Product Image

Calcium Magnesium 2:1 Ratio

Solaray
4.7
★ ★ ★ ★ ★
(4073 ratings)
Glutamic Acid 100 mg
Calcium 1000 mg
Magnesium 500 mg
Product Image
Score76
A practical high-dose two-to-one mineral formula, with basic forms and digestive tolerance as the main compromises.
How scoring works
Quantity:180 VegCap(s) • (45 servings)
Goals:
Bone Health
General Health
Heart Health
Testosterone Support
Energy

Score 76

A practical high-dose two-to-one mineral formula, with basic forms and digestive tolerance as the main compromises.
How scoring works
$17.29($0.38 per serving)
Vitacost
$ 17.29
Amazon
$ 17.29
iHerb
$ 17.29
Report prices

Analysis

The formula provides a two-to-one pattern of calcium and magnesium for bone and muscle nutrition. Amino-acid chelate forms improve part of the blend, while glutamic acid is a minor supporting addition.

Calcium carbonate and hydroxide and magnesium oxide lower average solubility compared with citrate or bisglycinate products. Repeated elemental quantities across forms make the actual source split unclear.

Four capsules per serving offer a substantial mineral intake at reasonable value. The product is best reserved for users with a defined need who can tolerate high supplemental magnesium.

Who is it for
  • Adults seeking a two-to-one calcium-magnesium ratio
  • Users with a defined high mineral need
  • People comfortable with four capsules
Best for
  • Bone mineral support
  • Combined calcium and magnesium
  • High-potency mineral intake

Pros

  • Provides substantial calcium and magnesium
  • Uses some amino-acid chelate forms
  • Maintains a clear two-to-one concept
  • Offers reasonable serving value

Cons

  • Includes calcium carbonate and hydroxide
  • Includes magnesium oxide
  • Mineral form splits are unclear
  • Requires four capsules

Warnings

  • The 500 mg magnesium amount may cause diarrhea or cramping
  • Count 1,000 mg supplemental calcium with dietary intake
  • Calcium and magnesium can reduce absorption of thyroid medicine and some antibiotics when taken together

Nutrient quality

74 High impact

Several weaker or vague forms limit ingredient quality. Aggressive dosing is the main concern.

.

Ingredient transparency

80 High impact

Most active amounts are clearly disclosed. Missing directions and inactive ingredients keep disclosure incomplete.

.

Customer satisfaction

70 High impact

The supplied average is strong and rests on a large review count. No review text was provided to assess recurring complaints or firsthand experiences.

.

Value for money

78 High impact

Serving efficiency is favorable for the disclosed formula. A focused active profile supports value.

.
Report analysis

Goals

Bone Health
Impact
High effect
A+ Goal FitC Strength of SupportB CoverageB Formula Quality
Magnesium · 500 mgCalcium · 1000 mg

Calcium and magnesium provide two important mineral inputs for skeletal structure and remodeling. Amino acid chelates improve the blend, but carbonate, hydroxide, and oxide make absorption quality uneven.

The calcium and magnesium amounts are both high for a single serving and may be better tolerated when divided. Magnesium at this level may cause diarrhea or cramping, while the absence of vitamin D and vitamin K leaves mineral transport support incomplete.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
General Health
Impact
High effect
A Goal FitC+ Strength of SupportC+ CoverageB Formula Quality
Magnesium · 500 mg

Calcium and magnesium provide foundational support for bone structure, muscle function, and nerve signaling. The two-to-one ratio is coherent, and both minerals include a chelated component.

Carbonate, hydroxide, and oxide forms lower expected absorption compared with a fully citrate or chelate-based formula. The large mineral serving may also cause digestive discomfort in sensitive users.

Study evidence
Magnesium Supportive 114 studies
Heart Health
Impact
High effect
B Goal FitB- Strength of SupportC CoverageB Formula Quality
Magnesium · 500 mg

Magnesium provides the clearest heart-relevant contribution through vascular tone and normal electrical signaling. Calcium adds muscle and electrical-signaling support but is not a broad cardiovascular active.

The 500 mg magnesium amount is substantial, but the oxide portion lowers expected absorption and the calcium-heavy design limits cardiovascular focus. The high mineral serving may cause diarrhea from magnesium or constipation from calcium in sensitive users.

Study evidence
Magnesium Supportive 158 studies
Testosterone Support
Impact
High effect
B Goal FitC+ Strength of SupportD+ CoverageB Formula Quality
Magnesium · 500 mg

Magnesium provides a relevant route to testosterone support. Dose or form uncertainty limits confidence in the practical contribution.

The formula remains narrow rather than comprehensive. The large magnesium amount may cause diarrhea, cramping, and fluid loss, especially because an oxide form is present.

Study evidence
Magnesium Disputed 5 studies
Energy
Impact
High effect
B- Goal FitB- Strength of SupportC- CoverageB- Formula Quality
Magnesium · 500 mg

Magnesium supports ATP-dependent metabolism, while calcium mainly serves muscle and skeletal functions. The magnesium amount is substantial, but oxide lowers absorption quality and the calcium-heavy design is not a direct energy formula.

The 500 mg supplemental magnesium amount, partly from oxide, can cause diarrhea or abdominal cramping. The substantial calcium amount may also cause constipation in sensitive users.

Study evidence
Magnesium Supportive 4 studies
Stress Relief
Impact
Moderate effect
C+ Goal FitC+ Strength of SupportC- CoverageC Formula Quality
Magnesium · 500 mg

Magnesium supports foundational nerve balance, but this is mainly a high-calcium mineral blend. The 500 mg magnesium amount is high and combines an amino-acid chelate with poorly absorbed oxide.

Calcium at twice the magnesium amount may compete with absorption and reduces stress focus. The high mineral load may cause digestive discomfort or loose stools in sensitive users.

Study evidence
Magnesium Supportive 13 studies

Ingredients

IngredientAmount per serving
Total Carbohydrate
1 Gram(s)
Calcium (Calcium Amino Acid Chelate, Calcium Carbonate, Calcium Hydroxide)
1000 mg
Magnesium (Magnesium Amino Acid Chelate, Magnesium Oxide)
500 mg
Glutamic Acid HCl
100 mg
Adults 18–50
Report overview
Glutamic Acid · 100 mg OverallScore82
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

The clearly disclosed glutamic acid hydrochloride provides an adequate supplemental amount and suits a mineral formula. The label does not confirm the biologically active L-isomer, which leaves some uncertainty about isomer specificity. Its serving cost remains reasonably efficient despite requiring four capsules.

B Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB+ Value

The amino acid chelate supports absorption, though carbonate and hydroxide reduce the consistency of the blend. The 1000 mg serving is larger than the amount usually absorbed most efficiently at once, so dividing it may improve use. The cost is favorable, and the supplied ingredient data shows no flagged additives.

D- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyB- Value

The blend pairs an amino acid chelate with low-absorption magnesium oxide and does not disclose their proportions. The 500 mg elemental dose is above the standard therapeutic range and may be harder on the digestive system. Value is fair because the serving is inexpensive but the blend includes low-absorption oxide.

Loading alternative details
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Treatment with alendronate plus calcium, alendronate alone, or calcium alone for postmenopausal low bone mineral density.
    Bonnick S; Broy S; Kaiser F; Teutsch C; Rosenberg E; DeLucca P; Melton M · Current medical research and opinion · 2007
    Randomized trial701 participantsBone Health forCalcium
  2. Associations of dietary calcium intake with metabolic syndrome and bone mineral density among the Korean population: KNHANES 2008-2011.
    Kim MK; Chon SJ; Noe EB; Roh YH; Yun BH; Cho S; Choi YS; Lee BS; Seo SK · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Cross-sectional study14,705 participantsBone Health forCalcium
  3. Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.
    Tihtonen K; Korhonen P; Isojärvi J; Ojala R; Ashorn U; Ashorn P; Tammela O · Annals of the New York Academy of Sciences · 2022
    Meta-analysis1,566 participants7 studies pooledBone Health forCalcium
  4. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  5. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD · The American journal of clinical nutrition · 2014
    Cohort study73,684 participantsBone Health forMagnesium
  6. Dialysate Magnesium and Coronary Artery Calcification, Bone Mineral Density, and Cramping in Maintenance Hemodialysis: A Quasi-experimental Study.
    Srisuwarn P; Sethakarun S; Nongnuch A; Jongjirasiri S; Sritara C; Klyprayong P; Disthabanchong S · Kidney medicine · 2022
    Non-randomized trial40 participantsBone Health forMagnesium
  7. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  8. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  9. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  10. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  11. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  12. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  13. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  14. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  15. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  16. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  17. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  18. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  19. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  20. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  21. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  22. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  23. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  24. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  25. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  26. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  27. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  28. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  29. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  30. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  31. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  32. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  33. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  34. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  35. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  36. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  37. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  38. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  39. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  40. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  41. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  42. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  43. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  44. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  45. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  46. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  47. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium