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Liver Guard

Source Naturals
4.5
★ ★ ★ ★ ★
(597 ratings)
Niacin 50 mg
Choline 50 mg
Riboflavin 8 mg
Thiamin 8 mg
Coenzyme Q-10 12 mg
Turmeric 150 mg
Product Image
Score71
A broad, moderately priced liver-antioxidant blend with a useful NAC and milk thistle core, but uneven doses and label ambiguity reduce confidence.
How scoring works
Quantity:120 Tablet(s) • (60 servings)
Goals:
Energy

Score 71

A broad, moderately priced liver-antioxidant blend with a useful NAC and milk thistle core, but uneven doses and label ambiguity reduce confidence.
How scoring works
$28.67($0.47 per serving)
Vitacost
$ 45.15
iHerb
$ 45.79
Amazon
$ 28.67
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Analysis

N-acetylcysteine at 350 mg, milk thistle at 250 mg, alpha-lipoic acid at 150 mg, and substantial vitamin C provide the clearest support. Dandelion, artichoke, turmeric, bupleurum, and calcium D-glucarate broaden the liver-focused profile.

Turmeric is not standardized, CoQ10 and choline are low, and several vitamins use standard rather than preferred forms. The supplied data repeats vitamin C, folate, magnesium, and zinc forms in a way that makes actual totals uncertain.

The serving cost is moderate for such a broad blend, but breadth should not be mistaken for strong dosing across every ingredient. It fits users seeking general antioxidant and liver-oriented support more than those targeting energy or any single nutrient.

Who is it for
  • Adults seeking broad liver-oriented antioxidant support
  • Users wanting NAC with milk thistle
  • People who can verify current label totals
Best for
  • N-acetylcysteine supplementation
  • Milk thistle support
  • Broad antioxidant coverage

Pros

  • Provides 350 mg N-acetylcysteine
  • Includes 250 mg milk thistle extract
  • Adds alpha-lipoic acid and mixed vitamin E
  • Moderate serving cost

Cons

  • Turmeric is not standardized
  • CoQ10 and choline are low
  • Several nutrient entries appear duplicated
  • Energy-specific support is limited

Warnings

  • Milk thistle, dandelion, and artichoke may not suit people with bile-duct obstruction or gallstone-related symptoms
  • Alpha-lipoic acid may lower blood glucose and warrants care with glucose-lowering medicines
  • Bupleurum has reported liver-related safety concerns in susceptible users, so stop if unusual fatigue, dark urine, or yellowing occurs

Nutrient quality

74 High impact

Several core liver-support ingredients are present at meaningful amounts. Duplicate nutrient entries and comparatively high vitamin doses make total exposure and balance less certain.

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Ingredient transparency

64 Moderate impact

The main active amounts are generally available and no broad proprietary blend obscures the formula. Complete usage directions and non-active ingredients are not supplied, while any noted duplicate or vague entries reduce clarity.

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Customer satisfaction

68 High impact

Aggregate satisfaction is strong and supported by a substantial evidence base. No firsthand experience details are supplied, so recurring complaints and purpose alignment remain uncertain.

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Value for money

81 Highest impact

Meaningful core doses and a substantial supply support good value. Label ambiguity and a broad secondary nutrient layer modestly reduce competitiveness.

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Goals

Impact
Moderate effect
C Goal FitD- Strength of SupportD+ CoverageD- Formula Quality
Vitamin B5 · 15 mgMagnesium · 50 mgRiboflavin · 8 mgThiamin · 8 mgVitamin B12 · 50 mcgPotassium · 48 mgCoenzyme Q-10 · 12 mg

B vitamins, alpha-lipoic acid, and a small CoQ10 amount touch several cellular-energy pathways. Most of the formula is aimed at liver and antioxidant support rather than fatigue or stamina.

CoQ10, magnesium, thiamin, and riboflavin are below stronger focused amounts, while many botanicals make the formula crowded. Niacin may also cause flushing or discomfort in sensitive users at the stated amount.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Magnesium Supportive 4 studies
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies

Ingredients

IngredientAmount per serving
Calories
5 Calorie(s)
Vitamin C (Ascorbic Acid, Ascorbyl Palmitate, Zinc Ascorbate)
250 mg
Vitamin E (D-Alpha-Tocopheryl Succinate)
67 mg
Thiamine (Vitamin B1)
8 mg
Riboflavin (Vitamin B2)
8 mg
Niacin
50 mg
Vitamin B6 (Pyridoxine Hydrochloride)
10 mg
Folate (Calcium Folinate, Folic Acid)
680 mcg DFE
Vitamin B12 (Cyanocobalamin)
50 mcg
Panthothenic Acid (Calcium D-Pantothenate)
15 mg
Calcium (Calcium D-Glucarate, Dicalcium Phosphate)
30 mg
Magnesium (Magnesium Amino Acid Complex, Magnesium Oxide)
50 mg
Zinc (OptiZinc, Zinc Ascorbate)
15 mg
Selenium (L-Selenomethionine)
50 mcg
Potassium (Potassium Citrate)
48 mg
N-Acetyl Cysteine
350 mg
Silymarin (Milk Thistle seed extract)
250 mg
Dandelion whole plant/root extract
175 mg
Turmeric rhizome extract
150 mg
Alpha-Lipoic Acid
150 mg
Bupleurum root extract
100 mg
Gamma-Vitamin E Complex
100 mg
Calcium D-Glucarate
100 mg
Oregon Grape
75 mg
Artichoke aerial parts extract (Cynarins)
75 mg
Choline (Choline Bitartrate)
50 mg
Inositol
50 mg
Coenzyme Q10
12 mg
Adults 18–50
Report overview
Niacin · 50 mg OverallScore61
D+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyB- Value

The niacin amount fits a broad multi-ingredient formula, but the chemical form is not identified. Standard tablet delivery offers no specialized release support, while the wider nutrient and botanical profile adds practical breadth. Niacin-specific value is limited by missing form detail, though the complete formula provides reasonable value for a combination product.

B Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value

The choline comes from bitartrate, a standard systemic form that fits liver-focused use better than targeted cognitive support. The label discloses only a modest amount of elemental choline, and reaching it requires two tablets. Cost per actual choline dose is relatively high despite a formula without listed artificial additives.

F Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyD- Value

Vitamin B2 is a conventional form that requires conversion before metabolic use. The dose is suited to low-level maintenance, while the tablet format supports slower release. Cost efficiency is limited for the potency supplied.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  2. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  3. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  4. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  5. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  6. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  7. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  8. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  9. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  10. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  11. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  12. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  13. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  14. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  15. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  16. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  17. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  18. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  19. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin