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Deanol

notesDescription

Deanol, chemically known as 2-(dimethylamino)ethanol or DMAE, is an organic compound that is naturally produced in small amounts within the human brain. It is structurally similar to choline and is considered a precursor to acetylcholine, a vital neurotransmitter involved in memory, learning, attention, and muscle contraction. Its primary mechanism of action is believed to involve increasing acetylcholine levels, thereby supporting various cognitive functions. Beyond its role in neurochemistry, Deanol has also gained popularity in topical applications. It is frequently incorporated into skincare products due to its purported ability to reduce the appearance of wrinkles, firm the skin, and improve overall skin tone. This effect is often attributed to its potential to stabilize cell membranes and protect against free radical damage. While Deanol is not classified as an essential nutrient, it is included in various dietary supplements, particularly those marketed for brain health, focus, and memory enhancement. It is also found in some sports nutrition products, with proponents suggesting it may help improve athletic performance and mood.

ecoSources
SalmonSardinesAnchovies
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check_circleOptimal Dosage
Minimum100 mg
Maximum400 mg
report_problemSafety & Toxicity
Toxicity Threshold800 mg
Toxicity EffectHeadache, irritability
track_changesGoals
Cognitive Support
psychology_altCognitive Support
Impact
Limited evidence
Typical dose:100–500 mg
The theory that Deanol (DMAE) significantly increases brain acetylcholine levels is not well-supported by robust clinical data. Human studies have yielded mixed to negative results regarding its efficacy for improving memory or focus, and its mechanism of action remains unclear. The 'BEST_EFFECTIVE' rating is not justified by the current scientific consensus.
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sync_altInteractions

add_circle_outlinePositive Interactions

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Choline
Deanol is a choline derivative, and both can act as precursors to acetylcholine. Combining them may provide a more robust supply for acetylcholine synthesis, potentially enhancing cognitive benefits.
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Alpha-GPC
Alpha-GPC is a highly bioavailable form of choline and a direct precursor to acetylcholine. Its co-administration with Deanol could amplify the support for cholinergic system function, leading to synergistic cognitive enhancement.
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Huperzine
Huperzine A inhibits acetylcholinesterase, the enzyme that breaks down acetylcholine. By slowing the breakdown of acetylcholine, Huperzine A can sustain the effects of increased acetylcholine production promoted by Deanol, potentially leading to enhanced and prolonged cognitive benefits.

remove_circle_outlineNegative Interactions

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Caffeine
Both Deanol and Caffeine can have stimulating effects on the central nervous system. Combining them may increase the risk of side effects such as anxiety, restlessness, insomnia, headaches, or increased heart rate.
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Theobromine
Theobromine, a mild stimulant, may have additive effects when combined with Deanol, potentially increasing the likelihood of overstimulation, jitteriness, or sleep disturbances.
analyticsProduct stats
sellPrice per product
Average$27.29
Median$25.24
restaurantPrice per serving
Average$0.74
Median$0.66
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bar_chartPaired ingredients

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