P-5-P 100 mg
Nutricost
P-5-P 100 mg
4.9
★ ★ ★ ★ ★
(417 ratings)
Vitamin B6 100 mg
Score 98.0
An excellent Vitamin B6 supplement, featuring the highly bioavailable P-5-P form at a robust 100mg dose for a competitive price, making it a top choice.
Quantity: 240 Capsule(s)Servings size: 1 Capsule(s) (240 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
General Health
leaderboard Score 98.0
An excellent Vitamin B6 supplement, featuring the highly bioavailable P-5-P form at a robust 100mg dose for a competitive price, making it a top choice.
insights Analysis
This Nutricost product excels by providing Vitamin B6 in its active coenzyme form, P-5-P, directly utilized by the body without the need for liver conversion. This makes it highly effective for supporting Energy, Brain Health, Mood Support, and General Health goals. The 100mg dosage is therapeutic and well-regarded for its potential impact. Online reviews, while fewer than some legacy brands, are consistently positive, reflecting satisfaction with the product's quality and efficacy. From a nutritional standpoint, P-5-P is often recommended over Pyridoxine HCl due to its superior absorption and reduced risk of potential neuropathy at high doses.
- Contains Pyridoxal 5-Phosphate (P-5-P), the most bioavailable and active form of Vitamin B6.
- Optimal 100mg dosage, suitable for significant therapeutic support for energy, brain health, and mood.
- Excellent price per serving for a P-5-P product, offering exceptional value.
- Bypasses the need for conversion, leading to more efficient utilization and potentially lower risk of side effects associated with high doses of Pyridoxine HCl.
- Fewer total reviews compared to older, more established brands, though review quality is high.
$21.95($0.09 per serving)
 iHerb | $ 21.95 |
bolt Effectiveness for goals
Yes, Vitamin B6 is a widely recognized and often recommended treatment for nausea and vomiting in pregnancy, commonly known as morning sickness. It is considered a first-line pharmacological therapy for mild to moderate symptoms. Pregnant individuals should consult their healthcare provider before taking any supplements.
Vitamin B6, or pyridoxine, is crucial for over 100 enzyme reactions, primarily involved in protein metabolism, red blood cell formation, and nervous system health. It plays a key role in metabolic processes that convert food into energy. Maintaining adequate B6 levels supports overall health and proper bodily functions.
Absolutely, Vitamin B6 is vital for brain development and function, and for maintaining a healthy nervous system. It is involved in the synthesis of several key neurotransmitters, such as serotonin, dopamine, and GABA, which regulate mood, sleep, and cognitive processes. Adequate B6 intake is essential for proper nerve signaling.
Some studies suggest that Vitamin B6 supplementation may help reduce certain PMS symptoms, particularly mood swings, irritability, and breast tenderness. The exact mechanism is not fully understood, but it may involve its role in neurotransmitter synthesis. However, evidence is mixed, and more robust research is needed.
Vitamin B6 is involved in the production of neurotransmitters like serotonin and norepinephrine, which are critical for mood regulation. Some research indicates that B6 supplementation may positively influence mood and reduce symptoms of depression, particularly in individuals with a deficiency. However, it should not replace prescribed treatments for mental health conditions.
schedule Dosage, timing & forms
The Recommended Dietary Allowance (RDA) for adult men and women (19-50 years) is 1.3 mg per day. For those over 50, it is 1.7 mg for men and 1.5 mg for women. These recommendations are for healthy individuals.
Yes, taking excessively high doses of Vitamin B6, particularly from supplements, can be harmful. The most well-known adverse effect is sensory neuropathy, which can cause numbness and tingling in the extremities. This risk increases with doses significantly above the Tolerable Upper Intake Level (UL) of 100 mg/day.
The Tolerable Upper Intake Level (UL) for Vitamin B6 in adults is 100 mg per day. Consuming amounts significantly above this UL, particularly from supplements, can lead to adverse effects like peripheral neuropathy. It is advisable not to exceed this limit without professional guidance.
There is no specific "best" time to take Vitamin B6; it can be taken at any time of day. Consistency in taking the supplement is generally more important than the exact timing. Some individuals may prefer to take it with a meal to avoid potential stomach upset.
Vitamin B6 supplements commonly contain pyridoxine hydrochloride (pyridoxine HCl). The active coenzyme form, pyridoxal 5'-phosphate (P5P), is also available in some supplements. Other forms like pyridoxal and pyridoxamine also exist in food.
health_and_safety Safety & interactions
Long-term intake of high doses, typically exceeding 200 mg per day, can lead to sensory peripheral neuropathy, characterized by numbness, tingling, and pain in the extremities. Other less common side effects might include skin lesions, photosensitivity, and gastrointestinal issues. These effects usually resolve after discontinuing supplementation.
For adults, the tolerable upper intake level (UL) for Vitamin B6 is set at 100 mg per day from supplements and fortified foods. Consuming amounts above this UL regularly increases the risk of adverse effects, primarily neurological damage. This limit is established to prevent potential harm.
The primary and most concerning symptom of Vitamin B6 toxicity, typically from chronic high doses, is sensory peripheral neuropathy. This involves symptoms like numbness, tingling, and burning pain, often starting in the hands and feet. Other less common signs might include skin lesions or gastrointestinal upset.
Yes, Vitamin B6 can interact with several medications. For instance, it may reduce the effectiveness of levodopa (used for Parkinson's disease) and can interact with anti-seizure medications like phenytoin and phenobarbital. It is important to consult a healthcare provider when combining Vitamin B6 supplements with prescription drugs.
Vitamin B6 is generally considered safe during pregnancy and breastfeeding when taken within recommended dietary allowances. Higher doses might be used under medical supervision for specific conditions like severe morning sickness. Always discuss any supplementation with a healthcare provider to ensure appropriate dosing.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B6 | 100 mg |
Categories
Vitamin B6 100.0
This product represents the gold standard in the Vitamin B6 category, combining the most bioavailable P-5-P form with an effective 100mg dosage and an excellent price point, making it highly competitive and superior to most alternatives.
Goals
Energy 100.0
With 100mg of highly bioavailable P-5-P, this product provides the optimal form and dose for efficient energy metabolism, directly supporting the body's energy pathways.
Brain Health 100.0
The P-5-P form at 100mg is ideal for neurotransmitter synthesis and overall brain function, offering superior support for cognitive processes compared to less active forms.
Mood Support 100.0
This product delivers the active P-5-P form in a sufficient dosage to directly aid in the production of serotonin and dopamine, essential for robust mood regulation and support.
Recommended Alternatives
95 Value 
Vitamin B-6 50 mg
Nature's Way
4.8
★★★★★
(1720 ratings)
Offers the superior P-5-P form at a lower 50mg dosage but for a significantly lower price per serving (6 vs 9). For individuals who don't need the maximum 100mg, this provides excellent value for the active B6 form.
90 Value 
P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength
Swanson
4.8
★★★★★
(1062 ratings)
Provides the highly bioavailable P-5-P form at a 40mg dosage for a lower price per serving (8 vs 9), representing strong value for an active B6 supplement, especially for those sensitive to 100mg.
75 Value 
B-6 100 mg
NOW
4.8
★★★★★
(6041 ratings)
While it's the HCl form, this alternative provides 100mg of B6 at a significantly lower price per serving (4 vs 9), offering excellent cost-efficiency for those primarily looking for a high dose of B6 on a budget.
90 Performance 
B-100
NOW
4.8
★★★★★
(9362 ratings)
While still Pyridoxine HCl for B6, this is a comprehensive B-Complex with 100mg B6, offering broader support from other B vitamins which can be synergistic for energy and overall health goals, making it 'better' for a more holistic approach.
85 Performance 
B-Complex '100'
Solgar
4.7
★★★★★
(446 ratings)
This Solgar B-Complex '100' also contains 100mg of B6 (HCl) along with other high-potency B vitamins. While it uses the HCl form for B6, the comprehensive nature of a B-complex can offer 'better' overall synergistic support for complex metabolic pathways.
80 Performance 
Hi Potency B Complex
Natural Factors
4.7
★★★★★
(13054 ratings)
This alternative is a high-potency B-complex providing 50mg of B6 (HCl) alongside other crucial B vitamins. For individuals needing broad B-vitamin support, a comprehensive complex can be 'better' than a standalone B6 supplement, even if the B6 form isn't P-5-P.
75 Budget
B-6 100 mg
NOW
4.8
★★★★★
(6041 ratings)
This alternative offers the same 100mg dosage but uses the Pyridoxine Hydrochloride form at a significantly lower price per serving (4 vs 9), providing a cheaper option, though not of the same superior P-5-P quality.
73 Budget 
B-6 100 mg
21st Century
4.7
★★★★★
(5959 ratings)
Offers 100mg of Pyridoxine Hydrochloride at a much lower price per serving (4 vs 9), making it a more budget-friendly option for the same dosage and common form of B6.
90 Budget
Vitamin B-6 50 mg
Nature's Way
4.8
★★★★★
(1720 ratings)
While a lower 50mg dose, it is also a P-5-P form and offers a slightly lower price per serving (6 vs 9), making it a cheaper option for the active form of B6 if a lower dose is sufficient.
95 Value
Vitamin B-6 50 mg
Nature's Way
4.8
★★★★★
(1720 ratings)
Offers the superior P-5-P form at a lower 50mg dosage but for a significantly lower price per serving (6 vs 9). For individuals who don't need the maximum 100mg, this provides excellent value for the active B6 form.
90 Value
P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength
Swanson
4.8
★★★★★
(1062 ratings)
Provides the highly bioavailable P-5-P form at a 40mg dosage for a lower price per serving (8 vs 9), representing strong value for an active B6 supplement, especially for those sensitive to 100mg.
75 Value
B-6 100 mg
NOW
4.8
★★★★★
(6041 ratings)
While it's the HCl form, this alternative provides 100mg of B6 at a significantly lower price per serving (4 vs 9), offering excellent cost-efficiency for those primarily looking for a high dose of B6 on a budget.
90 Performance
B-100
NOW
4.8
★★★★★
(9362 ratings)
While still Pyridoxine HCl for B6, this is a comprehensive B-Complex with 100mg B6, offering broader support from other B vitamins which can be synergistic for energy and overall health goals, making it 'better' for a more holistic approach.
85 Performance
B-Complex '100'
Solgar
4.7
★★★★★
(446 ratings)
This Solgar B-Complex '100' also contains 100mg of B6 (HCl) along with other high-potency B vitamins. While it uses the HCl form for B6, the comprehensive nature of a B-complex can offer 'better' overall synergistic support for complex metabolic pathways.
80 Performance
Hi Potency B Complex
Natural Factors
4.7
★★★★★
(13054 ratings)
This alternative is a high-potency B-complex providing 50mg of B6 (HCl) alongside other crucial B vitamins. For individuals needing broad B-vitamin support, a comprehensive complex can be 'better' than a standalone B6 supplement, even if the B6 form isn't P-5-P.