Product Image

Omeg-AGE

Kyolic
4.8
★ ★ ★ ★ ★
(74 ratings)
Vitamin K 135 mcg
Fish Oil 1368 mg
Product Image
Score71
Strong vitamin forms and aged garlic create broad cardiovascular support. Undisclosed EPA and DHA amounts and medication-sensitive vitamin K are major trade-offs.
How scoring works
Quantity:90 Softgel(s) • (30 servings)
Goals:
Heart Health
Anti-Aging
Cardiovascular Support
Bone Health
General Health
Anti-Inflammatory Support

Score 71

Strong vitamin forms and aged garlic create broad cardiovascular support. Undisclosed EPA and DHA amounts and medication-sensitive vitamin K are major trade-offs.
How scoring works
$41.54($1.38 per serving)
Pure Formulas
$ 41.54
iHerb
$ 49.99
Report prices

Analysis

MK-7 at 135 mcg, vitamin D3, natural vitamin E, methylfolate, methylcobalamin, and active B6 use well-chosen forms. Aged garlic at 900 mg adds a substantial botanical component.

Fish oil concentrate is listed at 1,368 mg without separate EPA and DHA amounts. That omission prevents assessment of omega-3 potency, concentration, and value.

The blend fits adults seeking broad cardiovascular and bone-support nutrients in one serving. Warfarin use, other blood-thinning medicines, or fish allergy require particular caution.

Who is it for
  • Adults seeking broad cardiovascular nutrition
  • Users who want D3 with MK-7
  • People comfortable with fish oil and aged garlic
Best for
  • Vitamin D3 and K2 coverage
  • Aged garlic supplementation
  • Broad healthy-aging support

Pros

  • Uses MK-7 vitamin K2
  • Includes methylfolate and methylcobalamin
  • Provides 900 mg aged garlic
  • Adds natural vitamin E

Cons

  • EPA and DHA amounts are not disclosed
  • Fish-oil concentration cannot be judged
  • Requires three softgels
  • Premium serving cost

Warnings

  • The 135 mcg vitamin K2 amount can oppose warfarin and requires prescriber-guided consistency.
  • Fish oil and aged garlic may add to bleeding risk with anticoagulant or antiplatelet medicines.
  • Fish oil makes the formula unsuitable for people with fish allergy.

Nutrient quality

90 Highest impact

Vitamin D3, natural vitamin E, MK-7, P5P, methylfolate, and methylcobalamin are favorable forms. Aged garlic is substantial, but the active omega amounts remain unknown.

Ingredient transparency

69 High impact

Vitamin and garlic amounts are clear, but fish oil lacks EPA, DHA, concentration, and molecular-form details. Daily directions and a complete inactive-ingredient list are not supplied.

Customer satisfaction

64 Moderate impact

The aggregate rating is very strong, but the evidence base is small. No detailed experience reports are supplied, so recurring complaints and purpose fit remain uncertain.

Value for money

59 Moderate impact

Premium vitamin forms and aged garlic provide real formula value. High serving cost and unquantified omega actives make comparison with cardiovascular competitors difficult.

Report analysis

Goals

Heart Health
Heart Health
Impact
Highest effect
A+ Goal FitB+ Strength of SupportA+ CoverageA+ Formula Quality
Vitamin K · 135 mcgVitamin B12 · 75 mcgVitamin B6 · 3 mgFolate · 620 mcg DFEVitamin D · 18.8 mcg

MK-7, aged garlic, fish oil, methylfolate, methylcobalamin, and Vitamin D3 address several major cardiovascular pathways. The combination supports calcium management, homocysteine metabolism, lipids, and vascular function.

Fish-oil weight is disclosed without separate EPA and DHA amounts, which prevents a confident omega-3 potency judgment. Vitamin K may reduce warfarin’s anticoagulant effect, so warfarin users need clinician-guided dosing.

Study evidence
Vitamin K Mixed 62 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
A Goal FitB Strength of SupportA- CoverageA+ Formula Quality
Folate · 620 mcg DFEVitamin B12 · 75 mcgVitamin K · 135 mcgVitamin D · 18.8 mcg

Fish oil, aged garlic, MK-7, vitamin D3, vitamin E, methylfolate, methylcobalamin, and active B6 address several age-related cardiovascular pathways. The combination supports lipid-related nutrition, calcium handling, methylation, and antioxidant defense.

EPA and DHA amounts are not disclosed, preventing a reliable assessment of omega-3 potency. The 135 mcg MK-7 amount is strong, but vitamin K can interfere with warfarin anticoagulation and requires prescriber-guided consistency.

Study evidence
Vitamin D Supportive 50 studies
Vitamin E Supportive 19 studies
Vitamin K Supportive 27 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A- Goal FitC+ Strength of SupportA- CoverageA Formula Quality
Vitamin K · 135 mcgVitamin D · 18.8 mcgFish Oil · 1368 mgVitamin B12 · 75 mcgVitamin B6 · 3 mgVitamin E · 29.3 mgFolate · 620 mcg DFE

Fish oil, MK-7, aged garlic, folate, and vitamin E address several important cardiovascular pathways. MK-7 and aged garlic are well sized, but the fish oil label does not reveal EPA or DHA amounts.

The combination is broad and biologically coherent for lipid, vascular, antioxidant, and calcium-management support. Vitamin K2 can oppose warfarin, and aged garlic may add to bleeding risk with anticoagulant or antiplatelet medicines.

Study evidence
Fish Oil Supportive 185 studies
Folate Supportive 93 studies
Vitamin E Mixed 79 studies
Vitamin K Supportive 40 studies
Bone Health
Bone Mineral Preservation
Bone Health
Impact
High effect
B+ Goal FitA- Strength of SupportC+ CoverageC+ Formula Quality
Vitamin K · 135 mcgVitamin D · 18.8 mcg

Vitamin D3 and MK-7 vitamin K2 provide strong support for calcium handling and bone remodeling. Bioactive B vitamins add secondary support, although no calcium or magnesium is supplied.

The forms and relevant amounts are clearly disclosed, and the D3-K2 pairing is coherent. People using warfarin or another vitamin K antagonist should account for the 135 mcg MK-7 dose with their prescriber.

Study evidence
Vitamin K Supportive 78 studies
General Health
General Health
Impact
High effect
B Goal FitC Strength of SupportB CoverageA- Formula Quality
Folate · 620 mcg DFEVitamin B12 · 75 mcgVitamin D · 18.8 mcgFish Oil · 1368 mgVitamin K · 135 mcg

Vitamin D3, MK-7, active B vitamins, aged garlic, and fish oil address several important wellness pathways. The vitamin K2 amount is especially well aligned with routine bone and cardiovascular support.

The fish oil label does not disclose EPA or DHA, so its active omega-3 contribution cannot be verified. Strong supporting nutrients make the formula coherent, but the largest oil ingredient remains insufficiently characterized.

Study evidence
Fish Oil Supportive 61 studies
Vitamin K Supportive 34 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
A- Goal FitD Strength of SupportB- CoverageA- Formula Quality
Vitamin D · 18.8 mcgFish Oil · 1368 mgVitamin E · 29.3 mg

Fish oil, aged garlic, vitamin D, and natural vitamin E provide broad and credible inflammatory support. The missing EPA and DHA breakdown prevents a reliable judgment of the central omega-fat dose.

Softgel delivery and antioxidant vitamin E suit the lipid formula, but purification and independent testing are not disclosed. Fish oil and aged garlic may add to bleeding risk when used with anticoagulant or antiplatelet medicines.

Study evidence
Fish Oil Supportive 68 studies
Vitamin D Supportive 101 studies
Vitamin E Supportive 20 studies

Ingredients

IngredientAmount per serving
Calories
25 Calorie(s)
Total Fat
2 Gram(s)
Total Carbohydrates
1 Gram(s)
Protein
1 Gram(s)
Vitamin D (Cholecalciferol)
 18.8 mcg
Vitamin E (D-Alpha-Tocopherol)
 29.3 mg
Vitamin K (Menaquinone-7)
 135 mcg
Vitamin B6 (Pyridoxal 5-Phosphate Monohydrate)
 3 mg
Folate (Calcium L-5-Methyltetrahydrofolate)
 620 mcg DFE
Vitamin B12 (Methylcobalamin)
 75 mcg
Aged Garlic extract powder
900 mg
Omega-3 Fish Oil concentrate
1368 mg
Adults 18–50 Dairy Free Sugar Free
Report overview
Vitamin K (Menaquinone-7) · 135 mcg OverallScore85
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

Menaquinone-7 provides the preferred long-lasting vitamin K2 form. The 135 mcg MK-7 dose falls within the preferred clinical range. Vitamin K can reduce warfarin's anticoagulant effect, so users of this medicine need clinician-guided dosing.

View ingredientView products
Fish Oil · 1368 mg OverallScore7
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The fish oil amount is shown, but EPA and DHA are not listed separately, so active dose and concentration cannot be verified. Molecular form, purification, fish species, and independent testing are not stated. Vitamin E supports oxidation protection, but missing active amounts prevent a value calculation.

View ingredientView products
Loading alternative details
87 Performance

Vitamin D3 25 mcg (1000 IU) & K2 120 mcg

Natural Factors
<p>Moderate vitamin D3 and clinical-range MK-7 create a balanced maintenance formula with clear active amounts and strong bone and cardiovascular alignment. It omits aged garlic and fish oil, but the vitamin K contribution is easier to judge than the original’s undisclosed EPA and DHA.</p>
75 Performance

Elite Omega-3 plus D & K Natural Lemon Flavor

Carlson
<p>Fish oil, vitamin D3, and menaquinone-7 preserve the original product’s main heart-and-bone structure in a more focused formula. EPA and DHA amounts are still not disclosed and aged garlic is absent, while vitamin K may counteract warfarin-type medicines.</p>
84 Performance

D3 + K2

Nature Made
<p>All-trans MK-7 and vitamin D3 provide well-defined forms with strong heart, bone, and cardiovascular alignment. The formula omits fish oil and aged garlic and its vitamin D amount is high, but the active doses are clearer than the original’s unquantified omega-3 contribution.</p>
88 Budget

Vitamin K2 MK-7 100 mcg

Nutricost
<p>A meaningful MK-7 amount provides focused vitamin K2 support at a tiny fraction of the original serving cost. The dry capsule lacks a stated lipid carrier and omits fish oil, garlic, and the original’s other vitamins, while vitamin K still conflicts with warfarin-type medicines.</p>
86 Budget

Liquid D-3 & MK-7

NOW
<p>Menaquinone-7 and vitamin D3 provide focused bone and cardiovascular support at a much lower serving cost. The formula omits fish oil and aged garlic, and both vitamin K and total vitamin D intake require attention.</p>
85 Budget

Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
<p>Natto-derived menaquinone-7 provides a clearly characterized vitamin K2 option at a much lower serving cost. It lacks fish oil, aged garlic, and the broader vitamin base, while vitamin K requires clinician-directed use with warfarin-type medicines.</p>
70 Value

Fish Oil 1000 mg

Spring Valley
<p>Triglyceride-form fish oil with a clearly stated combined EPA and DHA amount supplies more assessable omega-3 value at a far lower serving cost. The active dose is modest and individual fatty-acid, source, purity, and oxidation details remain incomplete, while vitamin K and garlic are absent.</p>
89 Value

Mega D-3 5000 IU & MK-7 180 mcg

NOW
<p>Branded MK-7 and vitamin D3 provide strong form quality and meaningful bone and heart support at a much lower serving cost. High vitamin D and a dry capsule are limitations, and the formula omits fish oil and aged garlic, but the K2 value is excellent.</p>
86 Value

