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Vitamin K2 Advantage 2200 mcg

4.8
★ ★ ★ ★ ★
(392 ratings)
Vitamin K 1820 mcg
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Score80
Best suited to adults using a professionally directed multi-form vitamin K plan; the total vitamin K exposure is very high and dry-tablet delivery lacks a fat carrier, making the formula more specialized than routine.
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Tablet
Quantity:60 Tablet(s) • (60 servings)
Goals:
Heart Health
Bone Health
Anti-Aging
General Health
Cardiovascular Support

Score 80

Best suited to adults using a professionally directed multi-form vitamin K plan; the total vitamin K exposure is very high and dry-tablet delivery lacks a fat carrier, making the formula more specialized than routine.
How scoring works
$21.45($0.35 per serving)
iHerb
$ 21.45
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Analysis

Branded MK-7, MK-4, and vitamin K1 create unusually broad vitamin K coverage with all major amounts disclosed. The label provides enough detail to judge the central vitamin strategy.

The total vitamin K exposure is very high and dry-tablet delivery lacks a fat carrier, making the formula more specialized than routine. Format, dose, and companion nutrients determine whether it is appropriate for daily use.

The best fit is adults using a professionally directed multi-form vitamin K plan. Vitamin K and vitamin D support normal physiology, but the practical benefit depends on baseline intake and individual need.

Who is it for
  • Adults using a professionally directed multi-form vitamin K plan
  • Adults whose current vitamin intake matches the listed potency
  • Users able to account for vitamin K medication interactions
Best for
  • Includes K1, MK-4, and branded MK-7
  • Deep vitamin K coverage
  • Users who accept that very high total vitamin k

Pros

  • Includes K1, MK-4, and branded MK-7
  • Deep vitamin K coverage
  • All form amounts are disclosed
  • Useful sixty-serving supply

Cons

  • Very high total vitamin K
  • Dry tablet lacks a fat carrier
  • Small calcium amount adds little
  • Overbuilt for routine maintenance

Warnings

  • The high combined K1, MK-4, and MK-7 exposure can strongly counteract warfarin and related vitamin K antagonist anticoagulants.
  • The 63 mg calcium can reduce absorption of levothyroxine and tetracycline or quinolone antibiotics, so doses should be separated.
  • Bile-acid sequestrants and orlistat can reduce absorption of the fat-soluble vitamin K forms in this tablet.

Nutrient quality

79 High impact

Branded MenaQ7 is a well-characterized MK-7 form, while MK-4 and K1 are also identified, and menaQ7 is present at a meaningful 180 mcg, with substantial additional K1 and MK-4. The very high total vitamin K amount is more aggressive than most general-use formulas, while k1, MK-4, and MK-7 provide broad vitamin K coverage, while the small calcium addition has limited impact.

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Ingredient transparency

85 Highest impact

Every listed active ingredient has a specific amount, and no proprietary blend hides the dose of a listed active ingredient. Serving count is supplied, but complete daily-use directions are not provided, while inactive ingredients and excipients are not included in the supplied label details.

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Customer satisfaction

71 High impact

The supplied average rating is strong, and the relatively limited review count reduces confidence in the average rating. Specific review themes are unavailable, so repeated negatives and real-world fit remain uncertain.

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Value for money

82 Highest impact

The ingredient forms and dosing generally justify the product positioning, and the moderate serving cost is reasonable for the disclosed actives. The small calcium addition has limited value but does not dominate the formula, while the formula and serving value compare well with similar products.

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Report analysis

Goals

Heart Health
Impact
Highest effect
A+ Goal FitA+ Strength of SupportB CoverageA- Formula Quality
Vitamin K · 180 mcg

Branded MenaQ7 supplies 180 mcg of MK-7 alongside 200 mcg of MK-4 and vitamin K1. The clearly disclosed forms provide strong depth for vitamin K-dependent calcium regulation.

The formula does not address lipids, nitric oxide, or cardiac energy, and the dry tablet lacks a stated fat carrier. The high total vitamin K amount can oppose warfarin-type anticoagulants and requires prescriber guidance for users of those medicines.

Study evidence
Vitamin K Mixed 62 studies
Bone Health
Impact
Highest effect
A Goal FitA+ Strength of SupportB- CoverageB+ Formula Quality
Vitamin K · 180 mcgCalcium · 63 mg

MK-7 and MK-4 support activation of proteins that help bind calcium into bone, while vitamin K1 adds another established vitamin K form. The branded MK-7 amount is strong and clearly disclosed.

The dry tablet lacks a lipid carrier, and the small calcium amount does not provide meaningful structural mineral support. The high total vitamin K content requires special care with warfarin and similar vitamin K antagonist medicines because it can counter their effect.

Study evidence
Calcium Supportive 144 studies
Vitamin K Supportive 78 studies
Anti-Aging
Impact
Highest effect
B+ Goal FitA Strength of SupportB CoverageA Formula Quality
Vitamin K · 180 mcg

Branded MK-7, MK-4, and K1 provide a substantial vitamin K profile for bone proteins and control of calcium placement in tissues. The 180 mcg MK-7 amount is well aligned with targeted cardiovascular and skeletal support.

The dry tablet lacks a stated fat-based carrier, which may limit absorption of these fat-soluble forms. The high total vitamin K content can counteract warfarin and similar vitamin K antagonists, so users of those medicines need consistent intake managed by their clinician.

Study evidence
Vitamin K Supportive 27 studies
General Health
Impact
Highest effect
A- Goal FitA- Strength of SupportC+ CoverageA- Formula Quality
Vitamin K · 180 mcg

Multiple vitamin K forms provide focused support for calcium handling, bone health, and vascular function. A useful MK-7 amount and a named branded source strengthen confidence in the formula.

The dry tablet lacks a fat-based delivery system, so taking it with food containing fat may improve practical absorption. The high vitamin K content is unsuitable for unsupervised use with warfarin or similar vitamin K antagonist medicines.

Study evidence
Vitamin K Supportive 34 studies
Cardiovascular Support
Impact
High effect
B- Goal FitA Strength of SupportD+ CoverageB- Formula Quality
Vitamin K · 180 mcg

MK-7 and MK-4 support calcium-regulating proteins and may help maintain arterial flexibility. The large K1 component is less targeted, while direct cardiovascular outcome evidence remains less conclusive.

The K2 amounts are meaningful and clearly separated, although the dry tablet lacks stated fat-based delivery. The high total vitamin K content can strongly interfere with warfarin and similar vitamin K antagonists.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin K1 (Phytonadione)
1820 mcg
Vitamin K2 (Menaquinone-4)
200 mcg
Vitamin K2 (Mena Q7)
180 mcg
Calcium (Dibasic Calcium Phosphate)
63 mg
Adults 18–50 Vegan Vegetarian
Report overview
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Branded MenaQ7 supplies a well-aligned 180 mcg MK-7 dose, supported by clearly disclosed MK-4 and K1 amounts. The dry tablet lacks stated fat-based delivery or meal guidance, which may limit absorption compared with an oil-based format. Its low serving cost supports strong value, although the high total vitamin K content warrants particular care for people using warfarin or similar vitamin K antagonist medicines.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis.
    Chen HG; Sheng LT; Zhang YB; Cao AL; Lai YW; Kunutsor SK; Jiang L; Pan A · European journal of nutrition · 2020
    Meta-analysis222,592 participants21 studies pooledGeneral Health forVitamin K
  2. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledGeneral Health Anti-Aging forVitamin K
  3. Vitamin K intake and all-cause and cause specific mortality.
    Zwakenberg SR; den Braver NR; Engelen AIP; Feskens EJM; Vermeer C; Boer JMA; Verschuren WMM; van der Schouw YT; Beulens JWJ · Clinical nutrition (Edinburgh, Scotland) · 2018
    Cohort study33,289 participantsGeneral Health forVitamin K
  4. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  5. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  6. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  7. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  8. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  9. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  10. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  11. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  12. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  13. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  14. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  15. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  16. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  17. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  18. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  19. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  20. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  21. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  22. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  23. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  24. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  25. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  26. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  27. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K