Product Image

B 100 Complex

Spring Valley
4.7
★ ★ ★ ★ ★
(634 ratings)
Riboflavin 100 mg
Thiamin 100 mg
Vitamin B5 100 mg
Vitamin B6 100 mg
Niacin 100 mg
Folate 400 mcg
Vitamin B12 100 mcg
Product Image
Score67
Best suited to energy, with the clearest benefits coming from the disclosed active ingredients. The formula does not address acute alertness, stress resilience, or major mitochondrial cofactors such as CoQ10.
How scoring works
Quantity:60 Tablet(s) • (60 servings)
Goals:
Energy
General Health

Score 67

Best suited to energy, with the clearest benefits coming from the disclosed active ingredients. The formula does not address acute alertness, stress resilience, or major mitochondrial cofactors such as CoQ10.
How scoring works

Also available as

1 option
50mg • 60 Tablet(s) servings 50mg • 60 Tablet(s) • 60 servings $4.74 ($0.07 per serving)
$6.52($0.10 per serving)
Walmart
$ 6.52
Report prices

Analysis

The complete B-vitamin profile provides focused support for normal energy metabolism when intake is low. Every chemical form is unspecified, preventing a confident absorption assessment. The very high vitamin B6 amount may cause tingling, numbness, or other nerve symptoms with prolonged daily use.

A complete B-vitamin set directly supports carbohydrate, fat, and protein metabolism. The complete B-vitamin set is supplied at very high amounts. The formula does not address acute alertness, stress resilience, or major mitochondrial cofactors such as CoQ10.

B vitamins may support homocysteine and energy metabolism when intake is inadequate. The label omits chemical forms and uses a very high B6 amount, weakening both quality and long-term suitability. The broad B-vitamin amounts are easy to see, but high quantity does not establish cardiovascular benefit.

Who is it for
  • People seeking energy support
  • People seeking general health support
  • People seeking metabolism boost support
Best for
  • Energy
  • General Health
  • Metabolism Boost

Pros

  • The complete B-vitamin profile provides focused support for normal energy metabolism when intake is low.
  • Every chemical form is unspecified, preventing a confident absorption assessment.
  • The very high vitamin B6 amount may cause tingling, numbness, or other nerve symptoms with prolonged daily use.
  • A complete B-vitamin set directly supports carbohydrate, fat, and protein metabolism.
  • The complete B-vitamin set is supplied at very high amounts.

Cons

  • The formula does not address acute alertness, stress resilience, or major mitochondrial cofactors such as CoQ10.
  • The very high vitamin B6 amount is not appropriate for indefinite daily use.
  • Most chemical forms are not identified, and several vitamins are supplied at very high amounts without a clear need.
  • The short label is focused, but missing chemical forms prevent a reliable assessment of absorption and active-form quality.
  • A B-complex alone does not address iron, zinc, vitamin D, structural proteins, or hormonal contributors to shedding.

Warnings

  • The very high vitamin B6 amount may cause tingling, numbness, or other nerve symptoms with prolonged daily use.
  • No ingredient directly targets thermogenesis, thyroid activity, glucose control, or mitochondrial transport.
  • Daily long-term use of 100 mg vitamin B6 carries a meaningful risk of tingling, numbness, or other nerve symptoms.
  • Long-term daily use may raise the risk of tingling, numbness, or other nerve symptoms.
  • Its 100 mg B6 amount is poorly suited to unsupervised long-term use.

Nutrient quality

60 Moderate impact

Chemical forms are not identified for the listed B vitamins. The vitamin B6 amount is excessive for routine long-term use and raises neuropathy concern.

Ingredient transparency

69 High impact

Listed active amounts are clear without a hidden proprietary dose. Complete directions and inactive-ingredient details remain incomplete.

Customer satisfaction

71 High impact

The aggregate rating and its volume provide a favorable top-level signal. Missing experience details prevent assessment of repeated complaints or purpose-specific satisfaction.

Value for money

69 High impact

The very low serving cost is undermined by missing form detail and excessive vitamin B6. Comparable formulas can provide a better balance of forms, safety, and cost.

Report analysis

Goals

Energy
Energy
Impact
High effect
B+ Goal FitC- Strength of SupportC+ CoverageA Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

A complete B-vitamin set directly supports carbohydrate, fat, and protein metabolism. The complete B-vitamin set is supplied at very high amounts.

The formula does not address acute alertness, stress resilience, or major mitochondrial cofactors such as CoQ10. The very high vitamin B6 amount is not appropriate for indefinite daily use.

General Health
General Health
Impact
High effect
B Goal FitD+ Strength of SupportC- CoverageB Formula Quality
Folate · 400 mcgVitamin B12 · 100 mcg

The full B-vitamin family provides focused support for energy metabolism, methylation, and neurological function. Folate and vitamin B12 are included at practical amounts alongside the other main B vitamins.

Most chemical forms are not identified, and several vitamins are supplied at very high amounts without a clear need. The vitamin B6 and niacin levels make this less suitable for automatic long-term stacking with other fortified products.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Metabolism Boost
Metabolism Boost
Impact
Moderate effect
D+ Goal FitD+ Strength of SupportD CoverageB+ Formula Quality
Biotin · 100 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

High amounts of B vitamins support the basic cofactor reactions used in cellular energy production. No ingredient directly targets thermogenesis, thyroid activity, glucose control, or mitochondrial transport.

The short label is focused, but missing chemical forms prevent a reliable assessment of absorption and active-form quality. Daily long-term use of 100 mg vitamin B6 carries a meaningful risk of tingling, numbness, or other nerve symptoms.

Study evidence
Vitamin B6 Supportive 16 studies
Hair Health
Hair Health
Impact
Moderate effect
D Goal FitC Strength of SupportD- CoverageC+ Formula Quality
Biotin · 100 mcg

Folate, biotin, B12, and niacin may support follicle activity when a B-vitamin deficiency is present. A B-complex alone does not address iron, zinc, vitamin D, structural proteins, or hormonal contributors to shedding.

All amounts are visible, but the available data does not identify the nutrient forms. Vitamin B6 is supplied at a very high level, and prolonged daily use can raise the risk of nerve injury.

Study evidence
Biotin Supportive 4 studies
Folate Mixed 15 studies
Niacin Disputed 2 studies
Vitamin B12 Disputed 17 studies
Stress Relief
Stress Relief
Impact
Moderate effect
D Goal FitD Strength of SupportF CoverageB+ Formula Quality
Folate · 400 mcgVitamin B12 · 100 mcgVitamin B6 · 100 mg

High-potency B vitamins offer indirect metabolic and nervous-system support during periods of stress. The formula lacks a dedicated adaptogen, magnesium source, or calming amino acid.

The vitamin B6 form is undisclosed and the amount reaches the chronic-use ceiling. Long-term daily use may raise the risk of tingling, numbness, or other nerve symptoms.

Study evidence
Folate Supportive 19 studies
Vitamin B6 Supportive 10 studies
Heart Health
Heart Health
Impact
Moderate effect
D+ Goal FitD- Strength of SupportC- CoverageC- Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 400 mcg

The B-complex covers a homocysteine-related pathway but gives little form information. Its 100 mg B6 amount is poorly suited to unsupervised long-term use.

Folate, B6, and B12 are logically grouped, yet their chemical forms cannot be evaluated. Chronic exposure to the high B6 serving may increase peripheral neuropathy risk.

Study evidence
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies

Ingredients

IngredientAmount per serving
Thiamine
100 mg
Riboflavin
100 mg
Niacin
100 mg
Vitamin B6
100 mg
Folate
400 mcg
Vitamin B12
100 mcg
Biotin
100 mcg
Pantothenic Acid
100 mg
Gluten Free Adults 18–50 Sugar Free
Report overview
Riboflavin · 100 mg OverallScore74
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The 100 mg serving provides high-potency support, but standard riboflavin requires conversion to its active coenzyme form. The hard-pressed one tablet may release more slowly, although no unnecessary artificial additives are listed. The serving offers exceptional value for its form and potency.

