Proline
Description
Proline is a unique, cyclic non-essential amino acid, meaning the body can synthesize it, though dietary intake also contributes. Its distinctive structure plays a critical role in forming the triple helix of collagen, the most abundant protein in the human body. This makes Proline indispensable for maintaining the structural integrity of various tissues. The primary function of Proline is its involvement in collagen synthesis, which is vital for the strength and elasticity of skin, tendons, ligaments, cartilage, and bones. It contributes significantly to tissue repair and regeneration, making it important for wound healing and recovery from injuries. Beyond structural support, Proline is also involved in various metabolic processes, including protein synthesis and cellular energy production. It is often sought for its benefits in promoting healthy skin, supporting joint mobility, and aiding in the body's natural healing processes.
Sources
Meat (beef, chicken, pork)FishDairy products (milk, cheese, yogurt)EggsBone brothLegumesAsparagusMushrooms
Cheapest Proline supplements
Best Proline supplements
Value Proline amino acid supplements
Optimal Dosage
Minimum500 mg
Maximum1000 mg
Safety & Toxicity
Goals
Bone Health
Impact
High effect
Typical dose:500–2000 mg
Proline is a critical building block for the collagen that forms about 30% of bone mass. Supplementing with proline supports the synthesis of this flexible framework. Its priority should be high, logically placed just below supplementing with whole collagen peptides.
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Skin Health
Impact
High effect
Typical dose:500–2000 mg
Proline is one of the primary amino acids that make up the structure of collagen. Supplementing with proline can provide the necessary raw materials to support the body's production of collagen, which is essential for skin firmness and elasticity. Its effect is most pronounced when paired with other cofactors like Vitamin C.
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Interactions
Positive Interactions
Vitamin C
Vitamin C is an essential cofactor for the enzymes involved in collagen synthesis, working synergistically with Proline to form stable collagen fibers.
Collagen
Proline is a major constituent of collagen; supplementing with both can enhance the body's collagen stores and synthesis.
Glycine
Glycine is another primary amino acid in collagen, working alongside Proline to build and maintain connective tissues.
Lysine
Lysine is important for collagen cross-linking, which enhances collagen's strength and stability, complementing Proline's role in collagen formation.
Lysine
Lysine is important for collagen cross-linking, which enhances collagen's strength and stability, complementing Proline's role in collagen formation.
Copper
Copper is required for lysyl oxidase, an enzyme that helps cross-link collagen and elastin, thus supporting the structural integrity built by Proline.
Zinc
Zinc plays a role in protein synthesis and wound healing, both of which are processes where Proline's role in collagen formation is crucial.
Hyaluronic Acid
Both Proline (via collagen) and Hyaluronic Acid contribute to skin hydration, elasticity, and joint lubrication, offering synergistic benefits for connective tissue health.
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Product stats
Price per product
Average$25.86
Median$22.99
Price per serving
Average$0.83
Median$0.53
Price per 100 mg
Average$0.70
Median$0.53
Price distribution
Price per serving distribution
Price per 100 mg
Reference amount: 100 mg
Paired ingredients