Product Image

Lights Out Sleep

ALLMAX
4.4
★ ★ ★ ★ ★
(567 ratings)
Theanine 50 mg
GABA 150 mg
Valerian 250 mg
Melatonin 3 mg
5-HTP 50 mg
Product Image
Score77
Standardized valerian and melatonin anchor a coherent sleep formula with GABA and smaller calming additions. Serotonin interactions and additive drowsiness remain important.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Sleep Support
Stress Relief
Mood Support

Score 77

Standardized valerian and melatonin anchor a coherent sleep formula with GABA and smaller calming additions. Serotonin interactions and additive drowsiness remain important.
How scoring works
$19.99($0.66 per serving)
iHerb
$ 23.11
Nutrition Faktory
$ 19.99
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Analysis

Valerian root extract is supplied at 250 mg and identifies valerenic acid, while 3 mg melatonin directly supports sleep timing. The active-marker percentage is not shown, but the extract is better characterized than generic valerian powder.

GABA at 150 mg, chamomile at 100 mg, and smaller 5-HTP, theanine, passionflower, lavender, and tyrosine amounts provide additional pathways. Active vitamin B6 supports neurotransmitter metabolism, though the long tail of small doses adds limited depth.

Two capsules and reasonable value support a practical bedtime routine. It fits sleep and nighttime stress goals, not daytime mood or focus use.

Who is it for
  • Adults seeking nighttime sleep support
  • People who want several calming pathways in one formula
  • Users not taking serotonergic medicines
Best for
  • Bedtime relaxation
  • Sleep-onset support
  • Valerian- and melatonin-based sleep support

Pros

  • Uses valerenic-acid-identified valerian extract
  • Provides 3 mg melatonin
  • Includes active vitamin B6
  • Clearly lists ingredient amounts

Cons

  • Valerian marker percentage is missing
  • Theanine and 5-HTP are lightly dosed
  • Several minor ingredients add limited depth
  • Not suitable for daytime use

Warnings

  • 5-HTP can interact with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines.
  • Melatonin, valerian, and the calming blend may impair alertness; do not drive after use.
  • Alcohol, sedatives, and other sleep medicines can increase drowsiness.

Nutrient quality

80 Highest impact

Active vitamin B6 and named botanical forms support quality, but marker strengths are not quantified; valerian, GABA, and melatonin are useful, while theanine and several herbs are modest. The listed amounts are generally moderate, though combined sedatives and 5-HTP require care; the main ingredients fit sleep onset and relaxation well; most additions are relevant, but very small tyrosine and lavender amounts add limited value.

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Ingredient transparency

77 High impact

Every listed active has a specific amount; no proprietary blend hides key doses. Ingredient identity is generally specific, while standardized marker percentages remain absent; serving directions and inactive ingredients are not included in the supplied details.

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Customer satisfaction

70 High impact

The supplied aggregate average is favorable, though no individual feedback is available; the large rating sample improves confidence in the aggregate average, but no individual feedback is supplied. Detailed feedback is absent, so repeated complaints cannot be assessed; real-world fit with the intended purpose remains uncertain.

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Value for money

79 High impact

The varied formula supports solid value for its positioning; several meaningful sleep actives are supplied at a reasonable serving cost. A few small additions contribute limited practical value; it compares favorably with many broad sleep blends.

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Goals

Sleep Support
Sleep Support
Impact
Highest effect
A Goal FitB Strength of SupportA- CoverageB- Formula Quality
Melatonin · 3 mgTheanine · 50 mg

Melatonin, 5-HTP, GABA, valerian, theanine, and calming botanicals make this a clearly sleep-specific formula. Physiological-dose melatonin and a typical starting 5-HTP amount anchor circadian and serotonin-related pathways.

Several secondary calming ingredients are modest or lack standardization, and the crowded blend raises the chance of additive sedation. 5-HTP can interact with serotonergic antidepressants, while the combined sedatives can impair driving and should not be casually mixed with alcohol or sleep medicines.

Study evidence
5-HTP Supportive 1 study
GABA Supportive 4 studies
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Valerian Supportive 31 studies
Stress Relief
Stress Relief
Impact
Highest effect
A- Goal FitB Strength of SupportA- CoverageB- Formula Quality
GABA · 150 mgVitamin B6 · 10 mgTheanine · 50 mg

Valerian, GABA, theanine, chamomile, passionflower, lavender, and 5-HTP combine several calming pathways relevant to acute stress and sleep. Valerian names valerenic acid, while GABA and several herbs reach useful supporting amounts.

The formula is more sedating than suitable for daytime stress management. The included 5-HTP can interact with SSRIs, SNRIs, MAO inhibitors, and other serotonergic medicines, while the combined calming ingredients may impair alertness.

Study evidence
5-HTP Supportive 18 studies
GABA Supportive 6 studies
Theanine Supportive 16 studies
Valerian Supportive 18 studies
Mood Support
Mood Support
Impact
High effect
B Goal FitB- Strength of SupportC+ CoverageC+ Formula Quality
Vitamin B6 · 10 mg5-HTP · 50 mg

Valerian, GABA, 5-HTP, theanine, calming herbs, and melatonin create a broad sleep-focused relaxation formula. P-5-P appropriately supports serotonin synthesis from 5-HTP, but several secondary actives are lightly dosed.

The formula may help nighttime calm more than daytime mood stability. Combining 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines can raise serotonin risk, while the sedating ingredients may impair alertness with alcohol or sedative medicines.

Study evidence
5-HTP Supportive 9 studies
GABA Supportive 12 studies
Theanine Supportive 12 studies
Valerian Supportive 17 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxal 5-Phosphate)
 10 mg
Valerian Root Extract (Valerenic Acid)
 250 mg
GABA
150 mg
Chamomile flower extract
100 mg
Passionflower
60 mg
5-HTP (Griffonia simplicifolia seed extract)
 50 mg
L-Theanine
50 mg
Lavender Extract (Lavandula angustifolia Extract)
 30 mg
L-Tyrosine
20 mg
Melatonin
3 mg
Gluten Free Adults 18–50 Vegan Women Vegetarian
Report overview
Theanine · 50 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value

The active L-isomer is identified, but the dose provides only mild support and lacks branded purity evidence. Its exact amount is clearly stated for a single-capsule serving. A clinically relevant 5-HTP dose improves value, though it may compound serotonergic medicines.

View ingredientView products
GABA · 150 mg OverallScore70
B- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD- Value

The 150 mg GABA dose is transparent and reasonable within a multi-ingredient sleep blend, though the source is unbranded. Capsule delivery is conventional, and the serving cost is high relative to the GABA amount. Melatonin, valerian, and 5-HTP may produce additive drowsiness, while 5-HTP can interact with serotonergic medicines.

View ingredientView products
Valerian (Valerenic Acid) · 250 mg OverallScore63
C- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD- Value

The 250 mg root extract reaches the stated mild-relaxation range and is clearly disclosed. Valerenic acid is named, but no standardized percentage or concentration ratio confirms extract potency. Capsule delivery manages odor well, while the serving cost is moderately above the collection median and melatonin may increase next-day drowsiness.

View ingredientView products
Loading alternative details
79 Performance

Superior Sleep

Doctor's Best
<p>Ashwagandha, theanine, GABA, melatonin, and 5-HTP are all supplied at meaningful amounts for sleep support. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
82 Performance

Tranquil Sleep

Natural Factors Stress-Relax
<p>Branded Suntheanine, physiological melatonin, and Griffonia-derived 5-HTP make a coherent bedtime blend in an enteric-coated softgel. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
76 Performance

Best-Rest Formula

Pure Encapsulations
<p>Branded L-theanine, active vitamin B6, substantial GABA, valerian, and several calming herbs create a technically strong sleep blend. Better-defined theanine, GABA, melatonin, valerian, or related calming ingredients improve formulation clarity over the original. Sedation and serotonin-related interactions still require attention when relevant.</p>
69 Budget

Sleep Support

Bluebonnet Targeted Choice
<p>Theanine, valerian, tart cherry, passionflower, 5-HTP, and chamomile form a coherent but lightly dosed sleep blend. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
72 Budget

Power to Sleep PM

Irwin Naturals
<p>Valerian, ashwagandha, hops, lemon balm, passionflower, and melatonin create broad nighttime support. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
78 Budget

Extra Strength Tranquil Sleep

Natural Factors Stress-Relax
<p>Branded Suntheanine and melatonin provide strong sleep-onset support in a clearly disclosed chewable. The lower serving cost improves economy while retaining meaningful sleep ingredients. Its narrower blend or different dosing may reduce pathway breadth compared with the original.</p>
77 Value

Sleep Support

The Vitamin Shoppe
<p>Useful amounts of L-theanine, GABA, melatonin, and 5-HTP create a strong sleep-oriented blend. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
87 Value

Sleep Regimen 3-in-1

NOW
<p>Melatonin, L-theanine, and Griffonia-derived 5-HTP create a focused, fully disclosed sleep formula with excellent serving value. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
82 Value

Tranquil Sleep

Natural Factors Stress-Relax
<p>Branded Suntheanine, physiological melatonin, and Griffonia-derived 5-HTP create a well-defined sleep formula in an enteric-coated softgel. A lower serving cost and clearly disclosed calming actives improve practical value over the original. The trade-off is a simpler formula or less comprehensive botanical coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
    Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
    Randomized trial202 participantsSleep Support forValerian
  2. Complementary and alternative treatments for insomnia disorder: a systematic umbrella review.
    Ell J; Schmid SR; Benz F; Spille L · Journal of sleep research · 2024
    Systematic review15 studies pooledSleep Support forValerian
  3. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  4. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  5. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  6. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  7. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  8. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  9. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  10. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  11. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  12. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsMood Support Stress Relief forGABA
  13. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  14. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  15. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  16. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  17. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  18. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  19. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  20. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine Stress Relief forGABA
  21. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  22. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsMood Support Sleep Support Stress Relief forValerian
  23. Chemotypic diversity and neuroactive potential of Valeriana jatamansi Jones: a systematic review on phytochemistry, pharmacology and standardisation challenges.
    Nisar S; Jan N; Hassan I; Andleeb L; Shabir PA · Natural product research · 2026
    Meta-analysis12 studies pooledMood Support forValerian
  24. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
    Shinjyo N; Waddell G; Green J · Journal of evidence-based integrative medicine · 2021
    Meta-analysis6,894 participants60 studies pooledMood Support forValerian
  25. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
    Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
    Randomized trial20 participantsMood Support forValerian
  26. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledMood Support Stress Relief forValerian
  27. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  28. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  29. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  30. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  31. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  32. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  33. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  34. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsSleep Support forTheanine
  35. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  36. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  37. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  38. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support forTheanine
  39. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
    Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Randomized trial40 participantsSleep Support forValerian
  40. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
    Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
    Randomized trial40 participantsSleep Support forValerian
  41. Valerian for sleep: a systematic review and meta-analysis.
    Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
    Meta-analysis1,093 participants16 studies pooledSleep Support forValerian
  42. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  43. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  44. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  45. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  46. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  47. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  48. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  49. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  50. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsStress Relief forTheanine
  51. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialStress Relief forTheanine
  52. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
    Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
    Randomized trial54 participantsStress Relief forValerian
  53. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
    Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
    Non-randomized trial54 participantsStress Relief forValerian
  54. Stress-induced insomnia treated with kava and valerian: singly and in combination.
    Wheatley D · Human psychopharmacology · 2019
    Single-arm trial24 participantsStress Relief forValerian