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Mega EPA/DHA

Life Extension
4.9
★ ★ ★ ★ ★
(10930 ratings)
EPA (Eicosapentaenoic Acid) 720 mg
Fish Oil 2000 mg
DHA 480 mg
Product Image
Score84
A concentrated EPA-and-DHA serving is clearly disclosed, but missing form and testing details limit confidence in oil quality.
How scoring works
Quantity:120 Softgel(s) • (60 servings)
Goals:
Heart Health
Anti-Inflammatory Support
Cardiovascular Support
Mental Focus

Score 84

A concentrated EPA-and-DHA serving is clearly disclosed, but missing form and testing details limit confidence in oil quality.
How scoring works
$22.50($0.37 per serving)
Pure Formulas
$ 22.50
iHerb
$ 22.50
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Analysis

The formula supplies 720 mg EPA and 480 mg DHA per serving, giving a high omega-3 dose. Both key omega-3s are quantified, so the active amount is easy to assess.

The concentrated serving fits adults seeking meaningful omega-3 intake for heart health and cardiovascular support. Added vitamin E provides antioxidant support for the oil. The amount of active omega-3 provided per serving also compares favorably with the product cost.

The label does not identify the omega-3 molecular form or provide independent purity and oxidation test results, so important quality details remain uncertain. The softgel(s) format may be convenient for routine use, but the disclosed facts do not establish freshness or contaminant control.

Who is it for
  • Adults seeking a concentrated daily fish-oil serving
  • People focused on cardiovascular or inflammatory support
Best for
  • Heart Health
  • Cardiovascular Support
  • Anti-Inflammatory Support

Pros

  • EPA and DHA are listed separately at 720 mg and 480 mg per serving
  • Concentrated active omega-3 amount per serving
  • Includes antioxidant vitamin E

Cons

  • Omega-3 molecular form is not identified
  • Independent purity and oxidation testing is not provided
  • Fish source or processing details are limited

Warnings

  • Avoid if you have a fish allergy because the active oil is fish-derived.
  • The 1200 mg combined EPA, DHA serving may add to bleeding risk with anticoagulant or antiplatelet medicines; discuss this dose with the prescribing clinician.
  • Fish oil can cause burping or stomach upset; taking it with a meal may improve tolerance.

Nutrient quality

86 Highest impact

A substantial EPA-forward dose and natural vitamin E create strong formula depth. Unknown oil form, source, purification, and testing reduce quality assurance.

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Ingredient transparency

82 Highest impact

Active amounts are individually disclosed, and no proprietary blend hides the supplied doses. Complete use directions, excipients, and some source or quality details remain unavailable.

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Customer satisfaction

74 High impact

Supplied aggregate data indicate very strong satisfaction with a very large response base. Specific comments are absent, so recurring complaints and purpose-specific experiences cannot be verified.

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Value for money

94 Highest impact

High active yield and a focused design provide excellent value. Sparse sourcing and testing detail are the main limitation.

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Report analysis

Goals

Heart Health
Heart Health
Impact
Highest effect
A+ Goal FitA+ Strength of SupportC+ CoverageA+ Formula Quality
EPA (Eicosapentaenoic Acid) · 720 mg

The concentrated omega-3 dose directly supports triglyceride management and cardiovascular health. It provides 720 mg of EPA and 480 mg of DHA from 2 g of fish oil for the stated purpose.

The formula is intentionally focused and does not add mineral or cardiac-energy pathways. Fish oil may increase bruising or bleeding tendency when combined with anticoagulant or antiplatelet medicines.

Study evidence
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Highest effect
A+ Goal FitA Strength of SupportB+ CoverageA+ Formula Quality
Fish Oil · 2000 mgVitamin E · 2.7 mcg

EPA and DHA directly influence inflammatory signaling and support production of inflammation-resolving mediators. The combined 1,200 mg amount is substantial and backed by strong human evidence.

The focused fish-oil formula clearly discloses both key fatty acids and includes vitamin E for oxidation protection. It provides deep omega-3 support without padding, though it does not add a separate botanical or mineral pathway.

Study evidence
Fish Oil Supportive 68 studies
Vitamin E Supportive 20 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A+ Goal FitB Strength of SupportB CoverageA+ Formula Quality
Fish Oil · 2000 mgVitamin E · 2.7 mcg

EPA and DHA directly support triglyceride management, inflammatory balance, and endothelial function. The combined amount is clearly listed and provides a useful everyday cardiovascular dose.

The label does not identify the oil’s molecular form, fish species, purification process, or independent testing. Added natural vitamin E helps protect the oil, but quality assurance remains less transparent than the active dose.

Study evidence
Fish Oil Supportive 185 studies
Vitamin E Mixed 79 studies
Mental Focus
Mental Focus
Impact
High effect
D+ Goal FitA- Strength of SupportC CoverageB+ Formula Quality

EPA and DHA are supplied at substantial, clearly disclosed amounts that may support the brain environment over time. Their role in acute attention is indirect, working mainly through membrane and inflammatory pathways rather than immediate alertness.

The softgel formula offers useful omega-3 depth but does not include stimulants, neurotransmitter precursors, or adaptogens. It fits long-term cognitive maintenance better than a product intended for a noticeable same-day focus effect.

Study evidence

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Fat
2 Gram(s)
Vitamin E
2.7 mcg
Fish Oil Concentrate
2000 mg
Eicosapentaenoic Acid
720 mg
Docosahexaenoic Acid
480 mg
Adults 18–50
Report overview
EPA (Eicosapentaenoic Acid) · 720 mg OverallScore68
D+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyA+ Value

The molecular form is unspecified; ePA density is modest, and only one protective antioxidant is evident. The serving provides a strong EPA amount with a clearly EPA-centric ratio. No purification or third-party verification is shown, while normalized cost is excellent.

View ingredientView products
Fish Oil · 2000 mg OverallScore58
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value

Molecular form, purification, and fish source are not disclosed. EPA and DHA are clearly listed at an effective dose and high concentration. D-alpha tocopherol protects the oil and active-dose value is excellent.

View ingredientView products
DHA · 480 mg OverallScore55
C- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyB+ Value

Vitamin E helps protect the oil from oxidation, but the DHA chemical form is not disclosed. The 480 mg DHA amount is substantial and the combined EPA and DHA concentration is moderate. Generic fish sourcing and absent purity certification limit transparency, while normalized DHA cost remains favorable.

View ingredientView products
Loading alternative details
86 Performance

Omega-3 Triglyceride Fish Oil 1100 mg

NATURELO Premium Supplements
<p>A molecularly distilled triglyceride fish oil with 729 mg EPA and 275 mg DHA provides more specific form and processing detail than the original. Molecular distillation adds some purity assurance, while missing independent testing, fish species, and antioxidant protection leave smaller quality gaps.</p>
87 Performance

Omega-3

Solgar
<p>A more concentrated serving provides 1,008 mg EPA and 756 mg DHA, giving greater omega-3 depth than the original's 720 mg EPA and 480 mg DHA. Mixed tocopherols aid oxidation control, but molecular form, fish source, purification method, and independent testing remain unclear.</p>
86 Performance

Purified & Clear Omega 3 Fish Oil 1000 mg

Doctor's Best
<p>A clearly quantified serving of 800 mg EPA and 400 mg DHA offers a more focused EPA-and-DHA profile than the original. The ethyl-ester form is less readily absorbed than triglyceride oil, and oxidation protection plus independent purity testing are not supplied.</p>
84 Budget

Fish Oil 1400 mg

Nature's Bounty
<p>A lower recurring cost provides 647 mg EPA and 253 mg DHA, compared with the original's 720 mg EPA and 480 mg DHA. The ethyl-ester form is less readily absorbed, while fish source, antioxidant protection, and independent purity testing are not stated.</p>
80 Budget

Super Omega-3

Country Life
<p>A lower recurring cost provides 400 mg EPA and 200 mg DHA, compared with the original's 720 mg EPA and 480 mg DHA. Molecular form, purification, oxidation protection, and independent testing are not disclosed.</p>
79 Budget

Omega-3 Fish Oil with Vitamin D 1000 mg Lemon Flavored

Swanson
<p>A lower recurring cost provides 180 mg EPA and 120 mg DHA, compared with the original's 720 mg EPA and 480 mg DHA. Very good serving-level affordability helps, while molecular form, oxidation protection, purification, and independent testing remain unknown.</p>
85 Value

Omega-3 Triglyceride Fish Oil 1100 mg

NATURELO Premium Supplements
<p>A favorable balance of active dose and recurring cost provides 729 mg EPA and 275 mg DHA with better practical value than the original. Molecular distillation adds some purity assurance, while missing independent testing, fish species, and antioxidant protection leave smaller quality gaps.</p>
84 Value

Alaska Wild Fish Oil Mega Omega-3

21st Century
<p>A favorable balance of active dose and recurring cost provides 965 mg EPA and 385 mg DHA with better practical value than the original. Molecular form, antioxidant protection, fish species, and independent purity testing are not disclosed.</p>
83 Value

Super Omega-3

Life Extension
<p>A favorable balance of active dose and recurring cost provides 700 mg EPA and 500 mg DHA with better practical value than the original. The large package provides strong active value, though the four-softgel serving is less convenient and oil-quality documentation remains incomplete.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  2. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  3. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  4. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  5. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  6. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  7. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  8. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  9. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  10. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  11. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  12. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  13. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  14. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  15. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  16. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  17. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  18. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  19. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  20. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  21. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.
    Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Saito Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Japan EPA lipid intervention study (JELIS) Investigators · Lancet (London, England) · 2007
    Randomized trial18,645 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  22. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS).
    Saito Y; Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; JELIS Investigators, Japan · Atherosclerosis · 2008
    Randomized trial14,981 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  23. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis.
    Dinu M; Sofi F; Lotti S; Colombini B; Mattioli AV; Catapano AL; Casula M; Baragetti A; Wong ND; Steg PG; Ambrosio G · European journal of preventive cardiology · 2024
    Meta-analysis134,144 participants18 studies pooledHeart Health forEPA (Eicosapentaenoic Acid)
  24. Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease.
    Matsuzaki M; Yokoyama M; Saito Y; Origasa H; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Matsuzawa Y; JELIS Investigators · Circulation journal : official journal of the Japanese Circulation Society · 2009
    Randomized trialHeart Health forEPA (Eicosapentaenoic Acid)
  25. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
    Skulas-Ray AC; Wilson PWF; Harris WS; Brinton EA; Kris-Etherton PM; Richter CK; Jacobson TA; Engler MB; Miller M; Robinson JG; Blum CB; Rodriguez-Leyva D; de Ferranti SD; Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology · Circulation · 2020
    OtherHeart Health forEPA (Eicosapentaenoic Acid)
  26. The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose-response meta-analysis.
    Suh SW; Lim E; Burm SY; Lee H; Bae JB; Han JW; Kim KW · BMC medicine · 2024
    Meta-analysis9,660 participants24 studies pooledMental Focus forEPA (Eicosapentaenoic Acid)
  27. EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD.
    Gustafsson PA; Birberg-Thornberg U; Duchén K; Landgren M; Malmberg K; Pelling H; Strandvik B; Karlsson T · Acta paediatrica (Oslo, Norway : 1992) · 2011
    Randomized trial92 participantsMental Focus forEPA (Eicosapentaenoic Acid)
  28. Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)-Should They Be Mandatory Supplements in Pregnancy?
    Amza M; Haj Hamoud B; Sima RM; Dinu MD; Gorecki GP; Popescu M; Gică N; Poenaru MO; Pleș L · Biomedicines · 2024
    Narrative reviewMental Focus forEPA (Eicosapentaenoic Acid)
  29. Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials.
    Patan MJ; Kennedy DO; Husberg C; Hustvedt SO; Calder PC; Khan J; Forster J; Jackson PA · The American journal of clinical nutrition · 2021
    Randomized trial310 participantsMental Focus forEPA (Eicosapentaenoic Acid)