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EsophaCool

4.5
★ ★ ★ ★ ★
(237 ratings)
Magnesium 200 mg
Product Image
Score72
A targeted DGL chewable for upper digestive comfort, not a strong general magnesium supplement because the mineral form is undisclosed.
How scoring works
Tablet
Quantity:60 Tablet(s) • (30 servings)
Goals:
Digestive Health

Score 72

A targeted DGL chewable for upper digestive comfort, not a strong general magnesium supplement because the mineral form is undisclosed.
How scoring works
$9.00($0.30 per serving)
Vitacost
$ 9.03
iHerb
$ 9.00
Pure Formulas
$ 9.00
Report prices

Analysis

GutGard deglycyrrhizinated licorice is the most distinctive ingredient and is aimed at soothing upper digestive discomfort. Removing most glycyrrhizin reduces a known licorice concern, while the chewable format supports local contact.

Calcium and magnesium add a buffering mineral component, but the magnesium source is not identified. That missing form information prevents a reliable judgment of absorption, tolerance, and collection quality.

The formula makes more sense for occasional reflux-oriented support than for energy, stress, heart, or testosterone goals. Its narrow role and low cost may appeal to the right user, but persistent symptoms should not be self-managed indefinitely.

Who is it for
  • Adults seeking a chewable for occasional upper digestive discomfort
  • People who want DGL with buffering minerals
Best for
  • Targeted esophageal or upper digestive soothing
  • Short-term chewable use

Pros

  • Uses deglycyrrhizinated licorice
  • Chewable format supports local exposure
  • Includes calcium and magnesium
  • Low serving cost

Cons

  • Magnesium form is not disclosed
  • Limited relevance outside digestive comfort
  • Does not address broader gut health pathways

Warnings

  • Persistent reflux, painful swallowing, bleeding, or unexplained weight loss requires medical assessment rather than continued self-treatment.
  • Calcium and magnesium can reduce absorption of some antibiotics and thyroid medicine, so follow prescribed spacing.
  • People with impaired kidney function may not clear supplemental magnesium safely.

Nutrient quality

73 High impact

The digestive-comfort extract and moderate mineral amounts fit the intended use. Unspecified calcium and magnesium forms prevent a confident quality assessment.

Ingredient transparency

76 High impact

All listed actives have amounts and no hidden blend is shown. Unspecified mineral forms, missing directions, and absent non-active ingredients limit transparency.

Customer satisfaction

64 Moderate impact

The aggregate satisfaction metric is strong and supported by a useful volume of ratings. Specific firsthand feedback is absent, so recurring complaints and purpose fit cannot be assessed.

Value for money

75 High impact

The focused digestive formula provides reasonable serving value. Unspecified mineral forms limit its competitiveness as a magnesium supplement.

Report analysis

Goals

Digestive Health
Digestive Health
Impact
High effect
B Goal FitB- Strength of SupportC CoverageA Formula Quality
Magnesium · 200 mg

Deglycyrrhizinated licorice provides targeted mucosal soothing for upper digestive comfort. Calcium and magnesium add buffering context, though the magnesium form is not disclosed.

The chewable format suits local exposure and the licorice extract identifies flavonoids. The formula avoids glycyrrhizin-related blood-pressure concerns, but persistent reflux or swallowing pain still requires medical assessment.

Study evidence
Magnesium Supportive 50 studies
General Health
Stress Resilience
General Health
Impact
Moderate effect
C- Goal FitC Strength of SupportD+ CoverageB+ Formula Quality
Magnesium · 200 mg

The chewable is mainly a digestive-comfort product rather than a broad daily-health supplement. Magnesium provides some foundational relevance, while deglycyrrhizinated licorice serves a narrower role.

The 200 mg magnesium amount is clearly stated, but its chemical form is missing. That omission prevents confidence about absorption and limits the formula's value for general mineral support.

Study evidence
Magnesium Supportive 114 studies
Heart Health
Healthy Blood Pressure
Heart Health
Impact
Moderate effect
C+ Goal FitC+ Strength of SupportD- CoverageD Formula Quality
Magnesium · 200 mg

Magnesium provides a relevant cardiovascular mechanism through normal rhythm and vascular function. The stated amount is useful, but the undisclosed form limits confidence in absorption.

Calcium and deglycyrrhizinated licorice shift the formula toward digestive support rather than broad heart support. It is a modest magnesium contribution, not a comprehensive cardiovascular formula.

Study evidence
Magnesium Supportive 158 studies
Bone Health
Bone Health
Impact
Moderate effect
C Goal FitD+ Strength of SupportD+ CoverageD+ Formula Quality
Magnesium · 200 mgCalcium · 200 mg

The chewable supplies calcium and magnesium, but it is primarily framed for digestive comfort. Both structural minerals are clearly listed at moderate amounts alongside deglycyrrhizinated licorice.

The chemical forms of calcium and magnesium are not disclosed, and vitamin D and vitamin K are absent. Missing form details and cofactors limit confidence in its use as a dedicated bone product.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Energy
Energy
Impact
Moderate effect
C+ Goal FitC Strength of SupportD- CoverageD Formula Quality
Magnesium · 200 mg

Magnesium reaches the stated threshold for energy-related enzyme support, but the formula is designed for digestive comfort. The elemental amount is clear and could contribute when magnesium intake is low.

No chemical magnesium form is disclosed, preventing an absorption assessment. Calcium and deglycyrrhizinated licorice do not add a meaningful second energy pathway.

Study evidence
Magnesium Supportive 4 studies
Stress Relief
Stress Relief
Impact
Moderate effect
C Goal FitD+ Strength of SupportD CoverageC- Formula Quality
Magnesium · 200 mg

Magnesium supports nervous-system regulation and muscle relaxation, with the clearest benefit when intake is inadequate. Its physiological role is established, while human evidence for reducing perceived stress in otherwise replete users is less robust than for targeted adaptogens or theanine.

The 200 mg magnesium amount reaches the lower edge of a meaningful supplemental range. The chemical form is not disclosed, preventing an absorption-quality judgment.

Study evidence
Magnesium Supportive 13 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
C- Goal FitD+ Strength of SupportF CoverageC- Formula Quality
Magnesium · 200 mg

Magnesium provides direct support for vascular tone and normal cardiac electrical activity. Human evidence is relevant, but the product does not address lipid management, nitric oxide production, or cardiac energy.

The magnesium amount is practical, but its chemical form is not disclosed and the chewable formula is designed for digestive comfort. Calcium and deglycyrrhizinated licorice do not broaden cardiovascular support in a meaningful way.

Study evidence
Magnesium Supportive 123 studies

Ingredients

IngredientAmount per serving
Calcium
200 mg
Magnesium
200 mg
GutGard Deglycyrrhizinated Licorice (DGL) extract (Total Flavonoids)
 75 mg
Adults 18–50
Report overview
Magnesium · 200 mg OverallScore42
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD+ Value

The elemental magnesium amount is clear, but its chemical form is not disclosed. Calcium and deglycyrrhizinated licorice make the formula more relevant to digestive comfort than dedicated magnesium support. The low serving cost is appealing, though missing source details prevent a confident quality assessment.

View ingredientView products
Loading alternative details
81 Performance

Ultra-Mag

Source Naturals
<p>A broad organic magnesium blend supplies strong form diversity and a substantial amount at an economical cost. Compared with EsophaCool, its magnesium form and supporting ingredients may be a better fit where the magnesium form is not disclosed, so absorption cannot be judged and the product is a weak choice for targeted magnesium repletion, while the label does not clarify each form share, while high supplemental magnesium and prolonged B6 use may affect tolerability.</p>
85 Performance

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate provides premium absorption quality, a useful elemental amount, and exceptional serving value in a clean powder. Compared with EsophaCool, its magnesium form and supporting ingredients may be a better fit where the magnesium form is not disclosed, so absorption cannot be judged and the product is a weak choice for targeted magnesium repletion, while the product is narrow rather than comprehensive, and its relatively weak satisfaction metric deserves consideration despite the strong formula.</p>
75 Performance

NeuroMag

Designs for Health
<p>Branded magnesium L-threonate provides a well-characterized specialty form at its typical elemental amount. Compared with EsophaCool, its magnesium form and supporting ingredients may be a better fit where the magnesium form is not disclosed, so absorption cannot be judged and the product is a weak choice for targeted magnesium repletion, while strong customer sentiment cannot fully offset a very high serving cost.</p>
80 Budget

Magnesium Caps 500 mg

Life Extension
<p>Citrate, succinate, and a named glycinate chelate strengthen a multi-form magnesium blend, while oxide lowers average absorption. Its lower recurring cost than EsophaCool makes it a more economical magnesium option, while the large supplemental amount may cause diarrhea or cramping, although the very low serving cost provides strong value for users who tolerate it.</p>
79 Budget

Target-Mins Magnesium Caps With Silica 300 mg

Country Life
<p>The mineral blend combines useful magnesium forms with oxide and a substantial horsetail-derived silica amount. Its lower recurring cost than EsophaCool makes it a more economical magnesium option, while strong customer sentiment and highly economical servings make the larger supply attractive.</p>
74 Budget

Magnesium 500 mg

Nature's Life
<p>Absorbable forms improve the blend, but magnesium oxide lowers its overall absorption quality. Its lower recurring cost than EsophaCool makes it a more economical magnesium option, while active doses are stated, while missing excipient and full use details limit transparency.</p>
84 Value

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate provides premium absorption quality and a useful elemental amount in a clean tablet. Compared with EsophaCool, its magnesium profile offers a practical quality-to-cost trade-off despite no confirmed cost advantage, while the focused formula offers strong value but remains limited to one foundational mineral pathway.</p>
91 Value

Krebs Magnesium Potassium Complex

Nature's Way
<p>Magnesium lysinate and malate provide favorable forms at a useful amount, with a modest potassium contribution. Compared with EsophaCool, its magnesium profile and lower recurring cost create a more favorable quality-to-cost balance, while the focused formula offers excellent serving value.</p>
88 Value

Magnesium Bisglycinate Powder

NOW
<p>Magnesium bisglycinate supplies a well-absorbed form at a practical, moderate amount. Compared with EsophaCool, its magnesium profile and lower recurring cost create a more favorable quality-to-cost balance, while no meaningful dose or formulation concern is evident from the supplied facts.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  2. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  3. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  4. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  5. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  6. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  7. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  8. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  9. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  10. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  11. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  12. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  13. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  14. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  15. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  16. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  17. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  18. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  19. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  20. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  21. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  22. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  23. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  24. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  25. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  26. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  27. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  28. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  29. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  30. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  31. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  32. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  33. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  34. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  35. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  36. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  37. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium