Product Image

5-HTP 100 mg Extra Strength

Swanson
4.8
★ ★ ★ ★ ★
(11444 ratings)
5-HTP 100 mg
Product Image
Score83
100 mg of 5-HTP provides standard serotonin-pathway support in a convenient format. The named Griffonia source helps, but missing standardization limits quality detail.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Mood Support
Sleep Support
Stress Relief
Weight Loss

Score 83

100 mg of 5-HTP provides standard serotonin-pathway support in a convenient format. The named Griffonia source helps, but missing standardization limits quality detail.
How scoring works
$7.99($0.13 per serving)
Walmart
$ 8.49
iHerb
$ 8.49
iHerb
$ 8.49
iHerb
$ 7.99
Report prices

Analysis

A standard 100 mg 5-HTP serving gives the formula a clear and focused role in serotonin-related mood and sleep support. The amount matches the practical middle ground represented in the supplied goal analyses without pushing into a high-strength serving.

Griffonia simplicifolia is identified as the source, although no active standardization percentage is supplied. The capsule(s) format is convenient, but it does not add a disclosed release or absorption feature.

The simple design makes the active easy to judge, although it covers only one main pathway. Cost efficiency is a clear strength for the disclosed amount. It best fits adults seeking a straightforward middle-dose option for mood or sleep support.

Who is it for
  • Adults seeking a standard 5-HTP amount
  • People focused on mood or sleep support
  • Users who prefer a simple capsule or tablet routine
Best for
  • Focused serotonin-pathway mood support
  • Indirect sleep support through serotonin and melatonin pathways
  • Stress accompanied by low mood or disrupted sleep

Pros

  • Clearly discloses 100 mg of 5-HTP
  • Capsule(s) format is easy to use
  • Names Griffonia simplicifolia as the botanical source
  • Focused formula is easy to assess
  • Good value for the disclosed active amount

Cons

  • No 5-HTP standardization percentage is provided
  • No controlled-release or enteric delivery feature is disclosed
  • Single-pathway formula offers limited support beyond serotonin production

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising medicines because serotonin toxicity can occur.
  • The 100 mg 5-HTP serving may cause nausea or digestive upset.
  • Avoid stacking it with other serotonin-focused supplements such as tryptophan or SAMe unless a qualified clinician has reviewed the combination.

Nutrient quality

85 Highest impact

Griffonia simplicifolia identifies the botanical source, but no active standardization percentage is supplied. The 5-HTP amount matches a common standard serving, while missing extract standardization limits source-potency confidence.

Ingredient transparency

81 Highest impact

Every listed active amount is disclosed, and no proprietary blend hides dosing. Complete directions, inactive ingredients, and some source or standardization details remain unavailable.

Customer satisfaction

71 High impact

The aggregate rating is favorable, and the very large review count makes it stable. No detailed feedback is supplied, so repeated complaints and purpose fit cannot be judged.

Value for money

96 Highest impact

A standard amount and very favorable serving economics create excellent value. Missing extract standardization is a minor limitation.

Report analysis

Goals

Mood Support
Impact
High effect
B+ Goal FitA Strength of SupportD+ CoverageA- Formula Quality
5-HTP · 100 mg

The direct serotonin precursor is supplied at a standard full serving with clear active disclosure. Griffonia is identified as the source, but the extract lacks a stated standardization and the capsule has no special release feature.

The formula is well focused for serotonin support but does not cover stress response or structural brain support. Combining 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising drugs may increase the risk of serotonin toxicity.

Study evidence
5-HTP Supportive 9 studies
Sleep Support
Impact
High effect
B Goal FitA- Strength of SupportC CoverageA Formula Quality

5-HTP supports serotonin and downstream melatonin production, giving it a plausible but indirect role in sleep. The single active does not directly address nervous system relaxation or circadian timing.

The amount is fully disclosed and fits a commonly used range, while the Griffonia source lacks stated standardization. Combining 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines may increase the risk of excessive serotonin.

Study evidence
5-HTP Supportive 1 study
Stress Relief
Impact
High effect
C Goal FitB Strength of SupportC- CoverageA Formula Quality

5-HTP may support mood when stress is tied to low mood or disrupted sleep, but it is not a broad stress-response formula. Evidence for direct stress relief remains less complete than for established adaptogens or L-theanine.

The 100 mg amount is a useful standalone dose and the Griffonia seed source is named, although no standardization percentage is supplied. Because 5-HTP raises serotonin, combining it with SSRIs, SNRIs, MAOIs, or other serotonin-modulating medicines may raise the risk of serotonin toxicity.

Study evidence
5-HTP Supportive 18 studies
Weight Loss
Impact
Moderate effect
D+ Goal FitB Strength of SupportF CoverageA Formula Quality

L-5-HTP from Griffonia seed extract may support appetite signaling through serotonin. The 100 mg serving is a standard, clearly stated amount.

Its evidence for lasting weight loss remains limited, and no thermogenic, fiber, protein, or muscle-preservation ingredient broadens the formula. Using 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines may raise serotonin-toxicity risk.

Study evidence
5-HTP Supportive 5 studies

Ingredients

IngredientAmount per serving
L-5 HTP (Griffonia simplicifolia seed extract)
100 mg
Adults 18–50
Report overview
C+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyA+ Value

Griffonia simplicifolia is identified as the botanical source, but the extract lacks a stated 5-HTP standardization percentage. The 100 mg serving matches the preferred standard amount, and the standard capsule provides basic delivery without a release-enhancing feature. the low normalized cost supports strong value; because 5-HTP raises serotonin, combining it with SSRIs, SNRIs, MAOIs, or other serotonin-modulating drugs may raise the risk of serotonin toxicity.

Loading alternative details
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  2. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
    Baraldi S; Hepgul N; Mondelli V; Pariante CM · Journal of clinical psychopharmacology · 2012
    Systematic review64 studies pooledMood Support for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Serotonin precursors in the treatment of depression.
    van Praag HM · Advances in biochemical psychopharmacology · 1982
    Narrative reviewMood Support for5-HTP
  8. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  9. Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Takahashi S; Takahashi R; Masumura I; Miike A · Folia psychiatrica et neurologica japonica · 1977
    Single-arm trial14 participantsMood Support for5-HTP
  10. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  11. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  12. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  13. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  14. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  15. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  16. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  17. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  18. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  19. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  20. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP