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DIM Detox

Pure Encapsulations
4.9
★ ★ ★ ★ ★
(66 ratings)
Methionine
Glycine 100 mg
Milk Thistle 150 mg
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Score71
A thoughtfully structured DIM and liver-support blend with good active disclosure, offset by high cost and a minor label ambiguity.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Detoxification

Score 71

A thoughtfully structured DIM and liver-support blend with good active disclosure, offset by high cost and a minor label ambiguity.
How scoring works
$58.00($1.93 per serving)
Vitacost
$ 58.00
Pure Formulas
$ 58.00
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Analysis

The formula combines 100 mg BioResponse DIM, 100 mg calcium D-glucarate, and 100 mg broccoli sprout concentrate. NAC, alpha-lipoic acid, milk thistle, methionine, glycine, and taurine add complementary pathways.

Most major active amounts are disclosed and reasonably balanced. HMRlignan appears twice at 10 mg for source and compound descriptions, which likely reflects one ingredient but creates label ambiguity.

The blend is more precisely constructed than a generic detox product, especially for estrogen-metabolism support. It is still a specialized and relatively expensive formula that warrants medication and hormone-condition screening.

Who is it for
  • Adults specifically seeking DIM-based support
  • People wanting DIM with NAC and milk thistle
Best for
  • Hormone-metabolism support
  • Broad liver antioxidant routines

Pros

  • Uses branded BioResponse DIM
  • Includes NAC and alpha-lipoic acid
  • Pairs DIM with calcium D-glucarate

Cons

  • High routine cost
  • Lignan label lines are ambiguous
  • Specialized formula is not for everyone

Warnings

  • DIM may alter hormone metabolism and may not suit hormone-sensitive conditions or hormone therapies without professional guidance.
  • Alpha-lipoic acid may add to glucose-lowering medication effects.

Nutrient quality

81 Highest impact

Branded DIM and lignan ingredients add specificity, while milk thistle lacks a standardization percentage. DIM and alpha-lipoic acid are useful, but NAC, methionine, glycine, and taurine are modest.

Ingredient transparency

81 Highest impact

All listed active ingredients have individual amounts. Excipients and daily directions are absent from the supplied data, which leaves some label details uncertain.

Customer satisfaction

66 High impact

The aggregate satisfaction average is exceptionally strong, though no detailed feedback is supplied. The available volume is useful but not extensive.

Value for money

48 Lower impact

The sophisticated, coherent formula supports quality but does not eliminate potency gaps. The serving cost is high for several modest supporting doses.

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Goals

Detoxification
Detoxification
Impact
Highest effect
A- Goal FitC+ Strength of SupportA- CoverageA Formula Quality
Milk Thistle · 150 mgTaurine · 100 mgGlycine · 100 mg

N-acetyl-L-cysteine, alpha-lipoic acid, milk thistle, methionine, glycine, taurine, broccoli concentrate, and calcium-D-glucarate create a strongly targeted formula. Together they support glutathione production, antioxidant recycling, conjugation, bile handling, and normal hormone-metabolite clearance.

Several amino acids and N-acetyl-L-cysteine are below common standalone targeted amounts, and milk thistle standardization is unclear. Even with those limits, the complementary design offers unusually broad and coherent pathway coverage.

Study evidence
Glycine Supportive 5 studies
Milk Thistle Supportive 46 studies
Taurine Supportive 2 studies

Ingredients

IngredientAmount per serving
BioResponse DIM Diindolylmethane Complex
100 mg
Calcium-D-Glucarate
100 mg
Broccoli (Brassica oleracea italica) sprout concentrate
100 mg
HMRlignan (7-Hydroxymatairesinol, Norway Spruce)
 10 mg
Alpha Lipoic Acid
200 mg
N-Acetyl-L-Cysteine
200 mg
Milk Thistle (Silybum marianum) extract (Silymarin)
 150 mg
L-Methionine
200 mg
Glycine
100 mg
Taurine
100 mg
Gluten Free Adults 18–50
Report overview
Methionine · 200 mg OverallScore75
A- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD- Value

L-methionine is precisely named, and the established brand offers good general quality assurance. The independently disclosed 200 mg amount reaches the moderate range but remains below standalone potency. High serving cost is partly supported by branded DIM, lignan, and standardized milk-thistle ingredients.

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Glycine · 100 mg OverallScore64
C Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyB- Value

The glycine amount is clear, but no premium grade, branded source, or purity certification is provided. Its 100 mg contribution is modest alone but works as part of the multi-active detoxification formula. Other well-chosen actives improve formula-level value despite weak glycine-only economics.

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Milk Thistle (Silymarin) · 150 mg OverallScore9
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

Silymarin is identified in a broad combination formula, but the standardization level and plant source are not disclosed. The actual active dose cannot be calculated, and the dry capsule has no specified absorption technology. A very high serving cost offers poor milk thistle-focused value.

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82 Performance

Liver Support Factors

Country Life
<p>Methionine is doubled to 400 mg and paired with choline, milk thistle, artichoke, and curcuminoids for focused liver support. It lacks DIM and calcium-D-glucarate, but provides greater depth in methyl-donor and lipotropic support.</p>
85 Performance

Lipotropic Complex

Integrative Therapeutics
<p>Methionine rises to 333 mg alongside choline, active B6, methylcobalamin, silymarin, dandelion, and ox bile. The formula is better suited to liver and bile support, though it does not replace DIM, lignan, calcium-D-glucarate, or NAC.</p>
80 Performance

Detox & Liver Health

Reg'Activ
<p>NAC and milk thistle are supplied in meaningful amounts with methionine and selenium in a concise formula. It omits DIM and the broader conjugation ingredients, but offers a clearer emphasis on antioxidant precursor support.</p>
76 Budget

Liver Refresh

NOW
<p>Silymarin, glutathione, NAC, alpha-lipoic acid, and polyphenols preserve several detox pathways for substantially less per serving. It does not provide DIM, lignan, calcium-D-glucarate, glycine, or taurine, so hormone-metabolism coverage is reduced.</p>
77 Budget

Advanced Liver Support

Super Nutrition
<p>Milk thistle, reduced glutathione, NAC, alpha-lipoic acid, grape polyphenols, and schisandra deliver broad liver support at a much lower cost. DIM, lignan, calcium-D-glucarate, glycine, and taurine are absent, making it less specialized for hormone metabolism.</p>
72 Budget

Liver Detox

Protocol For Life Balance
<p>A lower-cost combination of milk thistle, glutathione, NAC, alpha-lipoic acid, grape polyphenols, and schisandra retains much of the antioxidant support. The formula gives up DIM, lignan, calcium-D-glucarate, and most amino-acid breadth.</p>
84 Value

Glutathione Booster

Carlson
<p>NAC, milk thistle, alpha-lipoic acid, glutamine, glycine, and glutathione cover many of the same antioxidant pathways for less per serving. DIM, calcium-D-glucarate, lignan, and methionine are missing, but cofactor support from selenium and antioxidant vitamins improves practical value.</p>
80 Value

Super Thisilyn

Nature's Way
<p>Silymarin, methionine, NAC, artichoke, dandelion, turmeric, and alpha-lipoic acid create a coherent liver blend at a low serving cost. It does not address DIM or lignan pathways, yet its disclosed core ingredients offer better value for general liver support.</p>
78 Value

Liver Refresh

NOW
<p>Silymarin, glutathione, NAC, alpha-lipoic acid, grape polyphenols, and schisandra supply broad antioxidant support at a lower cost. The absence of DIM, lignan, calcium-D-glucarate, glycine, and taurine limits hormone-specific coverage.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
    Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
    Cohort study42 participantsDetoxification forGlycine
  2. Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
    Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
    Single-arm trial19 participantsDetoxification forGlycine
  3. Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
    Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
    Non-randomized trial21 participantsDetoxification forGlycine
  4. Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
    Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
    Methods validation study74 participantsDetoxification forGlycine
  5. The treatment of isovaleric acidemia with glycine supplement
    M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
    Non-randomized trial2 participantsDetoxification forGlycine
  6. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  7. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  8. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  9. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle
  10. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  11. Dietary amino acid taurine ameliorates liver injury in chronic hepatitis patients.
    Hu YH; Lin CL; Huang YW; Liu PE; Hwang DF · Amino acids · 2008
    Non-randomized trial24 participantsDetoxification forTaurine
  12. Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study.
    Schneider SM; Joly F; Gehrardt MF; Badran AM; Myara A; Thuillier F; Coudray-Lucas C; Cynober L; Trivin F; Messing B · The British journal of nutrition · 2006
    Single-arm trial32 participantsDetoxification forTaurine