight Loss

Score 79

A strongly dosed, transparent sleep blend with useful ingredients but significant serotonergic and sedation cautions.
How scoring works
$16.73($0.55 per serving)
iHerb
$ 16.81
Amazon
$ 0.00
Vitacost
$ 24.99
Pure Formulas
$ 16.73
Report prices

Analysis

Melatonin, theanine, and ashwagandha provide several complementary pathways for sleep preparation. The formula is compact and avoids a proprietary blend.

5-HTP is present at a substantial amount and may support serotonin-related sleep signaling. That dose also makes medicine interactions much more important than with a simple melatonin product.

The combination may suit adults who have already tolerated individual ingredients. It is less suitable as a first sleep supplement because it is difficult to identify which active causes an unwanted effect.

Who is it for
  • Adults seeking a multi-pathway sleep formula
  • Users already familiar with melatonin
  • People not taking serotonergic medicines
Best for
  • Sleep onset support
  • Evening relaxation
  • Stress-related sleep preparation

Pros

  • Strong theanine amount
  • Uses Sensoril ashwagandha
  • No proprietary blend

Cons

  • High combined sedative load
  • Difficult to isolate individual tolerance
  • Not well suited to first-time sleep-supplement users

Warnings

  • 5-HTP can interact with SSRIs, SNRIs, MAO inhibitors, and other serotonergic medicines
  • Melatonin and the other calming ingredients may cause next-day drowsiness
  • Do not drive or combine with alcohol after taking the formula

Nutrient quality

82 Highest impact

Strong doses and a coherent sleep-focused combination support effectiveness. High melatonin and serotonergic interaction risk materially reduce safety.

.

Ingredient transparency

83 Highest impact

Active names and doses are clearly disclosed. Non-active ingredients and complete usage directions remain missing.

.

Customer satisfaction

57 Moderate impact

The supplied average rating is mixed. No specific review comments were supplied, so repeated negative experiences cannot be assessed.

.

Value for money

88 Highest impact

Meaningful doses provide strong formula value. Safety and tolerability concerns are the main practical trade-off.

.
Report analysis

Goals

Stress Relief
Stress Relief
Impact
Highest effect
A+ Goal FitA Strength of SupportA+ CoverageA- Formula Quality
Ashwagandha · 250 mgGABA · 100 mgTheanine · 200 mg

Sensoril ashwagandha, theanine, GABA, 5-HTP, and melatonin provide strong adaptogenic and calming-neurotransmitter coverage. Ashwagandha and theanine use clinically aligned amounts, while the overall formula remains compact.

The combination is better suited to nighttime use because its calming ingredients may cause substantial drowsiness. The high 5-HTP amount can interact with SSRIs, SNRIs, MAO inhibitors, and other serotonergic medicines.

Study evidence
5-HTP Supportive 18 studies
Ashwagandha Supportive 47 studies
GABA Supportive 6 studies
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Sleep Support
Sleep Support
Impact
Highest effect
A+ Goal FitA Strength of SupportA+ CoverageA- Formula Quality
Melatonin · 5 mgTheanine · 200 mg

A purpose-built combination of melatonin, high-strength 5-HTP, optimal theanine, Sensoril, and GABA strongly targets sleep. The formula covers circadian timing, serotonin pathways, nervous-system relaxation, and stress resilience with meaningful amounts.

The melatonin amount is somewhat above a low physiological range, and the dense sedative stack may cause marked or next-day drowsiness in sensitive users. 5-HTP can interact with serotonergic antidepressants and should not be combined with serotonin-active medicines without professional review.

Study evidence
5-HTP Supportive 1 study
GABA Supportive 4 studies
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Mood Support
Mood Support
Impact
Highest effect
A Goal FitA Strength of SupportA CoverageA- Formula Quality
5-HTP · 200 mgAshwagandha · 250 mg

Sensoril ashwagandha, 5-HTP, L-theanine, GABA, and melatonin provide strong stress, serotonin, and relaxation coverage. Most actives reach clinically relevant or well-aligned amounts, and the branded ashwagandha improves confidence.

The combination is built for sleep and may be more sedating than a daytime mood formula. The 200 mg 5-HTP amount can interact with SSRIs, SNRIs, MAO inhibitors, and other serotonergic medicines, while the full stack may cause marked drowsiness.

Study evidence
5-HTP Supportive 9 studies
Ashwagandha Supportive 29 studies
GABA Supportive 12 studies
Theanine Supportive 12 studies
Brain Health
Brain Health
Impact
Highest effect
B Goal FitA- Strength of SupportB CoverageA- Formula Quality
Ashwagandha · 250 mg

Sensoril ashwagandha, theanine, GABA, 5-HTP, and melatonin provide a coherent route to better sleep and stress recovery. Improved sleep may indirectly support next-day clarity and memory consolidation.

The formula does not directly address neuronal membranes, memory signaling, or daytime cognitive performance. The 5-HTP can raise serotonin and should not be combined with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines without specific medical guidance, while melatonin may cause next-day drowsiness.

Study evidence
Ashwagandha Supportive 12 studies
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
Weight Loss
Weight Loss
Impact
Highest effect
C+ Goal FitA Strength of SupportB CoverageA Formula Quality
Ashwagandha · 250 mg

Sensoril ashwagandha, 5-HTP, and theanine may indirectly support weight management through stress, sleep, and appetite-related pathways. Each primary active reaches a meaningful amount and is clearly disclosed.

No thermogenic, fiber, protein, or metabolic mineral strategy is present, so the formula is not a comprehensive weight-loss product. 5-HTP can interact with serotonergic medicines, and the five-milligram melatonin amount can cause substantial drowsiness.

Study evidence
5-HTP Supportive 5 studies
Ashwagandha Disputed 4 studies
Theanine Not classified

No linked studies yet.

Mental Focus
Mental Focus
Impact
Moderate effect
D+ Goal FitB+ Strength of SupportC CoverageD Formula Quality
Theanine · 200 mg

L-theanine and a branded Ashwagandha extract are both supplied at strong, clearly stated amounts. They may support calmness and stress resilience, which can indirectly help concentration in tense situations.

The remaining formula is explicitly sleep oriented, with substantial 5-HTP, melatonin, and GABA that may impair daytime alertness. The 5-HTP may compound serotonergic medicines, and melatonin can cause next-day drowsiness in some users.

Study evidence
Ashwagandha Supportive 12 studies
Theanine Supportive 19 studies

Ingredients

IngredientAmount per serving
Sensoril Ashwagandha (Withania somnifera) root and leaf extract
250 mg
5-HTP (Griffonia Simplicifolia Seed Extract)
 200 mg
L-Theanine
200 mg
Gamma-Aminobutyric Acid
100 mg
Melatonin
5 mg
Gluten Free Adults 18–50 Vegan Women Vegetarian
Report overview
Theanine · 200 mg OverallScore92
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The active L-isomer is clearly disclosed at an optimal dose, though no branded theanine purity standard is given. Exact labeling supports confident dose verification. Clinically dosed Sensoril and 5-HTP raise an already competitive value, but 5-HTP may compound serotonergic medicines.

View ingredientView products
Ashwagandha · 250 mg OverallScore88
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

A clinically studied Sensoril extract is supplied at the top of its stated target range. The exact amount is transparent, while no dedicated absorption enhancer is listed. A near-median serving cost makes it a solid value for a branded and clinically aligned extract.

View ingredientView products
5-HTP (Griffonia Simplicifolia Seed Extract) · 200 mg OverallScore72
B- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyA- Value

The serving supplies a high-strength 5-HTP amount from a named Griffonia seed source. Vegetable capsules are suitable, though the extract standardization and a specific serotonin-medication warning are not shown. Cost efficiency is good for the active amount, but the combination of 5-HTP, melatonin, theanine, GABA, and ashwagandha may cause substantial drowsiness in sensitive users.

View ingredientView products
Loading alternative details
83 Performance

GABA Soothe

Jarrow Formulas
<p>Sensoril ashwagandha, theanine, and GABA create a concise calming formula with useful amounts and no melatonin or 5-HTP. That avoids the original's higher melatonin exposure and serotonin-related interaction concern, though direct sleep-onset support may be milder.</p>
82 Performance

Tranquil Sleep

Natural Factors Stress-Relax
<p>Branded theanine, melatonin, and 5-HTP form a focused bedtime blend with less melatonin than the original. The modest 5-HTP amount is secondary, but it still requires caution with serotonin-raising medicines.</p>
78 Performance

Serenelle

Quality Of Life
<p>Sensoril ashwagandha, theanine, PharmaGABA, and lemon balm provide strong calming support without melatonin or 5-HTP. The formula is better suited to stress-related sleep difficulty, although it is not designed as a direct sleep-onset aid.</p>
87 Budget

Sleep Regimen 3-in-1

NOW
<p>Theanine, melatonin, and 5-HTP preserve the core bedtime ingredients at substantially better serving value. It omits ashwagandha and GABA, while 5-HTP can interact with serotonin-raising medicines.</p>
77 Value

Lights Out Sleep

ALLMAX
<p>Valerian, GABA, melatonin, active vitamin B6, theanine, and 5-HTP provide broad bedtime coverage with good practical value. Several botanicals are modest or incompletely standardized, and 5-HTP still carries serotonin-related interaction risk.</p>
78 Value

Extra Strength Tranquil Sleep

Natural Factors Stress-Relax
<p>Branded theanine and fully disclosed melatonin provide clear sleep-onset support with solid serving value. The high melatonin amount may increase morning grogginess, while the small 5-HTP amount adds interaction risk without much depth.</p>
75 Value

Ultra Strength Goodbye Stress

OLLY
<p>Ashwagandha, GABA, theanine, and lemon balm offer a coherent non-melatonin option for stress-related sleep at reasonable value. All four amounts are modest, so it may be gentler than the original but also less direct for sleep onset.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
    Deshpande A; Irani N; Balkrishnan R; Benny IR · Sleep medicine · 2021
    Randomized trial150 participantsSleep Support forAshwagandha
  2. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  3. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  4. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  5. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
    Sletten TL; Magee M; Murray JM; Gordon CJ; Lovato N; Kennaway DJ; Gwini SM; Bartlett DJ; Lockley SW; Lack LC; Grunstein RR; Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group · PLoS medicine · 2019
    Randomized trial116 participantsSleep Support forMelatonin
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  8. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support forTheanine
  9. Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.
    Leonard M; Dickerson B; Estes L; Gonzalez DE; Jenkins V; Johnson S; Xing D; Yoo C; Ko J; Purpura M; Jäger R; Faries M; Kephart W; Sowinski R; Rasmussen CJ; Kreider RB · Nutrients · 2024
    Randomized trial59 participantsBrain Health Cognitive Support forAshwagandha
  10. Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study.
    Rai HP; Mishra DN · Journal of psychopharmacology (Oxford, England) · 2025
    Randomized trial40 participantsBrain Health Cognitive Support Mental Focus forAshwagandha
  11. Efficacy of Withania somnifera supplementation on adult's cognition and mood.
    Remenapp A; Coyle K; Orange T; Lynch T; Hooper D; Hooper S; Conway K; Hausenblas HA · Journal of Ayurveda and integrative medicine · 2022
    Randomized trial60 participantsBrain Health Cognitive Support forAshwagandha
  12. A clinical assessment of the therapeutic effects of Ashwagandha root extract on cognitive performance, sleep, and fatigue in children aged 6-12 years.
    Saxena A; Lopresti A; Sharif M; Elon N; Suri R; Langade DK · Frontiers in nutrition · 2026
    Randomized trial85 participantsBrain Health Mental Focus forAshwagandha
  13. Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study.
    Gopukumar K; Thanawala S; Somepalli V; Rao TSS; Thamatam VB; Chauhan S · Evidence-based complementary and alternative medicine : eCAM · 2022
    Randomized trial130 participantsBrain Health Stress Relief forAshwagandha
  14. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  15. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  16. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  17. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  18. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  19. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  20. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  21. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  22. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  23. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  24. A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study.
    Majeed M; Nagabhushanam K; Mundkur L · Medicine · 2023
    Randomized trial54 participantsCognitive Support Mental Focus forAshwagandha
  25. Efficacy and safety of ashwagandha root extract in children and adolescents with mild attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled trial.
    Naik S; Muralidhar G; Rao BS; Agarwal S; Jain M · Journal of medicine and life · 2026
    Randomized trial58 participantsCognitive Support Mental Focus forAshwagandha
  26. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  27. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  28. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.
    Choudhary D; Bhattacharyya S; Bose S · Journal of dietary supplements · 2018
    Randomized trial50 participantsMental Focus forAshwagandha
  29. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  30. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  31. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  32. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  33. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  34. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  35. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  36. A proprietary herbal extract of ashwagandha root for stress and anxiety in healthy adults: a randomized, double-blind, three-arm, placebo-controlled efficacy and safety study.
    West RE; Biswas A; Rao R; Tayade H; Ademola J · Journal of medicine and life · 2026
    Randomized trial141 participantsMood Support forAshwagandha
  37. Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta-analysis.
    Fatima K; Malik J; Muskan F; Raza G; Waseem A; Shahid H; Jaffery SF; Khan U; Zaheer MK; Shaikh Y; Rashid AM · Human psychopharmacology · 2024
    Meta-analysis254 participants5 studies pooledMood Support forAshwagandha
  38. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.
    Chandrasekhar K; Kapoor J; Anishetty S · Indian journal of psychological medicine · 2013
    Randomized trial64 participantsMood Support Stress Relief forAshwagandha
  39. Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study.
    McKinney E; Stewart J; Kewalramani R; Singh S · Trials · 2026
    Randomized trial186 participantsMood Support forAshwagandha
  40. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
    Zhang W; Yan Y; Wu Y; Yang H; Zhu P; Yan F; Zhao R; Tian P; Wang T; Fan Q; Su Z · Pharmacological research · 2022
    Meta-analysis29 participants29 studies pooledMood Support forAshwagandha
  41. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsMood Support Stress Relief forGABA
  42. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  43. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  44. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  45. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  46. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  47. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  48. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  49. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine Stress Relief forGABA
  50. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  51. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  52. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  53. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsProductivity Boost forTheanine
  54. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  55. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  56. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  57. Melatonin treatment for age-related insomnia.
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