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Vitamin K2+D3

4.8
★ ★ ★ ★ ★
(1261 ratings)
Vitamin K 100 mcg
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Score84
Best suited to adults wanting a balanced K2 and low-dose D3 formula; the dry tablet offers no stated fat-based delivery, but the nutrient balance is more moderate than high-dose D3 combinations.
How scoring works
Tablet
Quantity:60 Tablet(s) • (60 servings)
Goals:
Bone Health
Heart Health
General Health
Anti-Aging
Cardiovascular Support

Score 84

Best suited to adults wanting a balanced K2 and low-dose D3 formula; the dry tablet offers no stated fat-based delivery, but the nutrient balance is more moderate than high-dose D3 combinations.
How scoring works
$12.68($0.21 per serving)
iHerb
$ 13.76
Vitacost
$ 13.39
Pure Formulas
$ 12.68
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Analysis

A 100 mcg MK-7 tablet pairs with a modest 10 mcg vitamin D3 amount and a small calcium contribution. The label provides enough detail to judge the central vitamin strategy.

The dry tablet offers no stated fat-based delivery, but the nutrient balance is more moderate than high-dose D3 combinations. Format, dose, and companion nutrients determine whether it is appropriate for daily use.

The best fit is adults wanting a balanced K2 and low-dose D3 formula. Vitamin K and vitamin D support normal physiology, but the practical benefit depends on baseline intake and individual need.

Who is it for
  • Adults wanting a balanced K2 and low-dose D3 formula
  • Adults whose current vitamin intake matches the listed potency
  • Users able to account for vitamin K medication interactions
Best for
  • Long-acting MK-7
  • Moderate vitamin D3 amount
  • Users who accept that dry tablet lacks a fat carrier

Pros

  • Long-acting MK-7
  • Moderate vitamin D3 amount
  • Includes a small calcium contribution
  • Strong serving value

Cons

  • Dry tablet lacks a fat carrier
  • Calcium amount is too small for focused use
  • MK-7 source is not identified
  • No magnesium cofactor

Warnings

  • The 100 mcg MK-7 serving can counteract warfarin and related vitamin K antagonist anticoagulants.
  • The 110 mg calcium can reduce absorption of levothyroxine and tetracycline or quinolone antibiotics, so doses should be separated.
  • Bile-acid sequestrants and orlistat can reduce absorption of the fat-soluble vitamin D and K in this dry tablet.

Nutrient quality

89 Highest impact

MK-7 is a well-regarded long-acting form, though the tablet has no stated lipid carrier, and the 100 mcg MK-7 and 10 mcg vitamin D3 amounts are practical, while the calcium contribution is modest. The vitamin K2 amount is not obviously excessive for general supplementation, while vitamin D3, MK-7, and calcium form a coherent bone-support combination.

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Ingredient transparency

84 Highest impact

Every listed active ingredient has a specific amount, and no proprietary blend hides the dose of a listed active ingredient. Serving count is supplied, but complete daily-use directions are not provided, while inactive ingredients and excipients are not included in the supplied label details.

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Customer satisfaction

74 High impact

The supplied average rating is strong, and substantial review volume gives the average rating useful credibility. Specific review themes are unavailable, so repeated negatives and real-world fit remain uncertain.

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Value for money

86 Highest impact

The ingredient forms and dosing generally justify the product positioning, and the low serving cost provides strong practical value. The small calcium addition has limited value but does not dominate the formula, while the formula and serving value compare well with similar products.

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Report analysis

Goals

Bone Health
Impact
Highest effect
A Goal FitA- Strength of SupportB CoverageA+ Formula Quality
Vitamin K · 100 mcgCalcium · 110 mgVitamin D · 10 mcg

Menaquinone-7 and vitamin D3 create a focused pairing for calcium handling and bone-protein activation. A small calcium amount adds structural mineral but is not large enough to replace dietary calcium.

The preferred vitamin forms and clear amounts strengthen the formula. Vitamin K2 can oppose warfarin and related vitamin K antagonists, so users of those medicines need clinician-guided consistency.

Study evidence
Calcium Supportive 144 studies
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Heart Health
Impact
Highest effect
A Goal FitA Strength of SupportB CoverageA Formula Quality
Vitamin K · 100 mcgVitamin D · 10 mcg

Vitamin K2 as MK-7 and vitamin D3 form a strong calcium-management pair for vascular resilience. The 100 mcg MK-7 amount is well aligned with targeted use, while vitamin D3 provides routine maintenance support.

The dry tablet lacks a stated lipid carrier, and added calcium is not necessary for a heart-focused K2 product. Vitamin K2 can oppose warfarin and other vitamin K antagonists, so people using those medicines should not add it without prescriber guidance.

Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
General Health
Impact
Highest effect
A Goal FitB+ Strength of SupportB- CoverageA+ Formula Quality
Vitamin D · 10 mcgVitamin K · 100 mcg

Vitamin D3 and MK-7 form a logical pair for bone health and normal calcium handling. Both forms and amounts are clearly stated, with vitamin K2 supplied at a purposeful level.

The vitamin D amount is better suited to maintenance than to correcting low vitamin D status, and the tablet has no stated lipid carrier. Vitamin K2 can interfere with warfarin and other vitamin K antagonists, so users of those medicines need prescriber guidance before use.

Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Anti-Aging
Impact
Highest effect
B Goal FitA- Strength of SupportC+ CoverageA+ Formula Quality
Vitamin K · 100 mcgVitamin D · 10 mcg

Vitamin K2 and vitamin D3 form a complementary pairing for bone strength and healthy calcium handling with age. MK-7 is a favorable long-acting K2 form, while the vitamin D3 amount provides modest daily support.

The formula focuses on skeletal and vascular integrity rather than mitochondrial or neurological aging pathways. Vitamin K2 can counteract warfarin and related vitamin K antagonists, so consistent clinician-guided use is important with those medicines.

Study evidence
Vitamin K Supportive 27 studies
Cardiovascular Support
Impact
High effect
B- Goal FitA- Strength of SupportC- CoverageA Formula Quality
Vitamin K · 100 mcgVitamin D · 10 mcg

MK-7 and vitamin D3 form a focused pairing for calcium handling that may support arterial flexibility. The pathway is relevant, although direct cardiovascular outcome evidence is less certain than the biological rationale.

The MK-7 amount is clinically aligned and clearly disclosed. Vitamin K2 can interfere with warfarin and other vitamin K antagonists, so users of those medicines need specific medical guidance.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin D3 (Cholecalciferol)
10 mcg
Vitamin K-2 (Menaquinone-7)
100 mcg
Calcium (Dibasic Calcium Phosphate)
110 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

MK-7 is clearly identified at a clinically aligned dose, with vitamin D3 providing a complementary bone-support nutrient. The generic source lacks branded or all-trans purity assurance, and the dry tablet has no stated lipid base or meal guidance. Low serving cost supports strong value, but vitamin K2 can interfere with warfarin and other vitamin K antagonists.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis.
    Chen HG; Sheng LT; Zhang YB; Cao AL; Lai YW; Kunutsor SK; Jiang L; Pan A · European journal of nutrition · 2020
    Meta-analysis222,592 participants21 studies pooledGeneral Health forVitamin K
  2. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledGeneral Health Anti-Aging forVitamin K
  3. Vitamin K intake and all-cause and cause specific mortality.
    Zwakenberg SR; den Braver NR; Engelen AIP; Feskens EJM; Vermeer C; Boer JMA; Verschuren WMM; van der Schouw YT; Beulens JWJ · Clinical nutrition (Edinburgh, Scotland) · 2018
    Cohort study33,289 participantsGeneral Health forVitamin K
  4. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  5. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  6. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  7. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  8. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  9. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  10. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  11. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  12. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  13. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  14. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  15. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  16. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  17. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  18. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  19. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  20. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  21. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  22. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  23. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  24. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  25. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  26. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  27. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  28. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  29. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  30. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  31. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  32. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  33. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  34. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  35. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  36. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  37. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  38. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  39. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  40. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  41. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  42. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  43. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forVitamin D
  44. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K