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Marine Based Magnesium 500 mg Vanilla Cream Flavored

4.7
★ ★ ★ ★ ★
(98 ratings)
Magnesium 500 mg
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Score62
Magnesium hydroxide is not a strong choice for systemic absorption and is more likely to act in the digestive tract. Vanilla flavoring and the high hydroxide amount may not suit people who want a plain, gentle magnesium supplement.
How scoring works
Liquid
Quantity:16 Fluid Ounce(s) • (95 servings)
Goals:
Digestive Health
Energy
General Health

Score 62

Magnesium hydroxide is not a strong choice for systemic absorption and is more likely to act in the digestive tract. Vanilla flavoring and the high hydroxide amount may not suit people who want a plain, gentle magnesium supplement.
How scoring works
$22.49($0.23 per serving)
Vitacost
$ 22.49
iHerb
$ 22.49
iHerb
$ 22.49
Pure Formulas
$ 22.49
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Analysis

The liquid supplies 500 mg of magnesium from seawater-derived material and magnesium hydroxide, plus a small amount of calcium. Magnesium hydroxide is not a strong choice for systemic absorption and is more likely to act in the digestive tract.

The substantial amount may contribute to magnesium intake, but the form makes it a better fit for users who value a liquid format over efficient replenishment. A long bottle yield and low serving cost improve convenience for routine use.

Vanilla flavoring and the high hydroxide amount may not suit people who want a plain, gentle magnesium supplement. Choosing a dose that matches personal intake and tolerance is more useful than relying on the headline amount alone.

Who is it for
  • Adults who prefer liquid supplements
  • People seeking a large stated magnesium serving
  • Users comfortable with the digestive effects of magnesium hydroxide
Best for
  • Liquid magnesium supplementation
  • People who cannot swallow tablets or capsules
  • Low-cost magnesium intake

Pros

  • Clearly states 500 mg of magnesium per serving
  • Liquid format allows easier use for people who dislike pills
  • Includes small amounts of calcium from marine sources
  • Low serving cost for a high stated amount

Cons

  • Magnesium hydroxide has limited systemic absorption
  • The large amount may mainly produce digestive effects
  • The flavored liquid is less flexible than an unflavored option

Warnings

  • The large supplemental magnesium amount may cause loose stools, nausea, or abdominal cramping, especially when taken all at once.
  • Supplemental magnesium can accumulate with significant kidney impairment; use only with medical guidance in that situation.
  • Magnesium can reduce absorption of levothyroxine and tetracycline or quinolone antibiotics, so separate the doses as directed by a pharmacist.

Nutrient quality

60 Moderate impact

Magnesium hydroxide has low systemic absorption and commonly has a laxative effect. The 500 mg amount may cause diarrhea or cramping, especially in poorly absorbed forms.

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Ingredient transparency

71 High impact

The label leaves the elemental yield or the share from each form unclear. Missing other ingredients and complete intake directions leave important label details unresolved.

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Customer satisfaction

55 Moderate impact

The supplied average rating is strong and the rating volume provides an aggregate signal. No comment-level evidence is provided to assess recurring complaints or confirm how experience matches the intended purpose.

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Value for money

56 Moderate impact

Weak absorption or uncertain elemental yield limits effective value. Added actives have a practical role, though they reduce magnesium focus.

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Report analysis

Goals

Digestive Health
Impact
Highest effect
A- Goal FitA- Strength of SupportC- CoverageA Formula Quality
Magnesium · 500 mg

Magnesium hydroxide provides a strong osmotic laxative mechanism and can support short-term constipation relief. The product remains a single-pathway motility aid rather than comprehensive gut support.

The 500 mg elemental amount is high and the hydroxide form is clearly disclosed. Diarrhea, cramping, and electrolyte disturbance are practical risks, especially with kidney impairment or other magnesium products.

Study evidence
Magnesium Supportive 50 studies
Energy
Impact
High effect
A- Goal FitC Strength of SupportD CoverageA- Formula Quality
Magnesium · 500 mg

A large magnesium amount directly supports ATP-related enzyme activity and muscle function. The elemental amount is clearly disclosed in a flexible liquid serving.

Magnesium hydroxide has limited systemic absorption and the full amount may loosen stools in sensitive users. The narrow formula remains coherent but does not address mental alertness or stress resilience.

Study evidence
Magnesium Supportive 4 studies
General Health
Impact
High effect
A- Goal FitD+ Strength of SupportD CoverageB- Formula Quality
Magnesium · 500 mg

Magnesium is highly relevant to everyday metabolic, nerve, and muscle function. The large serving may help fill a gap, but its form limits confidence in systemic benefit.

Magnesium hydroxide has relatively low absorption and is more likely to loosen stools at the listed amount. Clear mineral quantities and a simple liquid format are useful, although calcium adds only modest breadth.

Study evidence
Magnesium Supportive 114 studies
Bone Health
Impact
Moderate effect
B Goal FitD+ Strength of SupportD CoverageB- Formula Quality
Magnesium · 500 mgCalcium · 50 mg

The liquid supplies magnesium and a small amount of calcium, but it is not a balanced bone formula. The elemental magnesium amount is large and clearly disclosed.

Magnesium hydroxide has limited absorption and the serving may exceed what sensitive users tolerate comfortably. The high magnesium amount can cause loose stools, while missing vitamin D and vitamin K limit skeletal synergy.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Heart Health
Impact
Moderate effect
C+ Goal FitC- Strength of SupportD- CoverageB- Formula Quality
Magnesium · 500 mg

A large magnesium serving is relevant to normal rhythm and vascular function. Magnesium hydroxide has limited systemic absorption and may loosen stools at the listed amount.

The formula stays focused on one established mineral pathway. It lacks complementary heart-focused actives and does not provide broad cardiovascular coverage.

Study evidence
Magnesium Supportive 158 studies
Cardiovascular Support
Impact
Moderate effect
C+ Goal FitD+ Strength of SupportD- CoverageB+ Formula Quality
Magnesium · 500 mg

Magnesium provides direct support for vascular tone and normal cardiac electrical activity. Human evidence is relevant, but the product does not address lipid management, nitric oxide production, or cardiac energy.

The 500 mg amount is high, while magnesium hydroxide has limited systemic absorption and is more likely to loosen stools. The liquid format does not overcome the weak chemical form.

Study evidence
Magnesium Supportive 123 studies

Ingredients

IngredientAmount per serving
Calories
10 Calorie(s)
Total Carbohydrates
2 Gram(s)
Calcium (Aquamin Red Algae, Seawater)
50 mg
Magnesium (Aquamin Seawater, Magnesium Hydroxide)
500 mg
Sodium
15 mg
Gluten Free Adults 18–50 Vegan Vegetarian
Report overview
F Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyD+ Value

The liquid provides a large elemental amount, but magnesium hydroxide has low systemic absorption potential. A full serving sits above the preferred range and may be more likely to loosen stools in sensitive users. Low serving cost helps, though the source quality keeps the value moderate rather than strong.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  2. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  3. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial.
    Kubota M; Ito K; Tomimoto K; Kanazaki M; Tsukiyama K; Kubota A; Kuroki H; Fujita M; Vandenplas Y · Nutrients · 2020
    Randomized trial60 participantsDigestive Health forMagnesium
  4. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  5. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  6. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  7. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  8. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  9. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  10. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  11. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  12. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  13. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  14. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  15. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  16. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  17. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  18. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  19. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  20. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  21. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  22. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  23. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  24. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  25. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  26. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  27. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  28. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  29. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  30. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  31. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  32. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  33. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  34. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  35. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  36. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  37. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  38. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  39. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  40. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  41. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  42. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  43. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  44. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  45. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium