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Methyl-Guard Plus

Thorne
4.9
★ ★ ★ ★ ★
(2912 ratings)
Vitamin B6 45 mg
Riboflavin 90 mg
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Score74
A potent active-form methylation formula led by trimethylglycine, P-5-P, riboflavin phosphate, and methylcobalamin. Verify the tiny supplied folate amount and monitor total B6 exposure.
How scoring works
Quantity:90 Capsule(s) • (30 servings)
Goals:

Score 74

A potent active-form methylation formula led by trimethylglycine, P-5-P, riboflavin phosphate, and methylcobalamin. Verify the tiny supplied folate amount and monitor total B6 exposure.
How scoring works
$62.00($2.06 per serving)
Pure Formulas
$ 62.00
Vitacost
$ 62.00
Vitacost
$ 62.00
iHerb
$ 62.00
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Analysis

Riboflavin-5-phosphate, P-5-P, methylcobalamin, and 1.8 g trimethylglycine support linked methylation and homocysteine pathways. The active forms and clearly stated amounts are major formulation strengths.

The folate entry is only 5 mcg DFE in the supplied data, which is unexpectedly small for a methylation product and should be verified. Vitamin B6 at 45 mg is high enough to make long-term cumulative exposure a concern.

It fits adults using a focused methylation formula with professional guidance rather than casual daily wellness supplementation. Users should confirm the folate label, account for other B6 sources, and expect a high-potency rather than balanced nutrient profile.

Who is it for
  • Adults seeking focused methylation support
  • Users wanting active B-vitamin forms
  • People using high-potency formulas with professional guidance
Best for
  • Methylation-pathway nutrient support
  • Trimethylglycine supplementation
  • Active B12, B6, and riboflavin intake

Pros

  • Uses active riboflavin and P-5-P
  • Provides methylcobalamin
  • Includes 1.8 g trimethylglycine
  • Core amounts are clearly stated

Cons

  • Vitamin B6 amount is high
  • Supplied folate amount appears unexpectedly low
  • High-potency rather than balanced profile
  • Incomplete inactive details

Warnings

  • Long-term 45 mg vitamin B6 intake can raise neuropathy risk
  • Verify the supplied folate amount against the manufacturer label
  • High-dose methyl donors may not suit every user and deserve clinician review when managing psychiatric medication

Nutrient quality

75 High impact

Betaine and vitamin B12 are substantial, but the supplied folate amount is negligible. Vitamin B6 at 45 mg is excessive for routine long-term use and raises neuropathy risk.

Ingredient transparency

81 Highest impact

Every listed active ingredient has a specific amount. No proprietary blend hides a listed active dose.

Customer satisfaction

73 High impact

The very strong rating is supported by a very large review base. No review text is available to assess recurring complaints or firsthand results.

Value for money

65 Moderate impact

Premium forms and substantial betaine support quality, but poor dose balance weakens the high cost. The serving is expensive despite the focused formula.

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Ingredients

IngredientAmount per serving
Riboflavin (Riboflavin 5'-Phosphate Sodium)
 90 mg
Vitamin B6 (Pyridoxal 5-Phosphate)
 45 mg
Folate
5 mcg DFE
Vitamin B12 (Methylcobalamin)
 3 mg
Betaine Anhydrous (Trimethylglycine)
 1.8 Gram(s)
Gluten Free Adults 18–50
Report overview
Vitamin B6 (Pyridoxal 5-Phosphate) · 45 mg OverallScore84
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Pyridoxal 5-phosphate supplies active B6 at a well-aligned amount alongside other methylation-focused nutrients. One capsule provides clear and convenient dosing, with no concerning additives listed. The serving cost is very high and substantially weakens value despite the specialized formula.

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Riboflavin (Riboflavin 5'-Phosphate Sodium) · 90 mg OverallScore80
A+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD+ Value

Bioactive R5P is supplied at a high-potency amount. The capsule supports quick release in the digestive tract. Premium R5P partly offsets the high serving cost.

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89 Performance

P-5-P 50 mg

Country Life
Active pyridoxal phosphate provides a clean, directly usable vitamin B6 form without the original’s poorly contributing folate entry. It is a focused B6 product rather than a complete methylation formula, and the amount remains above ordinary maintenance needs.
83 Performance

R-5-P Coenzymated Vitamin B-2 50 mg

Swanson Ultra
Active riboflavin phosphate provides clear form quality and a meaningful amount. The narrower capsule omits methylfolate, methylcobalamin, betaine, and vitamin B6, so it fits only isolated riboflavin needs.
81 Performance

Tri-B

Carlson
Vitamin B6, folate, and vitamin B12 create a simple combination relevant to homocysteine metabolism. Conventional forms, high folate, and elevated pyridoxine are less refined than the original’s active forms, but the formula avoids a questionable low folate declaration.
78 Budget

B-50 Complex

21st Century
A clearly disclosed B-complex with a long supply costs far less than the original methylation formula. Conventional forms and high vitamin B6 limit long-term routine use, while betaine and the original’s targeted methylation emphasis are absent.
83 Budget

B-2 100 mg

NOW
A focused riboflavin capsule provides a substantial amount at a very low serving cost. Standard riboflavin requires conversion and does not replace the original’s methylfolate, methylcobalamin, vitamin B6, or betaine.
89 Budget

P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength

Swanson
Active pyridoxal phosphate offers direct vitamin B6 support at a small fraction of the original’s cost. The single-nutrient formula cannot replace broader methylation support, and its amount is still high for indefinite daily use.
83 Value

BioCoenzymated Riboflavin 5'-Phosphate 50 mg

Natural Factors
Active riboflavin phosphate delivers strong form quality at a much lower serving cost. It is only a riboflavin supplement, so broader methylation ingredients would need to come from diet or another carefully selected formula.
79 Value

P-5-P 50 mg

NOW
A P-5-P-positioned formula with magnesium bisglycinate provides active-form value at a low serving cost. The ingredient entry does not fully confirm the vitamin B6 form, and users should avoid combining it with other high-dose B6 products.
87 Value

Vitamin B-6 50 mg

Nature's Way
A mixed active and precursor vitamin B6 blend offers a focused, low-cost way to obtain some ready-to-use P-5-P. It does not supply the original’s riboflavin, folate, vitamin B12, or betaine and remains a high-potency B6 option.
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