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Bone Strength

NATURELO Premium Supplements
4.7
★ ★ ★ ★ ★
(1606 ratings)
Calcium 600 mg
Vitamin K 60 mcg
Boron 3 mg
Silicon 3 mg
Product Image
Score76
The strongest feature is uses Aquamin calcium and magnesium; the main drawback is four capsules per serving.
How scoring works
Quantity:120 Capsule(s) • (30 servings)
Goals:
Bone Health
General Health
Testosterone Support

Score 76

The strongest feature is uses Aquamin calcium and magnesium; the main drawback is four capsules per serving.
How scoring works
$27.95($0.93 per serving)
iHerb
$ 27.95
Vitacost
$ 27.95
Pure Formulas
$ 27.95
Walmart
$ 27.95
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Analysis

Aquamin calcium and magnesium, vitamin D3, MK-7, chelated zinc, boron, and vitamin C provide broad and coherent bone support. The core ingredients address related nutritional pathways rather than relying on a single mineral.

Four capsules per serving and a modest silica amount reduce convenience and depth, while manganese sulfate is a basic form. These issues matter for daily use, label interpretation, and comparison with simpler formulas.

It fits adults wanting moderate calcium with D3, K2, magnesium, zinc, and boron in one formula. The most important trade-off is four capsules per serving.

Who is it for
  • adults wanting moderate calcium with D3, K2, magnesium, zinc, and boron in one formula
  • Adults comparing bone or general nutrient formulas by dose and form
Best for
  • Broad bone-support nutrients
  • Moderate calcium with D3, K2, and boron

Pros

  • Uses Aquamin calcium and magnesium
  • Includes vitamin D3 and MK-7
  • Provides chelated zinc and boron
  • Moderate calcium amount

Cons

  • Four capsules per serving
  • Silica amount is small
  • Uses manganese sulfate
  • Only 30 servings

Warnings

  • Vitamin K2 can interfere with warfarin dosing and should remain consistent under prescriber guidance.

Nutrient quality

85 Highest impact

Balanced minerals and well-chosen cofactors support the intended use. Incomplete magnesium detail and a token silica amount leave modest weaknesses.

.

Ingredient transparency

78 High impact

Core active amounts are mostly clear and easy to evaluate. Missing non-active ingredients and complete use directions leave meaningful label gaps.

.

Customer satisfaction

70 High impact

Aggregate satisfaction data are favorable and supported by substantial volume. Specific firsthand comments were not supplied, leaving repeated complaints and purpose fit uncertain.

.

Value for money

70 High impact

The core actives provide fair value for the category. Serving economics and formulation trade-offs keep it from standing out.

.
Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A+ Goal FitA Strength of SupportA CoverageA Formula Quality
Vitamin K · 60 mcgMagnesium · 200 mgCalcium · 600 mgVitamin D · 25 mcgManganese · 1 mgBoron · 3 mgZinc · 8 mgVitamin C · 60 mg

The formula combines calcium and magnesium with vitamin D3 and MK-7, covering mineral supply, absorption, and calcium placement. Boron, zinc, manganese, and silica add targeted support for the bone matrix and remodeling.

Most core amounts are practical, and the algae-derived calcium plus chelated zinc strengthen form quality. The silica contribution is small, while MK-7 can interfere with stable warfarin dosing.

Study evidence
Boron Supportive 5 studies
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Manganese Adverse 12 studies
Silicon Supportive 13 studies
Vitamin K Supportive 78 studies
Zinc Supportive 33 studies
General Health
General Health
Impact
Highest effect
A Goal FitA- Strength of SupportB+ CoverageA Formula Quality
Vitamin D · 25 mcgMagnesium · 200 mgVitamin K · 60 mcgBoron · 3 mgZinc · 8 mgVitamin C · 60 mg

The mineral-centered formula provides meaningful calcium and magnesium alongside vitamin D3, MK-7, zinc, and boron. These complementary nutrients make it useful for bone structure while also supporting broader foundational needs.

Several forms and amounts are clearly disclosed, including chelated zinc and boron citrate. Vitamin K can interfere with warfarin dose control, so people taking that anticoagulant need prescriber guidance before use.

Study evidence
Boron Supportive 6 studies
Magnesium Supportive 114 studies
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Zinc Supportive 60 studies
Testosterone Support
Testosterone Support
Impact
High effect
C Goal FitB Strength of SupportC- CoverageC+ Formula Quality
Magnesium · 200 mgZinc · 8 mgVitamin D · 25 mcgBoron · 3 mg

Boron provides a relevant route to testosterone support. The disclosed amount appears meaningful for that focused role.

The formula remains narrow rather than comprehensive. Vitamin K can oppose warfarin and related vitamin-K-antagonist medicines, so the intake should remain medically coordinated and consistent.

Study evidence
Boron Disputed 3 studies

Ingredients

IngredientAmount per serving
Vitamin C (Acerola Cherry Extract)
 60 mg
Vitamin D3 (Cholecalciferol)
 25 mcg
Calcium (Aquamin)
 600 mg
Magnesium (Aquamin Magnesium)
 200 mg
Zinc (Zinc Amino Acid Chelate)
 8 mg
Manganese (Manganese Sulfate)
 1 mg
Potassium (Potassium Chloride)
 50 mg
Vitamin K2 (Menaquinone-7)
 60 mcg
Boron (Boron Citrate)
 3 mg
Silica (Horsetail Herb Extract)
 3 mg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Calcium (Aquamin) · 600 mg OverallScore84
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Algae-derived Aquamin provides a high-quality calcium source. The 600 mg serving fits the efficient single-dose range, and vitamin D3 plus MK-7 add relevant bone-support cofactors. The high cost is the main trade-off.

View ingredientView products
Vitamin K (Menaquinone-7) · 60 mcg OverallScore64
C+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

The bone-support formula uses MK-7, but the amount stays in the maintenance range. Dry delivery without a lipid base may reduce absorption unless the serving is taken with dietary fat. The high serving cost and maintenance-level MK-7 dose limit value despite the broader mineral formula. Vitamin K can counteract warfarin and other vitamin K antagonists, so users of those medicines should keep intake consistent and coordinate changes with their prescriber.

View ingredientView products
Boron (Boron Citrate) · 3 mg OverallScore62
C Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

Boron citrate provides a useful organic form at an effective 3 mg dose. The compound and amount are disclosed, although no trademark or specific mineral-purity verification is shown. Its high serving cost results in poor value when boron is the main goal.

View ingredientView products
Loading alternative details
82 Performance

Ultra BoneUp

Jarrow Formulas
<p>It combines 400 mg of microcrystalline hydroxyapatite calcium, 166.7 mg of magnesium, 40 mcg of K2, 1 mg of boron, silicon, and type II collagen. The provided analysis shows stronger calcium, mineral, or overall formulation performance than the original in at least one central area, though the exact nutrient balance differs.</p>
77 Performance

Bone Boost

California Gold Nutrition
<p>It provides 600 mg of calcium from four sources, 250 mg of magnesium malate, 90 mcg of K2, 4 mg of boron, and chelated trace minerals. The provided analysis shows stronger calcium, mineral, or overall formulation performance than the original in at least one central area, though the exact nutrient balance differs.</p>
70 Performance

Dr. Strum's Intensive Bone Formula

Life Extension
<p>It provides 800 mg of calcium, 400 mg of magnesium, 1,173 mg of potassium, 200 mcg each of D3 and K2, 6 mg of boron, and silicon. The provided analysis shows stronger calcium, mineral, or overall formulation performance than the original in at least one central area, though the exact nutrient balance differs.</p>
85 Budget

BoneUp

Jarrow Formulas
<p>It provides 333.3 mg of microcrystalline hydroxyapatite calcium, 166.7 mg of magnesium, 15 mcg of K2, 8.3 mcg of D3, and 1 mg of boron. It lowers the serving cost while retaining substantial coverage of the original’s calcium, magnesium, vitamin K, silicon, or boron collections.</p>
81 Budget

Bone Restore with Vitamin K2

Life Extension
<p>It provides 700 mg of calcium from three sources, 300 mg of magnesium, 200 mcg of K2, 25 mcg of D3, 3 mg of boron, and silicon. It lowers the serving cost while retaining substantial coverage of the original’s calcium, magnesium, vitamin K, silicon, or boron collections.</p>
75 Budget

Stronger Bones

Garden of Life Dr. Formulated
<p>It provides 1,300 mg of eggshell calcium, 20 mcg of K2, 90 mcg of vitamin K, and 20 mcg of vitamin D. It lowers the serving cost while retaining substantial coverage of the original’s calcium, magnesium, vitamin K, silicon, or boron collections.</p>
82 Value

Vegetarian BoneUp

Jarrow Formulas
<p>It provides 333.3 mg of calcium citrate, 166.7 mg of magnesium, 15 mcg of K2, 8.3 mcg of D2, and 1 mg of boron. It balances broad bone-support coverage with a lower or moderate serving cost compared with the original. The trade-off is a lower amount or omission of at least one nutrient emphasized by the original.</p>
81 Value

Bone Restore

Life Extension
<p>It provides 700 mg of calcium from three sources, 300 mg of magnesium, 25 mcg of D3, 3 mg of boron, and 5 mg of silicon. It balances broad bone-support coverage with a lower or moderate serving cost compared with the original. The trade-off is a lower amount or omission of at least one nutrient emphasized by the original.</p>
70 Value

Vegan Plant-Based Calcium 1000 mg

PlantFusion
<p>It provides 1,000 mg of Aquamin calcium, 96 mg of magnesium, 85 mcg of K2, 20 mcg of D3, and algae-derived trace minerals. It balances broad bone-support coverage with a lower or moderate serving cost compared with the original. The trade-off is a lower amount or omission of at least one nutrient emphasized by the original.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  3. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  4. Associations of dietary calcium intake with metabolic syndrome and bone mineral density among the Korean population: KNHANES 2008-2011.
    Kim MK; Chon SJ; Noe EB; Roh YH; Yun BH; Cho S; Choi YS; Lee BS; Seo SK · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Cross-sectional study14,705 participantsBone Health forCalcium
  5. Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.
    Tihtonen K; Korhonen P; Isojärvi J; Ojala R; Ashorn U; Ashorn P; Tammela O · Annals of the New York Academy of Sciences · 2022
    Meta-analysis1,566 participants7 studies pooledBone Health forCalcium
  6. Bone turnover and the response to alendronate treatment in postmenopausal osteoporosis.
    Gonnelli S; Cepollaro C; Pondrelli C; Martini S; Montagnani A; Monaco R; Gennari C · Calcified tissue international · 1999
    Randomized trial100 participantsBone Health forCalcium
  7. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBone Health forBoron
  8. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBone Health forBoron
  9. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBone Health forBoron
  10. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBone Health forBoron
  11. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBone Health forBoron
  12. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  13. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  14. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  15. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  16. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  17. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  18. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  19. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  20. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  21. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  22. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  23. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  24. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  25. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  26. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese
  27. The effect of choline-stabilized orthosilicic acid in patients with peri-implantitis: an exploratory randomized, double-blind, placebo controlled study.
    Teughels W; Celik GU; Tarce M; De Cock I; Persyn SM; Haytac MC · BMC oral health · 2021
    Randomized trial21 participantsBone Health forSilicon
  28. Calcium Phosphate Modified with Silicon vs. Bovine Hydroxyapatite for Alveolar Ridge Preservation: Densitometric Evaluation, Morphological Changes and Histomorphometric Study.
    Cadenas-Vacas G; Martínez-Rodríguez N; Barona-Dorado C; Sánchez-Labrador L; Cortés-Bretón Brinkmann J; Meniz-García C; Martínez-González JM · Materials (Basel, Switzerland) · 2021
    Non-randomized trialBone Health forSilicon
  29. Silicon: a review of its potential role in the prevention and treatment of postmenopausal osteoporosis.
    Price CT; Koval KJ; Langford JR · International journal of endocrinology · 2013
    Narrative reviewBone Health forSilicon
  30. Osteogenic Effect of a Bioactive Calcium Alkali Phosphate Bone Substitute in Humans.
    Knabe C; Adel-Khattab D; Rezk M; Cheng J; Berger G; Gildenhaar R; Wilbig J; Günster J; Rack A; Heiland M; Knauf T; Stiller M · Bioengineering (Basel, Switzerland) · 2023
    Clinical trial38 participantsBone Health forSilicon
  31. Silicon and bone health.
    Jugdaohsingh R · The journal of nutrition, health & aging · 2007
    Narrative reviewBone Health forSilicon
  32. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  33. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  34. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  35. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  36. Increased incidence of fractures in middle-aged and elderly men with low intakes of phosphorus and zinc.
    Elmståhl S; Gullberg B; Janzon L; Johnell O; Elmståhl B · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1999
    Cohort study6,576 participantsBone Health forZinc
  37. Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.
    Berger PK; Pollock NK; Laing EM; Chertin V; Bernard PJ; Grider A; Shapses SA; Ding KH; Isales CM; Lewis RD · The Journal of nutrition · 2016
    Randomized trial147 participantsBone Health forZinc
  38. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth.
    Merialdi M; Caulfield LE; Zavaleta N; Figueroa A; Costigan KA; Dominici F; Dipietro JA · The American journal of clinical nutrition · 2004
    Randomized trial242 participantsBone Health forZinc
  39. The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
    Sadighi A; Roshan MM; Moradi A; Ostadrahimi A · Saudi medical journal · 2009
    Randomized trial60 participantsBone Health forZinc
  40. Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.
    Ceylan MN; Akdas S; Yazihan N · Biological trace element research · 2021
    Meta-analysis40 studies pooledBone Health forZinc
  41. Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea.
    Nikkhah S; Dolatian M; Naghii MR; Zaeri F; Taheri SM · Complementary therapies in clinical practice · 2015
    Randomized trial113 participantsGeneral Health forBoron
  42. Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies.
    Elewski BE; Aly R; Baldwin SL; González Soto RF; Rich P; Weisfeld M; Wiltz H; Zane LT; Pollak R · Journal of the American Academy of Dermatology · 2015
    Randomized trialGeneral Health forBoron
  43. The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.
    Toledo-Bahena ME; Bucko A; Ocampo-Candiani J; Herz-Ruelas ME; Jones TM; Jarratt MT; Pollak RA; Zane LT · Journal of drugs in dermatology : JDD · 2015
    Clinical trial336 participantsGeneral Health forBoron
  44. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA).
    Henriksson R; Capala J; Michanek A; Lindahl SA; Salford LG; Franzén L; Blomquist E; Westlin JE; Bergenheim AT; Swedish Brain Tumour Study Group · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2009
    Single-arm trial30 participantsGeneral Health forBoron
  45. Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1β, IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study
    Otilia-Constantina Rogoveanu, George Dan Mogosanu, Cornelia Bejenaru, Ludovic Everard Bejenaru, Octavian Croitoru, Johny Neamtu, Zbigniew Pietrzkowski, Tania Reyes-Izquierdo, Andrei Bita, Iulia Daria Scorei, Romulus Ion Scorei · Biological Trace Element Research · 2015
    Randomized trial78 participantsGeneral Health forBoron
  46. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  47. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  48. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  49. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  50. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  51. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  52. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  53. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  54. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  55. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  56. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  57. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledGeneral Health forVitamin K
  58. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  59. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  60. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
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    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
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    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  63. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  64. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  65. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
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    Nielsen FH · Environmental health perspectives · 1995
    Single-arm trial12 participantsTestosterone Support forBoron
  67. Plasma boron and the effects of boron supplementation in males.
    Green NR; Ferrando AA · Environmental health perspectives · 1995
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    Mohammad Reza Naghii, Mahmoud Mofid, Ali Reza Asgari, Mehdi Hedayati, Maryam-Saddat Daneshpour · Journal of Trace Elements in Medicine and Biology · 2011
    Non-randomized trial8 participantsTestosterone Support forBoron