MK-7 90 mcg

Jarrow Formulas
<p>Natural menaquinone-7 provides focused vitamin K2 support with excellent label clarity and low serving cost. Fish oil, aged garlic, and the broader vitamin base are absent, while vitamin K requires clinician-directed intake with warfarin-type medicines.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  2. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  3. Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials.
    Murali S; Smith ER; Tiong MK; Tan SJ; Toussaint ND · Journal of the American Heart Association · 2024
    Systematic review9,901 participants49 studies pooledCardiovascular Support forVitamin K
  4. Intake of dietary phylloquinone and menaquinones and risk of stroke.
    Vissers LE; Dalmeijer GW; Boer JM; Monique Verschuren WM; van der Schouw YT; Beulens JW · Journal of the American Heart Association · 2014
    Cohort study35,476 participantsCardiovascular Support forVitamin K
  5. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.
    van den Heuvel EG; van Schoor NM; Lips P; Magdeleyns EJ; Deeg DJ; Vermeer C; den Heijer M · Maturitas · 2014
    Cohort study577 participantsCardiovascular Support forVitamin K
  6. Regular use of fish oil supplements and course of cardiovascular diseases: prospective cohort study.
    Chen G; Qian ZM; Zhang J; Zhang S; Zhang Z; Vaughn MG; Aaron HE; Wang C; Lip GY; Lin H · BMJ medicine · 2024
    Cohort study415,737 participantsCardiovascular Support forFish Oil
  7. Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.
    Zhuang P; Liu X; Jia W; Zheng W; Wan X; Chen W; Gu J; Li Y; Lan X; Li H; Tong W; Wu Y; Wu X; Ao Y; Ye H; Wu F; Zhu L; Zhang L; Li Y; Meng D; Tian Y; Wang A; Wu S; Zhu F; Zhang Y; Shi H; Yu X; Zhang F; Zhang Y; Jiao J · Cardiovascular diabetology · 2026
    Randomized trial415 participantsCardiovascular Support forFish Oil
  8. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  9. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  10. Vitamin D, Marine n-3 Fatty Acids, and Primary Prevention of Cardiovascular Disease Current Evidence.
    Manson JE; Bassuk SS; Cook NR; Lee IM; Mora S; Albert CM; Buring JE; VITAL Research Group · Circulation research · 2020
    Randomized trial25,871 participantsCardiovascular Support forFish Oil
  11. Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.
    Pan Z; Zeng J; Chen Z; Chen S; Yang J; Li H; Wang S; Wang J; Li N; Gong Y; Liu M; Li C · The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Cohort study389,217 participantsAnti-Aging forVitamin D
  12. Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels.
    Schöttker B; Hagen L; Zhang Y; Gào X; Holleczek B; Gao X; Brenner H · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Cohort study9,940 participantsAnti-Aging forVitamin D
  13. Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study.
    Song S; Lim JY; Kim M; Won CW; Park HY · The journal of nutrition, health & aging · 2025
    Cohort study1,292 participantsAnti-Aging forVitamin D
  14. Vitamin D deficit is associated with accelerated brain aging in the general population.
    Terock J; Bonk S; Frenzel S; Wittfeld K; Garvert L; Hosten N; Nauck M; Völzke H; Van der Auwera S; Grabe HJ · Psychiatry research. Neuroimaging · 2022
    Cross-sectional study1,865 participantsAnti-Aging forVitamin D
  15. Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
    Zhao C; Tsapanou A; Manly J; Schupf N; Brickman AM; Gu Y · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort study1,759 participantsAnti-Aging forVitamin D
  16. Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study.
    Liu S; Luo J; Xiao Z; Wu W; Liang X; Ding S; Zhao Q; Zhao X; Wang Y; Ding D · Frontiers in nutrition · 2024
    Cohort study1,550 participantsAnti-Aging forVitamin E
  17. Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study.
    Morris MC; Wang Y; Barnes LL; Bennett DA; Dawson-Hughes B; Booth SL · Neurology · 2019
    Cohort study960 participantsAnti-Aging forVitamin E
  18. Low Intake of Vitamin E Accelerates Cellular Aging in Patients With Established Cardiovascular Disease: The CORDIOPREV Study.
    Corina A; Rangel-Zúñiga OA; Jiménez-Lucena R; Alcalá-Díaz JF; Quintana-Navarro G; Yubero-Serrano EM; López-Moreno J; Delgado-Lista J; Tinahones F; Ordovás JM; López-Miranda J; Pérez-Martínez P · The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Observational study1,002 participantsAnti-Aging forVitamin E
  19. The L-shaped link between total antioxidant capacity and phenotypic age acceleration: evidence from NHANES 2003-2010.
    Wu Y; Xiang M; Zhao Y; Zhang Y; Cheng W; Deng J · Biogerontology · 2025
    Cross-sectional study16,395 participantsAnti-Aging forVitamin E
  20. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults.
    Mangialasche F; Solomon A; Kåreholt I; Hooshmand B; Cecchetti R; Fratiglioni L; Soininen H; Laatikainen T; Mecocci P; Kivipelto M · Experimental gerontology · 2014
    Cohort study140 participantsAnti-Aging forVitamin E
  21. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  22. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  23. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  24. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  25. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  26. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  27. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  28. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  29. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  30. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  31. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsAnti-Inflammatory Support forVitamin D
  32. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  33. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  34. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsAnti-Inflammatory Support forVitamin D
  35. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsAnti-Inflammatory Support forVitamin D
  36. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  37. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  38. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  39. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  40. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  41. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  42. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  43. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  44. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  45. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  46. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  47. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  48. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  49. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  50. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  51. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  52. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  53. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  54. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  55. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  56. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  57. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  58. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  59. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  60. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  61. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  62. Parenteral Nutrition Containing Fish Oil for Hospitalized Non-Intensive Care Unit (ICU) Patients: A Systematic Review, Meta-Analysis, and Cost-Effectiveness Analysis.
    Pradelli L; Heller AR; Klek S; Mayer K; Rosenthal MD; Muscaritoli M · Nutrients · 2025
    Meta-analysis29 studies pooledGeneral Health forFish Oil
  63. Effects of fish oil during hemodialysis on nutritional status and quality of life: a randomized double-blinded trial.
    Zhang C; Ge C; Wang J; Sun D · Food & nutrition research · 2022
    Randomized trial103 participantsGeneral Health forFish Oil
  64. The effects of fish oil plus vitamin D3 intervention on non-alcoholic fatty liver disease: a randomized controlled trial.
    Guo XF; Wang C; Yang T; Ma WJ; Zhai J; Zhao T; Xu TC; Li J; Liu H; Sinclair AJ; Li D · European journal of nutrition · 2022
    Randomized trial111 participantsGeneral Health forFish Oil
  65. Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality.
    O'Keefe EL; O'Keefe JH; Tintle NL; Westra J; Albuisson L; Harris WS · Mayo Clinic proceedings · 2024
    Meta-analysis117,702 participants17 studies pooledGeneral Health forFish Oil
  66. Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review.
    Marik PE; Varon J · Clinical cardiology · 2010
    Meta-analysis39,044 participants11 studies pooledGeneral Health forFish Oil
  67. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  68. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  69. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  70. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  71. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K