Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis.
Chen HG; Sheng LT; Zhang YB; Cao AL; Lai YW; Kunutsor SK; Jiang L; Pan A · European journal of nutrition · 2020
Meta-analysis222,592 participants21 studies pooledflagGeneral Health forscienceVitamin K
- Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
Meta-analysis3,891 participants3 studies pooledflagGeneral Health flagAnti-Aging forscienceVitamin K
- Vitamin K intake and all-cause and cause specific mortality.
Zwakenberg SR; den Braver NR; Engelen AIP; Feskens EJM; Vermeer C; Boer JMA; Verschuren WMM; van der Schouw YT; Beulens JWJ · Clinical nutrition (Edinburgh, Scotland) · 2018
Cohort study33,289 participantsflagGeneral Health forscienceVitamin K
- Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
Randomized trial244 participantsflagBone Health forscienceVitamin K
- Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
Randomized trial92 participantsflagBone Health forscienceVitamin K
- Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
Meta-analysis6,759 participants19 studies pooledflagBone Health forscienceVitamin K
- Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
Randomized trial771 participantsflagBone Health forscienceVitamin K
- Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
Randomized trial30 participantsflagAnti-Aging forscienceVitamin K
- Vitamin K status and cognitive function in healthy older adults.
Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
Cross-sectional study320 participantsflagAnti-Aging forscienceVitamin K
- High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
Cohort study644 participantsflagAnti-Aging forscienceVitamin K
- Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
Cross-sectional study85 participantsflagAnti-Aging forscienceVitamin K
- What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
Manoj P; Derwin R; George S · International journal of older people nursing · 2023
Meta-analysis12,620 participants7 studies pooledflagBone Health forscienceCalcium
- Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
Randomized trial60 participantsflagBone Health forscienceCalcium
- The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
Randomized trial168 participantsflagBone Health forscienceCalcium
- The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
Randomized trial404 participantsflagBone Health forscienceCalcium
- Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
Randomized trial149 participantsflagBone Health forscienceCalcium
- Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
Randomized trial454 participantsflagBone Health forscienceVitamin D
- Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
Narrative reviewflagBone Health forscienceVitamin D
- Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
Meta-analysis1,786 participants20 studies pooledflagBone Health forscienceVitamin D
- Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
Randomized trial193 participantsflagBone Health forscienceVitamin D
- Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
Rasool N; Munir Y · European journal of clinical nutrition · 2026
Randomized trial612 participantsflagBone Health forscienceVitamin D
- Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
Meta-analysis13 studies pooledflagBone Health forscienceVitamin K
- Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
Meta-analysis6,853 participants9 studies pooledflagBone Health forscienceVitamin K
- Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
Randomized trial48 participantsflagBone Health forscienceVitamin K
- Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
Cohort study53,372 participantsflagCardiovascular Support flagHeart Health forscienceVitamin K
- Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
Randomized trial244 participantsflagCardiovascular Support flagHeart Health forscienceVitamin K
- Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
Randomized trial165 participantsflagCardiovascular Support forscienceVitamin K
- Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
Cohort study55,545 participantsflagCardiovascular Support flagHeart Health forscienceVitamin K
- Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
Cohort study56,048 participantsflagCardiovascular Support flagHeart Health forscienceVitamin K
- Vitamin D supplementation for prevention of mortality in adults.
Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
Meta-analysis95,286 participants159 studies pooledflagGeneral Health forscienceVitamin D
- Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
Randomized trial90 participantsflagGeneral Health forscienceVitamin D
- The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
Meta-analysis2,495 participants19 studies pooledflagGeneral Health forscienceVitamin D
- Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
Systematic review84 studies pooledflagGeneral Health forscienceVitamin D
- Meta-analysis of long-term vitamin D supplementation on overall mortality.
Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
Meta-analysis42 studies pooledflagGeneral Health forscienceVitamin D
- Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
Cohort study7,857 participantsflagGeneral Health forscienceVitamin K
- The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
Randomized trial49 participantsflagGeneral Health forscienceVitamin K
- Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
Meta-analysis7 studies pooledflagGeneral Health forscienceVitamin K
- Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
Cohort study1,436 participantsflagGeneral Health forscienceVitamin K
- Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
Randomized trial1,537 participantsflagHeart Health forscienceVitamin D
- Paricalcitol and endothelial function in chronic kidney disease trial.
Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
Randomized trial88 participantsflagHeart Health forscienceVitamin D
- Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
Meta-analysis81 studies pooledflagHeart Health forscienceVitamin D
- Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
Meta-analysis45 studies pooledflagHeart Health forscienceVitamin D
- Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
Meta-analysisflagHeart Health forscienceVitamin D
- The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
Randomized trial149 participantsflagHeart Health forscienceVitamin K