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Alive! Calcium Bone Formula

4.7
★ ★ ★ ★ ★
(3129 ratings)
Vitamin K 150 mcg
Magnesium 273 mg
Product Image
Score70
Broad bone nutrients are useful, but ambiguous mineral totals, opaque blends, and very high vitamin D weaken the formula.
How scoring works
Tablet
Quantity:180 Tablet(s) • (45 servings)
Goals:
Bone Health
General Health
Heart Health
Anti-Aging
Joint Health
Cardiovascular Support

Score 70

Broad bone nutrients are useful, but ambiguous mineral totals, opaque blends, and very high vitamin D weaken the formula.
How scoring works
$30.32($0.67 per serving)
Vitacost
$ 35.03
iHerb
$ 30.32
Vitacost
$ 35.03
Report prices

Analysis

Calcium from red algae, magnesium, vitamin D3, and MK-7 address the main nutrient pathways needed for bone maintenance. The same nutrients also provide some cardiovascular and general-health support.

Several magnesium forms are listed at the same amount, making the true total difficult to interpret from the supplied label. Fruit, vegetable, and greens blends add ingredients without enough detail to judge a meaningful contribution.

The four-tablet serving delivers broad mineral coverage but is cumbersome. Vitamin D reaches the usual adult daily upper intake level, so total intake from other products matters.

Who is it for
  • Adults seeking combined bone nutrients
  • People who prefer calcium and magnesium in one formula
Best for
  • Bone-mineral support
  • Vitamin D and K2 coverage

Pros

  • Includes calcium, magnesium, D3, and MK-7
  • Red-algae calcium source
  • Broad bone-pathway coverage

Cons

  • Duplicate mineral entries obscure totals
  • Four-tablet serving
  • Plant blends are poorly characterized

Warnings

  • Vitamin D3 at 100 mcg reaches the usual adult daily upper intake level, so account for other vitamin D sources
  • MK-7 can counter vitamin K antagonist medicines such as warfarin
  • Magnesium may loosen stools in sensitive users

Nutrient quality

75 High impact

The main bone nutrients use several sound forms and meaningful amounts. Mixed magnesium forms and an aggressive mineral load temper that strength.

Ingredient transparency

65 Moderate impact

Core nutrient amounts and forms are mostly easy to evaluate. Opaque plant blends, missing non-active ingredients, and incomplete directions leave notable gaps.

Customer satisfaction

73 High impact

The aggregate rating is favorable and backed by a very large review volume. No specific comments are available to assess recurring problems or real-world fit.

Value for money

68 High impact

The core mineral and vitamin combination provides reasonable value. The multi-tablet serving and low-value plant blends reduce efficiency.

Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A+ Goal FitA- Strength of SupportA- CoverageB- Formula Quality
Vitamin K · 150 mcgMagnesium · 273 mgCalcium · 1.3 Gram(s)Vitamin D · 100 mcgBoron · 177 mcg

Calcium, magnesium, vitamin D3, and MK-7 create comprehensive support for mineral supply, absorption, and proper calcium placement. Most major amounts are substantial, although magnesium oxide weakens the mixed magnesium profile.

Trace strontium and boron add only limited depth, while fruit and greens blends do not materially strengthen bone support. Vitamin K2 can counteract warfarin and related vitamin K antagonists, making clinician-guided consistency important for users of those medicines.

Study evidence
Boron Supportive 5 studies
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Strontium Not classified

No linked studies yet.

Vitamin K Supportive 78 studies
General Health
General Health
Impact
Highest effect
A- Goal FitB+ Strength of SupportB CoverageB+ Formula Quality
Vitamin D · 100 mcgMagnesium · 273 mgVitamin K · 150 mcgBoron · 177 mcg

Calcium, magnesium, vitamin D3, and vitamin K2 create a strong foundation for bone and mineral support. Magnesium oxide and the large tablet serving temper the otherwise coherent combination.

The formula also includes trace boron and strontium, but its fruit and greens blends are too small and opaque to add dependable breadth. The high vitamin D amount and substantial calcium intake deserve attention alongside food and other supplements.

Study evidence
Boron Supportive 6 studies
Magnesium Supportive 114 studies
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Heart Health
Heart Health
Impact
High effect
B- Goal FitA- Strength of SupportC+ CoverageB- Formula Quality
Vitamin K · 150 mcgMagnesium · 273 mgVitamin D · 100 mcg

Vitamin K2 as MK-7, vitamin D3, and magnesium create relevant support for calcium handling, vascular tone, and cardiac electrical function. The formula is still dominated by a large calcium amount and is designed mainly for bone health.

K2 and D3 are supplied at meaningful amounts, while magnesium uses a mixed form that includes oxide. Vitamin K2 can oppose warfarin, and the high supplemental calcium load may be unsuitable for users who have been advised to limit calcium.

Study evidence
Magnesium Supportive 158 studies
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Anti-Aging
Anti-Aging
Impact
High effect
B- Goal FitB+ Strength of SupportC CoverageC+ Formula Quality
Magnesium · 273 mgVitamin K · 150 mcgVitamin D · 100 mcg

Calcium, magnesium, vitamin D3, vitamin K2, strontium, and boron directly support skeletal integrity, an important structural need with aging. MK-7 also supports calcium handling, but the formula does not address mitochondrial decline, glycation, or neurological aging.

Key structural nutrients are substantially dosed, though magnesium includes oxide and repeated per-form totals reduce clarity. Vitamin K2 can counteract warfarin, while long-term high vitamin D intake can raise calcium and cause kidney or heart-rhythm problems.

Study evidence
Boron Not classified

No linked studies yet.

Magnesium Supportive 12 studies
Vitamin D Supportive 50 studies
Vitamin K Supportive 27 studies
Joint Health
Joint Stability
Joint Health
Impact
High effect
C+ Goal FitB- Strength of SupportC CoverageB- Formula Quality

Vitamin D3, K2 as MK-7, magnesium, calcium, boron, and strontium form a coherent bone-support formula around the joints. The K2 and vitamin D amounts are substantial, while mixed magnesium forms include lower-absorption oxide.

Large calcium content and unclear magnesium proportions reduce confidence in mineral balance and absorption. Vitamin K2 can oppose warfarin and related vitamin K antagonist medicines, so consistent intake and prescriber guidance are important.

Study evidence
Boron Supportive 3 studies
Magnesium Supportive 18 studies
Vitamin D Supportive 111 studies
Vitamin K Disputed 14 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B- Goal FitB Strength of SupportC- CoverageC Formula Quality
Vitamin K · 150 mcgMagnesium · 273 mgVitamin D · 100 mcg

Vitamin K2 as MK-7, vitamin D3, and magnesium provide a plausible vascular-calcium and blood-pressure support combination. The very large calcium dose makes this primarily a bone formula, not a balanced cardiovascular product.

K2 is well dosed and forms are disclosed, but magnesium includes oxide and repeated total amounts across sources. Vitamin K2 can interfere with warfarin and related vitamin K antagonist therapy, so use requires clinician-guided consistency.

Study evidence
Magnesium Supportive 123 studies
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Calories
5 Calorie(s)
Total Carbohydrates
1 Gram(s)
Vitamin D3 (Cholecalciferol)
 100 mcg
Calcium (Aquamin calcified mineral source Red Algae)
 1.3 Gram(s)
Magnesium (Aquamin calcified mineral source Red Algae, Magnesium Citrate, Magnesium Oxide)
 273 mg
Sodium
30 mg
Orchard Fruits & Garden Veggies Powder Blend
100 mg
Organic Greens Blend
100 mg
Strontium (Aquamin calcified mineral source Red Algae)
 9 mg
Boron (Aquamin calcified mineral source Red Algae)
 177 mcg
Vitamin K2 (Menaquinone-7)
 150 mcg
Gluten Free Adults 18–50 Dairy Free Women
Report overview
Vitamin K (Menaquinone-7) · 150 mcg OverallScore77
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

The MK-7 amount is clinically aligned and paired with substantial calcium, magnesium, and vitamin D3 for a bone-focused formula. Form and dose are clear, but the generic source and dry tablets limit absorption confidence. The multi-tablet serving and above-median cost make it less efficient for someone seeking vitamin K2 alone.

View ingredientView products
Magnesium (Aquamin calcified mineral source Red Algae, Magnesium Citrate, Magnesium Oxide) · 273 mg OverallScore49
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

The stated magnesium amount is useful, but the source combines citrate with poorly absorbed oxide and a marine mineral material without showing their proportions. A large calcium amount may compete with magnesium absorption despite the inclusion of vitamin D and boron. The costly multi-tablet serving offers weak value for systemic magnesium support.

View ingredientView products
Loading alternative details
91 Performance

Krebs Magnesium Potassium Complex

Nature's Way
<p>Magnesium lysinate and malate provide favorable forms at a useful amount with a modest potassium contribution. The formula improves magnesium quality and tablet burden, though it omits the original’s calcium, vitamin D3, and MK-7.</p>
84 Performance

D3 + K2

Nature Made
<p>All-trans MK-7 and vitamin D3 provide well-defined bone-support forms in a focused softgel. Vitamin D remains high and calcium and magnesium are absent, but form clarity is stronger than in the original mixed formula.</p>
86 Performance

Vitamin K2 MK-7 (Menaquinone-7) 90 mcg

Carlson
<p>A practical amount of MK-7 provides a well-regarded vitamin K2 form without the original’s large tablet serving. Calcium, magnesium, and vitamin D3 are absent, so it improves only the vitamin K portion of the formula.</p>
88 Budget

Vitamin K2 MK-7 100 mcg

Nutricost
<p>A meaningful MK-7 amount supplies a clearly identified vitamin K2 form at a much lower serving cost. Calcium and magnesium are absent, but the focused capsule avoids the original’s mixed magnesium forms and large tablet serving.</p>
85 Budget

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate provides a well-absorbed form and useful elemental amount at a lower serving cost. Vitamin K2, vitamin D3, and calcium are absent, but the mineral quality is more consistent than the original’s citrate-and-oxide mixture.</p>
87 Budget

Vitamin D3 25 mcg (1000 IU) & K2 120 mcg

Natural Factors
<p>Moderate vitamin D3 and MK-7 provide focused bone support at a lower serving cost. Calcium and magnesium are omitted, but the clearly identified vitamin K2 form and practical softgel improve simplicity.</p>
88 Value

Magnesium Bisglycinate Powder

NOW
<p>Magnesium bisglycinate provides an adjustable, well-absorbed amount at a low serving cost. It omits calcium, vitamin D3, and MK-7, but offers better magnesium form quality and value than the original oxide-containing blend.</p>
86 Value

Vitamins D3 2500 IU (62.5 mcg) & K2 120 mcg

NaturesPlus
<p>MK-7 and vitamin D3 provide focused bone and cardiovascular support at a very low serving cost. Calcium and magnesium are absent and the tablet lacks a lipid carrier, but the active forms offer a strong quality-to-cost trade-off.</p>
87 Value

Low Dose Vitamin K2 (MK-7) 45 mcg

Life Extension
<p>A conservative MK-7 amount provides clearly identified vitamin K2 across a long, economical supply. It does not replace calcium, magnesium, or vitamin D3, but it offers a less aggressive and simpler vitamin K option.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis.
    Chen HG; Sheng LT; Zhang YB; Cao AL; Lai YW; Kunutsor SK; Jiang L; Pan A · European journal of nutrition · 2020
    Meta-analysis222,592 participants21 studies pooledHeart Health General Health Cardiovascular Support forVitamin K
  2. Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.
    Cheung AM; Tile L; Lee Y; Tomlinson G; Hawker G; Scher J; Hu H; Vieth R; Thompson L; Jamal S; Josse R · PLoS medicine · 2009
    Randomized trial440 participantsBone Health General Health forVitamin K
  3. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support General Health forMagnesium
  4. The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis.
    Leenders NHJ; Vermeulen EA; van Ballegooijen AJ; Hoekstra T; de Vries R; Beulens JW; Vervloet MG · Clinical nutrition (Edinburgh, Scotland) · 2021
    Meta-analysis348,059 participants33 studies pooledCardiovascular Support General Health forMagnesium
  5. Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults.
    Joris PJ; Plat J; Bakker SJ; Mensink RP · Scientific reports · 2018
    Randomized trial52 participantsCardiovascular Support Heart Health forMagnesium
  6. Effects of Magnesium Citrate, Magnesium Oxide, and Magnesium Sulfate Supplementation on Arterial Stiffness: A Randomized, Double-Blind, Placebo-Controlled Intervention Trial.
    Schutten JC; Joris PJ; Groendijk I; Eelderink C; Groothof D; van der Veen Y; Westerhuis R; Goorman F; Danel RM; de Borst MH; Bakker SJL · Journal of the American Heart Association · 2022
    Randomized trial164 participantsHeart Health forMagnesium
  7. Magnesium Disorders and Prognosis in Heart Failure: A Systematic Review.
    Voultsos P; Bazmpani MA; Papanastasiou CA; Papadopoulos CE; Efthimiadis G; Karvounis H; Kalogeropoulos AP; Karamitsos TD · Cardiology in review · 2022
    Systematic review13,539 participants8 studies pooledHeart Health forMagnesium
  8. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  9. Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.
    Witham MD; Lees JS; White M; Band M; Bell S; Chantler DJ; Ford I; Fulton RL; Kennedy G; Littleford RC; McCrea IV; McGlynn D; Panarelli M; Ralston MR; Rutherford E; Severn A; Thomson N; Traynor JP; Struthers AD; Wetherall K; Mark PB · Journal of the American Society of Nephrology : JASN · 2021
    Randomized trial159 participantsHeart Health forVitamin K
  10. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  11. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsHeart Health Cardiovascular Support forVitamin K
  12. Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials.
    Murali S; Smith ER; Tiong MK; Tan SJ; Toussaint ND · Journal of the American Heart Association · 2024
    Systematic review9,901 participants49 studies pooledCardiovascular Support forVitamin K
  13. Impact of oral magnesium supplementation on glycemic and cardiometabolic outcomes in prediabetic adults: a systematic review and meta-analysis.
    Basit A; Kumar S; Ahmed H; Babar R; Saeed SS; Siddiqui TA; Khan S; Saeed A; Khan M; Hanif H; Fasih A; Shabbir S; Kumar H; Kumar L; Raja A; Kumar S; Chander S · Journal of diabetes and metabolic disorders · 2026
    Meta-analysis384 participants5 studies pooledCardiovascular Support forMagnesium
  14. Association between magnesium deficiency scores and hip bone health in adults: a population-based study.
    Li S; Chang W; Wu G; Wang K; Sun X; Sun H; Zhou J · Magnesium research · 2025
    Cross-sectional study13,259 participantsBone Health forMagnesium
  15. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD · The American journal of clinical nutrition · 2014
    Cohort study73,684 participantsBone Health forMagnesium
  16. Dialysate Magnesium and Coronary Artery Calcification, Bone Mineral Density, and Cramping in Maintenance Hemodialysis: A Quasi-experimental Study.
    Srisuwarn P; Sethakarun S; Nongnuch A; Jongjirasiri S; Sritara C; Klyprayong P; Disthabanchong S · Kidney medicine · 2022
    Non-randomized trial40 participantsBone Health forMagnesium
  17. Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03.
    Tanaka S; Miyazaki T; Uemura Y; Miyakawa N; Gorai I; Nakamura T; Fukunaga M; Ohashi Y; Ohta H; Mori S; Hagino H; Hosoi T; Sugimoto T; Itoi E; Orimo H; Shiraki M · Journal of bone and mineral metabolism · 2018
    Randomized trial1,874 participantsBone Health forVitamin K
  18. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  19. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  20. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  21. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  22. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  23. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsAnti-Aging forMagnesium
