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Megasorb B-Complex '50'

Solgar
4.8
★ ★ ★ ★ ★
(1241 ratings)
Vitamin B6 55 mg
Riboflavin 55 mg
Niacin 50 mg
Thiamin 50 mg
Vitamin B5 55 mg
Choline 21 mg
Product Image
Score76
Several active forms make this more refined than a standard B-50 formula. High vitamin B6 remains the decisive drawback for prolonged daily use.
How scoring works
Quantity:100 Tablet(s) • (142 servings)
Goals:
Energy
Metabolism Boost

Score 76

Several active forms make this more refined than a standard B-50 formula. High vitamin B6 remains the decisive drawback for prolonged daily use.
How scoring works
$17.76($0.12 per serving)
iHerb
$ 17.76
Daily Vita
$ 20.62
Vitacost
$ 19.05
Pure Formulas
$ 18.74
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Analysis

High amounts of thiamine, riboflavin, niacinamide, B6, folate, B12, and pantothenic acid make this a concentrated formula. Riboflavin 5-phosphate, pyridoxal 5-phosphate, D-biotin, and pantethine are useful form upgrades.

Not every ingredient receives the same attention to form quality. Thiamine mononitrate and cyanocobalamin are conventional choices, while 21 mg of choline and 24 mg of magnesium contribute little to focused support.

Vitamin B6 reaches 55 mg, which is more than most people need for routine daily supplementation. It may suit short-term, clinician-guided high-potency use, but a lower-B6 product is the safer choice for long-term maintenance.

Who is it for
  • Adults seeking a high-potency B complex
  • Users who value active B6 and riboflavin forms
  • People using it for a limited period with dose oversight
Best for
  • High-potency B-vitamin coverage
  • Active B6 and riboflavin supplementation
  • Short-term metabolic nutrient support

Pros

  • Includes riboflavin 5-phosphate
  • Includes pyridoxal 5-phosphate
  • Provides D-biotin and pantethine
  • Clearly states the main nutrient amounts

Cons

  • Vitamin B6 is high for long-term daily use
  • Uses cyanocobalamin
  • Choline is lightly dosed
  • Magnesium contributes only a small amount

Warnings

  • The 55 mg vitamin B6 amount may cause tingling, numbness, or other nerve symptoms with prolonged daily use.
  • Soy lecithin makes the product unsuitable for people with a soy allergy.
  • Avoid combining it with other B6 supplements because the serving is already high.

Nutrient quality

71 High impact

Riboflavin phosphate, pyridoxal phosphate, pantethine, magnesium citrate, and clear vitamin forms improve quality. The high vitamin B6 amount creates a meaningful neuropathy concern with long-term use.

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Ingredient transparency

81 Highest impact

Specific amounts are supplied for every listed active ingredient. No proprietary blend hides the listed doses.

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Customer satisfaction

72 High impact

The supplied aggregate rating is very strong. No complaint themes or purpose-specific experience details are supplied.

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Value for money

76 High impact

The formula offers reasonable value despite important quality or dose trade-offs. Soy lecithin and inositol are secondary but not dominant additions.

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Goals

Energy
Energy
Impact
Highest effect
B+ Goal FitB+ Strength of SupportC+ CoverageA Formula Quality
Vitamin B5 · 55 mgMagnesium · 24 mgRiboflavin · 55 mgThiamin · 50 mgVitamin B12 · 50 mcg

A focused B-complex directly supports the nutrient-dependent steps of energy metabolism. High thiamin and riboflavin with pantothenate and the wider B-vitamin family provide meaningful pathway depth.

The formula does not provide caffeine, a well-dosed adaptogen, creatine, or a high vitamin B12 amount for broader or acute effects. It is a coherent metabolic-support option rather than a fast-acting energy product.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
D+ Goal FitB Strength of SupportD+ CoverageB+ Formula Quality
Biotin · 50 mcgNiacin · 50 mgVitamin B12 · 50 mcgRiboflavin · 55 mgThiamin · 50 mgVitamin B5 · 55 mgVitamin B6 · 55 mgMagnesium · 24 mg

High-potency B vitamins support normal cellular energy production. Active P-5-P, riboflavin phosphate, and pantethine improve coenzyme-form quality.

The formula does not address thermogenesis, glycemic control, thyroid support, or mitochondrial transport directly. Its focused design offers depth in one pathway without unnecessary botanicals.

Study evidence
Riboflavin Mixed 5 studies
Vitamin B5 Supportive 12 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Mononitrate, Vitamin B1)
 50 mg
Riboflavin (Riboflavin 5-Phosphate)
 55 mg
Niacin (Niacinamide, Vitamin B3)
 50 mg
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
 55 mg
Folate
666 mcg DFE
Vitamin B12 (Cyanocobalamin)
 50 mcg
Biotin (D-Biotin)
 50 mcg
Pantothenic Acid (Calcium D-Pantothenate, Pantethine, Vitamin B5)
 55 mg
Choline (Choline Bitartrate)
 21 mg
Magnesium (Magnesium Citrate, Magnesium Oxide)
 24 mg
Soy Lecithin
50 mg
Inositol
50 mg
Gluten Free Adults 18–50 Vegan Dairy Free Sugar Free Vegetarian
Report overview
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride) · 55 mg OverallScore85
B Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyA+ Value

The blend includes active P-5-P alongside pyridoxine hydrochloride, offering better form quality than pyridoxine alone. The 55 mg serving is a substantial dose but sits above the preferred middle range. Very low serving cost supports strong value for a B-complex.

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Riboflavin (Riboflavin 5-Phosphate) · 55 mg OverallScore77
C+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyA+ Value

A blend of standard riboflavin and R5P adds some bioactive coenzyme-form support, while the hard-pressed tablet may release more slowly. The amount reaches the high-potency range for metabolic support. The low serving cost makes the clearly stated dose highly efficient.

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Niacin (Niacinamide, Vitamin B3) · 50 mg OverallScore76
B- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyC Value

The B-complex uses clearly named niacinamide at a useful general-support amount. The tablet has no stated release technology, though niacinamide itself has low flush potential. Its serving cost is favorable for a broad B-complex rather than a targeted niacin product.

View ingredientView products
Loading alternative details
79 Performance

B Complex Plus

Seeking Health
<p>It improves ingredient-form quality through active riboflavin, vitamin B6, and vitamin B12 forms at meaningful amounts. The niacin declaration is ambiguous and may carry flushing potential.</p>
80 Performance

B-Complex #12

Thorne
<p>It improves ingredient-form quality through a focused B-complex with methylcobalamin and substantial energy-metabolism coverage. Several forms are not identified, and vitamin B6 and niacin warrant attention alongside fortified foods or other supplements.</p>
80 Performance

B-100 Complex with B2 Coenzyme

Nature's Way
<p>It improves ingredient-form quality through active riboflavin and partial P-5-P within broad B-vitamin coverage. The total vitamin B6 amount is very high and may raise nerve-symptom risk with prolonged use.</p>
77 Budget

B-50

NOW
<p>It lowers the recurring cost while providing broad B-vitamin dosing and a large supply. Basic forms and high vitamin B6 reduce suitability for indefinite daily use.</p>
74 Budget

B-Complex '50'

Solgar
<p>It lowers the recurring cost while providing complete B-vitamin coverage aligned with energy metabolism. Conventional forms, high vitamin B6, and a tiny herbal blend limit the quality case.</p>
77 Budget

B-50 Complex 50 mg

Source Naturals
<p>It lowers the recurring cost while providing broad metabolic coverage with clearly stated amounts and substantial pantothenic acid. High folic acid and vitamin B6 reduce dose balance for routine use.</p>
77 Value

B-50 Complex

Nature's Way
<p>It balances formulation quality and cost through active riboflavin and a broad, clearly dosed B-complex base. Vitamin B6 remains unnecessarily high for routine long-term use.</p>
76 Value

Hi Potency B Complex

Natural Factors
<p>It balances formulation quality and cost through a complete high-potency B-vitamin pattern with coherent energy support. High folate and vitamin B6 make the formula unnecessarily aggressive for unsupervised daily use.</p>
75 Value

B-Complex 50

Bluebonnet
<p>It balances formulation quality and cost through a complete B-vitamin pattern with clear amounts and reasonable serving value. The formula still relies on basic forms and a high vitamin B6 amount.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  4. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  5. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  6. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.
    González-Domínguez R; Castellano-Escuder P; Lefèvre-Arbogast S; Low DY; Du Preez A; Ruigrok SR; Lee H; Helmer C; Pallàs M; Urpi-Sarda M; Sánchez-Pla A; Korosi A; Lucassen PJ; Aigner L; Manach C; Thuret S; Samieri C; Andres-Lacueva C · Alzheimer's research & therapy · 2022
    Observational studyMetabolism Boost forVitamin B5
  7. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  8. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  9. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Boost forRiboflavin
  10. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  11. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  12. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  13. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  14. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  15. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  16. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  17. Exploring auxotrophy and engineering vitamin B6 prototrophy in the acetogen Clostridium sp. AWRP.
    Kwon SJ; Lee J; Lee HS · Applied and environmental microbiology · 2024
    Clinical trialMetabolism Boost forVitamin B5
  18. Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy.
    Spry C; van Schalkwyk DA; Strauss E; Saliba KJ · Infectious disorders drug targets · 2010
    Narrative reviewMetabolism Boost forVitamin B5
  19. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  20. Serum metabolites of hypertension among Chinese adolescents aged 12-17 years.
    Sun J; Ding W; Liu X; Zhao M; Xi B · Journal of human hypertension · 2022
    Other77 participantsMetabolism Boost forVitamin B5
  21. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  22. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  23. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  24. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  25. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6