Vitamin D3 5000 IU
INNATE Response Formulas
Vitamin D3 5000 IU
4.8
★ ★ ★ ★ ★
(226 ratings)
Vitamin K 120 mcg
Score 80.0
A D3/K2 (MK-7) combo from a quality brand, featuring a strong D3 dose but a lower K2 dose, offering good benefits but at a premium price.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Bone Health
Heart Health
Cardiovascular Support
General Health
leaderboard Score 80.0
A D3/K2 (MK-7) combo from a quality brand, featuring a strong D3 dose but a lower K2 dose, offering good benefits but at a premium price.
insights Analysis
The INNATE Response Formulas Vitamin D3 5000 IU (with implied K2 80mcg MK-7) is a solid supplement for supporting calcium metabolism, bone density, and arterial health. The Vitamin D3 at 5000 IU is an effective dosage for many adults, and the inclusion of MK-7, the superior form of K2, ensures that calcium is properly directed. However, the 80mcg MK-7 dosage, while beneficial, is on the lower side compared to the 100-180mcg often recommended for optimal D3/K2 synergy. The brand is known for its quality focus, but the high price per serving and lower review count indicate it might be a more niche or premium option compared to more widely adopted alternatives.
- Contains a high, effective dose of Vitamin D3 (5000 IU).
- Includes Menaquinone-7 (MK-7) for Vitamin K2, which is the superior form.
- Offers the synergistic combination of D3 and K2 crucial for bone and cardiovascular health.
- From INNATE Response Formulas, a brand generally associated with high-quality and natural ingredient focus.
- The Vitamin K2 (MK-7) dosage (80mcg) is on the lower side compared to optimal synergistic doses (e.g., 100-180mcg) found in other D3/K2 combos.
- High price per serving (63 cents) makes it less competitive value-wise compared to many equally effective options.
- Lower number of reviews suggests less widespread adoption or consumer awareness.
$37.99($0.63 per serving)
 Pure Formulas | $ 37.99 | |
 Walmart | $ 37.99 | |
 iHerb | $ 37.99 |
bolt Effectiveness for goals
Vitamin K is essential for proper blood clotting and plays a significant role in bone metabolism. It helps the body produce proteins necessary for these vital bodily functions.
Vitamin K activates proteins such as osteocalcin, which are crucial for incorporating calcium into the bone matrix. This mechanism supports bone mineralization and helps maintain bone density.
Vitamin K1 (phylloquinone) is primarily effective for blood coagulation and is abundant in green leafy vegetables. Vitamin K2 (menaquinones) is more involved in bone and cardiovascular health, found in fermented foods and animal products, and has different bioavailabilities.
Emerging research suggests that Vitamin K, particularly K2, may help prevent arterial calcification by activating matrix Gla protein. This protein helps inhibit calcium deposition in soft tissues, supporting arterial flexibility.
Vitamin K works synergistically with calcium by helping to direct calcium to the bones and away from soft tissues like arteries. It activates proteins like osteocalcin for bone binding and matrix Gla protein to inhibit soft tissue calcification.
schedule Dosage, timing & forms
Recommended dosages for Vitamin K vary by age and form (K1 vs K2). For adults, the Adequate Intake (AI) for Vitamin K is 120 mcg per day for men and 90 mcg per day for women. Specific supplemental dosages may differ depending on individual needs and health goals.
Yes, dosages can differ between Vitamin K1 and K2 due to their varying potencies and half-lives. While K1 is measured in micrograms (mcg) for general intake, K2 (especially MK-7) may be effective at lower microgram doses due to its longer half-life. It's important to check the specific form and dosage on the supplement label.
Yes, Vitamin K is a fat-soluble vitamin, meaning it is best absorbed when taken with a meal containing some dietary fat. This helps facilitate its absorption into the body.
The two main forms of Vitamin K found in supplements are Vitamin K1 (phylloquinone) and Vitamin K2 (menaquinone). Vitamin K2 further has various subtypes, with MK-4 and MK-7 being the most common in supplements. Each form may have distinct roles and bioavailability.
There is no established Upper Limit (UL) for Vitamin K from food or supplements, as toxicity is rare. However, high doses of synthetic Vitamin K (menadione, K3) can be toxic, though this form is not typically found in supplements. Always adhere to recommended dosages and consult a healthcare provider if you have concerns.
health_and_safety Safety & interactions
Vitamin K plays a crucial role in blood clotting, which is the opposite effect of anticoagulant medications such as warfarin. Consuming inconsistent amounts of Vitamin K can alter warfarin's effectiveness, potentially making the blood thinner less effective or increasing bleeding risk. Individuals taking warfarin should maintain a consistent intake of Vitamin K and consult their healthcare provider.
Individuals taking anticoagulant medications like warfarin should consult their doctor before taking Vitamin K supplements due to potential interactions. People with certain liver conditions or those with a G6PD deficiency should also seek medical advice before supplementation. Always discuss new supplements with a healthcare provider.
Vitamin K supplements are generally considered safe for most healthy individuals when taken at recommended dosages. Side effects are uncommon but can include upset stomach, diarrhea, or allergic reactions in sensitive individuals. High doses of synthetic Vitamin K (menadione, K3) can be toxic, but this form is rarely used in supplements.
Vitamin K is essential during pregnancy and breastfeeding, and adequate intake is important for both mother and child. However, supplementation during these periods should only be undertaken under the guidance of a healthcare professional. High doses are generally not recommended without specific medical advice.
There is currently no established Tolerable Upper Intake Level (UL) for Vitamin K from food or supplements due to its low potential for toxicity. However, excessive intake, especially of synthetic forms, could potentially have adverse effects. It is always best to adhere to recommended dosages on supplement labels or as advised by a healthcare professional.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin D3 | 125 mcg |
Vitamin K | 120 mcg |
Vitamin K2 | 80 mcg |
Categories
Vitamin K 80.0
The inclusion of 80mcg of Menaquinone-7 (MK-7) is a respectable dose of the preferred form of Vitamin K2. While not the highest dose available, it provides effective support for Vitamin K-dependent processes, making it a good source.
Goals
Bone Health 85.0
The combination of Vitamin D3 5000 IU (for calcium absorption) and MK-7 K2 (for calcium targeting to bones) creates a strong synergistic effect for supporting bone density and strength. The 80mcg K2 is beneficial, though a higher dose would make it even more optimal.
Heart Health 80.0
MK-7 K2 at 80mcg contributes to heart health by helping to prevent arterial calcification, which maintains arterial flexibility. The D3 also plays a supporting role in overall cardiovascular function, making it a good, though not top-tier, option for this goal.
Similar to heart health, the product aids in maintaining healthy cardiovascular function by utilizing K2 to direct calcium away from arteries and into bones. While the K2 dose is good, increasing it slightly could provide more pronounced benefits.
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