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5-HTP 200 mg

NutraBio
4.7
★ ★ ★ ★ ★
(771 ratings)
5-HTP 200 mg
Vitamin B6 50 mg
Product Image
Score78
Potent, convenient, and good value, but the unstated 5-HTP standardization and 50 mg B6 amount create important quality and long-term safety trade-offs.
How scoring works
Quantity:90 Capsule(s) • (90 servings)
Goals:
Mood Support
Sleep Support
Stress Relief
Weight Loss

Score 78

Potent, convenient, and good value, but the unstated 5-HTP standardization and 50 mg B6 amount create important quality and long-term safety trade-offs.
How scoring works
$21.99($0.24 per serving)
iHerb
$ 21.99
iHerb
$ 21.99
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Analysis

The 200 mg 5-HTP amount provides a potent single-ingredient focus for serotonin-related mood and sleep goals. A one-capsule serving keeps use straightforward and offers strong active-dose value.

Griffonia simplicifolia is named, but no standardization percentage is supplied for the source material. Vitamin B6 reaches 50 mg as pyridoxine hydrochloride, which is much more than most people need for routine support.

The formula is best suited to experienced users who have already assessed lower amounts and medication compatibility. Both the serotonergic action of 5-HTP and the chronic-use risk from high B6 matter more than the otherwise simple label.

Who is it for
  • Experienced 5-HTP users seeking a high-strength capsule
  • Adults prioritizing mood or sleep support
Best for
  • High-strength 5-HTP supplementation
  • One-capsule mood and sleep support

Pros

  • Provides 200 mg of 5-HTP
  • Simple one-capsule serving
  • Strong value for the active amount

Cons

  • Griffonia standardization is not stated
  • B6 amount is excessive for basic support
  • High 5-HTP amount may be unsuitable for new users

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising agents because serotonin excess may occur
  • Long-term daily intake of 50 mg pyridoxine may cause tingling, numbness, or other nerve symptoms
  • 5-HTP may cause nausea or drowsiness, so assess tolerance before driving

Nutrient quality

76 High impact

The 5-HTP source is identified, while vitamin B6 uses conventional pyridoxine hydrochloride. The 5-HTP amount is substantial for its intended use.

Ingredient transparency

82 Highest impact

Both active ingredients have explicit amounts. Inactive capsule ingredients are not disclosed.

Customer satisfaction

69 High impact

The supplied average and volume indicate strong aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

83 Highest impact

The substantial 5-HTP amount supports the cost, but excessive vitamin B6 reduces formula quality. Serving value appears reasonable for a high-strength 5-HTP product.

Report analysis

Goals

Mood Support
Mood Support
Impact
Highest effect
A- Goal FitA- Strength of SupportC+ CoverageA+ Formula Quality
Vitamin B6 · 50 mg5-HTP · 200 mg

5-HTP directly supports serotonin synthesis, and vitamin B6 supplies a necessary conversion cofactor. The focused pairing is strongly aligned with mood support, although response and tolerability vary.

The 5-HTP amount is potent and fully disclosed, while Griffonia standardization is not stated. Combining 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines can cause serotonin excess, and long-term 50 mg vitamin B6 intake may increase nerve-damage risk.

Study evidence
5-HTP Supportive 9 studies
Vitamin B6 Supportive 19 studies
Sleep Support
Sleep Support
Impact
High effect
B- Goal FitA- Strength of SupportC+ CoverageB+ Formula Quality

5-HTP provides a direct precursor for serotonin and melatonin synthesis, so the formula is meaningfully related to sleep. Evidence for supplemental 5-HTP improving sleep is less established than evidence for melatonin itself.

The active amount is substantial and clearly disclosed, with vitamin B6 included as a cofactor. The high B6 amount may raise neuropathy risk with long-term use, and 5-HTP can be unsafe with serotonergic medicines such as SSRIs or MAO inhibitors.

Study evidence
5-HTP Supportive 1 study
Vitamin B6 Disputed 7 studies
Stress Relief
Stress Relief
Impact
High effect
C+ Goal FitB+ Strength of SupportC- CoverageA- Formula Quality
Vitamin B6 · 50 mg

5-HTP supports serotonin production and may help stress-related mood or sleep, but it is less directly targeted than established calming or adaptogenic ingredients. Human evidence is mixed and depends on the specific use.

The 200 mg 5-HTP amount is potent, and vitamin B6 supports its conversion pathway. Avoid combining 5-HTP with serotonin-raising medicines such as SSRIs or MAO inhibitors, while the 50 mg vitamin B6 amount is also unsuitable for casual long-term stacking with other high-B6 products.

Study evidence
5-HTP Supportive 18 studies
Vitamin B6 Supportive 10 studies
Weight Loss
Weight Loss
Impact
High effect
D+ Goal FitB+ Strength of SupportD+ CoverageB Formula Quality

The high-strength 5-HTP amount may help appetite control when cravings or emotional eating are prominent. Weight-loss evidence remains limited, and no thermogenic, fiber, or lean-mass pathway is present.

The 200 mg serving is fully disclosed, but Griffonia standardization is absent and 50 mg vitamin B6 is unusually high for daily long-term use. Avoid combining 5-HTP with serotonin-raising medicines, while prolonged high vitamin B6 intake from multiple sources can damage nerves.

Study evidence
5-HTP Supportive 5 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 50 mg
5-HTP (Griffonia simplicifolia)
 200 mg
Gluten Free Adults 18–50 Kosher Dairy Free Sugar Free Vegetarian
Report overview
5-HTP (Griffonia simplicifolia) · 200 mg OverallScore75
B- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyA+ Value

The high-strength amount and vegetable capsule support users seeking a potent 5-HTP serving. Griffonia is identified, but the source lacks a standardization percentage and no specialized release system is stated. Avoid combining 5-HTP with serotonin-raising drugs, while the unusually high vitamin B6 amount may be unsuitable for long-term use alongside other B6 sources because excess intake can harm nerves.

View ingredientView products
Vitamin B6 (Pyridoxine Hydrochloride) · 50 mg OverallScore68
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

The formula pairs a preferred-range dose of pyridoxine hydrochloride with 200 mg of 5-HTP. One capsule is convenient and the serving cost is reasonable for the combination. The 5-HTP may compound serotonergic effects with medicines such as SSRIs or MAO inhibitors, creating a product-specific interaction concern.

View ingredientView products
Loading alternative details
81 Performance

5-HTP Plus+ 200 mg

NatureWise
<p>The same high-strength 5-HTP concept is paired with active pyridoxal 5-phosphate rather than a large pyridoxine dose. Extract standardization is absent, and the substantial 5-HTP exposure requires particular caution with serotonergic medicines.</p>
80 Performance

5-HTP 5-Hydroxytryptophan 100 mg

Natural Factors Stress-Relax
<p>A lower 5-HTP amount with time-release delivery may offer a more measured option than the original high-strength capsule. It removes the excessive B6 dose, but extract standardization and serotonin-related interaction concerns remain.</p>
84 Performance

5-HTP 50 mg

NOW
<p>A starting-level 5-HTP amount avoids the original product's high 5-HTP and vitamin B6 exposure. It may be easier to titrate cautiously, though it still interacts with serotonin-raising medicines.</p>
83 Budget

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
<p>A lower-cost formula halves the 5-HTP amount and greatly reduces vitamin B6 while adding vitamin C. It may be a more moderate starting point than the original, but 5-HTP still should not be combined with serotonergic medicines without clinician approval.</p>
83 Budget

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
<p>A cheaper serving uses half as much 5-HTP and substantially less vitamin B6, with vitamin C included. The more moderate amounts improve balance, although serotonin-related medicine interactions remain.</p>
85 Budget

5-HTP 100 mg

NOW
<p>A lower-cost single-active capsule provides a standard 5-HTP amount without the original high vitamin B6 dose. Griffonia seed is named but not standardized, and serotonin-raising medicines remain a safety concern.</p>
83 Value

5-HTP 200mg

Best Naturals
<p>The same high 5-HTP amount is available at lower serving cost without the original high vitamin B6 dose. The Griffonia source lacks a standardization percentage, and strong serotonin exposure still requires medication screening.</p>
85 Value

5-HTP 100 mg

Doctor's Best
<p>A standard 5-HTP serving provides a more moderate dose and much better routine value. The focused formula omits B6 and keeps the same important serotonergic medicine warning.</p>
80 Value

5-HTP 100 mg Time Release

Natrol
<p>A time-release standard 5-HTP amount may spread exposure and improve stomach comfort for some users. It costs slightly more per serving than the original, but avoids excessive B6 and may offer a more balanced dose.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  2. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
    Baraldi S; Hepgul N; Mondelli V; Pariante CM · Journal of clinical psychopharmacology · 2012
    Systematic review64 studies pooledMood Support for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Serotonin precursors in the treatment of depression.
    van Praag HM · Advances in biochemical psychopharmacology · 1982
    Narrative reviewMood Support for5-HTP
  8. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  9. Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Takahashi S; Takahashi R; Masumura I; Miike A · Folia psychiatrica et neurologica japonica · 1977
    Single-arm trial14 participantsMood Support for5-HTP
  10. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  11. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  12. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  13. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  14. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  15. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  16. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  17. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  18. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  19. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  20. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  21. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  22. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  23. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  24. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  25. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  26. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forVitamin B6
  27. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  28. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  29. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6
  30. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  31. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  32. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  33. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  34. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP