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Vitamin D3 5000 IU

4.8
★ ★ ★ ★ ★
(245 ratings)
Vitamin K 120 mcg
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Score77
Best suited to adults with a defined need for high-dose vitamin D plus two vitamin K forms; the 125 mcg vitamin D amount reaches the usual adult daily upper limit, while the dry capsule provides no stated lipid carrier.
How scoring works
Capsule
Quantity:60 Capsule(s) • (60 servings)
Goals:
Bone Health
General Health
Heart Health
Anti-Aging
Cardiovascular Support

Score 77

Best suited to adults with a defined need for high-dose vitamin D plus two vitamin K forms; the 125 mcg vitamin D amount reaches the usual adult daily upper limit, while the dry capsule provides no stated lipid carrier.
How scoring works
$37.99($0.63 per serving)
iHerb
$ 37.99
Pure Formulas
$ 37.99
Walmart
$ 37.99
Vitacost
$ 37.99
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Analysis

Vitamin D3, vitamin K1, and MK-7 form a coherent calcium-management combination with clear amounts. The label provides enough detail to judge the central vitamin strategy.

The 125 mcg vitamin D amount reaches the usual adult daily upper limit, while the dry capsule provides no stated lipid carrier. Format, dose, and companion nutrients determine whether it is appropriate for daily use.

The best fit is adults with a defined need for high-dose vitamin D plus two vitamin K forms. Vitamin K and vitamin D support normal physiology, but the practical benefit depends on baseline intake and individual need.

Who is it for
  • Adults with a defined need for high-dose vitamin D plus two vitamin K forms
  • Adults whose current vitamin intake matches the listed potency
  • Users able to account for vitamin K medication interactions
Best for
  • Combines vitamin D3, K1, and MK-7
  • All active amounts are disclosed
  • Users who accept that vitamin d amount is high for routine use

Pros

  • Combines vitamin D3, K1, and MK-7
  • All active amounts are disclosed
  • Strong alignment with bone support
  • One-capsule serving

Cons

  • Vitamin D amount is high for routine use
  • Dry capsule lacks a stated fat carrier
  • Higher serving cost
  • Not suited to users needing K2 without high-dose D3

Warnings

  • The 125 mcg vitamin D3 serving reaches the usual adult daily upper limit and should not be stacked casually with other vitamin D products.
  • Vitamin K1 and MK-7 can counteract warfarin and related vitamin K antagonist anticoagulants.
  • High vitamin D intake may worsen hypercalcemia or some kidney-stone risks, particularly when calcium intake is also high.

Nutrient quality

82 Highest impact

Cholecalciferol and MK-7 are useful forms, though the dry capsule has no stated lipid carrier, and the 80 mcg MK-7 amount is useful, while the 125 mcg vitamin D3 amount is concentrated. The vitamin D3 amount reaches a concentrated daily level that may be excessive when status is already adequate, while vitamin D3 and K2 form a coherent combination for calcium handling and bone support.

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Ingredient transparency

85 Highest impact

Every listed active ingredient has a specific amount, and no proprietary blend hides the dose of a listed active ingredient. Serving count is supplied, but complete daily-use directions are not provided, while inactive ingredients and excipients are not included in the supplied label details.

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Customer satisfaction

69 High impact

The supplied average rating is strong, and the relatively limited review count reduces confidence in the average rating. Specific review themes are unavailable, so repeated negatives and real-world fit remain uncertain.

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Value for money

68 High impact

Useful ingredient forms support fair value despite incomplete delivery details, and the high serving cost weakens value relative to simpler alternatives. The focused active profile is not inflated by low-value additions, while the product is reasonably competitive but lacks a clear quality or value advantage.

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Report analysis

Goals

Bone Health
Impact
Highest effect
A+ Goal FitA- Strength of SupportA CoverageA+ Formula Quality
Vitamin K · 80 mcgVitamin D · 125 mcg

The formula directly targets mineral structure, absorption, and remodeling with multiple bone-specific actives. Hydroxyapatite calcium, vitamin D, vitamin K, magnesium, and boron have strong complementary skeletal rationale.

The formula provides useful amounts across calcium, magnesium, vitamin D, K2, boron, and phosphorus. The formula covers mineral structure, absorption, remodeling, and trace-mineral support.

Study evidence
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
General Health
Impact
Highest effect
A Goal FitB+ Strength of SupportB- CoverageA+ Formula Quality
Vitamin D · 125 mcgVitamin K · 80 mcg

Vitamin D3, vitamin K1, and MK-7 form a focused combination for calcium handling, bone support, and other foundational functions. The amounts and vitamin forms are clearly disclosed, and MK-7 gives the formula a useful long-acting K2 component.

The vitamin D3 amount is high for routine unsupervised maintenance, so total intake and blood status matter when using it regularly. Both vitamin K forms can interfere with warfarin dose control, making the formula unsuitable without prescriber guidance for people taking that anticoagulant.

Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Heart Health
Impact
Highest effect
B+ Goal FitB+ Strength of SupportC+ CoverageA Formula Quality
Vitamin K · 80 mcgVitamin D · 125 mcg

Vitamin K2 as MK-7 provides a targeted 80 mcg amount for calcium regulation and arterial health. Vitamin D3 complements K2 by supporting calcium handling, although the D3 amount is high for routine use without checking total intake.

The dry capsule does not provide a stated lipid carrier for the fat-soluble vitamins. Added vitamin K1 overlaps with MK-7 and both forms can complicate stable warfarin dosing.

Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Anti-Aging
Impact
High effect
B+ Goal FitB Strength of SupportC CoverageA Formula Quality
Vitamin K · 80 mcgVitamin D · 125 mcg

Vitamin D3, vitamin K1, and MK-7 jointly support bone maintenance and calcium regulation. The combination has a meaningful healthy-aging role, especially for skeletal and vascular function.

The MK-7 amount is practical but below the stronger daily range used by some products, and the dry capsule has no stated fat-based delivery. The concentrated vitamin D3 may not suit users with adequate status, while both vitamin K forms can disrupt stable warfarin dosing.

Study evidence
Vitamin K Supportive 27 studies
Cardiovascular Support
Impact
High effect
B Goal FitB- Strength of SupportC CoverageA Formula Quality
Vitamin K · 80 mcgVitamin D · 125 mcg

Vitamin D3 and MK-7 form a useful pair for calcium regulation and vascular integrity. The K2 amount offers maintenance support, while the 125 mcg vitamin D3 dose is much higher than routine daily needs.

The dry capsule has no stated fat carrier, which may make delivery less reliable than an oil softgel. Both K1 and K2 can oppose warfarin-type anticoagulants, and the concentrated vitamin D3 dose is better matched to a documented need with calcium and vitamin D monitoring.

Study evidence
Vitamin D Mixed 170 studies
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin D3 (Cholecalciferol)
125 mcg
Vitamin K (Phytonadione)
120 mcg
Vitamin K2 (Menaquinone-7)
80 mcg
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
C+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD+ Value

The combination provides MK-7 in a practical maintenance amount, alongside separately disclosed vitamin K1 and vitamin D3. The dry capsule lacks stated fat-based delivery, and reaching the preferred MK-7 intake would require more than one serving. The high vitamin D3 amount may not suit people who already get substantial vitamin D, while both vitamin K forms can interfere with warfarin dose management.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  3. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  4. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  5. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  6. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  7. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  8. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  9. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  10. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  11. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  12. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  13. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  14. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  15. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  16. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  17. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forVitamin D
  18. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  19. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  20. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  21. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support Heart Health forVitamin D
  22. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  23. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  24. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  25. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  26. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  27. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  28. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  29. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  30. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  31. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  32. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  33. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  34. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  35. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  36. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  37. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  38. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  39. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K