Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review.
Rawji A; Peltier MR; Mourtzanakis K; Awan S; Rana J; Pothen NJ; Afzal S · Cureus · 2024
Systematic review15 studies pooledflagStress Relief forscienceMagnesium
- Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
Randomized trial126 participantsflagStress Relief forscienceMagnesium
- Effects of zinc and magnesium supplements on postpartum depression and anxiety: A randomized controlled clinical trial.
Fard FE; Mirghafourvand M; Mohammad-Alizadeh Charandabi S; Farshbaf-Khalili A; Javadzadeh Y; Asgharian H · Women & health · 2017
Randomized trial99 participantsflagStress Relief forscienceMagnesium
- The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
Meta-analysis787 participants8 studies pooledflagDigestive Health forscienceMagnesium
- Diagnosis of magnesium-induced diarrhea.
Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
Clinical trial19 participantsflagDigestive Health forscienceMagnesium
- Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
Meta-analysis119,755 participants4 studies pooledflagBone Health forscienceMagnesium
- Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
Systematic review386 participants8 studies pooledflagBone Health forscienceMagnesium
- Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
Randomized trial48 participantsflagBone Health forscienceMagnesium
- An update on magnesium and bone health.
Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
Narrative reviewflagBone Health forscienceMagnesium
- Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
Cross-sectional study1,343 participantsflagBone Health forscienceMagnesium
- Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
Meta-analysis313,041 participants16 studies pooledflagCardiovascular Support forscienceMagnesium
- Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
Meta-analysis532,979 participants19 studies pooledflagCardiovascular Support forscienceMagnesium
- Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
Meta-analysis544,581 participants18 studies pooledflagCardiovascular Support flagHeart Health forscienceMagnesium
- Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
Meta-analysisflagCardiovascular Support flagHeart Health forscienceMagnesium
- Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
Meta-analysis200,934 participants20 studies pooledflagCardiovascular Support forscienceMagnesium
- Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study.
McKinney E; Stewart J; Kewalramani R; Singh S · Trials · 2026
Randomized trial186 participantsflagEnergy forscienceAshwagandha
- Efficacy and Safety of Low-Dose Ashwagandha Supplementation on Exercise Endurance: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial.
Prajapati H; Satia M; Shah D; Basera I; Shah T · Phytotherapy research : PTR · 2026
Randomized trialflagEnergy forscienceAshwagandha
- Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.
Leonard M; Dickerson B; Estes L; Gonzalez DE; Jenkins V; Johnson S; Xing D; Yoo C; Ko J; Purpura M; Jäger R; Faries M; Kephart W; Sowinski R; Rasmussen CJ; Kreider RB · Nutrients · 2024
Randomized trial59 participantsflagEnergy forscienceAshwagandha
- Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits.
Vittal M; Vinciguerra M · Biogerontology · 2025
Narrative reviewflagEnergy forscienceAshwagandha
- Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study.
Kale S; Lopresti A; Suri R; Garg N; Langade D · Journal of psychoactive drugs · 2026
Randomized trial120 participantsflagEnergy forscienceAshwagandha
- Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
Randomized trial80 participantsflagEnergy forscienceMagnesium
- Total magnesium intake and risk of frailty in older women.
Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
Cohort study81,524 participantsflagEnergy flagFitness forscienceMagnesium
- Red blood cell magnesium and chronic fatigue syndrome.
Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
Randomized trial32 participantsflagEnergy forscienceMagnesium
- Exercise, magnesium and immune function.
Laires MJ; Monteiro C · Magnesium research · 2008
Narrative reviewflagEnergy forscienceMagnesium
- Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial.
Ziegenfuss TN; Kedia AW; Sandrock JE; Raub BJ; Kerksick CM; Lopez HL · Nutrients · 2019
Randomized trial38 participantsflagFitness forscienceAshwagandha
- Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults.
Choudhary B; Shetty A; Langade DG · Ayu · 2016
Randomized trial50 participantsflagFitness flagGeneral Health forscienceAshwagandha
- Effects of Ashwagandha ( Withania somnifera) standardized root extract on physical endurance and VO 2max in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study.
Verma N; Gupta SK; Patil S; Tiwari S; Mishra AK · F1000Research · 2024
Randomized trial80 participantsflagFitness flagGeneral Health forscienceAshwagandha
- Effects of Withania somnifera (L.) Dunal (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
Zhu X; Zeng Q; Lei Y; Xu D · Frontiers in pharmacology · 2026
Meta-analysis1,249 participants20 studies pooledflagFitness flagTestosterone Support forscienceAshwagandha
- Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists.
Shenoy S; Chaskar U; Sandhu JS; Paadhi MM · Journal of Ayurveda and integrative medicine · 2013
Randomized trial40 participantsflagFitness forscienceAshwagandha
- Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
Welch AA; Skinner J; Hickson M · Nutrients · 2018
Cross-sectional study156,575 participantsflagFitness forscienceMagnesium
- Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women.
Welch AA; Kelaiditi E; Jennings A; Steves CJ; Spector TD; MacGregor A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
Cross-sectional study2,570 participantsflagFitness forscienceMagnesium
- Nutritional intake as a determinant of high-speed resistance and multicomponent training efficacy on strength in older women at risk of sarcopenia. A randomized clinical trial.
Polo-Ferrero L; Recio-Rodriguez JI; González-Manzano S; MartÃn-Vallejo J; Barbero-Iglesias FJ; Montero-ErrasquÃn B; Cruz-Jentoft AJ; Méndez-Sánchez R · Clinical nutrition (Edinburgh, Scotland) · 2025
Randomized trial80 participantsflagFitness forscienceMagnesium
- Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
van Dronkelaar C; Fultinga M; Hummel M; Kruizenga H; Weijs PJM; Tieland M · Journal of the American Medical Directors Association · 2023
Systematic review45 studies pooledflagFitness forscienceMagnesium
- A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
Deshpande A; Irani N; Balkrishnan R; Benny IR · Sleep medicine · 2021
Randomized trial150 participantsflagGeneral Health flagSleep Support forscienceAshwagandha
- Withania somnifera (L.) Dunal as Add-On Therapy for COPD Patients: A Randomized, Placebo-Controlled, Double-Blind Study.
Singh P; Salman KA; Shameem M; Warsi MS · Frontiers in pharmacology · 2022
Randomized trial150 participantsflagGeneral Health forscienceAshwagandha
- Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
Cheah KL; Norhayati MN; Husniati Yaacob L; Abdul Rahman R · PloS one · 2021
Meta-analysis400 participants5 studies pooledflagGeneral Health forscienceAshwagandha
- Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
Meta-analysis1,257 participants20 studies pooledflagGeneral Health forscienceMagnesium
- Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
Woods KL; Fletcher S · Lancet (London, England) · 1994
Randomized trial2,316 participantsflagGeneral Health forscienceMagnesium
- Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
Cohort study10,999 participantsflagGeneral Health forscienceMagnesium
- Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
Cohort study9,359 participantsflagGeneral Health forscienceMagnesium
- The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
Randomized trial64 participantsflagGeneral Health forscienceMagnesium
- Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
Meta-analysis1,325 participants24 studies pooledflagHeart Health forscienceMagnesium
- The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
Guerrero-Romero F; RodrÃguez-Morán M · Journal of human hypertension · 2009
Randomized trial82 participantsflagHeart Health forscienceMagnesium
- Positive effects of magnesium supplementation in metabolic syndrome.
Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
Randomized trial54 participantsflagHeart Health forscienceMagnesium
- Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial.
Thanawala S; Shah R; Alluri KV; Bhupathiraju K; Desomayanandanam P; Bhuvenendran A · Medicine · 2026
Randomized trial135 participantsflagSleep Support forscienceAshwagandha
- Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study.
Gopukumar K; Thanawala S; Somepalli V; Rao TSS; Thamatam VB; Chauhan S · Evidence-based complementary and alternative medicine : eCAM · 2022
Randomized trial130 participantsflagSleep Support flagStress Relief forscienceAshwagandha
- Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study.
Langade D; Thakare V; Kanchi S; Kelgane S · Journal of ethnopharmacology · 2021
Randomized trial80 participantsflagSleep Support forscienceAshwagandha
- Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study.
Langade D; Kanchi S; Salve J; Debnath K; Ambegaokar D · Cureus · 2020
Randomized trial60 participantsflagSleep Support forscienceAshwagandha
- Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
Randomized trial320 participantsflagSleep Support forscienceMagnesium
- Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
Cohort study3,964 participantsflagSleep Support forscienceMagnesium
- Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
Randomized trial120 participantsflagSleep Support forscienceMagnesium
- The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
Randomized trial46 participantsflagSleep Support forscienceMagnesium
- A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
Randomized trial175 participantsflagSleep Support forscienceMagnesium
- An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.
Lopresti AL; Smith SJ; Malvi H; Kodgule R · Medicine · 2019
Randomized trial60 participantsflagStress Relief forscienceAshwagandha
- Shoden promotes Relief from stress and anxiety: A randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels.
Mishra DN; Kumar M · Heliyon · 2024
Randomized trial60 participantsflagStress Relief forscienceAshwagandha
- A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.
Chandrasekhar K; Kapoor J; Anishetty S · Indian journal of psychological medicine · 2013
Randomized trial64 participantsflagStress Relief forscienceAshwagandha
- Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study.
Salve J; Pate S; Debnath K; Langade D · Cureus · 2020
Randomized trial60 participantsflagStress Relief forscienceAshwagandha
- Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
Randomized trial137 participantsflagStress Relief forscienceMagnesium
- Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
Non-randomized trial60 participantsflagStress Relief forscienceMagnesium
- Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
Randomized trial45 participantsflagStress Relief forscienceMagnesium
- Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
Randomized trialflagStress Relief forscienceMagnesium
- Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: A randomized controlled trial.
Chauhan S; Srivastava MK; Pathak AK · Health science reports · 2024
Randomized trial50 participantsflagTestosterone Support forscienceAshwagandha
- Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review.
Smith SJ; Lopresti AL; Teo SYM; Fairchild TJ · Advances in nutrition (Bethesda, Md.) · 2021
Systematic review32 studies pooledflagTestosterone Support forscienceAshwagandha
- Do "testosterone boosters" really increase serum total testosterone? A systematic review.
Morgado A; Tsampoukas G; Sokolakis I; Schoentgen N; Urkmez A; Sarikaya S · International journal of impotence research · 2024
Systematic review3 studies pooledflagTestosterone Support forscienceAshwagandha
- Safety and Tolerability of Withania somnifera Root Extract in Healthy Male Participants: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Vaidya N; Agarwal R; Kshirsagar P; Ganu G; Nagore D; Mehta A; Vora A; Nair S · Food science & nutrition · 2025
Randomized trial40 participantsflagTestosterone Support forscienceAshwagandha
- Magnesium and anabolic hormones in older men.
Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
Cohort study399 participantsflagTestosterone Support forscienceMagnesium
- Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
Cross-sectional study313 participantsflagTestosterone Support forscienceMagnesium
- Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
Randomized trial64 participantsflagTestosterone Support forscienceMagnesium
- The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
Meta-analysis1,600 participants25 studies pooledflagTestosterone Support forscienceMagnesium
- Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
Non-randomized trial20 participantsflagTestosterone Support forscienceMagnesium