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Vitamin B-Complex 100

Solaray
4.7
★ ★ ★ ★ ★
(2529 ratings)
PABA 100 mg
Thiamin 100 mg
Niacin 100 mg
Riboflavin 100 mg
Vitamin B6 100 mg
Vitamin B5 100 mg
Choline 39 mg
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Score69
Complete and economical B-vitamin coverage is offset by conventional forms and a 100 mg vitamin B6 dose that is too aggressive for routine long-term use.
How scoring works
Quantity:250 VegCap(s) • (250 servings)
Goals:
Energy
Metabolism Boost

Score 69

Complete and economical B-vitamin coverage is offset by conventional forms and a 100 mg vitamin B6 dose that is too aggressive for routine long-term use.
How scoring works
$51.99($0.20 per serving)
Pure Formulas
$ 51.99
Vitacost
$ 51.99
iHerb
$ 51.99
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Analysis

Thiamine, riboflavin, niacinamide, vitamin B6, folate, vitamin B12, biotin, and pantothenic acid create broad support for normal energy metabolism. Most core B vitamins are supplied at 100 mg or a similarly high multiple of daily needs, so the formula is better described as high potency than balanced maintenance nutrition.

Pyridoxine hydrochloride and cyanocobalamin are conventional forms that require conversion before use. Choline at 39 mg is only a small addition, and PABA and inositol provide limited practical depth beside the main B vitamins.

Folate at 680 mcg DFE is clearly stated and provides substantial coverage. The simple serving and complete disclosure support ease of use, but the dose pattern is more aggressive than most adults need every day.

Who is it for
  • Adults seeking a high-potency B-complex for limited or clinician-directed use
  • People who value a simple once-daily serving
  • Users who have checked total vitamin B6 and folic acid intake from other products
Best for
  • Broad B-vitamin coverage
  • Supporting normal energy metabolism when intake is inadequate
  • Users prioritizing low serving cost over premium coenzyme forms

Pros

  • Includes all core B vitamins with stated amounts
  • Uses non-flushing niacinamide
  • Provides substantial thiamine, riboflavin, and pantothenic acid
  • Simple daily serving is easy to follow

Cons

  • 100 mg pyridoxine is unnecessarily high for a daily maintenance formula
  • Uses conventional cyanocobalamin and pyridoxine hydrochloride
  • Choline is modest at 39 mg
  • PABA and inositol add little to the core energy rationale

Warnings

  • Prolonged use of 100 mg vitamin B6 may cause tingling, numbness, or other nerve symptoms; stop use and seek advice if these occur.
  • Niacinamide at this amount may cause nausea or stomach discomfort in sensitive users.
  • PABA can interfere with sulfonamide antibiotics, so concurrent use should be reviewed with the prescriber.

Nutrient quality

61 Moderate impact

High amounts provide depth across the B-vitamin family. Very high B6 and niacinamide with basic forms make the formula unbalanced for routine use.

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Ingredient transparency

71 High impact

Most active amounts are stated without a hidden blend. Repeated vitamin labels, generic folate, missing directions, and absent excipients reduce precision.

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Customer satisfaction

71 High impact

The aggregate satisfaction signal is strong and supported by extensive volume. Missing review details prevent assessment of recurring complaints or purpose fit.

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Value for money

74 High impact

The large supply improves serving economics for users seeking high potency. Aggressive doses and basic forms still make gentler active-form products more competitive.

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Report analysis

Goals

Energy
Impact
High effect
B Goal FitB- Strength of SupportC+ CoverageB Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

A complete B-complex supports carbohydrate metabolism, cellular energy production, and nervous-system function. It may help fatigue caused by inadequate B-vitamin intake, but it does not provide an acute stimulant or a well-supported adaptogen.

All amounts are disclosed, though cyanocobalamin, pyridoxine, thiamine mononitrate, and other conventional forms are less refined than active alternatives. The very high pyridoxine amount creates a meaningful neuropathy risk with long-term daily use, especially alongside other vitamin B6 products.

Study evidence
Thiamin Disputed 12 studies
Metabolism Boost
Impact
Moderate effect
D Goal FitC- Strength of SupportD CoverageB+ Formula Quality
Biotin · 100 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

B vitamins support cellular energy metabolism, but they do not meaningfully raise metabolic rate in people whose needs are already met. The formula is best suited to correcting nutrient gaps rather than thermogenesis or fat oxidation.

The 100 mg B-vitamin pattern is substantial, yet no caffeine, green tea, carnitine, chromium, iodine, or CoQ10 is included. Basic pyridoxine and cyanocobalamin forms limit quality and do not add a targeted metabolic mechanism.

Study evidence
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Mononitrate)
100 mg
Riboflavin (Vitamin B2)
100 mg
Niacin (Niacinamide, Vitamin B3)
100 mg
Vitamin B6 (Pyridoxine Hydrochloride)
100 mg
Folate
680 mcg DFE
Vitamin B12 (Cyanocobalamin)
100 mcg
Biotin
100 mcg
Pantothenic Acid (Calcium D-Pantothenate)
100 mg
Choline (Choline Bitartrate)
39 mg
Para Aminobenzoic Acid
100 mg
Inositol
100 mg
Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
PABA · 100 mg OverallScore89
A Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA- Value

Clearly identified PABA delivers a robust standalone-range dose. Immediate release is appropriate at this amount, while missing excipient details leave additive cleanliness uncertain. The one-capsule serving is convenient, and the normalized PABA cost offers good value.

B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

A clearly labeled standard thiamine form provides a high-potency dose suited to targeted metabolic and neurological support. Its water-soluble form is dependable but lacks the absorption advantages of premium alternatives. The complex formula is cost-efficient for the amount of thiamine supplied.

B+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value

The 100 mg niacinamide dose is well aligned with general and skin-focused use, though it is not a nicotinic-acid or NAD+ formula. A standard capsule provides straightforward delivery without specialized release technology. The effective amount and practical per-dose cost give the B-complex solid value.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  2. High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial.
    Bager P; Bossen L; Gantzel R; Grønbæk H · PloS one · 2024
    Randomized trial36 participantsEnergy forThiamin
  3. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  4. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  5. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.
    Christen S; Redeuil K; Goulet L; Giner MP; Breton I; Rota R; Frézal A; Nazari A; Van den Abbeele P; Godin JP; Nutten S; Cuenoud B · Nature metabolism · 2026
    Randomized trial65 participantsMetabolism Boost forNiacin
  6. Lipid-lowering therapies, glucose control and incident diabetes: evidence, mechanisms and clinical implications.
    Zafrir B; Jain M · Cardiovascular drugs and therapy · 2015
    Narrative reviewMetabolism Boost forNiacin
  7. Insights Into Thiamine Supplementation in Patients With Septic Shock.
    Costa NA; Pereira AG; Sugizaki CSA; Vieira NM; Garcia LR; de Paiva SAR; Zornoff LAM; Azevedo PS; Polegato BF; Minicucci MF · Frontiers in medicine · 2022
    Narrative reviewMetabolism Boost forThiamin
  8. Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials.
    Nakanishi N; Abe Y; Matsuo M; Tampo A; Yamada K; Hatakeyama J; Yoshida M; Yamamoto R; Higashibeppu N; Nakamura K; Kotani J · Clinical nutrition (Edinburgh, Scotland) · 2024
    Meta-analysis3,494 participants35 studies pooledMetabolism Boost forThiamin
  9. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  10. Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B6 metabolism.
    Whyte MP; Zhang F; Mack KE; Wenkert D; Gottesman GS; Ericson KL; Cole JT; Coburn SP · Bone · 2024
    Non-randomized trial149 participantsMetabolism Boost forVitamin B6
  11. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  12. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  13. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.
    González-Domínguez R; Castellano-Escuder P; Lefèvre-Arbogast S; Low DY; Du Preez A; Ruigrok SR; Lee H; Helmer C; Pallàs M; Urpi-Sarda M; Sánchez-Pla A; Korosi A; Lucassen PJ; Aigner L; Manach C; Thuret S; Samieri C; Andres-Lacueva C · Alzheimer's research & therapy · 2022
    Observational studyMetabolism Boost forVitamin B5
  14. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  15. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  16. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  17. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  18. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  19. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  20. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  21. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  22. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6