Product Image

Hydroxycut Hardcore Super Elite

MuscleTech
4.6
★ ★ ★ ★ ★
(114 ratings)
Caffeine 290 mg
Choline 100 mg
Huperzine 10 mcg
Product Image
Score75
A potent stimulant blend may support short-term energy and focus. High caffeine and huperzine make sleep disruption, palpitations, and interactions the central drawbacks.
How scoring works
Quantity:120 Capsule(s) • (60 servings)
Goals:
Energy
Metabolism Boost
Weight Loss
Mental Focus
Productivity Boost
Fitness

Score 75

A potent stimulant blend may support short-term energy and focus. High caffeine and huperzine make sleep disruption, palpitations, and interactions the central drawbacks.
How scoring works
$9.99($0.16 per serving)
iHerb
$ 49.99
Nutrition Faktory
$ 9.99
Report prices

Analysis

Caffeine at 290 mg is the dominant energy and focus driver. Green coffee, alpha-lipoic acid, mangiferin, grains of paradise, cayenne, and piperine provide additional metabolic and absorption-oriented support.

Choline appears in two label entries, but the supplied data do not clearly establish the total active amount. Huperzine A is small yet still relevant because it acts on acetylcholine breakdown and can interact with cholinergic medicines.

The formula fits stimulant-tolerant adults seeking short-term energy or workout intensity. It is poorly suited to caffeine-sensitive users, late-day dosing, or anyone already consuming substantial caffeine.

Who is it for
  • Stimulant-tolerant adults
  • Users seeking pre-workout-style energy
  • People able to avoid other caffeine sources
Best for
  • Short-term energy
  • Workout intensity
  • Stimulant-based focus

Pros

  • Clearly states 290 mg caffeine
  • Green coffee is standardized to chlorogenic acids
  • Includes 200 mg alpha-lipoic acid
  • Mangiferin and grains of paradise are disclosed
  • Low serving cost

Cons

  • High stimulant burden
  • Choline total is ambiguous
  • Huperzine adds complexity
  • Not suitable for late-day use
  • Weight-management effect depends heavily on caffeine

Warnings

  • The 290 mg caffeine dose may cause insomnia, anxiety, tremor, or palpitations
  • Huperzine may cause nausea or slow heart rate and can interact with cholinergic or anticholinergic medicines
  • Piperine can alter absorption of some medications
  • Alpha-lipoic acid may lower blood glucose alongside glucose-lowering medication

Nutrient quality

70 High impact

Caffeine anhydrous and several standardized extracts are clear, while choline bitartrate is a basic form. Caffeine and several thermogenic or focus actives are supplied at material amounts.

.

Ingredient transparency

80 Highest impact

Most active amounts and several extract markers are clear, though the two choline entries complicate total interpretation. Complete non-active ingredient details are not included in the supplied label data.

.

Customer satisfaction

65 Moderate impact

The supplied average rating provides limited high-level context. Detailed firsthand feedback is unavailable, so recurring complaints and purpose fit cannot be assessed.

.

Value for money

83 Highest impact

The low serving cost buys substantial stimulant and thermogenic doses. Effective dose value is strong for users who can tolerate the high stimulant load.

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Report analysis

Goals

Energy
Energy
Impact
Highest effect
A+ Goal FitA+ Strength of SupportB+ CoverageC+ Formula Quality
Thiamin · 0.3 mgCaffeine · 290 mg

Caffeine anhydrous provides rapid and well-supported alertness, while choline and alpha-lipoic acid add cognitive and metabolic context. The 290 mg caffeine amount is clearly disclosed and likely to feel strong.

Multiple botanical stimulatory extracts make the formula busier and less predictable than a simple caffeine product. The caffeine load may cause jitteriness, rapid heartbeat, or sleep disruption, especially when combined with other stimulants.

Study evidence
Caffeine Supportive 68 studies
Metabolism Boost
Metabolism Boost
Impact
Highest effect
A- Goal FitA- Strength of SupportA- CoverageB Formula Quality
Thiamin · 0.3 mgCaffeine · 290 mg

Caffeine, green coffee, alpha-lipoic acid, grains of paradise, and cayenne combine direct thermogenesis with glucose and energy support. Several lead ingredients have meaningful amounts, making the formula strongly aligned with short-term metabolic stimulation.

The 290 mg caffeine serving can cause jitters, rapid heartbeat, anxiety, or sleep loss, and undisclosed synephrine from bitter orange may intensify those effects. Huperzine A and multiple stimulant-adjacent botanicals also make the product a poor fit for stimulant-sensitive users or anyone combining it with other caffeine sources.

Study evidence
Caffeine Disputed 40 studies
Weight Loss
Weight Loss
Impact
Highest effect
B+ Goal FitA- Strength of SupportB+ CoverageB- Formula Quality
Caffeine · 290 mg

The formula directly targets energy expenditure with 290 mg caffeine, green coffee, grains of paradise, cayenne, and black pepper. Alpha-lipoic acid and choline add metabolic support, while most amounts are clearly disclosed.

The high caffeine amount can cause jitteriness, rapid heartbeat, or sleep disruption, especially when combined with other stimulants. Several smaller extracts have limited weight-loss evidence, so the strongest practical effect is stimulation rather than broad fat loss.

Study evidence
Caffeine Disputed 14 studies
Mental Focus
Mental Focus
Impact
Highest effect
A- Goal FitB+ Strength of SupportB+ CoverageC+ Formula Quality
Choline · 249 mgCaffeine · 290 mgHuperzine · 10 mcg

Caffeine provides a pronounced acute alertness effect, while choline and Huperzine A target acetylcholine-related focus. The combination covers several useful cognitive mechanisms, but the Huperzine A amount is modest.

The high caffeine load lacks L-theanine or another clear buffer for stimulant effects. A 290 mg caffeine serving may cause jitters, a rapid heartbeat, or sleep disruption, especially when combined with other stimulants.

Study evidence
Caffeine Supportive 128 studies
Choline Supportive 22 studies
Huperzine Not classified

No linked studies yet.

Productivity Boost
Productivity Boost
Impact
High effect
A- Goal FitA- Strength of SupportB+ CoverageD Formula Quality
Huperzine · 10 mcgCaffeine · 290 mg

A high caffeine amount, choline, mango extract, and huperzine A create a strong acute stimulation and attention formula. Caffeine is the main reliable driver, while the low huperzine amount and modest choline contribution add uncertain depth.

The thermogenic ingredients broaden stimulation but also increase side-effect risk and make the design less balanced for sustained work. The 290 mg caffeine amount may cause anxiety, palpitations, higher blood pressure, or insomnia, especially when combined with other stimulants.

Study evidence
Caffeine Supportive 108 studies
Huperzine No effect 1 study
Fitness
Fitness
Impact
High effect
B- Goal FitB+ Strength of SupportB- CoverageC Formula Quality
Caffeine · 290 mg

The 290 mg caffeine anhydrous amount can improve alertness, perceived effort, and training output for caffeine-tolerant adults. Choline and several standardized extracts add focus and thermogenic pathways around that strong stimulant core.

Many secondary ingredients have weaker sports-performance evidence or modest amounts, making the formula busier than necessary. The caffeine dose may cause jitters, rapid heartbeat, anxiety, or sleep disruption, and piperine may increase exposure to some medicines by slowing their breakdown.

Study evidence
Caffeine Supportive 255 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride)
 0.3 mg
Choline (Choline Bitartrate)
 100 mg
Caffeine Anhydrous
290 mg
Choline Bitartrate
249 mg
Green Coffee extract (Chlorogenic Acids)
 200 mg
ALA
200 mg
Zynamite Mango extract (Mangiferin)
 100 mg
Jujube fruit extract
50 mg
Grains of Paradise extract
20 mg
Cayenne Pepper
10 mg
Bioperine Black Pepper extract (Piperine)
 5.3 mg
Huperzine-A (Huperzia serrata)
 10 mcg
Adults 18–50
Report overview
Caffeine · 290 mg OverallScore87
B Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

Caffeine anhydrous supplies a strong, clearly disclosed dose suited to users seeking pronounced stimulation. The amount remains within the stated strong-dose band, though caffeine-sensitive users may experience jitters or sleep disruption. A very low serving cost provides excellent value, while the formula offers no sustained-release feature.

View ingredientView products
Choline (Choline Bitartrate) · 100 mg OverallScore71
B Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD+ Value
The clearly stated bitartrate yield provides a moderate choline amount but is not a premium cognitive source. Two capsules are practical, and the low serving cost gives fair choline efficiency. The 290 mg caffeine dose may cause jitters, sleep disruption, or a rapid heartbeat in caffeine-sensitive users.
View ingredientView products
Huperzine (Huperzia serrata) · 10 mcg OverallScore60
A+ Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value

The capsule provides a clearly measured Huperzine A amount from Huperzia serrata, but the dose is too low to match the usual cognitive range. Its low serving price does not translate into strong active-value because many servings would be needed to reach a typical amount. The serving also contains 290 mg of caffeine, which may cause jitteriness, sleep disruption, or a rapid heartbeat in caffeine-sensitive users.

View ingredientView products
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Pre JYM
<p>Fully disclosed citrulline malate, creatine, beta-alanine, betaine, taurine, amino acids, tyrosine, and caffeine provide much deeper training support. Caffeine remains high enough to cause jitteriness, rapid heartbeat, anxiety, or sleep disruption, while some cognitive actives are modest.</p>
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C4 Ultimate Strawberry Watermelon

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54 Performance

LFG Burn Tropical

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<p>Branded performance ingredients and strong core doses provide deeper pre-workout support for intense training. The two listed caffeine forms imply excessive exposure, and caffeine combined with mucuna and huperzine raises cardiovascular, sleep, and cholinergic concerns.</p>
76 Budget

Brain Elevate

NOW
<p>Ginkgo, huperzine, rosemary, and gotu kola provide focused cognitive support at slightly lower serving cost without a large caffeine dose. The formula does not replace the original’s acute energy, thermogenic, or weight-management ingredients.</p>
75 Value

Brain Elevate

NOW
<p>The focused ginkgo, huperzine, rosemary, and gotu kola blend provides a long supply for mental-focus use without heavy stimulant exposure. Serving cost is slightly higher and the formula does not cover acute energy or weight management.</p>
70 Value

Brain Regain

Protocol For Life Balance
<p>Ginkgo, huperzine, rosemary, and gotu kola offer a simpler cognitive formula without 290 mg caffeine. Core amounts are modest and value is weaker, while fitness and thermogenic goals are not addressed.</p>
50 Value

Animal Cuts Powder Blue Ice Pop Flavor

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<p>Taurine, choline, caffeine, and several metabolic complexes retain energy and weight-management positioning at a moderate serving cost. Hidden blend amounts and a water-shedding complex reduce dose confidence and may increase dehydration risk during exercise.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis.
    Shi X; Xue W; Liang S; Zhao J; Zhang X · Nutrition journal · 2017
    Meta-analysis7 studies pooledMetabolism Boost forCaffeine
  2. Using coffee to compensate for poor sleep: Impact on vigilance and implications for workplace performance.
    Anderson JR; Hagerdorn PL; Gunstad J; Spitznagel MB · Applied ergonomics · 2018
    Randomized trial69 participantsMental Focus forCaffeine
  3. Caffeine administration at night during extended wakefulness effectively mitigates performance impairment but not subjective assessments of fatigue and sleepiness.
    Paech GM; Banks S; Pajcin M; Grant C; Johnson K; Kamimori GH; Vedova CB · Pharmacology, biochemistry, and behavior · 2017
    Randomized trial24 participantsEnergy forCaffeine
  4. High-power therapeutic ultrasound for treatment of abdominal localized adiposity-double-blind randomized clinical trial.
    da Silva Siqueira K; Maia JM · Lasers in medical science · 2020
    Randomized trial90 participantsWeight Loss forCaffeine
  5. Neurocognitive effects of acute choline supplementation in low, medium and high performer healthy volunteers.
    Knott V; de la Salle S; Choueiry J; Impey D; Smith D; Smith M; Beaudry E; Saghir S; Ilivitsky V; Labelle A · Pharmacology, biochemistry, and behavior · 2016
    Randomized trial24 participantsMental Focus forCholine
  6. No effects of caffeine on cycling to exhaustion and perceptual responses in non-caffeine-restricted subjects.
    Weippert M; Behrens M; Schlegel M; Schröder T; Tillmann M; Rühe N; Römer R; Mau-Möller A; Bruhn S · Journal of the International Society of Sports Nutrition · 2025
    Randomized trial56 participantsEnergy forCaffeine
  7. Physiological and cognitive responses to caffeine during repeated, high-intensity exercise.
    Crowe MJ; Leicht AS; Spinks WL · International journal of sport nutrition and exercise metabolism · 2007
    Randomized trial17 participantsMental Focus forCaffeine
  8. Maternal, but not paternal or grandparental, caffeine intake is associated with childhood obesity and adiposity: The Lifeways Cross-Generation Cohort Study.
    Chen LW; Murrin CM; Mehegan J; Kelleher CC; Phillips CM; Cross-Generation Cohort Study for the Lifeways · The American journal of clinical nutrition · 2020
    Cohort study558 participantsWeight Loss forCaffeine
  9. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women.
    Bracco D; Ferrarra JM; Arnaud MJ; Jéquier E; Schutz Y · The American journal of physiology · 1995
    Clinical trial20 participantsMetabolism Boost forCaffeine
  10. Associations between maternal folate status and choline intake during pregnancy and neurodevelopment at 3-4 years of age in the Alberta Pregnancy Outcomes and Nutrition (APrON) study.
    Irvine N; England-Mason G; Field CJ; Letourneau N; Bell RC; Giesbrecht GF; Kinniburgh DW; MacDonald AM; Martin JW; Dewey D; APrON Study Team · Journal of developmental origins of health and disease · 2023
    Cohort study309 participantsMental Focus forCholine
  11. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features.
    Juliano LM; Griffiths RR · Psychopharmacology · 2005
    Systematic review66 studies pooledEnergy forCaffeine
  12. Caffeinated Coffee and Tea Consumption, Genetic Variation and Cognitive Function in the UK Biobank.
    Cornelis MC; Weintraub S; Morris MC · The Journal of nutrition · 2020
    Cross-sectional study445,786 participantsMental Focus forCaffeine
  13. Decaffeinated coffee improves insulin sensitivity in healthy men.
    Reis CEG; Paiva CLRDS; Amato AA; Lofrano-Porto A; Wassell S; Bluck LJC; Dórea JG; da Costa THM · The British journal of nutrition · 2019
    Randomized trial17 participantsMetabolism Boost forCaffeine
  14. Safety and efficacy of long-term treatment with ephedrine, caffeine and an ephedrine/caffeine mixture.
    Toubro S; Astrup AV; Breum L; Quaade F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1993
    Randomized trial180 participantsWeight Loss forCaffeine
  15. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.
    Poly C; Massaro JM; Seshadri S; Wolf PA; Cho E; Krall E; Jacques PF; Au R · The American journal of clinical nutrition · 2012
    Cohort study1,391 participantsMental Focus forCholine
  16. A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, and Cognitive Performance.
    Krieger J; Schrautemeier A; Hagele A; Gaige C; Mennemeyer O; Tolbert S; Iannotti J; Kerksick C; Noonan C; Mumford P · Nutrients · 2025
    Randomized trial60 participantsMetabolism Boost forCaffeine
  17. Acute effects of caffeine on attention: a comparison of non-consumers and withdrawn consumers.
    Smith AP; Christopher G; Sutherland D · Journal of psychopharmacology (Oxford, England) · 2013
    Randomized trial70 participantsMental Focus forCaffeine
  18. Differential cognitive effects of energy drink ingredients: caffeine, taurine, and glucose.
    Giles GE; Mahoney CR; Brunyé TT; Gardony AL; Taylor HA; Kanarek RB · Pharmacology, biochemistry, and behavior · 2013
    Randomized trial48 participantsEnergy forCaffeine
  19. Does caffeine ingestion before a short-term sprint interval training promote body fat loss?
    Ferreira GA; Felippe LC; Bertuzzi R; Bishop DJ; Ramos IS; De-Oliveira FR; Lima-Silva AE · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2020
    Randomized trial20 participantsWeight Loss forCaffeine
  20. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly.
    Fioravanti M; Yanagi M · The Cochrane database of systematic reviews · 2005
    Meta-analysis14 studies pooledMental Focus forCholine
  21. Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
    Wingelaar-Jagt YQ; Bottenheft C; Riedel WJ; Ramaekers JG · Journal of psychopharmacology (Oxford, England) · 2023
    Randomized trial32 participantsMental Focus forCaffeine
  22. Caffeine-Containing Energy Shots Cause Acute Impaired Glucoregulation in Adolescents.
    Shearer J; Reimer RA; Hittel DS; Gault MA; Vogel HJ; Klein MS · Nutrients · 2021
    Randomized trial20 participantsMetabolism Boost forCaffeine
  23. Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study.
    Ozan M; Buzdagli Y; Eyipinar CD; Baygutalp NK; Yüce N; Oget F; Kan E; Baygutalp F · Nutrients · 2022
    Randomized trial20 participantsEnergy forCaffeine
  24. Eight Weeks of Sprint Interval Training With Adding Caffeine Ingestion Leads to Greater Improvements in Health-Related Physiological Parameters in Obese Male Adults.
    Zhiang J; Song Q · Physiological research · 2026
    Randomized trial30 participantsWeight Loss forCaffeine
  25. Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
    Obeid R; Derbyshire E; Schön C · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis30 studies pooledMental Focus forCholine
  26. The effects of L-theanine, caffeine and their combination on cognition and mood.
    Haskell CF; Kennedy DO; Milne AL; Wesnes KA; Scholey AB · Biological psychology · 2008
    Randomized trialMental Focus forCaffeine
  27. Oolong tea increases metabolic rate and fat oxidation in men.
    Rumpler W; Seale J; Clevidence B; Judd J; Wiley E; Yamamoto S; Komatsu T; Sawaki T; Ishikura Y; Hosoda K · The Journal of nutrition · 2001
    Randomized trial12 participantsMetabolism Boost forCaffeine
  28. Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study.
    Fuller DT; Smith ML; Boolani A · Nutrients · 2021
    Randomized trialEnergy forCaffeine
  29. An Examination of a Novel Weight Loss Supplement on Anthropometry and Indices of Cardiovascular Disease Risk.
    Sowinski RJ; Grubic TJ; Dalton RL; Schlaffer J; Reyes-Elrod AG; Jenkins VM; Williamson S; Rasmussen C; Murano PS; Earnest CP; Kreider RB · Journal of dietary supplements · 2021
    Randomized trial68 participantsWeight Loss forCaffeine
  30. Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies.
    Akison LK; Kuo J; Reid N; Boyd RN; Moritz KM · Alcoholism, clinical and experimental research · 2019
    Systematic reviewMental Focus forCholine
  31. Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson's disease according to task demands.
    Sharma K; Fallon SJ; Davis T; Ankrett S; Munro G; Christopher G; Coulthard E · Psychopharmacology · 2022
    Randomized trial68 participantsMental Focus forCaffeine
  32. Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial.
    MacKenzie T; Comi R; Sluss P; Keisari R; Manwar S; Kim J; Larson R; Baron JA · Metabolism: clinical and experimental · 2008
    Randomized trial16 participantsMetabolism Boost forCaffeine
  33. Effect of Caffeine on Golf Performance and Fatigue during a Competitive Tournament.
    Mumford PW; Tribby AC; Poole CN; Dalbo VJ; Scanlan AT; Moon JR; Roberts MD; Young KC · Medicine and science in sports and exercise · 2016
    Randomized trial12 participantsEnergy forCaffeine
  34. Maternal caffeine intake during pregnancy, early growth, and body fat distribution at school age.
    Voerman E; Jaddoe VW; Gishti O; Hofman A; Franco OH; Gaillard R · Obesity (Silver Spring, Md.) · 2017
    Cohort study7,857 participantsWeight Loss forCaffeine
  35. Cytidinediphosphocholine (CDP choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly.
    Fioravanti M; Yanagi M · The Cochrane database of systematic reviews · 2004
    Meta-analysisMental Focus forCholine
  36. The combined effects of L-theanine and caffeine on cognitive performance and mood.
    Owen GN; Parnell H; De Bruin EA; Rycroft JA · Nutritional neuroscience · 2009
    Randomized trial27 participantsMental Focus forCaffeine
  37. Effect of caffeine intake on fat oxidation rate during exercise: is there a dose-response effect?
    Gutiérrez-Hellín J; Aguilar-Navarro M; Ruiz-Moreno C; Muñoz A; Varillas-Delgado D; Amaro-Gahete FJ; Del Coso J · European journal of nutrition · 2023
    Randomized trial18 participantsMetabolism Boost Energy forCaffeine
  38. Effects of Caffeine Intake on Cognitive Performance Related to Total Sleep Deprivation and Time on Task: A Randomized Cross-Over Double-Blind Study.
    Quiquempoix M; Sauvet F; Erblang M; Van Beers P; Guillard M; Drogou C; Trignol A; Vergez A; Léger D; Chennaoui M; Gomez-Merino D; Rabat A · Nature and science of sleep · 2022
    Randomized trial24 participantsEnergy forCaffeine
  39. Prenatal Substance Exposure and Obesity: Trajectories of Tri-Ponderal Mass Index in Early Adolescence.
    Li R; Wigley IM; Suuronen I; Jolly A; Tuulari JJ · American journal of preventive medicine · 2025
    Cohort study7,881 participantsWeight Loss forCaffeine
  40. Choline concentrations in human maternal and cord blood and intelligence at 5 y of age.
    Signore C; Ueland PM; Troendle J; Mills JL · The American journal of clinical nutrition · 2008
    Cohort study404 participantsMental Focus forCholine
  41. The effect of mouth rinsing with different concentrations of caffeine solutions on reaction time.
    Virdinli SG; Kutlay E; Yuzbasioglu Y; Vollaard NBJ; Rudarli Nalcakan G · Journal of sports sciences · 2022
    Randomized trial45 participantsMental Focus forCaffeine
  42. Comparison of changes in energy expenditure and body temperatures after caffeine consumption.
    Koot P; Deurenberg P · Annals of nutrition & metabolism · 1995
    Randomized trial12 participantsMetabolism Boost forCaffeine
  43. Caffeine Supplementation and Physical Performance, Muscle Damage and Perception of Fatigue in Soccer Players: A Systematic Review.
    Mielgo-Ayuso J; Calleja-Gonzalez J; Del Coso J; Urdampilleta A; León-Guereño P; Fernández-Lázaro D · Nutrients · 2019
    Systematic review17 participants17 studies pooledEnergy forCaffeine
  44. Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents.
    Nilsson TK; Hurtig-Wennlöf A; Sjöström M; Herrmann W; Obeid R; Owen JR; Zeisel S · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016
    Cross-sectional study324 participantsMental Focus forCholine
  45. Caffeine treatment prevented from weight regain after calorie shifting diet induced weight loss.
    Davoodi SH; Hajimiresmaiel SJ; Ajami M; Mohseni-Bandpei A; Ayatollahi SA; Dowlatshahi K; Javedan G; Pazoki-Toroudi H · Iranian journal of pharmaceutical research : IJPR · 2014
    Non-randomized trial60 participantsWeight Loss forCaffeine
  46. Caffeine attenuates scopolamine-induced memory impairment in humans.
    Riedel W; Hogervorst E; Leboux R; Verhey F; van Praag H; Jolles J · Psychopharmacology · 1996
    Randomized trial16 participantsMental Focus forCaffeine
  47. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?
    Acheson KJ; Gremaud G; Meirim I; Montigon F; Krebs Y; Fay LB; Gay LJ; Schneiter P; Schindler C; Tappy L · The American journal of clinical nutrition · 2004
    Randomized trial8 participantsMetabolism Boost forCaffeine
  48. Prenatal choline, cannabis, and infection, and their association with offspring development of attention and social problems through 4 years of age.
    Hunter SK; Hoffman MC; D'Alessandro A; Wyrwa A; Noonan K; Zeisel SH; Law AJ; Freedman R · Psychological medicine · 2023
    Cohort study183 participantsMental Focus forCholine
  49. Interventions associated with brown adipose tissue activation and the impact on energy expenditure and weight loss: A systematic review.
    Perez LC; Perez LT; Nene Y; Umpierrez GE; Davis GM; Pasquel FJ · Frontiers in endocrinology · 2022
    Systematic review47 studies pooledWeight Loss forCaffeine
  50. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine.
    Haskell CF; Kennedy DO; Wesnes KA; Scholey AB · Psychopharmacology · 2005
    Randomized trial48 participantsEnergy forCaffeine
  51. Caffeine-containing energy drink improves physical performance of elite rugby players during a simulated match.
    Del Coso J; Ramírez JA; Muñoz G; Portillo J; Gonzalez-Millán C; Muñoz V; Barbero-Álvarez JC; Muñoz-Guerra J · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
    Randomized trial26 participantsEnergy forCaffeine
  52. Effect of caffeine ingestion on cycling performance: a systematic review and meta-analysis.
    Wu J; Xu K; Yin M; Ding X; Wang T; Zhang Q; Wu X; Xiao N · Frontiers in nutrition · 2026
    Meta-analysis226 participants20 studies pooledFitness forCaffeine
  53. Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis.
    Wang Z; Qiu B; Gao J; Del Coso J · Nutrients · 2023
    Meta-analysis254 participants21 studies pooledFitness forCaffeine
  54. Acute Effects of Caffeine Supplementation on Movement Velocity in Resistance Exercise: A Systematic Review and Meta-analysis.
    Raya-González J; Rendo-Urteaga T; Domínguez R; Castillo D; Rodríguez-Fernández A; Grgic J · Sports medicine (Auckland, N.Z.) · 2021
    Meta-analysis12 studies pooledFitness forCaffeine
  55. Sex Differences in the Ergogenic Response of Acute Caffeine Intake on Muscular Strength, Power and Endurance Performance in Resistance-Trained Individuals: A Randomized Controlled Trial.
    Montalvo-Alonso JJ; Ferragut C; Del Val-Manzano M; Valadés D; Roberts J; Pérez-López A · Nutrients · 2024
    Randomized trial76 participantsFitness forCaffeine
  56. Can I Have My Coffee and Drink It? A Systematic Review and Meta-analysis to Determine Whether Habitual Caffeine Consumption Affects the Ergogenic Effect of Caffeine.
    Carvalho A; Marticorena FM; Grecco BH; Barreto G; Saunders B · Sports medicine (Auckland, N.Z.) · 2022
    Meta-analysis60 studies pooledFitness forCaffeine
  57. Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation.
    Wesensten NJ; Killgore WD; Balkin TJ · Journal of sleep research · 2006
    Randomized trial48 participantsMental Focus forCaffeine
  58. Effects of caffeine on mood and performance: a study of realistic consumption.
    Brice CF; Smith AP · Psychopharmacology · 2003
    Clinical trial24 participantsMental Focus forCaffeine
  59. Effects of caffeine or diphenhydramine on visual vigilance.
    Fine BJ; Kobrick JL; Lieberman HR; Marlowe B; Riley RH; Tharion WJ · Psychopharmacology · 1995
    Randomized trial24 participantsMental Focus forCaffeine
  60. Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
    Wozniak JR; Fink BA; Fuglestad AJ; Eckerle JK; Boys CJ; Sandness KE; Radke JP; Miller NC; Lindgren C; Brearley AM; Zeisel SH; Georgieff MK · Journal of neurodevelopmental disorders · 2021
    Randomized trial31 participantsMental Focus forCholine
  61. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
    Ross RG; Hunter SK; McCarthy L; Beuler J; Hutchison AK; Wagner BD; Leonard S; Stevens KE; Freedman R · The American journal of psychiatry · 2013
    Randomized trialMental Focus forCholine
  62. Caffeine Increases Work Done above Critical Power, but Not Anaerobic Work.
    Silveira R; Andrade-Souza VA; Arcoverde L; Tomazini F; Sansonio A; Bishop DJ; Bertuzzi R; Lima-Silva AE · Medicine and science in sports and exercise · 2018
    Randomized trial9 participantsMetabolism Boost forCaffeine
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    Zwyghuizen-Doorenbos A; Roehrs TA; Lipschutz L; Timms V; Roth T · Psychopharmacology · 1990
    Randomized trial24 participantsProductivity Boost forCaffeine
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    Irwin C; McCartney D; Grant G; Delang N; Bartrim K; Cox GR; Desbrow B · Perceptual and motor skills · 2023
    Randomized trial22 participantsProductivity Boost forCaffeine
  65. Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land.
    Lieberman HR; Tharion WJ; Shukitt-Hale B; Speckman KL; Tulley R · Psychopharmacology · 2003
    Randomized trial68 participantsProductivity Boost forCaffeine
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    McLellan TM; Caldwell JA; Lieberman HR · Neuroscience and biobehavioral reviews · 2017
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    Wang R; Wang W; Meng L; Hao G; Gu G · Frontiers in nutrition · 2026
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    Wessinger CM; Inman CL; Weinstock J; Weiss EP · International journal of exercise science · 2025
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    Lopez-Garcia E; van Dam RM; Rajpathak S; Willett WC; Manson JE; Hu FB · The American journal of clinical nutrition · 2006
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    Tabrizi R; Saneei P; Lankarani KB; Akbari M; Kolahdooz F; Esmaillzadeh A; Nadi-Ravandi S; Mazoochi M; Asemi Z · Critical reviews in food science and nutrition · 2020
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