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Target-Mins Calcium Magnesium Complex With Vitamin D3

Country Life
4.7
★ ★ ★ ★ ★
(4042 ratings)
Phosphorus 468 mg
Calcium 1000 mg
Magnesium 500 mg
Product Image
Score80
A concentrated calcium-magnesium formula with several useful forms and clear bone-health relevance. Mixed absorption quality and large mineral amounts are the main trade-offs.
How scoring works
Quantity:90 Tablet(s) • (45 servings)
Goals:
Bone Health
General Health
Energy
Heart Health
Cardiovascular Support

Score 80

A concentrated calcium-magnesium formula with several useful forms and clear bone-health relevance. Mixed absorption quality and large mineral amounts are the main trade-offs.
How scoring works
$16.15($0.35 per serving)
Vitacost
$ 19.29
Vitacost
$ 19.29
Walmart
$ 20.83
Amazon
$ 16.15
iHerb
$ 19.29
Pure Formulas
$ 19.29
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Analysis

Calcium and magnesium are both supplied at substantial amounts, with citrate, aspartate, and other named forms broadening the blend. Hydroxyapatite contributes phosphorus, and vitamin D3 adds modest support for calcium use.

Included citrate and taurinate are useful form choices, but magnesium oxide makes absorption quality uneven. Phosphorus from hydroxyapatite adds structural support, although no vitamin K is included for broader bone-focused coverage.

The two-tablet serving suits people seeking a concentrated bone-mineral product rather than a general multivitamin. Vitamin D3 gives this version a more complete bone-support profile, although the large mineral amounts still require careful fit.

Who is it for
  • Adults seeking concentrated calcium and magnesium support
  • People who prefer a multi-form mineral blend
Best for
  • Bone-mineral intake
  • Muscle and nerve support
  • Filling combined calcium and magnesium gaps

Pros

  • Substantial calcium and magnesium amounts
  • Uses several named mineral forms
  • Includes vitamin D3 for calcium utilization
  • Offers good value

Cons

  • Magnesium oxide lowers overall form quality
  • Large mineral serving may be difficult to tolerate
  • No vitamin K for broader bone support
  • Two-tablet serving may be inconvenient for some users

Warnings

  • The 500 mg supplemental magnesium amount may cause diarrhea, cramping, or nausea, especially when taken at once.
  • A 1,000 mg calcium serving may not suit people with hypercalcemia, recurrent calcium-based kidney stones, or a clinician-directed calcium restriction.
  • Calcium and magnesium can reduce absorption of levothyroxine and tetracycline or quinolone antibiotics, so doses should be separated as directed.

Nutrient quality

83 Highest impact

Citrate, hydroxyapatite, taurate, and vitamin D3 give the mineral blend useful quality. High calcium and magnesium amounts plus magnesium oxide reduce absorption efficiency and may affect tolerance.

Ingredient transparency

79 High impact

Every listed active has a stated amount, and no proprietary blend obscures the core formula. Daily-use directions and non-active ingredients are missing from the supplied details.

Customer satisfaction

70 High impact

The supplied average rating is strong and is supported by a large review count. No detailed feedback is available to assess recurring concerns or purpose-specific experiences.

Value for money

87 Highest impact

Substantial core minerals, vitamin D3, and several useful forms provide good value. A large mineral serving and included magnesium oxide remain the main trade-offs.

Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A+ Goal FitA Strength of SupportA- CoverageA- Formula Quality
Phosphorus · 468 mgMagnesium · 500 mgCalcium · 1000 mgVitamin D · 10 mcg

Calcium, magnesium, phosphorus, and vitamin D3 cover structural minerals plus absorption signaling. Substantial doses and several favorable forms give the formula strong bone-health depth, although magnesium oxide is included.

The design still lacks vitamin K2 and collagen support, and the form-specific mineral contributions are unclear. High supplemental calcium and magnesium can cause digestive effects and deserve extra caution in people with impaired kidney function.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Phosphorus Supportive 44 studies
Vitamin D Supportive 202 studies
General Health
General Health
Impact
Highest effect
A Goal FitB+ Strength of SupportB CoverageA Formula Quality
Vitamin D · 10 mcgMagnesium · 500 mg

Calcium, magnesium, phosphorus, and vitamin D3 form a coherent foundation for skeletal and muscle support. Vitamin D3 adds useful calcium-absorption support to the mineral blend.

The calcium and magnesium amounts are high, and magnesium oxide weakens the otherwise varied form profile. Total intake from food and other supplements matters because a full serving may be more than some users need.

Study evidence
Magnesium Supportive 114 studies
Vitamin D Supportive 115 studies
Energy
Energy
Impact
High effect
A- Goal FitB Strength of SupportC CoverageB+ Formula Quality
Vitamin D · 10 mcgMagnesium · 500 mg

Magnesium supports ATP-dependent enzymes, and vitamin D3 adds a complementary role in muscle and mineral function. The 500 mg magnesium amount is substantial, but oxide weakens the blend of forms.

Coverage remains centered on mineral metabolism rather than alertness or stress resilience. Supplemental magnesium at this amount may loosen stools, and calcium should be separated from levothyroxine because it can reduce medicine absorption.

Study evidence
Magnesium Supportive 4 studies
Vitamin D Supportive 32 studies
Heart Health
Heart Health
Impact
High effect
B Goal FitC+ Strength of SupportC CoverageC+ Formula Quality
Magnesium · 500 mgVitamin D · 10 mcg

Magnesium supports heart rhythm and vascular tone, but the disclosed amount sits above the usual supplemental target. Vitamin D adds a related calcium-management pathway, but the high-calcium design remains bone-focused.

Taurinate and citrate improve the source blend, while included oxide lowers absorption quality. The calcium-heavy formula provides only moderate cardiovascular focus.

Study evidence
Magnesium Supportive 158 studies
Vitamin D Mixed 164 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B Goal FitC+ Strength of SupportD+ CoverageC+ Formula Quality
Magnesium · 500 mgVitamin D · 10 mcg

Magnesium supports vascular tone and heart rhythm, while the large calcium component and vitamin D makes the product less cardiovascular-focused. Human evidence supports magnesium for blood pressure and rhythm in appropriate users, especially when magnesium status is low.

The 500 mg magnesium amount is above the usual supplemental range, while 1,000 mg of calcium and 10 mcg of vitamin D are also supplied. Magnesium taurate, citrate, and aspartate are useful forms, but magnesium oxide weakens the blend. A 500 mg supplemental magnesium serving may cause diarrhea or cramping, particularly in sensitive users.

Study evidence
Magnesium Supportive 123 studies
Vitamin D Mixed 170 studies
Stress Relief
Stress Relief
Impact
Moderate effect
C- Goal FitB- Strength of SupportD CoverageB- Formula Quality
Vitamin D · 10 mcgMagnesium · 500 mg

Magnesium can support nervous system regulation when intake or status is inadequate. Direct stress relief is less certain for people who already obtain enough magnesium.

The 500 mg amount is high and mixes useful taurate, citrate, and aspartate with poorly absorbed oxide. Calcium and vitamin D make the formula more bone-focused, and the high magnesium amount may cause loose stools.

Study evidence
Magnesium Supportive 13 studies
Vitamin D Supportive 41 studies

Ingredients

IngredientAmount per serving
Vitamin D (Cholecalciferol, Vitamin D3)
 10 mcg
Calcium (Calcium Aspartate, Calcium Citrate, Calcium Hydroxyapatite)
 1000 mg
Phosphorus (Calcium Hydroxyapatite)
 468 mg
Magnesium (Magnesium Aspartate, Magnesium Citrate, Magnesium Oxide, Magnesium Taurinate)
 500 mg
Gluten Free Adults 18–50 Kosher Dairy Free Vegetarian
Report overview
Phosphorus (Calcium Hydroxyapatite) · 468 mg OverallScore93
A+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyA+ Value

Calcium hydroxyapatite gives the phosphorus a bone-like mineral form and is explicitly named. The 468 mg amount is in the higher supplemental range, while two tablets keep the serving practical and vitamin D3 adds complementary bone support. Favorable serving economics strengthen its fit for users who want a combined mineral formula.

View ingredientView products
Calcium (Calcium Aspartate, Calcium Citrate, Calcium Hydroxyapatite) · 1000 mg OverallScore82
A+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB+ Value

The blend combines citrate with hydroxyapatite and other calcium forms, while vitamin D3 adds a relevant absorption cofactor. Its large single serving may exceed the amount absorbed efficiently at one time, so dividing the tablets across meals may be more practical. The serving cost remains reasonable for a mixed-form formula with added vitamin D.

View ingredientView products
Magnesium (Magnesium Aspartate, Magnesium Citrate, Magnesium Oxide, Magnesium Taurinate) · 500 mg OverallScore65
D Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyC Value

The magnesium blend contains premium taurate and moderate citrate and aspartate, but oxide reduces absorption quality. The 500 mg amount is above the preferred therapeutic range, while vitamin D adds useful bone-health synergy to the calcium-magnesium pairing. Its below-median serving cost is favorable despite the lack of patented chelates.

View ingredientView products
Loading alternative details
86 Performance

Calcium & Magnesium Citrate Powder with Vitamin D3

NOW
The balanced calcium and magnesium citrate formula avoids the original’s long mineral blend and provides strong bone, general-health, and digestive fit. Cholecalciferol preserves the original product’s vitamin D3 coverage. Phosphorus is omitted and calcium is lower.
80 Performance

Bone Builder Forte

Metagenics
Microcrystalline hydroxyapatite supplies calcium and phosphorus in a focused bone formula, paired with substantially more vitamin D3 than the original. Magnesium is omitted and mineral amounts are lower, so the advantage is targeted bone support rather than broad calcium-magnesium coverage.
79 Performance

Liquid Calcium Magnesium Citrate & Vitamin D3 Lemon Flavor

Bluebonnet
Calcium citrate plus magnesium citrate and aspartate offer a simpler, well-defined mineral blend with strong bone and stress-support alignment. Cholecalciferol preserves the original product’s vitamin D3 coverage. Lower mineral amounts and no phosphorus are the main trade-offs.
85 Budget

Cal/Mag 500 mg/250 mg

NaturesPlus
The lower serving cost retains calcium and magnesium in explicitly named amino acid chelates, avoiding the original mixture that includes magnesium oxide. The amounts are lower and phosphorus and vitamin D is omitted, so it provides lighter mineral coverage.
88 Budget

Calcium Hydroxyapatite Caps

NOW
The lower serving cost keeps calcium and phosphorus together as hydroxyapatite with strong ingredient clarity. Magnesium and vitamin D is omitted, making it a focused calcium option rather than a complete replacement for the original.
80 Budget

Calcium Mag & D Complex

Nature's Way
The lower serving cost supplies calcium and magnesium through several named forms, including citrate and aspartate. It retains cholecalciferol, although its amount is lower than in the original. Phosphorus is omitted and both main mineral amounts are lower.
85 Value

Cal/Mag Caps

NaturesPlus
Calcium and magnesium amino acid chelates provide a concise formula with favorable nutrient-quality and value evidence. The amounts are lower and phosphorus and vitamin D is absent, but the simpler blend avoids magnesium oxide.
82 Value

Calcium & Magnesium Mineral Complex

Nature's Way
The lower serving cost combines calcium carbonate, citrate, and malate with magnesium bisglycinate, citrate, and oxide. It offers better form diversity and strong value evidence, though it halves the mineral amounts and omits phosphorus and vitamin D.
81 Value

Target-Mins Calcium Magnesium Potassium 500 mg : 500 mg : 99 mg

Country Life
The closely matched mineral families retain magnesium while adding potassium and carrying strong value evidence. Vitamin D is omitted, and calcium and phosphorus are lower than in the original.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of dietary calcium intake with metabolic syndrome and bone mineral density among the Korean population: KNHANES 2008-2011.
    Kim MK; Chon SJ; Noe EB; Roh YH; Yun BH; Cho S; Choi YS; Lee BS; Seo SK · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Cross-sectional study14,705 participantsBone Health forCalcium
  2. Calcium supplementation and bone mineral density in postmenopausal women using estrogen replacement therapy.
    Haines CJ; Chung TK; Leung PC; Hsu SY; Leung DH · Bone · 1995
    Randomized trialBone Health forCalcium
  3. Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.
    Tihtonen K; Korhonen P; Isojärvi J; Ojala R; Ashorn U; Ashorn P; Tammela O · Annals of the New York Academy of Sciences · 2022
    Meta-analysis1,566 participants7 studies pooledBone Health forCalcium
  4. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  5. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD · The American journal of clinical nutrition · 2014
    Cohort study73,684 participantsBone Health forMagnesium
  6. Dairy product consumption, eating habits, sedentary behaviour and physical activity association with bone mineral density among adolescent boys: a cross-sectional observational study.
    Kopiczko A; Czapla M; Juárez-Vela R; Ross C; Uchmanowicz B · BMC pediatrics · 2024
    Cross-sectional study115 participantsBone Health forPhosphorus
  7. Association between serum phosphorus levels and pelvic bone mineral density in U.S. adults aged 18-59 years.
    Jiang T; Pan Y; Xu J; Ge J; Ji S; Li T; Zhang Y · BMC musculoskeletal disorders · 2025
    Cross-sectional study5,589 participantsBone Health forPhosphorus
  8. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  9. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  10. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  11. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  12. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  13. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  14. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  15. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  16. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  17. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  18. Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial.
    Insogna KL; Rauch F; Kamenický P; Ito N; Kubota T; Nakamura A; Zhang L; Mealiffe M; San Martin J; Portale AA · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Single-arm trial14 participantsBone Health forPhosphorus
  19. Early high calcium and phosphorus intake by parenteral nutrition prevents short-term bone strength decline in preterm infants.
    Pereira-da-Silva L; Costa A; Pereira L; Filipe A; Virella D; Leal E; Moreira A; Rosa M; Mendes L; Serelha M · Journal of pediatric gastroenterology and nutrition · 2011
    Randomized trialBone Health forPhosphorus
  20. Phosphate Metabolism in Health and Disease.
    Peacock M · Calcified tissue international · 2021
    Narrative reviewBone Health forPhosphorus
  21. Expert consensus on clinical management of metabolic bone disease of prematurity (2021).
    Yan-Mei C; Xin-Zhu L; Rong Z; Xi-Hong L; Xiao-Mei T; Ping-Yang C; Zhi-Chun F; Nutritional Committee of Neonatology Branch of Chinese Medical Doctor Association; Neonatal Nutrition and Health Management Group, Professional Committee of Child Health, Chinese Medical Doctor Association; Editorial Committee of Chinese Journal of Contemporary Pediatrics. · Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Guideline / consensusBone Health forPhosphorus
  22. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  23. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  24. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  25. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  26. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  27. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  28. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  29. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  30. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium Cardiovascular Support Heart Health forVitamin D
  31. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  32. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  33. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  34. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  35. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support Heart Health forVitamin D
  36. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  37. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  38. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  39. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  40. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  41. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  42. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  43. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  44. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  45. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  46. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  47. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  48. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  49. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  50. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  51. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  52. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  53. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  54. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  55. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  56. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  57. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  58. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  59. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  60. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  61. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  62. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  63. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  64. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  65. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  66. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  67. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  68. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  69. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  70. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  71. Association of serum 25-hydroxyvitamin D with sleep disorders in individuals with prediabetes and diabetes: a prospective cohort study.
    Liu G; Li H; Ma Y; Shi Y; Han J; Li F; Fang L; Tian S; Cheng Y · Frontiers in endocrinology · 2025
    Cohort study81,533 participantsSleep Support forVitamin D
  72. A meta-analysis: Does vitamin D play a promising role in sleep disorders?
    Yan S; Tian Z; Zhao H; Wang C; Pan Y; Yao N; Guo Y; Wang H; Li B; Cui W · Food science & nutrition · 2024
    Meta-analysisSleep Support forVitamin D
  73. Influence of sunlight on the association between 25-hydroxyvitamin D levels and sleep quality in Brazilian adults: A population-based study.
    de Menezes-Júnior LAA; Sabião TDS; de Moura SS; Batista AP; de Menezes MC; Carraro JCC; Andrade ACS; Machado-Coelho GLL; Meireles AL · Nutrition (Burbank, Los Angeles County, Calif.) · 2023
    Cross-sectional study1,709 participantsSleep Support forVitamin D
  74. Serum 25(OH)D levels and obstructive sleep apnea syndrome severity in patients without comorbidities: a systematic review and meta-analysis.
    Serafin M; Vaninetti M; Mohamed I; Strambi LF; Caprioglio A · Sleep & breathing = Schlaf & Atmung · 2024
    Meta-analysis3,573 participants24 studies pooledSleep Support forVitamin D
  75. Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies.
    Abboud M · Nutrients · 2022
    Meta-analysis19 studies pooledSleep Support forVitamin D
  76. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  77. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  78. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  79. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  80. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  81. Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study.
    Zaromytidou E; Koufakis T; Dimakopoulos G; Drivakou D; Konstantinidou S; Rakitzi P; Grammatiki M; Manthou E; Notopoulos A; Iakovou I; Gotzamani-Psarrakou A; Kotsa K · Metabolites · 2023
    Randomized trial90 participantsStress Relief forVitamin D
  82. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
    Charoenporn V; Tungsukruthai P; Teacharushatakit P; Hanvivattanakul S; Sriyakul K; Sukprasert S; Kamalashiran C; Tungsukruthai S; Charernboon T · Psychiatry and clinical neurosciences · 2024
    Randomized trial80 participantsStress Relief forVitamin D
  83. The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review.
    Głąbska D; Kołota A; Lachowicz K; Skolmowska D; Stachoń M; Guzek D · Nutrients · 2021
    Systematic review24 studies pooledStress Relief forVitamin D
  84. Vitamin D3 enhances mood in healthy subjects during winter.
    Lansdowne AT; Provost SC · Psychopharmacology · 1998
    Randomized trial44 participantsStress Relief forVitamin D
  85. Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary Hyperparathyroidism: A Randomized Clinical Trial.
    Shoji T; Nakatani S; Kabata D; Mori K; Shintani A; Yoshida H; Takahashi K; Ota K; Fujii H; Ueda S; Nishi S; Nakatani T; Yoshiyama M; Goto K; Hamada T; Imanishi M; Ishimura E; Kagitani S; Kato Y; Kumeda Y; Maekawa K; Matsumura T; Nagayama H; Obi Y; Ohno Y; Sai Y; Sakurai M; Sasaki S; Shidara K; Shoji S; Tsujimoto Y; Yamakawa K; Yasuda H; Yodoi S; Inaba M; Emoto M · Clinical journal of the American Society of Nephrology : CJASN · 2021
    Randomized trial326 participantsStress Relief forVitamin D