Product Image

Sunny Mood with 5-HTP

Irwin Naturals
4.6
★ ★ ★ ★ ★
(123 ratings)
Theanine 50 mg
5-HTP 100 mg
Chromium 100 mcg
Rhodiola
Protein 1 Gram(s)
Product Image
Score73
A well-aligned mood and stress blend led by 5-HTP, lemon balm, passionflower, rhodiola, and theanine. Modest secondary doses and serious serotonin-related interactions are the main trade-offs.
How scoring works
Quantity:80 Softgel(s) • (40 servings)
Goals:
Stress Relief
Mood Support
Sleep Support
Cognitive Support

Score 73

A well-aligned mood and stress blend led by 5-HTP, lemon balm, passionflower, rhodiola, and theanine. Modest secondary doses and serious serotonin-related interactions are the main trade-offs.
How scoring works
$26.34($0.65 per serving)
iHerb
$ 26.34
Pure Formulas
$ 27.99
Vitacost
$ 27.99
Report prices

Analysis

5-HTP provides the central serotonin-precursor component, while lemon balm, passionflower, theanine, and magnesium add calming support. Rhodiola, saffron, damiana, vitamin D3, and flaxseed oil broaden the design toward daytime mood and stress resilience.

The 5-HTP amount is meaningful and its Griffonia source is named. Theanine, magnesium, saffron, and rhodiola are supporting rather than targeted amounts, while most botanical extracts lack marker percentages.

It may suit adults seeking a combined mood-and-relaxation formula who do not use serotonin-raising medicines. The mix is not ideal for focused weight loss or acute energy, and calming botanicals may make some users drowsy.

Who is it for
  • Adults seeking non-stimulant mood and stress support
  • People not using serotonin-raising medicines
Best for
  • Mood support centered on 5-HTP
  • Calm and stress support with several complementary botanicals

Pros

  • Meaningful 5-HTP amount
  • Griffonia source is identified
  • Coherent calming botanical blend
  • Includes D3 and magnesium citrate
  • Softgel oil base

Cons

  • Rhodiola and theanine are modestly dosed
  • Botanical standardization is limited
  • Saffron amount is small
  • Not well aligned with weight loss
  • Two-softgel serving

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, triptans, or other serotonin-raising products because excessive serotonin can be dangerous.
  • Lemon balm, passionflower, theanine, and 5-HTP may cause drowsiness or add to sedative effects.
  • Rhodiola may feel activating and may not suit people with bipolar disorder or those using activating psychiatric medicines.
  • Chromium may add to glucose-lowering effects in people using diabetes medicines.

Nutrient quality

75 High impact

A useful 5-HTP amount anchors the mood-focused formula, with citrate magnesium, chromium picolinate, and vitamin D3 in favorable forms. Most calming botanicals, saffron, theanine, rhodiola, and magnesium are modest, while the long list dilutes dose quality.

Ingredient transparency

75 High impact

Active amounts are stated, and no large proprietary blend hides the main doses. Duplicate saffron entries, sparse extract standardization, missing directions, and absent softgel excipients limit precision.

Customer satisfaction

68 High impact

The supplied aggregate rating is strong and supported by a useful amount of feedback. No comments were supplied, so recurring complaints and mood-specific experiences cannot be verified.

Value for money

72 High impact

The accessible daily cost and useful 5-HTP amount support reasonable value. Several supporting ingredients are too light or poorly standardized to make the formula a clear category leader.

Report analysis

Goals

Stress Relief
Stress Relief
Impact
Highest effect
B+ Goal FitB Strength of SupportB+ CoverageB+ Formula Quality
Vitamin D · 15 mcgMagnesium · 75 mgTheanine · 50 mg

5-HTP, lemon balm, passionflower, rhodiola, and theanine may support mood and relaxation through several pathways. The 5-HTP amount is meaningful within the formula.

Rhodiola and theanine are modest, and botanical standardization is limited. 5-HTP should not be combined casually with serotonergic medicines because excessive serotonin can be dangerous.

Study evidence
5-HTP Supportive 18 studies
Rhodiola Supportive 16 studies
Theanine Supportive 16 studies
Mood Support
Mood Support
Impact
High effect
B+ Goal FitC Strength of SupportB- CoverageB+ Formula Quality
Magnesium · 75 mgVitamin D · 15 mcg5-HTP · 100 mg

A 100 mg 5-HTP amount directly supports serotonin production, while rhodiola, L-theanine, and calming botanicals address stress. Magnesium and saffron add secondary support across several mood pathways.

The central 5-HTP dose is useful, but rhodiola, L-theanine, magnesium, and saffron are modest or lightly dosed. 5-HTP may interact with antidepressants and other serotonin-raising medicines.

Study evidence
5-HTP Supportive 9 studies
Magnesium Supportive 60 studies
Rhodiola Supportive 15 studies
Theanine Supportive 12 studies
Sleep Support
Sleep Support
Impact
High effect
C+ Goal FitB Strength of SupportB CoverageC+ Formula Quality
Magnesium · 75 mgTheanine · 50 mg

Five-hydroxytryptophan, lemon balm, passionflower, theanine, and magnesium can support calm and serotonin-related sleep preparation. The product is designed for daytime mood, lacks melatonin, and includes rhodiola that may feel activating near bedtime.

The formula covers serotonin production, botanical relaxation, stress resilience, and modest mineral support. Several calming ingredients complement one another, but the mood-focused adaptogen mix is not fully optimized for sleep.

Study evidence
5-HTP Supportive 1 study
Magnesium Supportive 23 studies
Theanine Supportive 8 studies
Cognitive Support
Cognitive Support
Impact
High effect
C Goal FitC Strength of SupportC+ CoverageB- Formula Quality
Magnesium · 75 mgVitamin D · 15 mcgTheanine · 50 mg

Rhodiola and L-theanine may support stress-related fatigue and calm focus, while magnesium provides general neurological support. 5-HTP shifts part of the formula toward mood rather than memory or processing speed.

The rhodiola and theanine amounts are moderate, and no botanical standardization is shown. The combination is relevant to cognitive strain but not a comprehensive memory or attention formula.

Study evidence
Magnesium Supportive 24 studies
Rhodiola Supportive 7 studies
Theanine Supportive 25 studies
Energy
Energy
Impact
Moderate effect
C Goal FitC Strength of SupportD+ CoverageB- Formula Quality
Vitamin D · 15 mcgMagnesium · 75 mgIron · 0.7 mg

Rhodiola offers modest stress-resilience support, but 5-HTP shifts the formula toward mood rather than energy. Magnesium and rhodiola remain below stronger target amounts.

The principal doses are disclosed, though extract standardization is limited. 5-HTP can interact with serotonergic medicines and does not provide acute alertness.

Study evidence
Magnesium Supportive 4 studies
Rhodiola Supportive 18 studies
Theanine Not classified

No linked studies yet.

Mental Focus
Mental Focus
Impact
Moderate effect
C Goal FitC- Strength of SupportC- CoverageC- Formula Quality
Vitamin D · 15 mcgMagnesium · 75 mgTheanine · 50 mg

Rhodiola and L-theanine provide modest resilience and calm-focus support, while 5-HTP and calming botanicals target mood. The formula is more aligned with emotional balance than acute attention or processing speed.

Rhodiola and theanine are below stronger focus ranges, and no stimulant or substantial precursor is present. 5-HTP can interact with serotonergic medicines such as antidepressants and may increase serotonin-related adverse effects.

Study evidence
Rhodiola Supportive 15 studies
Theanine Supportive 19 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Fat
1.5 Gram(s)
Total Carbohydrates
1 Gram(s)
Protein
1 Gram(s)
Vitamin D3 (Cholecalciferol)
 15 mcg
Iron
0.7 mg
Magnesium (Magnesium Citrate)
 75 mg
Chromium (Chromium Picolinate)
 100 mcg
Flaxseed Oil
1500 mg
Lemon Balm leaf extract
150 mg
Damiana leaf extract
100 mg
5-Hydroxytryptophan (Griffonia simplicifolia)
 100 mg
Passionflower Aerial Extract
100 mg
Rhodiola root extract
100 mg
L-Theanine
50 mg
Saffron Flower, Stigma Extract (Saffron Flower Extract, Saffron Stigma Extract)
 5 mg
BioPerine Complex
3 mg
Adults 18–50 Women
Report overview
Theanine · 50 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value

The explicitly identified L-theanine is individually disclosed at a mild supporting dose. Its generic form has no branded source or purity claim, which limits evidence for premium ingredient quality. Theanine is premium on its own, but a meaningful 5-HTP dose and several botanical extracts improve the wider formula's value.

View ingredientView products
5-HTP (Griffonia simplicifolia) · 100 mg OverallScore60
C+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value

The 100 mg serving matches the central target dose and identifies Griffonia simplicifolia as its source. Missing standardization and a standard liquid-softgel format limit quality and comfort advantages. Cost efficiency is modest, while the supplied label details omit a specific warning about combining 5-HTP with SSRIs or other serotonin-modulating medicines.

View ingredientView products
Chromium (Chromium Picolinate) · 100 mcg OverallScore47
B- Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value

Chromium picolinate provides a high-quality form, but its amount only reaches the bottom of the low-dose band. The label does not separate compound and elemental weights, while the mood-focused actives do not add metabolic value. A high normalized chromium cost makes the formula poor value for this collection.

View ingredientView products
Loading alternative details
92 Performance

Cortisol Calm

Pure Encapsulations
<p>A more focused ingredient profile improves alignment with the main goals: standardized ashwagandha, rhodiola, magnolia, and theanine provide well-focused stress and calm-energy support. Duplicate vitamin entries and missing inactive ingredients slightly reduce label clarity.</p>
89 Performance

Sunny Mood with Rhodiola

Irwin Naturals
<p>A more focused ingredient profile improves alignment with the main goals: standardized rhodiola, theanine, magnesium, lemon balm, passionflower, and saffron provide stronger daytime mood and focus support. Fish oil is lightly concentrated, and calming herbs may cause drowsiness or interact with blood-thinning medicines.</p>
90 Performance

Pure Energy

Swanson
<p>A more focused ingredient profile improves alignment with the main goals: clearly dosed caffeine, rhodiola, and L-theanine create a concise formula for energy and mental focus. Caffeine may worsen anxiety or sleep and should not be combined freely with other stimulants.</p>
93 Budget

Sleep Regimen 3-in-1

NOW
<p>A lower-cost serving improves affordability while keeping relevant ingredients: melatonin, L-theanine, and Griffonia-derived 5-HTP provide focused sleep and mood support at strong serving value. The 5-HTP extract lacks standardization and can interact with serotonin-raising medicines.</p>
70 Budget

PureBalance Seratonin

Quality Of Life
<p>A lower-cost serving improves affordability while keeping relevant ingredients: 5-HTP, theanine, and rhodiola provide a plausible lower-cost mood and stress base. The amounts are modest and a large proprietary blend hides key doses and safety details.</p>
78 Budget

Sleep Support

Bluebonnet Targeted Choice
<p>A lower-cost serving improves affordability while keeping relevant ingredients: theanine, valerian, tart cherry, passionflower, 5-HTP, and chamomile provide economical sleep and relaxation support. The ingredients are lightly dosed, and 5-HTP can interact with serotonergic medicines.</p>
88 Value

Tranquil Sleep

Natural Factors Stress-Relax
<p>The mix of relevant ingredients and practical serving value is more favorable: suntheanine, physiological melatonin, and Griffonia-derived 5-HTP create a clearly defined bedtime blend. The modest 5-HTP amount can still interact with SSRIs, SNRIs, MAO inhibitors, triptans, or other serotonergic medicines.</p>
80 Value

Extra Strength Sleep Blackberry Zen

OLLY
<p>The mix of relevant ingredients and practical serving value is more favorable: melatonin, L-theanine, and calming herbs provide a practical sleep-onset gummy. Supporting ingredients are modest, and the melatonin amount may cause morning grogginess or vivid dreams.</p>
76 Value

Double Potency 5-HTP Extra

Irwin Naturals
<p>The mix of relevant ingredients and practical serving value is more favorable: meaningful 5-HTP and theanine provide a familiar mood and relaxation core. Supporting ingredients are modest, fish-oil details are incomplete, and 5-HTP can interact dangerously with serotonergic medicines.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.
    Mao JJ; Xie SX; Zee J; Soeller I; Li QS; Rockwell K; Amsterdam JD · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2015
    Randomized trial57 participantsMood Support forRhodiola
  2. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsMood Support Stress Relief Sleep Support forTheanine
  3. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  4. Scientific Opinion on the substantiation of a health claim related to Rhodiola rosea L. extract and reduction of mental fatigue pursuant to Article 13(5) of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusStress Relief forRhodiola
  5. Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.
    Maes M; Vandewoude M; Schotte C; Maes L; Martin M; Blockx P · Acta psychiatrica Scandinavica · 1990
    Clinical trial120 participantsStress Relief for5-HTP
  6. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledMood Support forTheanine
  7. Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
    Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
    Randomized trial120 participantsStress Relief forTheanine
  8. [Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea].
    Yu HL; Zhang PP; Zhang C; Zhang X; Li ZZ; Li WQ; Fu AS · Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2019
    Randomized trial90 participantsStress Relief Mood Support forRhodiola
  9. Gastrointestinal distress to serotonergic challenge: a risk marker for emotional disorder?
    Campo JV; Dahl RE; Williamson DE; Birmaher B; Perel JM; Ryan ND · Journal of the American Academy of Child and Adolescent Psychiatry · 2003
    Cohort study23 participantsStress Relief for5-HTP
  10. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  11. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  12. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  13. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  14. Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.
    Urata M; Sakurai H; Ueno F; Maruki T; Tada T; Uchida T; Matsumoto Y; Murao M; Tomita M; Baba H; Kato M; Tsuboi T; Watanabe K · Neuropsychopharmacology reports · 2025
    Meta-analysis1,049 participants2 studies pooledMood Support forRhodiola
  15. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  16. Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.
    Łuszczak J; Kocki J · Annals of agricultural and environmental medicine : AAEM · 2026
    Systematic review19 studies pooledStress Relief Cognitive Support forRhodiola
  17. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsStress Relief Mood Support forTheanine
  18. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsStress Relief Mental Focus forTheanine
  19. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  20. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
    Olsson EM; von Schéele B; Panossian AG · Planta medica · 2009
    Randomized trial60 participantsMood Support Cognitive Support forRhodiola
  21. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  22. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.
    Lekomtseva Y; Zhukova I; Wacker A · Complementary medicine research · 2019
    Single-arm trial100 participantsStress Relief Energy forRhodiola
  23. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support Stress Relief forTheanine
  24. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsStress Relief Cognitive Support Sleep Support forTheanine
  25. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  26. The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men.
    Duncan MJ; Clarke ND · Journal of sports medicine (Hindawi Publishing Corporation) · 2015
    Clinical trial10 participantsMood Support forRhodiola
  27. Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).
    Bertolini F; Robertson L; Bisson JI; Meader N; Churchill R; Ostuzzi G; Stein DJ; Williams T; Barbui C · The Cochrane database of systematic reviews · 2022
    Systematic review2,023 participants13 studies pooledStress Relief for5-HTP
  28. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence.
    Ivanova Stojcheva E; Quintela JC · Molecules (Basel, Switzerland) · 2022
    Narrative reviewStress Relief forRhodiola
  29. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine
  30. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses.
    Yoto A; Motoki M; Murao S; Yokogoshi H · Journal of physiological anthropology · 2013
    Randomized trial14 participantsStress Relief forTheanine
  31. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence.
    Sarris J; Panossian A; Schweitzer I; Stough C; Scholey A · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2012
    Systematic review66 studies pooledMood Support forRhodiola
  32. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  33. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  34. The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment.
    Schutgens FW; Neogi P; van Wijk EP; van Wijk R; Wikman G; Wiegant FA · Phytotherapy research : PTR · 2009
    Randomized trial30 participantsStress Relief forRhodiola
  35. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialStress Relief forTheanine
  36. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  37. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms.
    Kasper S; Dienel A · Neuropsychiatric disease and treatment · 2020
    Single-arm trial118 participantsMood Support forRhodiola
  38. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  39. Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
    Baraldi S; Hepgul N; Mondelli V; Pariante CM · Journal of clinical psychopharmacology · 2012
    Systematic review64 studies pooledMood Support for5-HTP
  40. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.
    Sarris J; Ravindran A; Yatham LN; Marx W; Rucklidge JJ; McIntyre RS; Akhondzadeh S; Benedetti F; Caneo C; Cramer H; Cribb L; de Manincor M; Dean O; Deslandes AC; Freeman MP; Gangadhar B; Harvey BH; Kasper S; Lake J; Lopresti A; Lu L; Metri NJ; Mischoulon D; Ng CH; Nishi D; Rahimi R; Seedat S; Sinclair J; Su KP; Zhang ZJ; Berk M · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2022
    Guideline / consensusStress Relief forRhodiola
  41. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
    Zhang W; Yan Y; Wu Y; Yang H; Zhu P; Yan F; Zhao R; Tian P; Wang T; Fan Q; Su Z · Pharmacological research · 2022
    Meta-analysis29 participants29 studies pooledMood Support forTheanine
  42. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD).
    Bystritsky A; Kerwin L; Feusner JD · Journal of alternative and complementary medicine (New York, N.Y.) · 2008
    Single-arm trial10 participantsMood Support Stress Relief forRhodiola
  43. Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies.
    Sobczak S; Honig A; van Duinen MA; Riedel WJ · Bipolar disorders · 2003
    Systematic review15 studies pooledStress Relief for5-HTP
  44. Stress management and the role of Rhodiola rosea: a review.
    Anghelescu IG; Edwards D; Seifritz E; Kasper S · International journal of psychiatry in clinical practice · 2019
    Narrative reviewStress Relief forRhodiola
  45. Serotonin precursors in the treatment of depression.
    van Praag HM · Advances in biochemical psychopharmacology · 1982
    Narrative reviewMood Support for5-HTP
  46. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans.
    Lu K; Gray MA; Oliver C; Liley DT; Harrison BJ; Bartholomeusz CF; Phan KL; Nathan PJ · Human psychopharmacology · 2005
    Randomized trial16 participantsMood Support forTheanine
  47. Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials.
    Moragrega I; Ríos JL · Planta medica · 2022
    Systematic reviewMood Support forRhodiola
  48. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  49. Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Takahashi S; Takahashi R; Masumura I; Miike A · Folia psychiatrica et neurologica japonica · 1977
    Single-arm trial14 participantsMood Support for5-HTP
  50. Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia.
    Lopes Sakamoto F; Metzker Pereira Ribeiro R; Amador Bueno A; Oliveira Santos H · Pharmacological research · 2020
    Narrative reviewMood Support forTheanine
  51. Antidepressants effects of Rhodiola capsule combined with sertraline for major depressive disorder: A randomized double-blind placebo-controlled clinical trial.
    Gao L; Wu C; Liao Y; Wang J · Journal of affective disorders · 2021
    Methods validation study100 participantsMood Support forRhodiola
  52. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
    Sarris J; McIntyre E; Camfield DA · CNS drugs · 2013
    Narrative reviewStress Relief forRhodiola
  53. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study.
    Sarzi Puttini P; Caruso I · The Journal of international medical research · 1992
    Single-arm trial50 participantsStress Relief for5-HTP
  54. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.
    Doyle LW; Crowther CA; Middleton P; Marret S; Rouse D · The Cochrane database of systematic reviews · 2009
    Meta-analysis6,145 participants5 studies pooledCognitive Support forMagnesium
  55. Effects of magnesium valproate adjuvant therapy on patients with dementia: A systematic review and meta-analysis.
    Zhang C; Sun L; Sun H · Medicine · 2022
    Meta-analysis1,899 participants22 studies pooledCognitive Support forMagnesium
  56. Effects of magnesium supplementation on serum brain-derived neurotrophic factor levels and cognitive function in patients undergoing fluoxetine therapy for depression.
    Noor NJ; Syamsuddin S; Liaury K; Tawali S; Idris I; Azis I; Lisal ST · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsCognitive Support forMagnesium
  57. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsCognitive Support Energy forMagnesium
  58. Could intraoperative magnesium sulphate protect against postoperative cognitive dysfunction?
    Hassan WF; Tawfik MH; Nabil TM; Abd Elkareem RM · Minerva anestesiologica · 2021
    Randomized trial80 participantsCognitive Support forMagnesium
  59. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
    Panossian A; Wikman G · Current clinical pharmacology · 2009
    Narrative reviewCognitive Support Mental Focus forRhodiola
  60. Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
    Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
    Single-arm trial50 participantsCognitive Support forRhodiola
  61. Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy.
    Al-Kuraishy HM · Journal of intercultural ethnopharmacology · 2016
    Clinical trial112 participantsCognitive Support forRhodiola
  62. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsCognitive Support forTheanine
  63. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledCognitive Support Mental Focus forTheanine
  64. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  65. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  66. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  67. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  68. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  69. The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.
    Wang J; Zhao H; Yu L; Zhao K; Jiang W; Liu S; Dai J; Xu L; Sun P; Yun H; Liu C · Nutrients · 2025
    Randomized trial48 participantsEnergy forRhodiola
  70. Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial.
    Dou Y; Wang Y; Zhang W; Jiang Y; Zhang J; Yang T; Han Z; Li Y; Liu C; Ren D · Nutrients · 2026
    Randomized trial24 participantsEnergy Mental Focus forRhodiola
  71. Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach.
    Tao B; Sun H; Li H; Xu Z; Xu Y; Chen L; Ma C; Zhang X; Yu L; Bao S; Liu C · Metabolites · 2025
    Randomized trial96 participantsEnergy forRhodiola
  72. Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women.
    Wang IL; Su Y; Zhang L; Tang M; Chen YM · Frontiers in physiology · 2025
    Randomized trial30 participantsEnergy forRhodiola
  73. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.
    Hung SK; Perry R; Ernst E · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
    Systematic review11 studies pooledMental Focus forRhodiola
  74. Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
    Koozehchian MS; Newton AT; Mabrey G; Bonness FM; Rafajlovska R; Naderi A · Nutrients · 2025
    Randomized trial27 participantsMental Focus forRhodiola
  75. Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men.
    Jówko E; Sadowski J; Długołęcka B; Gierczuk D; Opaszowski B; Cieśliński I · Journal of sport and health science · 2022
    Randomized trial26 participantsMental Focus forRhodiola
  76. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialMental Focus forTheanine
  77. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  78. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  79. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support forMagnesium
  80. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  81. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  82. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  83. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  84. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  85. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  86. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  87. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  88. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  89. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  90. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  91. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine