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Methyl-Guard Plus

Thorne
4.9
★ ★ ★ ★ ★
(2701 ratings)
Vitamin B6 45 mg
Riboflavin 90 mg
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Score93

A professional-grade methylation support formula with active B vitamins and high-dose TMG.

How scoring works
Quantity:90 Capsule(s) • (30 servings)
Goals:

Score 93

A professional-grade methylation support formula with active B vitamins and high-dose TMG.

How scoring works
$62.00($2.06 per serving)
Pure Formulas
$ 62.00
Vitacost
$ 62.00
Vitacost
$ 62.00
iHerb
$ 62.00
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Analysis

This formula provides very high doses of riboflavin 5-phosphate and P5P, along with 3 mg of methylcobalamin. It also includes 1.8 grams of betaine anhydrous (TMG), which is a powerful dose for supporting the methylation cycle. This combination is specifically designed for cardiovascular and neurological metabolic support.

By using only the most bioactive forms, this supplement ensures that your body can immediately use the nutrients for energy and detoxification. It is a premium, high-potency product that provides significant nutritional depth. It fits perfectly for someone looking for the highest standard of metabolic and heart support.

Pros

  • High 1.8 g dose of TMG
  • Uses bioactive R5P and P5P
  • Strong 3 mg methyl-B12
  • Elite professional brand
  • Supports methylation cycle
  • High-purity ingredients

Cons

  • Very expensive per serving
  • Requires three capsules daily
  • Low folate dose

Warnings

  • May cause digestive changes
  • Folate dose is very low here
  • Consult doctor for high-dose B6

Nutrient quality

97 Highest impact

Comprehensive use of bioactive coenzyme forms like R5P and P5P ensures maximum metabolic efficiency. Synergistic pairing of B-vitamins with trimethylglycine provides advanced support for methylation pathways.

Ingredient transparency

99 Highest impact

Labeling is exceptionally detailed, providing specific biochemical forms and amounts for all complex components. Full disclosure of excipients and serving details reflects a high standard of professional transparency.

Customer satisfaction

98 Highest impact

Exceptional ratings and a large review volume reflect high consumer trust in this professional-grade formula. Feedback consistently highlights the effectiveness of the product for complex metabolic needs.

Value for money

74 High impact

Premium price reflects the high cost of bioactive ingredients and comprehensive multi-nutrient profile. While the daily cost is high, the synergistic value and ingredient quality justify the investment.

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Ingredients

IngredientAmount per serving
Riboflavin (Riboflavin 5'-Phosphate Sodium)
 90 mg
Vitamin B6 (Pyridoxal 5-Phosphate)
 45 mg
Folate
5 mcg DFE
Vitamin B12 (Methylcobalamin)
 3 mg
Betaine Anhydrous (Trimethylglycine)
 1.8 Gram(s)
Gluten Free Adults 18–50
Report overview
Vitamin B6 (Pyridoxal 5-Phosphate) · 45 mg OverallScore84
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
Thorne Methyl-Guard Plus is an advanced formula designed to support methylation and heart health through active vitamin forms. It is a premium product that prioritizes metabolic efficiency and high-quality ingredients.
View ingredientView products
Riboflavin (Riboflavin 5'-Phosphate Sodium) · 90 mg OverallScore80
A+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD+ Value
This premium supplement uses the highly bioavailable coenzyme form of riboflavin for immediate metabolic activity. While expensive, it is one of the most effective and high-quality ways to support energy and methylation processes.
View ingredientView products
97 Value

R-5-P Coenzymated Vitamin B-2 50 mg

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BioCoenzymated Riboflavin 5'-Phosphate 50 mg

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P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength

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Vitamin B Complex

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Nu-Thera Multivitamin with P5P

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Activated Homocysteine

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98 Budget

P-5-P 50 mg

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B-2 100 mg

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Vitamin B6 50 mg

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97 Value

R-5-P Coenzymated Vitamin B-2 50 mg

Swanson Ultra
4.8
★★★★★
(993 ratings)
Bioactive riboflavin 5'-phosphate supports efficient cellular energy and metabolic processes with enhanced absorption. This coenzyme form offers high biological utility for individuals focusing on B2 status.
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96 Value

BioCoenzymated Riboflavin 5'-Phosphate 50 mg

Natural Factors
4.9
★★★★★
(8157 ratings)
A highly bioavailable coenzyme format ensures immediate metabolic utility for cellular energy pathways. This bioactive R5P approach facilitates efficient absorption compared to standard riboflavin sources.
Other sellers (2)
98 Value

P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength

Swanson
4.8
★★★★★
(2590 ratings)
Pyridoxal 5-phosphate provides an active form of vitamin B6 for neurotransmitter synthesis and metabolic efficiency. This coenzyme form bypasses hepatic conversion for a more direct impact on neurological health.
Other sellers (1)
97 Performance

Vitamin B Complex

California Gold Nutrition
4.8
★★★★★
(7084 ratings)
Coenzymated forms like riboflavin 5-phosphate and pyridoxal 5-phosphate support efficient mitochondrial energy production. The use of Magnafolate Pro ensures superior bioavailability for the methylation cycle and neurological maintenance.
Other sellers (0)
99 Performance

Nu-Thera Multivitamin with P5P

Kirkman
4.9
★★★★★
(493 ratings)
Focused inclusion of P-5-P and calcium folinate ensures superior biological activity for sensitive metabolic pathways. This high-purity formula provides highly bioavailable nutrients to support efficient nutrient utilization.
Other sellers (1)
95 Performance

Activated Homocysteine

Swanson
4.8
★★★★★
(168 ratings)
Combining pyridoxal 5-phosphate with methylcobalamin and betaine supports efficient metabolic processing of markers like homocysteine. The use of coenzyme forms ensures direct metabolic readiness for cardiovascular and neurological health.
Other sellers (0)
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