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GABA Calm

Source Naturals Serene Science
4.4
★ ★ ★ ★ ★
(3644 ratings)
GABA 125 mg
Glycine 50 mg
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Score76
Convenient, inexpensive GABA is the clear benefit. Token companion doses and activating tyrosine reduce its sleep and stress depth.
How scoring works
Quantity:120 Liquid(s) • (120 servings)
Goals:
Mood Support
Stress Relief

Score 76

Convenient, inexpensive GABA is the clear benefit. Token companion doses and activating tyrosine reduce its sleep and stress depth.
How scoring works

Also available as

1 option
Orange Flavor GABA 125 mg, Glycine 50 mg • 120 Liquid(s) • 120 servings $18.88 ($0.15 per serving)
$14.26($0.11 per serving)
Pure Formulas
$ 19.25
Vitacost
$ 19.25
iHerb
$ 19.25
iHerb
$ 19.25
Amazon
$ 14.26
Walmart
$ 19.25
Report prices

Analysis

GABA at 125 mg provides the main calming action in a portable dissolving format. The 120-serving bottle makes occasional use economical.

Glycine, magnesium, taurine, and N-acetyl tyrosine are supplied at very small amounts. Tyrosine may feel activating, which works against a purely relaxing or bedtime profile.

The exact active amounts are easy to assess and the cost is low. The blend should not be mistaken for a meaningful magnesium, glycine, or taurine supplement.

Who is it for
  • Adults seeking occasional GABA support
  • People who prefer lozenges
  • Value-focused calming supplement users
Best for
  • Portable relaxation support
  • Occasional stress relief
  • Low-dose GABA use

Pros

  • Provides 125 mg GABA
  • Offers 120 servings
  • Low serving cost
  • Convenient dissolving format

Cons

  • Glycine is only 50 mg
  • Magnesium and taurine are token doses
  • Tyrosine may be activating
  • GABA source is unbranded

Warnings

  • GABA may cause drowsiness
  • Alcohol and sedatives may increase drowsiness
  • Tyrosine can interact with MAO inhibitors or thyroid medicines

Nutrient quality

74 High impact

The magnesium complex is named, while the amino acids use conventional forms without premium sourcing. GABA is useful for a calming blend, but glycine, tyrosine, taurine, and magnesium are very small.

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Ingredient transparency

78 High impact

Active amounts are stated and no proprietary blend hides a core dose. Missing excipient details and complete use directions leave the supplied label information incomplete.

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Customer satisfaction

65 High impact

The supplied aggregate satisfaction average provides a broad signal, while the response volume determines how stable it appears. No comment-level evidence is available to assess repeated complaints or confirm intended-use experiences.

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Value for money

87 Highest impact

Useful active delivery supports favorable serving value. Several token supporting amounts add limited value beside GABA.

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Goals

Mood Support
Mood Support
Impact
High effect
C+ Goal FitC Strength of SupportC+ CoverageA- Formula Quality
Magnesium · 5 mg

GABA and glycine provide direct calming intent, with tyrosine and taurine adding secondary neurotransmitter support. Most amounts are modest and oral GABA evidence remains uncertain.

A rapidly dissolving format may improve practical use, but magnesium is only a token amount. The calming ingredients may increase drowsiness when combined with alcohol or sedative medicines.

Study evidence
GABA Supportive 12 studies
Glycine Mixed 3 studies
Magnesium Supportive 60 studies
Stress Relief
Stress Relief
Impact
Moderate effect
C Goal FitC- Strength of SupportD+ CoverageC- Formula Quality
Magnesium · 5 mgGlycine · 50 mgGABA · 125 mg

GABA gives the lozenge a direct calming mechanism, but most supporting ingredients are supplied in very small amounts. Evidence for oral GABA reducing stress remains limited because its entry into the brain is uncertain.

Magnesium, glycine, and taurine are far below commonly meaningful standalone amounts, so pathway depth is weak. N-acetyl L-tyrosine may feel activating for some users and works against a uniformly calming design.

Study evidence
GABA Supportive 6 studies
Glycine Supportive 1 study
Magnesium Supportive 13 studies
Taurine Supportive 5 studies

Ingredients

IngredientAmount per serving
Magnesium (Magnesium Amino Acid Complex)
 5 mg
GABA
125 mg
Glycine
50 mg
N-Acetyl L-Tyrosine
25 mg
Taurine
20 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
GABA · 125 mg OverallScore80
B+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyB- Value

The 125 mg GABA dose is suitable for a multi-ingredient calming blend, and the dissolving lozenge may support convenient delivery. The unbranded source lacks the quality assurance associated with naturally fermented PharmaGABA. The low serving cost offers reasonable value, although two servings are needed to reach a standard 250 mg GABA dose.

View ingredientView products
Glycine · 50 mg OverallScore42
F Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value

The glycine amount is far below the level commonly used when glycine is the main sleep ingredient. Its role is better viewed as a small part of a multi-active calming lozenge. Clear quantity disclosure helps, but source purity, excipients, and glycine-specific value remain weak or uncertain.

View ingredientView products
Loading alternative details
85 Performance

Pharma GABA 250 mg

Natural Factors Stress-Relax
Pharma GABA supplies a clearly named 200 to 250 mg form in a focused calming formula. Its formulation quality and curcumin focus compare favorably with the original, although the formula does not retain the original product’s glycine component.
83 Performance

GABA 500 mg

Swanson
A focused 500 mg GABA serving provides a clearly disclosed and practical amount of the main calming ingredient. Its formulation quality and curcumin focus compare favorably with the original, although the formula does not retain the original product’s glycine component.
83 Performance

GABA 750 mg

NOW
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. Its formulation quality and curcumin focus compare favorably with the original, although the formula does not retain the original product’s glycine component.
84 Budget

GABA

NOW
A focused 500 mg GABA serving provides a clearly disclosed and practical amount of the main calming ingredient. A lower serving cost improves everyday value, although the formula does not retain the original product’s glycine component.
81 Budget

GABA Powder

Source Naturals Serene Science
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. A lower serving cost improves everyday value, although the formula does not retain the original product’s glycine component.
83 Budget

GABA 500 mg

Nutricost
Curcumin remains the main active, but the supplied label does not clearly state its active curcuminoid yield. A lower serving cost improves everyday value, although some active-form details remain incomplete.
84 Value

GABA 500 mg

NOW
A focused 500 mg GABA serving provides a clearly disclosed and practical amount of the main calming ingredient. Useful formulation quality and efficient serving economics create a favorable quality-to-cost balance, although the formula does not retain the original product’s glycine component.
81 Value

GABA 750 mg

Source Naturals Serene Science
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. Useful formulation quality and efficient serving economics create a favorable quality-to-cost balance, although the formula does not retain the original product’s glycine component.
82 Value

GABA 750 mg

AN Amazing Nutrition Amazing Formulas
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. Useful formulation quality and efficient serving economics create a favorable quality-to-cost balance, although the formula does not retain the original product’s glycine component.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  2. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
    Bannai M; Kawai N · Journal of pharmacological sciences · 2012
    Narrative reviewSleep Support forGlycine
  3. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  4. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure.
    Díaz-Flores M; Cruz M; Duran-Reyes G; Munguia-Miranda C; Loza-Rodríguez H; Pulido-Casas E; Torres-Ramírez N; Gaja-Rodriguez O; Kumate J; Baiza-Gutman LA; Hernández-Saavedra D · Canadian journal of physiology and pharmacology · 2014
    Randomized trial60 participantsStress Relief forGlycine
  5. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  6. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  7. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  8. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  9. [Augmentation of antipsychotics with glycine may ameliorate depressive and extrapyramidal symptoms in schizophrenic patients--a preliminary 10-week open-label study].
    Strzelecki D; Kropiwnicki P; Rabe-Jabłońska J · Psychiatria polska · 2014
    Single-arm trial29 participantsMood Support forGlycine
  10. Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.
    Pålsson E; Jakobsson J; Södersten K; Fujita Y; Sellgren C; Ekman CJ; Ågren H; Hashimoto K; Landén M · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015
    Cross-sectional study327 participantsMood Support forGlycine
  11. Erythrocyte glycine in depressed, hypomanic, and euthymic bipolar patients treated with lithium carbonate.
    Peselow ED; Deutsch SI; Stanley M; Banay-Schwartz M; Virgilio J; Fieve RR · Psychopharmacology · 1983
    Cross-sectional study27 participantsMood Support forGlycine
  12. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  13. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  14. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  15. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  16. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  17. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsStress Relief forGABA
  18. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  19. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  20. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA
  21. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  22. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  23. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  24. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  25. Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial.
    Moludi J; Qaisar SA; Kadhim MM; Ahmadi Y; Davari M · Nutrition & metabolism · 2022
    Randomized trial120 participantsStress Relief forTaurine
  26. Effects of taurine supplementation on VDT work induced visual stress.
    Zhang M; Bi LF; Ai YD; Yang LP; Wang HB; Liu ZY; Sekine M; Kagamimori S · Amino acids · 2005
    Randomized trial25 participantsStress Relief forTaurine
  27. Taurine supplementation attenuates delayed increase in exercise-induced arterial stiffness.
    Ra SG; Choi Y; Akazawa N; Ohmori H; Maeda S · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017
    Randomized trial29 participantsStress Relief forTaurine
  28. Correlations between dietary taurine intake and life stress in Korean college students.
    Sung MJ; Chang KJ · Advances in experimental medicine and biology · 2009
    Observational studyStress Relief forTaurine
  29. Profiling inflammatory and oxidative stress biomarkers following taurine supplementation: a systematic review and dose-response meta-analysis of controlled trials.
    Faghfouri AH; Seyyed Shoura SM; Fathollahi P; Shadbad MA; Papi S; Ostadrahimi A; Faghfuri E · European journal of clinical nutrition · 2022
    Meta-analysisStress Relief forTaurine