  24. Higher Magnesium Intake Is Associated with a Lower Risk of Frailty in Older Adults.
    Dominguez LJ; Mérida DM; Donat-Vargas C; Banegas JR; Veronese N; Barbagallo M; Rodríguez-Artalejo F; Guallar-Castillón P · Journal of the American Medical Directors Association · 2024
    Cohort study1,900 participantsAnti-Aging forMagnesium
  25. Ca:Mg Ratio, APOE Cytosine Modifications, and Cognitive Function: Results from a Randomized Trial.
    Zhu X; Borenstein AR; Zheng Y; Zhang W; Seidner DL; Ness R; Murff HJ; Li B; Shrubsole MJ; Yu C; Hou L; Dai Q · Journal of Alzheimer's disease : JAD · 2021
    Randomized trial250 participantsAnti-Aging forMagnesium
  26. The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES.
    Ma J; Li P; Jiang Y; Yang X; Luo Y; Tao L; Guo X; Gao B · Nutrients · 2024
    Cross-sectional study4,692 participantsAnti-Aging forMagnesium
  27. Interpretable machine learning with SHAP analysis identifies redox-modulating dietary antioxidants for predicting accelerated biological aging.
    Zhang B; Zhang X; Ma L; Li D; Li Y; Lin S; Peng L; He L · Experimental gerontology · 2026
    Cross-sectional study8,125 participantsAnti-Aging forMagnesium
  28. Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.
    Pan Z; Zeng J; Chen Z; Chen S; Yang J; Li H; Wang S; Wang J; Li N; Gong Y; Liu M; Li C · The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Cohort study389,217 participantsAnti-Aging forVitamin D
  29. Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels.
    Schöttker B; Hagen L; Zhang Y; Gào X; Holleczek B; Gao X; Brenner H · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Cohort study9,940 participantsAnti-Aging forVitamin D
  30. Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study.
    Song S; Lim JY; Kim M; Won CW; Park HY · The journal of nutrition, health & aging · 2025
    Cohort study1,292 participantsAnti-Aging forVitamin D
  31. Vitamin D deficit is associated with accelerated brain aging in the general population.
    Terock J; Bonk S; Frenzel S; Wittfeld K; Garvert L; Hosten N; Nauck M; Völzke H; Van der Auwera S; Grabe HJ · Psychiatry research. Neuroimaging · 2022
    Cross-sectional study1,865 participantsAnti-Aging forVitamin D
  32. Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
    Zhao C; Tsapanou A; Manly J; Schupf N; Brickman AM; Gu Y · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort study1,759 participantsAnti-Aging forVitamin D
  33. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  34. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  35. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  36. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  37. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  38. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBone Health forBoron
  39. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBone Health forBoron
  40. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBone Health forBoron
  41. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBone Health forBoron
  42. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBone Health forBoron
  43. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  44. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  45. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  46. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  47. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  48. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  49. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  50. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  51. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  52. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  53. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  54. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  55. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  56. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  57. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  58. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  59. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium Heart Health forVitamin D
  60. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  61. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  62. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  63. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  64. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  65. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  66. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  67. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  68. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  69. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  70. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  71. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  72. Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea.
    Nikkhah S; Dolatian M; Naghii MR; Zaeri F; Taheri SM · Complementary therapies in clinical practice · 2015
    Randomized trial113 participantsGeneral Health forBoron
  73. Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies.
    Elewski BE; Aly R; Baldwin SL; González Soto RF; Rich P; Weisfeld M; Wiltz H; Zane LT; Pollak R · Journal of the American Academy of Dermatology · 2015
    Randomized trialGeneral Health forBoron
  74. The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.
    Toledo-Bahena ME; Bucko A; Ocampo-Candiani J; Herz-Ruelas ME; Jones TM; Jarratt MT; Pollak RA; Zane LT · Journal of drugs in dermatology : JDD · 2015
    Clinical trial336 participantsGeneral Health forBoron
  75. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA).
    Henriksson R; Capala J; Michanek A; Lindahl SA; Salford LG; Franzén L; Blomquist E; Westlin JE; Bergenheim AT; Swedish Brain Tumour Study Group · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2009
    Single-arm trial30 participantsGeneral Health forBoron
  76. Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1β, IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study
    Otilia-Constantina Rogoveanu, George Dan Mogosanu, Cornelia Bejenaru, Ludovic Everard Bejenaru, Octavian Croitoru, Johny Neamtu, Zbigniew Pietrzkowski, Tania Reyes-Izquierdo, Andrei Bita, Iulia Daria Scorei, Romulus Ion Scorei · Biological Trace Element Research · 2015
    Randomized trial78 participantsGeneral Health forBoron
  77. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  78. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  79. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  80. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  81. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  82. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  83. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  84. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  85. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  86. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  87. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  88. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  89. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  90. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  91. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  92. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  93. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  94. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  95. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  96. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  97. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  98. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K
  99. Essentiality of boron for healthy bones and joints.
    Newnham RE · Environmental health perspectives · 1995
    Randomized trial20 participantsJoint Health forBoron
  100. Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study
    Zbigniew Pietrzkowski, Michael J Phelan, Robert Keller, Cynthia Shu, Ruby Argumedo, Tania Reyes-Izquierdo · Clinical Interventions in Aging · 2014
    Randomized trial60 participantsJoint Health forBoron
  101. A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis
    Romulus Scorei, Paul Mitrut, Iulian Petrisor, Iulia Scorei · Biological Trace Element Research · 2011
    Randomized trial60 participantsJoint Health forBoron
  102. Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis.
    Zeng C; Li YS; Wei J; Xie DX; Xie X; Li LJ; Gao SG; Luo W; Xiong YL; Xiao WF; Lei GH · Scientific reports · 2018
    Meta-analysis16 studies pooledJoint Health forMagnesium
  103. Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis.
    Zeng C; Wei J; Terkeltaub R; Yang T; Choi HK; Wang YL; Xie DX; Hunter DJ; Zhang Y; Li H; Cui Y; Li LJ; Lei GH · Arthritis research & therapy · 2018
    Cross-sectional study13,947 participantsJoint Health forMagnesium
  104. Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: data from the Osteoarthritis Initiative.
    Shmagel A; Onizuka N; Langsetmo L; Vo T; Foley R; Ensrud K; Valen P · Osteoarthritis and cartilage · 2019
    Cohort study2,548 participantsJoint Health forMagnesium
  105. Associations of magnesium depletion score with the incidence and mortality of osteoarthritis: a nationwide study.
    Ma R; Zhang C; Liu J; Ren J; Huang H; Wang G; Ding Y; Li X · Frontiers in immunology · 2025
    Observational study19,394 participantsJoint Health forMagnesium
  106. Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis.
    Zhang Y; Chen T; Luo P; Li S; Zhu J; Xue S; Cao P; Zhu Z; Li J; Wang X; Wluka AE; Cicuttini F; Ruan G; Ding C · Nutrients · 2022
    Cohort study392 participantsJoint Health forMagnesium
  107. Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis.
    Wang X; Cicuttini F; Jin X; Wluka AE; Han W; Zhu Z; Blizzard L; Antony B; Winzenberg T; Jones G; Ding C · Osteoarthritis and cartilage · 2018
    Randomized trial413 participantsJoint Health forVitamin D
  108. Vitamin D Deficiency Leads to Poorer Health Outcomes and Greater Length of Stay After Total Knee Arthroplasty and Supplementation Improves Outcomes: A Systematic Review and Meta-Analysis.
    Vivek K; Kamal R; Perera E; Gupte CM · JBJS reviews · 2024
    Meta-analysis146,054 participants10 studies pooledJoint Health forVitamin D
  109. Does vitamin D improve symptomatic and structural outcomes in knee osteoarthritis? A systematic review and meta-analysis.
    Zhao ZX; He Y; Peng LH; Luo X; Liu M; He CS; Chen J · Aging clinical and experimental research · 2021
    Meta-analysis1,599 participants6 studies pooledJoint Health forVitamin D
  110. Baseline 25-hydroxyvitamin D levels predict the effects of vitamin D supplementation on joint symptoms and cartilage loss in patients with knee osteoarthritis.
    Wang T; Zheng S; Jin X; Cen H; Zhu Z; Han W; Wluka A; Cicuttini F; Cao P; Ding C · Rheumatology advances in practice · 2025
    Randomized trial413 participantsJoint Health forVitamin D
  111. The Efficacy and Safety of Disease-Modifying Osteoarthritis Drugs for Knee and Hip Osteoarthritis-a Systematic Review and Network Meta-Analysis.
    Yang W; Sun C; He SQ; Chen JY; Wang Y; Zhuo Q · Journal of general internal medicine · 2021
    Meta-analysis11,890 participants28 studies pooledJoint Health forVitamin D
  112. Low vitamin K status is associated with osteoarthritis in the hand and knee.
    Neogi T; Booth SL; Zhang YQ; Jacques PF; Terkeltaub R; Aliabadi P; Felson DT · Arthritis and rheumatism · 2006
    Cohort study672 participantsJoint Health forVitamin K
  113. Associations Between Dietary Intake of Vitamin K and Changes in Symptomatic and Structural Changes in Patients With Knee Osteoarthritis.
    Liao Z; Chang J; Zhu Z; Han W; Meng T; Zheng S; Tu L; Antony B; Winzenberg T; Wluka AE; Cicuttini F; Ding C · Arthritis care & research · 2023
    Cohort study259 participantsJoint Health forVitamin K
  114. Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study.
    Oka H; Akune T; Muraki S; En-yo Y; Yoshida M; Saika A; Sasaki S; Nakamura K; Kawaguchi H; Yoshimura N · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2010
    Cross-sectional study719 participantsJoint Health forVitamin K
  115. The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence.
    Chin KY · Nutrients · 2021
    Narrative reviewJoint Health forVitamin K
  116. Vitamin K deficiency is associated with incident knee osteoarthritis.
    Misra D; Booth SL; Tolstykh I; Felson DT; Nevitt MC; Lewis CE; Torner J; Neogi T · The American journal of medicine · 2013
    Cohort study1,180 participantsJoint Health forVitamin K
  117. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  118. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  119. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  120. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  121. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  122. Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study.
    Zaromytidou E; Koufakis T; Dimakopoulos G; Drivakou D; Konstantinidou S; Rakitzi P; Grammatiki M; Manthou E; Notopoulos A; Iakovou I; Gotzamani-Psarrakou A; Kotsa K · Metabolites · 2023
    Randomized trial90 participantsStress Relief forVitamin D
  123. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
    Charoenporn V; Tungsukruthai P; Teacharushatakit P; Hanvivattanakul S; Sriyakul K; Sukprasert S; Kamalashiran C; Tungsukruthai S; Charernboon T · Psychiatry and clinical neurosciences · 2024
    Randomized trial80 participantsStress Relief forVitamin D
  124. The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review.
    Głąbska D; Kołota A; Lachowicz K; Skolmowska D; Stachoń M; Guzek D · Nutrients · 2021
    Systematic review24 studies pooledStress Relief forVitamin D
  125. Vitamin D3 enhances mood in healthy subjects during winter.
    Lansdowne AT; Provost SC · Psychopharmacology · 1998
    Randomized trial44 participantsStress Relief forVitamin D
  126. Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary Hyperparathyroidism: A Randomized Clinical Trial.
    Shoji T; Nakatani S; Kabata D; Mori K; Shintani A; Yoshida H; Takahashi K; Ota K; Fujii H; Ueda S; Nishi S; Nakatani T; Yoshiyama M; Goto K; Hamada T; Imanishi M; Ishimura E; Kagitani S; Kato Y; Kumeda Y; Maekawa K; Matsumura T; Nagayama H; Obi Y; Ohno Y; Sai Y; Sakurai M; Sasaki S; Shidara K; Shoji S; Tsujimoto Y; Yamakawa K; Yasuda H; Yodoi S; Inaba M; Emoto M · Clinical journal of the American Society of Nephrology : CJASN · 2021
    Randomized trial326 participantsStress Relief forVitamin D