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Double Potency 5-HTP Extra

Irwin Naturals
4.6
★ ★ ★ ★ ★
(578 ratings)
Theanine 100 mg
5-HTP 100 mg
Fish Oil 800 mg
Product Image
Score61
A broad calming blend led by useful 5-HTP and L-theanine amounts. Unquantified EPA and DHA, weak extract detail, and significant medication interactions limit its fit.
How scoring works
Quantity:60 Softgel(s) • (30 servings)
Goals:
Mood Support
Sleep Support
Stress Relief
Cognitive Support

Score 61

A broad calming blend led by useful 5-HTP and L-theanine amounts. Unquantified EPA and DHA, weak extract detail, and significant medication interactions limit its fit.
How scoring works
$19.99($0.66 per serving)
iHerb
$ 19.99
Pure Formulas
$ 19.99
Amazon
$ 19.99
Vitacost
$ 19.99
Report prices

Analysis

One hundred milligrams each of 5-HTP and L-theanine form the most useful part of the formula for mood-related relaxation and sleep support. Lemon balm, holy basil, saffron, and modest magnesium add related pathways, although several extract markers are missing.

Eight hundred milligrams of fish oil sounds substantial, but separate EPA and DHA amounts are not provided. The formula therefore cannot be judged as a serious fish-oil product, while the large ingredient list raises cost without giving every addition equal practical weight.

The softgels fit adults whose main needs are evening calm, mood support, or stress-related sleep difficulty. People seeking alertness, direct cardiovascular support, or predictable omega-three dosing should choose a more focused product.

Who is it for
  • Adults seeking mood-related relaxation support
  • People whose sleep is disrupted by mental tension
  • Users who want 5-HTP and L-theanine in one formula
Best for
  • Evening calm
  • Mood support
  • Stress-related sleep routines

Pros

  • Useful 100 mg 5-HTP amount
  • Useful 100 mg L-theanine amount
  • Several complementary calming ingredients
  • Softgel delivery for the fat-soluble components
  • Most principal active amounts are listed

Cons

  • EPA and DHA amounts are not disclosed
  • Several botanical extracts lack standardization details
  • Many secondary ingredients add uncertain value
  • Weak fit for focus or cardiovascular goals
  • Premium positioning for uneven formula depth

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, triptans, or other serotonin-raising medicines because excessive serotonin can be dangerous
  • 5-HTP, lemon balm, and other calming ingredients may cause drowsiness; avoid driving until individual response is known
  • BioPerine may change exposure to medicines processed by CYP3A4 or P-glycoprotein
  • Fish oil makes the softgels unsuitable for people with a fish allergy

Nutrient quality

72 High impact

The softgel suits the oil-based formula, while theanine and 5-HTP are supplied in meaningful amounts. Unquantified EPA and DHA plus numerous modest additions make the blend less coherent and harder to judge.

Ingredient transparency

57 Moderate impact

Main active amounts are disclosed, but EPA, DHA, several marker compounds, and some extract details are missing or malformed. Daily directions and the complete inactive-ingredient list are also not supplied.

Customer satisfaction

65 Moderate impact

The supplied average is favorable and the aggregate pool is moderate. No specific feedback is provided to assess recurring complaints or whether experience matches the intended uses.

Value for money

50 Lower impact

Meaningful theanine and 5-HTP amounts plus several supporting actives partly justify the premium. Poor fish-oil disclosure and numerous uncertain additions weaken value per effective serving.

Report analysis

Goals

Mood Support
Mood Support
Impact
Highest effect
A- Goal FitB+ Strength of SupportA- CoverageB+ Formula Quality
Vitamin B6 · 10 mgMagnesium · 50 mgVitamin D · 12.5 mcg5-HTP · 100 mg

Five-HTP, L-theanine, lemon balm, holy basil, saffron, magnesium, vitamin B6, and fish oil address neurotransmitter and stress-response pathways. The 5-HTP and theanine amounts are meaningful, while several botanicals are less clearly standardized or more modestly dosed.

Vitamin B6 logically supports neurotransmitter synthesis, but the long formula mixes strong actives with less certain additions. Five-HTP can raise serotonin, so combining it with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines may increase adverse effects.

Study evidence
5-HTP Supportive 9 studies
Magnesium Supportive 60 studies
Theanine Supportive 12 studies
Vitamin B6 Supportive 19 studies
Sleep Support
Sleep Support
Impact
Highest effect
B+ Goal FitA- Strength of SupportB+ CoverageC Formula Quality
Magnesium · 50 mgTheanine · 100 mg

The formula combines 5-HTP and L-theanine at meaningful amounts with several calming botanicals. Its main actives address serotonin production, mental relaxation, and stress-related barriers to sleep.

Many additional ingredients broaden the concept but are too lightly dosed or poorly characterized to establish equal depth. The 100 mg 5-HTP serving can interact with SSRIs, SNRIs, MAO inhibitors, and other serotonin-raising medicines, increasing the risk of serotonin-related adverse effects.

Study evidence
5-HTP Supportive 1 study
Magnesium Supportive 23 studies
Theanine Supportive 8 studies
Stress Relief
Stress Relief
Impact
High effect
B+ Goal FitB- Strength of SupportB CoverageB- Formula Quality
Vitamin D · 12.5 mcgMagnesium · 50 mgVitamin B6 · 10 mgTheanine · 100 mg

L-theanine and 5-HTP provide direct support for relaxed attention, mood, and sleep-related stress. Lemon balm and holy basil add calming pathways, though their extract details are limited.

The main amino-acid amounts are meaningful, while several botanicals and nutrients contribute less certain depth. The 5-HTP should not be combined with SSRIs, SNRIs, MAO inhibitors, or other serotonergic drugs because serotonin-related adverse effects can increase.

Study evidence
5-HTP Supportive 18 studies
Theanine Supportive 16 studies
Cognitive Support
Cognitive Support
Impact
High effect
C+ Goal FitC+ Strength of SupportB- CoverageC+ Formula Quality
Vitamin B6 · 10 mgMagnesium · 50 mgVitamin D · 12.5 mcgTheanine · 100 mg

L-theanine, 5-HTP, lemon balm, and magnesium support calmness and mood-related cognition rather than memory or alertness. Evidence varies across the blend and is strongest for theanine and correction of nutrient gaps.

Most active amounts are disclosed, but fish-oil EPA and DHA are not quantified and several extracts lack standardization details. Combining 5-HTP with serotonergic antidepressants, monoamine oxidase inhibitors, or other serotonin-raising products may increase serotonin-syndrome risk.

Study evidence
Magnesium Supportive 24 studies
Theanine Supportive 25 studies
Weight Loss
Weight Loss
Impact
Moderate effect
C- Goal FitB- Strength of SupportC CoverageC Formula Quality
Vitamin D · 12.5 mcgMagnesium · 50 mg

5-HTP may influence appetite through serotonin, while theanine, lemon balm, holy basil, and saffron target stress-related eating. The formula is primarily a mood and relaxation product rather than a direct fat-loss aid.

Fish oil lacks EPA and DHA amounts, and several botanicals are modest or hidden within a small blend. Because 5-HTP raises serotonin, combining it with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines may increase serotonin-toxicity risk.

Study evidence
5-HTP Supportive 5 studies
Fish Oil Disputed 30 studies
Theanine Not classified

No linked studies yet.

Productivity Boost
Productivity Boost
Impact
Moderate effect
C Goal FitB- Strength of SupportC CoverageD+ Formula Quality
Vitamin B6 · 10 mgMagnesium · 50 mgTheanine · 100 mg

L-theanine and several calming botanicals may support focused work when stress or restlessness is the main barrier. The formula lacks an alertness driver, and 5-HTP, lemon balm, and the broader calming stack may reduce drive or cause drowsiness in some users.

The main active amounts are disclosed and the theanine amount reaches a useful level, but several extracts lack standardization or complete amounts. Combining 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines can increase serotonin-toxicity risk.

Study evidence
Theanine Supportive 5 studies

Ingredients

IngredientAmount per serving
Calories
15 Calorie(s)
Total Fat
1 Gram(s)
Cholesterol
5 mg
Total Carbohydrates
1 Gram(s)
Protein
1 Gram(s)
Vitamin D
12.5 mcg
Vitamin B6
10 mg
Magnesium
50 mg
Fish Oil
800 mg
5-HTP
100 mg
Lemon Balm extract
100 mg
L-Theanine
100 mg
Damiana extract
75 mg
Holy Basil extract
75 mg
Saffr'active Saffron extract
5 mg
BioPerine Complex
3 mg
Bioperine Black Pepper extract
0 NP
Ginger extract
0 NP
Adults 18–50 Women
Report overview
Theanine · 100 mg OverallScore82
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

The formula provides an optimal amount of clearly disclosed L-Theanine, but its generic source has no added purity evidence. A clinically meaningful 5-HTP dose and several calming botanicals broaden the formula's purpose and partly support its premium price. The 5-HTP content may raise serotonin-excess risk when combined with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines.

View ingredientView products
5-HTP · 100 mg OverallScore60
C+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value

The serving delivers the collection's standard amount of 5-HTP from Griffonia simplicifolia, but no standardization percentage is shown. The liquid softgel includes several complementary ingredients yet lacks a specialized delayed-release feature. Because 5-HTP can raise serotonin, combining it with SSRIs, MAO inhibitors, or other serotonin-modulating medicines could increase the risk of serotonin-related adverse effects.

View ingredientView products
Fish Oil · 800 mg OverallScore3
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The fish oil does not quantify EPA or DHA, leaving its active dose, concentration, and value unknown. Molecular form, source, purification, testing, and antioxidant protection are also not stated. The included 5-HTP can interact with serotonergic medicines such as SSRIs or MAO inhibitors and may raise the risk of serotonin excess.

View ingredientView products
Loading alternative details
77 Performance

Sleep Support

The Vitamin Shoppe
Theanine, GABA, melatonin, and 5-HTP form a more clearly sleep-oriented formula with visible amounts. The 5-HTP dose is high and raw valerian is less concentrated, but the purpose is more focused than the original broad mood blend.
77 Performance

Lights Out Sleep

ALLMAX
Valerian, GABA, melatonin, active vitamin B6, and calming herbs create broader sleep-specific coverage. Theanine is modest and 5-HTP can interact with serotonin-raising medicines, but the nighttime design is more coherent.
82 Performance

Sleep Nighttime Powder

youtheory
Glycine, theanine, magnesium citrate, tryptophan, 5-HTP, and low-dose melatonin create a well-dosed nighttime formula. Tryptophan and 5-HTP can dangerously add to serotonergic medicines, but active amounts are clearer and more purposeful.
87 Budget

Sleep Regimen 3-in-1

NOW
A focused combination of theanine, 5-HTP, and melatonin costs much less per serving and avoids a crowded blend. It drops fish oil and several supporting ingredients, while 5-HTP still carries serotonin-interaction risk.
82 Budget

Tranquil Sleep

Natural Factors Stress-Relax
Branded Suntheanine, melatonin, and modest 5-HTP provide a clearer bedtime formula at lower recurring cost. Fish oil and mood-support extras are absent, while serotonergic medicine interactions remain relevant.
79 Budget

Superior Sleep

Doctor's Best
A lower serving cost provides meaningful ashwagandha, theanine, GABA, melatonin, and 5-HTP amounts. The 5 mg melatonin and 200 mg 5-HTP amounts are aggressive, so morning grogginess and serotonin interactions require care.
69 Value

Sleep Support

Bluebonnet Targeted Choice
A lower serving cost retains theanine and 5-HTP while adding valerian, tart cherry, passionflower, and chamomile. The blend is lightly dosed and standards are incomplete, but its sleep focus is clearer.
73 Value

Sunny Mood with 5-HTP

Irwin Naturals
A similar serving cost combines a standard 5-HTP amount with rhodiola, theanine, passionflower, saffron, magnesium, and vitamin D3. Supporting doses are modest and fish oil is absent, but the broad mood-and-stress purpose is more coherent.
78 Value

Extra Strength Tranquil Sleep

Natural Factors Stress-Relax
A long supply combines branded Suntheanine with melatonin at a lower recurring cost. The 6 mg melatonin dose is high and 5-HTP is token, but formula disclosure and serving value are stronger.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  2. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  3. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  4. Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.
    Maes M; Vandewoude M; Schotte C; Maes L; Martin M; Blockx P · Acta psychiatrica Scandinavica · 1990
    Clinical trial120 participantsStress Relief for5-HTP
  5. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  6. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledStress Relief Mood Support forTheanine
  7. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialStress Relief Brain Health forTheanine
  8. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  9. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  10. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  11. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledMood Support Productivity Boost forTheanine
  12. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  13. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  14. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  15. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  16. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  17. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  18. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  19. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  20. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  21. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  22. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  23. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.
    Doyle LW; Crowther CA; Middleton P; Marret S; Rouse D · The Cochrane database of systematic reviews · 2009
    Meta-analysis6,145 participants5 studies pooledCognitive Support forMagnesium
  24. Effects of magnesium valproate adjuvant therapy on patients with dementia: A systematic review and meta-analysis.
    Zhang C; Sun L; Sun H · Medicine · 2022
    Meta-analysis1,899 participants22 studies pooledCognitive Support forMagnesium
  25. Effects of magnesium supplementation on serum brain-derived neurotrophic factor levels and cognitive function in patients undergoing fluoxetine therapy for depression.
    Noor NJ; Syamsuddin S; Liaury K; Tawali S; Idris I; Azis I; Lisal ST · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsCognitive Support forMagnesium
  26. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsCognitive Support forMagnesium
  27. Could intraoperative magnesium sulphate protect against postoperative cognitive dysfunction?
    Hassan WF; Tawfik MH; Nabil TM; Abd Elkareem RM · Minerva anestesiologica · 2021
    Randomized trial80 participantsCognitive Support forMagnesium
  28. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  29. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  30. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  31. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  32. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  33. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  34. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  35. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  36. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support forMagnesium
  37. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  38. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  39. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  40. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine
  41. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  42. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  43. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support forVitamin B6
  44. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  45. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  46. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  47. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  48. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsProductivity Boost forTheanine
  49. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  50. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  51. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  52. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  53. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  54. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  55. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  56. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
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