Product Image

Methyl-Guard

Thorne
4.9
★ ★ ★ ★ ★
(3372 ratings)
Vitamin B6 20.4 mg
Product Image
Score92

A high-quality, comprehensive blend of active B vitamins (P5P B6, Folate, Methyl B12) and TMG, specifically designed to support methylation and related metabolic functions from a professional brand.

How scoring works
Quantity:180 Capsule(s) • (60 servings)
Goals:

Score 92

A high-quality, comprehensive blend of active B vitamins (P5P B6, Folate, Methyl B12) and TMG, specifically designed to support methylation and related metabolic functions from a professional brand.

How scoring works
$56.00($0.93 per serving)
Pure Formulas
$ 56.00
Vitacost
$ 56.00
Vitacost
$ 56.03
Walmart
$ 56.00
iHerb
$ 56.00
Report prices

Analysis

Thorne's Methyl-Guard is a specialized blend formulated to support methylation processes in the body, which are crucial for numerous biochemical reactions, including neurotransmitter synthesis and homocysteine metabolism. It contains active forms of B vitamins: 20.4 mg of Pyridoxal 5-Phosphate (active B6), 2 mg DFE of Folate, and 1.2 mg of Methylcobalamin (active B12).

The inclusion of 1.8 grams of Betaine Anhydrous (Trimethylglycine or TMG) further supports methylation and homocysteine regulation. This is a premium product designed for comprehensive cellular support, reflected in its ingredient quality and professional-grade brand reputation.

Pros

  • Contains active forms of B6 (P5P), Folate, and B12 (Methylcobalamin).
  • Includes Betaine Anhydrous (TMG) for enhanced methylation support.
  • Comprehensive blend targets multiple crucial metabolic pathways.
  • From Thorne, a highly respected professional-grade brand.
  • Significant customer satisfaction with over 3200 reviews.

Cons

  • Very high price per serving, positioning it as a premium product.
  • 60 servings (effectively a 30-day supply if taking 2 caps/day) offers a relatively short duration.
  • May be an overly complex or expensive option for general B6 needs alone.
  • The specific form of Folate is not explicitly provided (e.g., L-5-MTHF).

Warnings

  • Individuals on blood-thinning medications should consult a professional due to B vitamins' potential effects on homocysteine.
  • High doses of B vitamins can mask B12 deficiency symptoms; ensure proper diagnosis if supplementing.
  • Consult a healthcare professional if pregnant, nursing, or have a medical condition due to the comprehensive nature of the blend.
Report analysis

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxal 5-Phosphate)
 20.4 mg
Folate
2 mg DFE
Vitamin B12 (Methylcobalamin)
 1.2 mg
Betaine Anhydrous (Trimethylglycine)
 1.8 Gram(s)
Gluten Free Adults 18–50
Report overview
Vitamin B6 (Pyridoxal 5-Phosphate) · 20.4 mg OverallScore75
A+ Ingredient Form & BioavailabilityB- Potency & Safety ProfileD- Formulation SynergyB Price & Product Utility
Methyl-Guard is specifically designed for high-efficiency methylation, using active P-5-P and methylated cofactors. It offers a targeted, highly bioavailable dose of B6, though it requires multiple capsules and lacks mineral synergy.
View ingredientView products
88 Value

P-5-P 100 mg

Nutricost
4.8
★★★★★
(758 ratings)
This offers a higher dose of the activated P-5-P form with a comparable score at a dramatically lower price, presenting excellent value for those seeking potent P-5-P for methylation support.
Other sellers (0)
85 Value

P-5-P 50 mg

Nutricost
4.8
★★★★★
(1111 ratings)
Provides the activated P-5-P form at a significantly lower price, representing great value for an activated B6 supplement that supports methylation pathways.
Other sellers (0)
88 Value

P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength

Swanson
4.8
★★★★★
(2741 ratings)
Delivers a potent dose of the activated P-5-P form with a high score for a much lower price, making it a strong value choice for supporting methylation.
Other sellers (1)
90 Performance

Pyridoxal 5'-Phosphate Caps 100 mg

Life Extension
4.9
★★★★★
(3352 ratings)
This product offers a higher rated P-5-P form of B6 at a more potent 100 mg dose, which may provide enhanced support for various metabolic and neurological functions, including methylation processes.
Other sellers (3)
88 Performance

B6 Complex

Pure Encapsulations
4.8
★★★★★
(38 ratings)
While the score is similar, this is a comprehensive B-complex that includes both Pyridoxine HCl and P-5-P forms of B6, along with other essential B vitamins and folate, complementing the methylation support goals of your current product.
Other sellers (1)
88 Performance

Super Nu-Thera with Extra P5P

Kirkman
4.7
★★★★★
(38 ratings)
This is a robust multi-vitamin/mineral formula that includes a substantial amount of P-5-P, alongside other B vitamins and nutrients, providing comprehensive support for various bodily processes including methylation.
Other sellers (1)
85 Budget

P-5-P 50 mg

Nutricost
4.8
★★★★★
(1111 ratings)
Offers the activated P-5-P form of B6, a key ingredient in your current product, at a significantly lower cost, providing a concentrated source of this component.
Other sellers (0)
88 Budget

P-5-P 100 mg

Nutricost
4.8
★★★★★
(758 ratings)
Delivers a higher 100 mg dose of P-5-P at a substantially lower price, offering a potent and economical way to supplement activated B6 for methylation support.
Other sellers (0)
88 Budget

P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength

Swanson
4.8
★★★★★
(2741 ratings)
Provides a comparable dose of P-5-P at a much more affordable price per serving, making it a budget-friendly option for obtaining activated B6 for metabolic needs.
Other sellers (1)
88 Value

P-5-P 100 mg

Nutricost
4.8
★★★★★
(758 ratings)
This offers a higher dose of the activated P-5-P form with a comparable score at a dramatically lower price, presenting excellent value for those seeking potent P-5-P for methylation support.
Other sellers (0)
85 Value

P-5-P 50 mg

Nutricost
4.8
★★★★★
(1111 ratings)
Provides the activated P-5-P form at a significantly lower price, representing great value for an activated B6 supplement that supports methylation pathways.
Other sellers (0)
88 Value

P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength

Swanson
4.8
★★★★★
(2741 ratings)
Delivers a potent dose of the activated P-5-P form with a high score for a much lower price, making it a strong value choice for supporting methylation.
Other sellers (1)
90 Performance

Pyridoxal 5'-Phosphate Caps 100 mg

Life Extension
4.9
★★★★★
(3352 ratings)
This product offers a higher rated P-5-P form of B6 at a more potent 100 mg dose, which may provide enhanced support for various metabolic and neurological functions, including methylation processes.
Other sellers (3)
88 Performance

B6 Complex

Pure Encapsulations
4.8
★★★★★
(38 ratings)
While the score is similar, this is a comprehensive B-complex that includes both Pyridoxine HCl and P-5-P forms of B6, along with other essential B vitamins and folate, complementing the methylation support goals of your current product.
Other sellers (1)
88 Performance

Super Nu-Thera with Extra P5P

Kirkman
4.7
★★★★★
(38 ratings)
This is a robust multi-vitamin/mineral formula that includes a substantial amount of P-5-P, alongside other B vitamins and nutrients, providing comprehensive support for various bodily processes including methylation.
Other sellers (1)
Report alternatives