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MagSRT

Jigsaw Health
4.7
★ ★ ★ ★ ★
(6714 ratings)
Magnesium 500 mg
Folate 200 mcg
Product Image
Score79
Dimagnesium malate pairs with active vitamin B6, methylfolate, and methylcobalamin in a focused, well-formed magnesium formula. The large supplemental magnesium amount may cause diarrhea or abdominal cramping in sensitive users, and the higher serving cost reduces value.
How scoring works
Quantity:240 Tablet(s) • (60 servings)
Goals:
Energy
General Health
Cardiovascular Support
Stress Relief
Heart Health
Fitness
Bone Health
Sleep Support
Testosterone Support

Score 79

Dimagnesium malate pairs with active vitamin B6, methylfolate, and methylcobalamin in a focused, well-formed magnesium formula. The large supplemental magnesium amount may cause diarrhea or abdominal cramping in sensitive users, and the higher serving cost reduces value.
How scoring works

Also available as

1 option
120 servings B9 200 mcg, Magnesium 500 mg • 120 Tablet(s) • 30 servings $27.97 ($0.93 per serving)
$46.19($0.76 per serving)
Walmart
$ 49.97
Vitacost
$ 49.97
Vitacost
$ 49.97
Amazon
$ 46.19
iHerb
$ 49.97
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Analysis

Dimagnesium malate pairs with active vitamin B6, methylfolate, and methylcobalamin in a focused, well-formed magnesium formula. The large supplemental magnesium amount may cause diarrhea or abdominal cramping in sensitive users, and the higher serving cost reduces value.

Dimagnesium malate provides a well-absorbed form with supportive active vitamin B6. The elemental dose is clear but sits above the preferred range.

Dimagnesium malate and active vitamin B6 directly support ATP metabolism and cellular fuel use. Evidence supports magnesium for normal energy metabolism, while the added B vitamins are relevant metabolic cofactors.

Who is it for
  • Adults focused on energy
  • Adults focused on general health
  • Adults focused on cardiovascular support
Best for
  • Magnesium supplementation
  • Folate supplementation

Pros

  • Provides a disclosed 500.00mg of magnesium
  • Provides a disclosed 5.00mg of vitamin b6
  • Provides a disclosed 6.00mcg of vitamin b12

Cons

  • The magnesium amount may cause digestive upset
  • The serving cost is relatively high
  • The formula is narrow outside magnesium and B vitamins

Warnings

  • The large supplemental magnesium amount may cause diarrhea or abdominal cramping in sensitive users.
  • People with impaired kidney function should not use high-dose magnesium without medical guidance.
  • Magnesium can reduce absorption of some antibiotics and thyroid medicine unless doses are separated.

Nutrient quality

86 Highest impact

Favorable forms and a substantial magnesium amount provide meaningful, focused support. The large supplemental amount may reduce tolerance for sensitive users.

.

Ingredient transparency

81 Highest impact

Active ingredients, forms, and amounts are fully clear without a hidden blend. Missing use directions, excipients, and sustained-release materials are the remaining gaps.

.

Customer satisfaction

71 High impact

The aggregate satisfaction signal is strong and supported by extensive volume. Missing review details prevent assessment of tolerance complaints or purpose fit.

.

Value for money

76 High impact

Strong forms and complete active disclosure justify moderate serving value. Less costly magnesium products may compete on price but often lack the same cofactor quality.

.
Report analysis

Goals

Energy
Energy
Impact
Highest effect
A Goal FitA+ Strength of SupportB CoverageA+ Formula Quality
Magnesium · 500 mgVitamin B12 · 6 mcg

Dimagnesium malate and active vitamin B6 directly support ATP metabolism and cellular fuel use. Evidence supports magnesium for normal energy metabolism, while the added B vitamins are relevant metabolic cofactors.

The magnesium amount exceeds the preferred minimum, though vitamin B12 remains below the targeted threshold. Dimagnesium malate, methylcobalamin, active vitamin B6, and methylfolate are clearly disclosed high-quality forms.

Study evidence
Magnesium Supportive 4 studies
General Health
General Health
Impact
Highest effect
A+ Goal FitA- Strength of SupportB CoverageA Formula Quality
Folate · 200 mcgVitamin B12 · 6 mcgMagnesium · 500 mg

Dimagnesium malate supplies a bioavailable foundational mineral for energy, nerve, and muscle function. Active vitamin B6, methylfolate, and methylcobalamin add coherent support for cellular metabolism.

The 500 mg magnesium amount is above a typical maintenance range despite clear elemental disclosure. The four-tablet serving is substantial, but the formula provides meaningful depth across connected metabolic pathways.

Study evidence
Folate Supportive 80 studies
Magnesium Supportive 114 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A- Goal FitB+ Strength of SupportB CoverageA Formula Quality
Magnesium · 500 mgVitamin B12 · 6 mcgVitamin B6 · 5 mgFolate · 200 mcg

Absorbable dimagnesium malate supports vascular tone and heart rhythm, while active B vitamins add homocysteine-related support. The combination covers more than one cardiovascular pathway with clear ingredient forms.

The magnesium amount sits above the preferred range used here and may reduce tolerability for some people. The B-vitamin amounts are supportive rather than a substitute for a dedicated homocysteine strategy.

Study evidence
Folate Supportive 93 studies
Magnesium Supportive 123 studies
Stress Relief
Stress Relief
Impact
Highest effect
A- Goal FitB+ Strength of SupportB+ CoverageA- Formula Quality
Magnesium · 500 mgFolate · 200 mcgVitamin B12 · 6 mcgVitamin B6 · 5 mg

Dimagnesium malate provides substantial foundational support for nervous-system regulation, with active forms of vitamin B6, folate, and B12 adding neurotransmitter support. The formula is well targeted to chronic stress resilience, though it does not contain a direct calming amino acid or adaptogenic herb.

The elemental magnesium amount is clearly stated but exceeds the preferred supplemental range. Four tablets are needed, and the large dose may cause digestive discomfort in sensitive people.

Study evidence
Folate Supportive 19 studies
Magnesium Supportive 13 studies
Vitamin B6 Supportive 10 studies
Heart Health
Heart Health
Impact
Highest effect
B+ Goal FitA- Strength of SupportB- CoverageA Formula Quality
Magnesium · 500 mgVitamin B12 · 6 mcgVitamin B6 · 5 mgFolate · 200 mcg

Dimagnesium malate may support heart rhythm and vascular tone, while active B vitamins add metabolic support. The sustained-release design may improve tolerance across a four-tablet serving.

The magnesium amount is above the preferred routine range, and no patented magnesium source is identified. The high supplemental magnesium amount may cause diarrhea or abdominal cramping.

Study evidence
Magnesium Supportive 158 studies
Fitness
Fitness
Impact
High effect
C Goal FitA Strength of SupportC CoverageA- Formula Quality
Magnesium · 500 mg

Magnesium malate supports muscle contraction and energy metabolism, especially when training or diet leaves magnesium intake low. Active B-vitamin forms complement energy pathways, although they are unlikely to improve performance when nutrient status is adequate.

The disclosed mineral amount and defined forms make the formula easy to assess. Its strong focus on micronutrient support leaves power, blood flow, and exercise recovery proteins uncovered.

Study evidence
Magnesium Disputed 29 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxal 5-Phosphate Monohydrate)
 5 mg
Folate (Quatrefolic 5-Methyltetrahydrofolic Acid Glucosamine Salt)
 200 mcg
Vitamin B12 (Methylcobalamin)
 6 mcg
Magnesium (DiMagnesium Malate)
 500 mg
Malic Acid (DiMagnesium Malate)
 1436 mg
Gluten Free Adults 18–50 Vegan Vegetarian
Report overview
Magnesium (DiMagnesium Malate) · 500 mg OverallScore73
B- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value
+2

Dimagnesium malate provides a well-absorbed form with supportive active vitamin B6. The elemental dose is clear but sits above the preferred range. The higher serving cost is partly justified by formulation quality, though no patented magnesium material is named.

View ingredientView products
Folate (Quatrefolic 5-Methyltetrahydrofolic Acid Glucosamine Salt) · 200 mcg OverallScore70
A+ Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyD- Value

Quatrefolic provides a validated body-ready folate form within a magnesium-focused formula. The amount is below the target range, and methylcobalamin is present below the preferred level. Value is average for active folate because most of the serving is designed around magnesium.

View ingredientView products
Loading alternative details
91 Performance

Krebs Magnesium Potassium Complex

Nature's Way
<p>Magnesium lysinate and malate provide favorable forms, while 95 mg potassium adds useful mineral breadth. The 250 mg magnesium amount is more moderate than the original’s dose, though folate, B6, and B12 are not included.</p>
85 Performance

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate gives this focused powder a clearly identified premium form at 200 mg. It may suit users wanting a more moderate amount, but it does not preserve the original’s malate or active B-vitamin cofactors.</p>
82 Performance

Albion DiMagnesium Malate

Swanson Ultra
<p>Albion dimagnesium malate closely matches the original’s central ingredient in a clearly disclosed 400 mg formula. The focused alternative removes folate, B6, B12, and added malic acid, while the substantial magnesium amount may still loosen stools.</p>
80 Budget

Magnesium Caps 500 mg

Life Extension
<p>A much lower serving cost preserves the original’s 500 mg magnesium amount across citrate, succinate, glycinate, and oxide forms. Oxide lowers average form quality, and the large amount may cause diarrhea or cramping while active folate, B6, and B12 are absent.</p>
83 Budget

Magnesium Citrate 420 mg

Nutricost
<p>A substantially lower serving cost provides 420 mg magnesium citrate in a focused formula. Citrate may loosen stools, and the simpler product does not include the original’s active folate, B6, B12, or malic acid.</p>
88 Budget

Magnesium Bisglycinate Powder

NOW
<p>Low serving cost and 250 mg magnesium bisglycinate offer a well-formed, adjustable alternative. The amount is gentler than the original’s 500 mg, but the powder omits malate and the active B-vitamin cofactors.</p>
85 Value

Magnesium Bisglycinate 200 mg

Natural Factors
<p>A moderate 200 mg bisglycinate amount provides a strong quality-to-cost balance with a simple label. The lower dose may be easier to fit into routine use, although the original’s malate and active B-vitamin cofactors are absent.</p>
82 Value

Advanced Magnesium Complex

AOR Advanced Orthomolecular Research Advanced
<p>Glycinate, malate, aspartate, and ascorbate provide broad form coverage with useful glycine at favorable serving value. The label does not separate elemental magnesium by form, and the formula omits the original’s folate, B6, and B12.</p>
85 Value

Cal/Mag 500 mg/250 mg

NaturesPlus
<p>Amino-acid-chelated magnesium and calcium offer a balanced mineral formula at strong serving value. Magnesium is supplied at a more moderate 250 mg, but calcium replaces the original’s active folate, B6, B12, and added malic acid.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  2. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  3. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  4. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  5. Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial.
    Yoneda H; Tomita T; Kitano T; Morishita D; Kodani M; Nishii N; Sei H; Eda H; Sato T; Kawai M; Yokoyama Y; Igeta M; Okugawa T; Fukui H; Shinzaki S · Neurogastroenterology and motility · 2026
    Randomized trial40 participantsDigestive Health forMagnesium
  6. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  7. Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.
    Wei H; Jin Z; Zhou L; Tang G; Chai S; Che X; Tan Y; Zeng W · Frontiers in endocrinology · 2025
    Cross-sectional study1,315 participantsBone Health forFolate
  8. Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
    Liu CT; Karasik D; Xu H; Zhou Y; Broe K; Cupples LA; Cpgm de Groot L; Ham A; Hannan MT; Hsu YH; Jacques P; McLean RR; Paul L; Selhub J; Trajanoska K; van der Velde N; van Schoor N; Kiel DP · The American journal of clinical nutrition · 2021
    Cohort study4,310 participantsBone Health forFolate
  9. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledBone Health forFolate Bone Health forVitamin B6
  10. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
    Cagnacci A; Baldassari F; Rivolta G; Arangino S; Volpe A · Bone · 2004
    Cross-sectional study161 participantsBone Health forFolate
  11. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women.
    Rejnmark L; Vestergaard P; Hermann AP; Brot C; Eiken P; Mosekilde L · Calcified tissue international · 2008
    Cohort study1,869 participantsBone Health forFolate
  12. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  13. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  14. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  15. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  16. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  17. The Effects of the AGE Inhibitor Pyridoxamine on Bone in Older Women With Type 2 Diabetes: A Randomized Clinical Trial.
    Brossfield AV; McMahon DJ; Fernando J; Omeragic B; Majeed R; Agarwal S; Sroga GE; Wang B; Vashishth D; Rubin MR · The Journal of clinical endocrinology and metabolism · 2025
    Randomized trial55 participantsBone Health forVitamin B6
  18. Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study.
    Dai Z; Wang R; Ang LW; Yuan JM; Koh WP · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Cohort study63,257 participantsBone Health forVitamin B6
  19. Hip fracture patients may be vitamin B6 deficient. Controlled study of serum pyridoxal-5'-phosphate.
    Reynolds TM; Marshall PD; Brain AM · Acta orthopaedica Scandinavica · 1993
    Case-control study103 participantsBone Health forVitamin B6
  20. Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls.
    Saito M; Fujii K; Marumo K · Calcified tissue international · 2006
    Case-control study50 participantsBone Health forVitamin B6
  21. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  22. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  23. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  24. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  25. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  26. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  27. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  28. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  29. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  30. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  31. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  32. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  33. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  34. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  35. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy Fitness forMagnesium
  36. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  37. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsFitness forMagnesium
  38. Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women.
    Welch AA; Kelaiditi E; Jennings A; Steves CJ; Spector TD; MacGregor A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Cross-sectional study2,570 participantsFitness forMagnesium
  39. Nutritional intake as a determinant of high-speed resistance and multicomponent training efficacy on strength in older women at risk of sarcopenia. A randomized clinical trial.
    Polo-Ferrero L; Recio-Rodriguez JI; González-Manzano S; Martín-Vallejo J; Barbero-Iglesias FJ; Montero-Errasquín B; Cruz-Jentoft AJ; Méndez-Sánchez R · Clinical nutrition (Edinburgh, Scotland) · 2025
    Randomized trial80 participantsFitness forMagnesium
  40. Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
    van Dronkelaar C; Fultinga M; Hummel M; Kruizenga H; Weijs PJM; Tieland M · Journal of the American Medical Directors Association · 2023
    Systematic review45 studies pooledFitness forMagnesium
  41. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  42. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  43. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  44. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  45. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  46. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  47. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  48. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  49. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  50. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  51. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  52. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  53. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  54. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  55. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  56. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  57. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  58. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  59. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  60. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  61. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  62. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  63. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  64. Influence of folic acid on postprandial endothelial dysfunction.
    Wilmink HW; Stroes ES; Erkelens WD; Gerritsen WB; Wever R; Banga JD; Rabelink TJ · Arteriosclerosis, thrombosis, and vascular biology · 2000
    Randomized trial20 participantsStress Relief forFolate
  65. The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial.
    Bahmani F; Karamali M; Shakeri H; Asemi Z · Clinical endocrinology · 2015
    Randomized trial69 participantsStress Relief forFolate
  66. Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials.
    Taylor MJ; Carney SM; Goodwin GM; Geddes JR · Journal of psychopharmacology (Oxford, England) · 2004
    Meta-analysis247 participants3 studies pooledStress Relief forFolate
  67. Depressive symptoms and associated factors among women preparing for pregnancy: a population-based study from the Seoul metropolitan preconception health management program.
    Lee HJ; Shin W; Han JY; Choi HZ; Kang J; Woo SY · BMC women's health · 2026
    Cross-sectional study14,004 participantsStress Relief forFolate
  68. Folate administration decreases oxidative status and blood pressure in postmenopausal women.
    Cagnacci A; Cannoletta M; Xholli A; Piacenti I; Palma F; Palmieri B · European journal of nutrition · 2016
    Randomized trial30 participantsStress Relief forFolate
  69. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  70. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  71. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  72. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  73. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium Stress Relief forVitamin B6
  74. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsStress Relief forVitamin B6
  75. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  76. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  77. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6
  78. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  79. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  80. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  81. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  82. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium