Product Image

Relieve-R

LifeSeasons
4.2
★ ★ ★ ★ ★
(88 ratings)
Thiamin 50 mg
Vitamin B6 50 mg
Vitamin B12 1000 mcg
Theanine 75 mg
Acetyl L-Carnitine 100 mg
Product Image
Score67
Quality B-vitamin forms and a balanced caffeine-theanine pair are offset by a conflicted pain-and-alertness blend. White willow, tetrahydropalmatine, and high B6 require careful use.
How scoring works
Quantity:46 Capsule(s) • (23 servings)
Goals:
Energy
General Health
Productivity Boost

Score 67

Quality B-vitamin forms and a balanced caffeine-theanine pair are offset by a conflicted pain-and-alertness blend. White willow, tetrahydropalmatine, and high B6 require careful use.
How scoring works
$29.99($1.30 per serving)
iHerb
$ 29.99
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Analysis

Methylcobalamin, pyridoxal 5-phosphate, and benfotiamine are well-chosen vitamin forms. Caffeine and theanine are balanced at 75 mg each, which may provide moderate alertness with less edge than caffeine alone.

White willow bark and tetrahydropalmatine shift the product toward discomfort support rather than general energy or cognitive use. Acetyl-L-carnitine is only 100 mg, so it contributes little to a focused carnitine formula.

The exact doses are visible, but the combination carries more interaction concerns than a routine daily supplement. It best fits occasional use by someone who understands the stimulant, salicylate, and sedating components.

Who is it for
  • Adults seeking occasional discomfort and alertness support
  • Users who tolerate moderate caffeine
  • People who value active B-vitamin forms
Best for
  • Occasional daytime use
  • Moderate caffeine with theanine
  • Active B-vitamin coverage

Pros

  • Uses methylcobalamin and active B6
  • Balances caffeine with equal theanine
  • Clearly discloses all active amounts
  • Includes standardized white willow salicin

Cons

  • Acetyl-L-carnitine is lightly dosed
  • Mixes stimulating and sedating pathways
  • High serving cost for the targeted actives
  • Poor fit for broad daily wellness

Warnings

  • White willow salicin may increase bleeding risk with anticoagulant or antiplatelet medicines and may not suit people with aspirin sensitivity.
  • Tetrahydropalmatine may cause sedation, while caffeine may cause jitteriness or sleep disruption; avoid driving until the combined effect is known.
  • The 50 mg vitamin B6 amount may raise the risk of tingling, numbness, or nerve injury with prolonged daily use.

Nutrient quality

64 Moderate impact

Several actives fit short-term relief and alertness, but some supporting amounts are light. High vitamin B6 and a complicated stimulant-sedative balance weaken suitability for broad routine use.

Ingredient transparency

79 High impact

The supplied active label gives exact amounts without concealing a blend. Usage directions and inactive ingredients are not provided.

Customer satisfaction

61 Moderate impact

The favorable rating offers some support, but the review base is relatively small. Missing review text leaves tolerance issues and intended-use experiences uncertain.

Value for money

62 Moderate impact

Specialized extracts provide some justification for the cost. Light acetyl-L-carnitine dosing and a short bottle life weaken serving value.

Report analysis

Goals

Energy
Essential Energy Nutrients
Energy
Impact
Highest effect
A- Goal FitA- Strength of SupportA- CoverageC+ Formula Quality
Vitamin D · 25 mcgThiamin · 50 mgVitamin B12 · 1000 mcgAcetyl L-Carnitine · 100 mgCaffeine · 75 mg

Methylcobalamin, benfotiamine, caffeine, and theanine support metabolic and focused-energy pathways. The caffeine and theanine amounts are balanced for moderate alertness, while acetyl-L-carnitine is lightly dosed.

White willow and tetrahydropalmatine reflect a pain-relief purpose and weaken the formula focus for energy. Prolonged daily use also raises specific concerns because white willow can increase bleeding risk and the high vitamin B6 amount may raise neuropathy risk.

Study evidence
Acetyl L-Carnitine Supportive 19 studies
Caffeine Supportive 68 studies
Theanine Not classified

No linked studies yet.

Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
General Health
Daily Energy Vitality
General Health
Impact
High effect
D+ Goal FitB Strength of SupportC CoverageB+ Formula Quality
Vitamin B12 · 1000 mcgVitamin D · 25 mcg

Active B vitamins and vitamin D contribute some foundational support, but the formula primarily targets short-term symptom relief and alertness. White willow, caffeine, fragrant angelica, and tetrahydropalmatine make it less appropriate as a general daily supplement.

Most ingredient forms and amounts are clearly disclosed, including methylcobalamin and active B6. The high B6 amount and medication-sensitive botanicals create more safety trade-offs than a routine wellness formula should carry. White willow supplies salicylates that may increase bleeding risk with anticoagulants or antiplatelet medicines, and caffeine plus tetrahydropalmatine may produce conflicting stimulation and sedation.

Study evidence
Vitamin B12 Adverse 66 studies
Vitamin D Supportive 115 studies
Productivity Boost
Cognitive Energy and Stamina
Productivity Boost
Impact
High effect
B- Goal FitC+ Strength of SupportC+ CoverageC Formula Quality
Vitamin B12 · 1000 mcgVitamin B12 · 1000 mcgVitamin B6 · 50 mgAcetyl L-Carnitine · 100 mgAcetyl L-Carnitine · 100 mgTheanine · 75 mgCaffeine · 75 mg

Caffeine and L-theanine provide a recognizable alertness and calm-focus pairing. The formula is mainly designed for discomfort support, so several ingredients do not directly serve productivity.

Both members of the focus pair are modest, and acetyl-L-carnitine is far below a meaningful neurological amount. Active B vitamins improve form quality, but the overall stack lacks depth and clear focus.

Study evidence
Acetyl L-Carnitine Supportive 1 study
Acetyl L-Carnitine Supportive 1 study
Caffeine Supportive 108 studies
Theanine Supportive 5 studies
Brain Health
Essential Brain Nutrition
Brain Health
Impact
Moderate effect
C- Goal FitB- Strength of SupportC CoverageD+ Formula Quality
Vitamin B12 · 1000 mcgVitamin B6 · 50 mgVitamin D · 25 mcgThiamin · 50 mg

Caffeine with theanine may support alertness, while active B vitamins provide neurological cofactors. The product primarily targets pain relief, and acetyl-L-carnitine is far below a meaningful cognitive amount.

White willow may increase bleeding risk with anticoagulants, and prolonged 50 mg vitamin B6 intake may cause nerve symptoms. Caffeine may also cause jitteriness or sleep disruption in stimulant-sensitive users.

Study evidence
Acetyl L-Carnitine Supportive 19 studies
Theanine Supportive 17 studies
Vitamin B6 Supportive 29 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
C Goal FitC Strength of SupportC CoverageD- Formula Quality
Thiamin · 50 mgVitamin B6 · 50 mgVitamin B12 · 1000 mcgVitamin D · 25 mcgAcetyl L-Carnitine · 100 mgTheanine · 75 mg

Caffeine with L-theanine offers a recognized focus pairing, while active B vitamins and ALCAR add neurological support. Theanine and ALCAR are low for targeted cognition, and tetrahydropalmatine adds a sedating pathway that conflicts with daytime focus.

White willow can increase bleeding risk with anticoagulants or aspirin sensitivity, and caffeine may not suit stimulant-sensitive users. Prolonged daily use of the high B6 amount may also raise neuropathy risk.

Study evidence
Acetyl L-Carnitine Supportive 20 studies
Theanine Supportive 25 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
D+ Goal FitB+ Strength of SupportD- CoverageF Formula Quality
Vitamin D · 25 mcgVitamin B12 · 1000 mcgVitamin B6 · 50 mg

Active B6 and B12 provide some support for homocysteine metabolism. Missing folate leaves that pathway incomplete, while the rest of the blend is aimed mainly at pain and alertness.

The vitamin amounts and forms are clearly stated. White willow and caffeine add practical concerns that are unrelated to routine cardiovascular support.

Study evidence
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies

Ingredients

IngredientAmount per serving
Vitamin D3 (Cholecalciferol)
 25 mcg
Vitamin B6 (Pyridoxal 5-Phosphate)
 50 mg
Vitamin B12 (Methylcobalamin)
 1000 mcg
White Willow bark extract (Salicin)
 300 mg
Fragrant Angelica root extract
100 mg
Acetyl-L-Carnitine HCl
100 mg
Caffeine (Coffea arabica)
 75 mg
L-Theanine
75 mg
Benfotiamine
50 mg
L-Tetrahydropalmatine (Corydalis yanhusuo)
 50 mg
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
Thiamin · 50 mg OverallScore84
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

Benfotiamine is a fat-soluble thiamin form with strong absorption and tissue-penetration potential. The 50 mg serving enters the preferred high-potency range. The exact 50 mg thiamin amount is clearly disclosed outside any proprietary blend, but the cost per active dose is high even under the premium-form threshold.

View ingredientView products
Vitamin B6 (Pyridoxal 5-Phosphate) · 50 mg OverallScore84
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Pyridoxal 5-phosphate provides B6 in its active coenzyme form. The 50 mg serving falls within the preferred potency range. The two-capsule serving is practical, but value is poor even with the active form.

View ingredientView products
Vitamin B12 (Methylcobalamin) · 1000 mcg OverallScore79
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The bioactive methylcobalamin form is a meaningful strength. The amount per serving is well aligned with people who have higher B12 needs. Cost efficiency is weak when the price is compared with the B12 delivered.

View ingredientView products
Loading alternative details
82 Performance

PQQ Energy

NOW
<p>PQQ, methylcobalamin, CoQ10, and acetyl-L-carnitine give this option a clearer cellular-energy focus than the original’s complex relief blend. It avoids white willow and tetrahydropalmatine, though the carnitine and CoQ10 amounts remain modest.</p>
72 Performance

Focus-R

LifeSeasons
<p>More L-theanine and methylcobalamin shift the formula toward calm focus while retaining the original’s caffeine amount. Kava, ginkgo, and multiple botanicals introduce their own sedation, liver, and bleeding cautions, so it is not a simple low-risk choice.</p>
78 Performance

Methylfolate B Complex

Codeage
<p>Active riboflavin, B6, methylfolate, methylcobalamin, and betaine provide more coherent B-vitamin and methylation support than the original. It avoids stimulant, salicylate, and sedative ingredients, but its concentrated nutrient amounts suit targeted use better than basic maintenance.</p>
81 Budget

Tri-B

Carlson
<p>A simple vitamin B6, folate, and B12 formula offers far better value and avoids white willow, caffeine, and tetrahydropalmatine. Conventional forms and concentrated folate reduce refinement, and it does not target short-term relief.</p>
81 Budget

Activated Homocysteine

Swanson
<p>Active B6, methylfolate, methylcobalamin, and betaine give stronger B-vitamin form quality at lower serving cost. It avoids the original’s stimulant and salicylate concerns, although the vitamin B6 amount is still aggressive for long-term use.</p>
82 Budget

BioActive Vitamin B

Terry Naturally
<p>Active forms of vitamin B6, B12, and folate provide a compact, lower-cost alternative for energy and general nutrient support. The formula avoids white willow and tetrahydropalmatine but does not provide acetyl-L-carnitine, theanine, or acute relief ingredients.</p>
78 Value

Homocysteine Defense

Source Naturals
<p>A meaningful betaine amount with B6, folate, and B12 provides focused cardiovascular nutrient support at better value. Older vitamin forms and elevated pyridoxine limit long-term appeal, but the formula avoids the original’s willow and sedative ingredients.</p>
79 Value

Homocysteine Modulators

Solgar
<p>Betaine plus B6, folate, and B12 offers focused cardiovascular support without the original’s stimulant and white-willow combination. Value is favorable, although older vitamin forms and high B6 are important trade-offs.</p>
74 Value

HomocysteX Plus

Seeking Health
<p>Active B6, riboflavin, folate, and trimethylglycine give a more coherent nutrient formula at lower serving cost. It avoids the original’s caffeine, willow, and tetrahydropalmatine, though the concentrated blend is intended for targeted rather than general use.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.
    Malaguarnera M; Vacante M; Giordano M; Pennisi G; Bella R; Rampello L; Malaguarnera M; Li Volti G; Galvano F · The American journal of clinical nutrition · 2011
    Randomized trial121 participantsEnergy forAcetyl L-Carnitine
  2. Carnitine for fatigue in multiple sclerosis.
    Tejani AM; Wasdell M; Spiwak R; Rowell G; Nathwani S · The Cochrane database of systematic reviews · 2010
    Systematic review1 studies pooledEnergy forAcetyl L-Carnitine
  3. Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.
    Malaguarnera M; Gargante MP; Cristaldi E; Vacante M; Risino C; Cammalleri L; Pennisi G; Rampello L · Digestive diseases and sciences · 2008
    Randomized trial125 participantsCognitive Support Brain Health forAcetyl L-Carnitine
  4. A 1-year controlled trial of acetyl-l-carnitine in early-onset AD.
    Thal LJ; Calvani M; Amato A; Carta A · Neurology · 2000
    Randomized trial229 participantsCognitive Support forAcetyl L-Carnitine
  5. Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach.
    Brooks JO; Yesavage JA; Carta A; Bravi D · International psychogeriatrics · 1998
    Randomized trial334 participantsCognitive Support forAcetyl L-Carnitine
  6. Long-term acetyl-L-carnitine treatment in Alzheimer's disease.
    Spagnoli A; Lucca U; Menasce G; Bandera L; Cizza G; Forloni G; Tettamanti M; Frattura L; Tiraboschi P; Comelli M · Neurology · 1991
    Randomized trial130 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  7. Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome.
    Herrmann WM; Dietrich B; Hiersemenzel R · International journal of clinical pharmacology research · 1990
    Randomized trialBrain Health forAcetyl L-Carnitine
  8. Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial.
    Malaguarnera M; Vacante M; Motta M; Giordano M; Malaguarnera G; Bella R; Nunnari G; Rampello L; Pennisi G · Metabolic brain disease · 2012
    Randomized trial61 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  9. Acetyl-L-carnitine in the treatment of mildly demented elderly patients.
    Passeri M; Cucinotta D; Bonati PA; Iannuccelli M; Parnetti L; Senin U · International journal of clinical pharmacology research · 1990
    Randomized trial60 participantsBrain Health forAcetyl L-Carnitine
  10. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support forTheanine
  11. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health forTheanine
  12. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support forTheanine
  13. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  14. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Productivity Boost forTheanine
  15. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
    Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
    Meta-analysis21 studies pooledBrain Health forVitamin B6
  16. Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
    Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
    Cross-sectional study266 participantsBrain Health forVitamin B6
  17. A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
    Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Randomized trial180 participantsBrain Health forVitamin B6
  18. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsBrain Health forVitamin B6
  19. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
    Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
    Scoping review12 studies pooledBrain Health forVitamin B6
  20. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support forVitamin B12
  21. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  22. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  23. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  24. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  25. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  26. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  27. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  28. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support forVitamin B6
  29. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  30. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys.
    Torrioli MG; Vernacotola S; Peruzzi L; Tabolacci E; Mila M; Militerni R; Musumeci S; Ramos FJ; Frontera M; Sorge G; Marzullo E; Romeo G; Vallee L; Veneselli E; Cocchi E; Garbarino E; Moscato U; Chiurazzi P; D'Iddio S; Calvani M; Neri G · American journal of medical genetics. Part A · 2008
    Randomized trial63 participantsCognitive Support forAcetyl L-Carnitine
  31. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue.
    Malaguarnera M; Gargante MP; Cristaldi E; Colonna V; Messano M; Koverech A; Neri S; Vacante M; Cammalleri L; Motta M · Archives of gerontology and geriatrics · 2008
    Randomized trial96 participantsCognitive Support forAcetyl L-Carnitine
  32. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  33. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support forTheanine
  34. The supplementation of acetyl-L-carnitine decreases fatigue and increases quality of life in patients with hepatitis C treated with pegylated interferon-α 2b plus ribavirin.
    Malaguarnera M; Vacante M; Bertino G; Neri S; Malaguarnera M; Gargante MP; Motta M; Lupo L; Chisari G; Bruno CM; Pennisi G; Bella R · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2012
    Randomized trial60 participantsEnergy forAcetyl L-Carnitine
  35. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy.
    Malaguarnera M; Bella R; Vacante M; Giordano M; Malaguarnera G; Gargante MP; Motta M; Mistretta A; Rampello L; Pennisi G · Scandinavian journal of gastroenterology · 2011
    Randomized trial67 participantsEnergy forAcetyl L-Carnitine
  36. A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy.
    Sun Y; Shu Y; Liu B; Liu P; Wu C; Zheng R; Zhang X; Zhuang Z; Deng Y; Zheng L; Xu Q; Jiang B; Ouyang X; Gao J; Xu N; Li X; Jiang S; Liang C; Yao Y · Experimental and therapeutic medicine · 2020
    Randomized trial239 participantsEnergy forAcetyl L-Carnitine
  37. Metabolomic biomarkers for (R, S)-ketamine and (S)-ketamine in treatment-resistant depression and healthy controls: A systematic review.
    Kumar R; Nuñez NA; Joshi N; Joseph B; Verde A; Seshadri A; Cuellar Barboza AB; Prokop LJ; Medeiros GC; Singh B · Bipolar disorders · 2024
    Systematic reviewEnergy forAcetyl L-Carnitine
  38. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine.
    Haskell CF; Kennedy DO; Wesnes KA; Scholey AB · Psychopharmacology · 2005
    Randomized trial48 participantsEnergy forCaffeine
  39. Caffeine-containing energy drink improves physical performance of elite rugby players during a simulated match.
    Del Coso J; Ramírez JA; Muñoz G; Portillo J; Gonzalez-Millán C; Muñoz V; Barbero-Álvarez JC; Muñoz-Guerra J · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
    Randomized trial26 participantsEnergy forCaffeine
  40. Differential cognitive effects of energy drink ingredients: caffeine, taurine, and glucose.
    Giles GE; Mahoney CR; Brunyé TT; Gardony AL; Taylor HA; Kanarek RB · Pharmacology, biochemistry, and behavior · 2013
    Randomized trial48 participantsEnergy forCaffeine
  41. Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study.
    Ozan M; Buzdagli Y; Eyipinar CD; Baygutalp NK; Yüce N; Oget F; Kan E; Baygutalp F · Nutrients · 2022
    Randomized trial20 participantsEnergy forCaffeine
  42. Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study.
    Fuller DT; Smith ML; Boolani A · Nutrients · 2021
    Randomized trialEnergy forCaffeine
  43. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  44. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  45. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  46. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  47. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  48. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  49. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
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    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
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    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
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    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  53. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
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    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
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    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
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    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
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    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
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    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
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    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
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    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
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    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
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    Meta-analysis42 studies pooledGeneral Health forVitamin D
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    Malaguarnera G; Pennisi M; Gagliano C; Vacante M; Malaguarnera M; Salomone S; Drago F; Bertino G; Caraci F; Nunnari G; Malaguarnera M · Hepatitis monthly · 2014
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    Zwyghuizen-Doorenbos A; Roehrs TA; Lipschutz L; Timms V; Roth T · Psychopharmacology · 1990
    Randomized trial24 participantsProductivity Boost forCaffeine
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    Irwin C; McCartney D; Grant G; Delang N; Bartrim K; Cox GR; Desbrow B · Perceptual and motor skills · 2023
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    Lieberman HR; Tharion WJ; Shukitt-Hale B; Speckman KL; Tulley R · Psychopharmacology · 2003
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    McLellan TM; Caldwell JA; Lieberman HR · Neuroscience and biobehavioral reviews · 2017
    Narrative reviewProductivity Boost forCaffeine
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    Wang R; Wang W; Meng L; Hao G; Gu G · Frontiers in nutrition · 2026
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  69. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
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  70. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsProductivity Boost forTheanine
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    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
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    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
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