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Magnesium Complex

4.6
★ ★ ★ ★ ★
(26672 ratings)
Magnesium 500 mg
Product Image
Score76
A high-dose citrate-and-oxide blend offers inexpensive, focused magnesium support but leaves absorption uncertain. Digestive effects may be more noticeable than systemic benefits.
How scoring works
Capsule
Quantity:60 Capsule(s) • (60 servings)
Goals:
Heart Health
Energy
Bone Health
Digestive Health
General Health
Cardiovascular Support
Stress Relief

Score 76

A high-dose citrate-and-oxide blend offers inexpensive, focused magnesium support but leaves absorption uncertain. Digestive effects may be more noticeable than systemic benefits.
How scoring works
$19.95($0.33 per serving)
iHerb
$ 20.35
Amazon
$ 19.95
Walmart
$ 19.95
Pure Formulas
$ 34.95
Vitacost
$ 21.79
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Analysis

Magnesium citrate provides moderate absorption, while magnesium oxide contributes a less efficiently absorbed source. The label lists a very large amount beside both forms without showing how the total is divided.

The blend may support muscle, nerve, energy, and cardiovascular functions when magnesium intake is low. Its strongest practical effect may be stool softening because both the amount and selected forms can draw water into the bowel.

A single-capsule serving is convenient and the formula stays focused on one mineral. People seeking predictable systemic support may prefer a disclosed glycinate, malate, or citrate formula with a more moderate amount.

Who is it for
  • Adults seeking magnesium-based motility support
  • People with low magnesium intake who tolerate citrate and oxide
Best for
  • Occasional constipation support
  • A simple one-capsule magnesium routine

Pros

  • Includes some moderately absorbed magnesium citrate
  • Substantial labeled magnesium amount
  • Simple single-mineral design

Cons

  • Magnesium oxide weakens absorption quality
  • The amount contributed by each form is not disclosed
  • The very large serving may be more than many users need

Warnings

  • The 500 mg supplemental amount may cause diarrhea, cramping, or urgency, especially when started at the full serving.
  • Magnesium can bind tetracycline or quinolone antibiotics and oral bisphosphonates, so these medicines should be taken several hours apart.
  • Impaired kidney function can reduce magnesium clearance, making a large supplemental amount less appropriate without clinical guidance.

Nutrient quality

73 High impact

Citrate offers moderate absorption, but the oxide component lowers the blend quality. The magnesium amount is substantial, although the split between citrate and oxide is not disclosed.

Ingredient transparency

83 Highest impact

The total elemental magnesium amount is clearly stated. Both magnesium source forms are named, but their individual shares are missing.

Customer satisfaction

72 High impact

The aggregate rating is strong and the available feedback volume gives it useful support. No specific review comments are supplied to assess recurring benefits or complaints.

Value for money

75 High impact

The useful amount and simple design support reasonable value despite mixed absorption quality. No low-value active extras dilute the magnesium formula.

Report analysis

Goals

Heart Health
Impact
High effect
A- Goal FitB Strength of SupportC- CoverageA- Formula Quality
Magnesium · 500 mg

Magnesium directly supports heart rhythm and vascular tone, and the listed total amount is substantial. Citrate offers moderate absorption.

Magnesium oxide lowers the blend quality, and the label does not disclose how the total is divided between forms. The high supplemental amount may cause diarrhea or stomach cramping in sensitive users.

Study evidence
Magnesium Supportive 158 studies
Energy
Impact
High effect
B Goal FitB Strength of SupportC- CoverageA- Formula Quality
Magnesium · 500 mg

The high magnesium amount can support ATP-dependent metabolism when magnesium status is low. Citrate improves the blend, but magnesium oxide lowers systemic absorption quality.

The single-mineral formula does not address alertness, broader mitochondrial cofactors, or stress resilience. The large supplemental amount and oxide component may cause diarrhea or abdominal cramping in sensitive users.

Study evidence
Magnesium Supportive 4 studies
Bone Health
Impact
High effect
B Goal FitC+ Strength of SupportD+ CoverageA Formula Quality
Magnesium · 500 mg

Magnesium contributes to bone mineral structure and supports vitamin D activation. The serving supplies a substantial elemental amount.

Citrate is paired with poorly absorbed oxide, and the high amount may cause diarrhea or stomach cramping. As a magnesium-only product, it does not provide calcium, vitamin D, K2, or collagen.

Study evidence
Magnesium Supportive 48 studies
Digestive Health
Impact
High effect
B Goal FitB Strength of SupportD CoverageB Formula Quality
Magnesium · 500 mg

Magnesium citrate and oxide provide substantial osmotic support for occasional constipation. The formula remains limited to motility and does not support the gut barrier, microbiome, enzymes, or mucosa.

Citrate is well aligned with stool softening, while oxide contributes low absorption and a greater laxative burden. A 500 mg supplemental amount can cause cramping or diarrhea, and impaired kidney function increases the risk of magnesium accumulation.

Study evidence
Magnesium Supportive 50 studies
General Health
Impact
High effect
A Goal FitD+ Strength of SupportD+ CoverageB Formula Quality
Magnesium · 500 mg

Magnesium is well aligned with foundational health, and citrate provides some absorption advantage over oxide. The undisclosed split between the two forms makes the effective quality difficult to judge.

The high elemental amount may cause diarrhea or stomach cramping, especially because citrate and oxide can both have laxative effects. A more moderate serving built around a fully disclosed, better-absorbed magnesium form would be more suitable for routine use.

Study evidence
Magnesium Supportive 114 studies
Cardiovascular Support
Impact
High effect
B- Goal FitB- Strength of SupportD+ CoverageA- Formula Quality
Magnesium · 500 mg

Magnesium supports vascular relaxation and normal cardiac electrical function, giving the product direct cardiovascular relevance. The blend includes citrate but also a large oxide component with weaker absorption.

The total listed amount is substantial, although the elemental contribution from each form is not clearly separated. A high supplemental magnesium amount may cause diarrhea, especially because citrate and oxide can both loosen stools.

Study evidence
Magnesium Supportive 123 studies

Ingredients

IngredientAmount per serving
Magnesium (Magnesium Citrate, Magnesium Oxide)
500 mg
Adults 18–50
Report overview
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyC Value
+2

Magnesium citrate offers moderate absorption, but the added magnesium oxide lowers the blend quality for systemic use. The label presents a high elemental amount in a convenient single capsule, though the split between forms is not disclosed. Magnesium citrate and the large supplemental dose may cause diarrhea or stomach cramping in sensitive users.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  2. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  3. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  4. Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults.
    Joris PJ; Plat J; Bakker SJ; Mensink RP · Scientific reports · 2018
    Randomized trial52 participantsCardiovascular Support forMagnesium
  5. Serum magnesium and outcomes in heart failure with reduced ejection fraction: the GALACTIC-HF trial.
    Chimura M; Docherty KF; Jhund PS; Yang M; Ono R; Henderson AD; Metra M; Liu G; Divanji PH; Heitner SB; Kupfer S; Malik FI; Felker GM; Solomon SD; Teerlink JR; McMurray JJV · European heart journal · 2026
    Randomized trial6,147 participantsCardiovascular Support forMagnesium
  6. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  7. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  8. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  9. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  10. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  11. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  12. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  13. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  14. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  15. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  16. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  17. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  18. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  19. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  20. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  21. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  22. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy Fitness forMagnesium
  23. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  24. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsFitness forMagnesium
  25. Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women.
    Welch AA; Kelaiditi E; Jennings A; Steves CJ; Spector TD; MacGregor A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Cross-sectional study2,570 participantsFitness forMagnesium
  26. Nutritional intake as a determinant of high-speed resistance and multicomponent training efficacy on strength in older women at risk of sarcopenia. A randomized clinical trial.
    Polo-Ferrero L; Recio-Rodriguez JI; González-Manzano S; Martín-Vallejo J; Barbero-Iglesias FJ; Montero-Errasquín B; Cruz-Jentoft AJ; Méndez-Sánchez R · Clinical nutrition (Edinburgh, Scotland) · 2025
    Randomized trial80 participantsFitness forMagnesium
  27. Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
    van Dronkelaar C; Fultinga M; Hummel M; Kruizenga H; Weijs PJM; Tieland M · Journal of the American Medical Directors Association · 2023
    Systematic review45 studies pooledFitness forMagnesium
  28. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  29. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  30. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  31. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  32. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  33. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  34. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  35. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  36. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  37. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  38. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  39. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  40. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  41. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  42. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  43. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  44. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  45. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  46. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  47. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  48. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  49. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  50. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium