Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity.
Oda K; Danko J; Villasante E; Bergmann-Leitner E; Lee R; Wijayalath W · Frontiers in immunology · 2025
Randomized trialflagImmunity forscienceMelatonin
- Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality.
Tan DX; Reiter RJ · Life sciences · 2022
Narrative review19 participantsflagImmunity forscienceMelatonin
- Influenza vaccine response is predicted by chronotype and differentially associated with pre- and post-vaccination sleep.
Harrison EM; Lee RU; Porter CK; Isidean SD; Easterling AP; White L; Boulifard DA; DeTizio K; Liang Z; Sedegah M; Danko J; Glickman GL · Brain, behavior, & immunity - health · 2026
Randomized trialflagImmunity forscienceMelatonin
- A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study (MAVRICS).
Lee RU; Watson NL; Glickman GL; White L; Isidean SD; Porter CK; Hollis-Perry M; Walther SR; Maiolatesi S; Sedegah M; Ganeshan H; Huang J; Boulifard DA; Ewing D; Sundaram AK; Harrison EM; DeTizio K; Belmonte M; Belmonte A; Inoue S; Easterling A; Cooper ES; Danko J · Human vaccines & immunotherapeutics · 2024
Randomized trial108 participantsflagImmunity forscienceMelatonin
- THE EFFECT OF MELATONIN ON THE SERUM LEVEL OF INTERLEUKIN 31 IN HERPESVIRUS SKIN DISEASES ON THE BACKGROUND OF HIV.
Dorosh D; Liadova T; Popov M; Volobuieva O; Pavlikova K; Tsivenko O; Chernuskiy V; Hrek I; Kushnir V; Volobuiev D · Georgian medical news · 2024
Non-randomized trial40 participantsflagImmunity forscienceMelatonin
- Sleep, Dietary Melatonin Supplementation, and COVID-19.
Gasmi A; Semenova Y; Noor S; Benahmed AG; Bjørklund G · Current medicinal chemistry · 2024
Narrative reviewflagImmunity forscienceMelatonin
- Meta-analysis: melatonin for the treatment of primary sleep disorders.
Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
Meta-analysis1,683 participants19 studies pooledflagSleep Support forscienceMelatonin
- The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
Meta-analysis409 participants8 studies pooledflagSleep Support forscienceMelatonin
- Melatonin treatment for age-related insomnia.
Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
Randomized trial30 participantsflagSleep Support forscienceMelatonin
- Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
Salanitro M; Wrigley T; Ghabra H; de Haan E; Hill CM; Solmi M; Cortese S · Neuroscience and biobehavioral reviews · 2022
Meta-analysis1,998 participants34 studies pooledflagSleep Support forscienceMelatonin
- Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
Meta-analysis516 participants8 studies pooledflagSleep Support forscienceMelatonin
- Unintended consequences: college students' melatonin usage, sleep disturbance, and depressive symptoms.
Peltz JS; Rogge R · Sleep and biological rhythms · 2025
Cohort study331 participantsflagSleep Support forscienceMelatonin
- Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
Meta-analysis516 participants10 studies pooledflagBrain Health forscienceMelatonin
- Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
Meta-analysis788 participants9 studies pooledflagBrain Health forscienceMelatonin
- Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
Randomized trial80 participantsflagBrain Health forscienceMelatonin
- Melatonin supplementation reduces delirium incidence in critically ill patients: a systematic review and meta-analysis.
Wu X; Hu P; Wu H; Zhang K; Ying J · Frontiers in pharmacology · 2026
Meta-analysis3,706 participants22 studies pooledflagBrain Health forscienceMelatonin
- Melatonin for women in pregnancy for neuroprotection of the fetus.
Wilkinson D; Shepherd E; Wallace EM · The Cochrane database of systematic reviews · 2016
Systematic reviewflagBrain Health forscienceMelatonin
- Association between circadian rhythm disturbances and cognitive decline in the elderly: a systematic review.
Lopes LG; Oliveira AS; Fingergut CC; Brito GNE; Gonzalez JVP; Donato KO; Cruz MME; Salles C · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
Systematic review5,731 participants10 studies pooledflagBrain Health forscienceMelatonin
- Melatonin for preventing and treating jet lag.
Herxheimer A; Petrie KJ · The Cochrane database of systematic reviews · 2001
Systematic review10 studies pooledflagGeneral Health forscienceMelatonin
- Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life.
Schroder CM; Malow BA; Maras A; Melmed RD; Findling RL; Breddy J; Nir T; Shahmoon S; Zisapel N; Gringras P · Journal of autism and developmental disorders · 2019
Randomized trial125 participantsflagGeneral Health forscienceMelatonin
- Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
Fatemeh G; Sajjad M; Niloufar R; Neda S; Leila S; Khadijeh M · Journal of neurology · 2022
Meta-analysis23 studies pooledflagGeneral Health forscienceMelatonin
- Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses.
Choi K; Lee YJ; Park S; Je NK; Suh HS · Sleep medicine reviews · 2022
Meta-analysis24 studies pooledflagGeneral Health forscienceMelatonin
- Effectiveness of melatonin for the treatment of nocturia: a randomized controlled trial.
Leerasiri P; Pariyaeksut P; Hengrasmee P; Asumpinwong C · International urogynecology journal · 2023
Randomized trial60 participantsflagGeneral Health forscienceMelatonin
- Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis.
Chojnacki C; Wisniewska-Jarosinska M; Walecka-Kapica E; Klupinska G; Jaworek J; Chojnacki J · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2012
Randomized trial60 participantsflagImmunity forscienceMelatonin
- Pineal-opioid system interactions in the control of immunoinflammatory responses.
Lissoni P; Barni S; Tancini G; Fossati V; Frigerio F · Annals of the New York Academy of Sciences · 1995
Clinical trial130 participantsflagImmunity forscienceMelatonin
- Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
Randomized trial791 participantsflagSleep Support forscienceMelatonin
- Effects of exogenous melatonin on sleep: a meta-analysis.
Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
Meta-analysis284 participants8 studies pooledflagSleep Support forscienceMelatonin