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Methyl-Guard

4.9
★ ★ ★ ★ ★
(3400 ratings)
Vitamin B6 20.4 mg
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Score76
A strong active-form methylation formula with substantial betaine, balanced by high cost and a three-capsule serving.
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Capsule
Quantity:180 Capsule(s) • (60 servings)
Goals:

Score 76

A strong active-form methylation formula with substantial betaine, balanced by high cost and a three-capsule serving.
How scoring works
$56.00($0.93 per serving)
iHerb
$ 56.00
Vitacost
$ 56.03
Pure Formulas
$ 56.00
Walmart
$ 56.00
Vitacost
$ 56.00
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Analysis

The formula combines 20.4 mg of P-5-P with 1.2 mg of methylcobalamin, folate, and 1.8 g of betaine. Those ingredients address complementary methylation pathways and are clearly quantified.

The B6 amount is well targeted and uses the active coenzyme form. The folate chemical form is not identified in the supplied data, so buyers should verify whether it matches their intended form.

Three capsules deliver a substantial betaine serving but make daily use less convenient. It suits users seeking a complete methylation formula more than those wanting inexpensive B6 alone.

Who is it for
  • Adults seeking broad methylation support
  • People wanting P-5-P and methylcobalamin together
  • Users comfortable with three capsules
Best for
  • Methylation cofactor coverage
  • Betaine supplementation
  • Active B6 and B12 intake

Pros

  • Uses P-5-P
  • Includes methylcobalamin
  • Provides 1.8 g of betaine

Cons

  • High serving cost
  • Three-capsule dose
  • Folate form is unspecified in supplied data

Warnings

  • Verify the folate form on the current label if methylfolate is specifically required
  • Betaine may cause stomach upset or a fishy body odor in sensitive users
  • Count the B6 amount when combining with other methylation products

Nutrient quality

87 Highest impact

Active B-vitamin forms and substantial betaine create a coherent targeted formula. Unspecified folate chemistry and high amounts reduce suitability for casual use.

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Ingredient transparency

76 High impact

All listed active amounts are clear and no proprietary blend hides a dose. Inactive ingredients and complete daily-use directions are not supplied.

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Customer satisfaction

74 High impact

The supplied aggregate rating is exceptionally strong. The very large review count makes the rating highly reliable.

.

Value for money

65 High impact

Strong forms and coherent dosing provide meaningful formula value. A high serving cost makes the product expensive for continued use.

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Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxal 5-Phosphate)
 20.4 mg
Folate
2 mg DFE
Vitamin B12 (Methylcobalamin)
 1.2 mg
Betaine Anhydrous (Trimethylglycine)
 1.8 Gram(s)
Gluten Free Adults 18–50
Report overview
Vitamin B6 (Pyridoxal 5-Phosphate) · 20.4 mg OverallScore82
A+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyF Value

The 20.4 mg dose is well targeted and supplied entirely as active P-5-P. Three capsules are somewhat less convenient, but the form and amount are clearly disclosed. High serving cost produces poor value despite excellent B6 quality.

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89 Performance

P-5-P 50 mg

Country Life
<p>Active pyridoxal phosphate provides a meaningful B6 serving in a focused format. Compared with the original, the active B6 form avoids a conversion step, although the supplied dose may still exceed ordinary nutritional needs.</p>
89 Performance

BioCoenzymated Pyridoxal 5'-Phosphate 50 mg

Natural Factors
<p>Active pyridoxal phosphate provides a meaningful B6 serving in a focused format. Compared with the original, the active B6 form avoids a conversion step, although the supplied dose may still exceed ordinary nutritional needs.</p>
89 Performance

P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength

Swanson
<p>Active pyridoxal phosphate provides a meaningful B6 serving in a focused format. Compared with the original, the active B6 form avoids a conversion step, although the supplied dose may still exceed ordinary nutritional needs.</p>
80 Budget

B6 100 mg

Spring Valley
<p>Pyridoxine hydrochloride provides a clearly stated but very high B6 serving. Its lower serving cost improves affordability versus the original, although the supplied safety and form limitations still matter for long-term use.</p>
80 Budget

B-6 100 mg

21st Century
<p>Pyridoxine hydrochloride provides a clearly stated but very high B6 serving. Its lower serving cost improves affordability versus the original, although the supplied safety and form limitations still matter for long-term use.</p>
80 Budget

B-6 100 mg

NOW
<p>Pyridoxine hydrochloride provides a clearly stated but very high B6 serving. Its lower serving cost improves affordability versus the original, although the supplied safety and form limitations still matter for long-term use.</p>
87 Value

Vitamin B-6 50 mg

Nature's Way
<p>A mixed active and precursor B6 blend provides a meaningful B6 serving in a focused format. It combines retaining an active or partly active B6 form with a lower serving cost, although the dose and long-term-use cautions remain important.</p>
84 Value

P-5-P 50 mg

Nutricost
<p>Active P-5-P provides ready-to-use vitamin B6 in a simple high-potency capsule. It combines retaining an active or partly active B6 form with a lower serving cost, although the dose and long-term-use cautions remain important.</p>
85 Value

Vitamin B6 25 mg

Solgar
<p>Pyridoxine hydrochloride provides a meaningful B6 serving in a focused format. It combines keeping the ingredient panel focused and clearly stated with a lower serving cost, although the dose and long-term-use cautions remain important.</p>
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