View ingredientView products
Thiamin · 100 mg OverallScore68
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The thiamin chemical form is not disclosed, which leaves source quality and absorption potential uncertain. The clearly stated amount reaches the high-potency range, although the conventional delivery format offers no special absorption advantage. A low serving cost and substantial dose make the active-dose value favorable for a B-complex.

View ingredientView products
Vitamin B5 · 100 mg OverallScore54
C- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value

The 100 mg pantothenic acid dose supports general maintenance but does not reach the intensive-support range. The label gives only generic pantothenic acid, leaving its bound chemical form uncertain. Incomplete excipient disclosure and a high normalized active cost weaken its fit for focused B5 use.

View ingredientView products
Loading alternative details
81 Performance

Fully Active B Complex with Quatrefolic

Doctor's Best
<p>Its label clearly provides 40 mg of Vitamin C as Ascorbic Acid, making it a more clearly defined vitamin b12 and niacin and thiamin and vitamin b6 and folate and riboflavin and vitamin b5 option. Compared with the original, its ingredient and goal alignment is stronger, although the input does not provide independent testing or absorption evidence.</p>
85 Performance

B-Complex Plus

Pure Encapsulations
<p>Its label clearly provides 100 mg of Thiamine as Thiamine Hydrochloride, making it a more clearly defined vitamin b12 and niacin and thiamin and vitamin b6 and riboflavin and vitamin b5 option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s folate coverage.</p>
73 Performance

B-50 Gels

Carlson
<p>Its label clearly provides 1 g of Total Fat, making it a more clearly defined niacin and thiamin and vitamin b6 and riboflavin and vitamin b5 option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s vitamin b12 and folate coverage.</p>
71 Budget

B 50 Complex

Thompson
<p>Its label clearly provides 50 mg of Thiamine as Thiamine Mononitrate, preserving relevant niacin and thiamin and vitamin b6 and folate and riboflavin and vitamin b5 coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s vitamin b12 coverage.</p>
74 Budget

B 50 Complex

Spring Valley
<p>Its label clearly provides 50 mg of Thiamine, preserving relevant niacin and thiamin and vitamin b6 and folate and riboflavin and vitamin b5 coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s vitamin b12 coverage.</p>
78 Budget

Coenzyme B-Complex Advanced

Country Life
<p>Its label clearly provides 5 mg of BioPQQ as Pyrroloquinoline Quinone Disodium Salt, preserving relevant vitamin b12 and niacin and thiamin and vitamin b6 and riboflavin and vitamin b5 coverage. It is not lower-cost than the original, but it is the closest remaining eligible fit for this category; it does not retain the original product’s folate coverage.</p>
75 Value

B-Complex

Paradise Earth's Blend
<p>Its label clearly provides 10 mg of Vitamin B-1 as Benfotiamine, keeping the formula relevant to vitamin b12 and niacin and thiamin and vitamin b6 and folate and riboflavin and vitamin b5. Compared with the original, the somewhat higher serving cost and ingredient detail create a useful quality-to-cost balance, although the input does not provide independent testing or absorption evidence.</p>
80 Value

B-Complex '100'

Solgar
<p>Its label clearly provides 100 mg of Thiamine as Thiamine Mononitrate, keeping the formula relevant to vitamin b12 and niacin and thiamin and vitamin b6 and riboflavin and vitamin b5. Compared with the original, the somewhat higher serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s folate coverage.</p>
73 Value

B-50 Gels

Carlson
<p>Its label clearly provides 1 g of Total Fat, keeping the formula relevant to niacin and thiamin and vitamin b6 and riboflavin and vitamin b5. Compared with the original, the somewhat higher serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s vitamin b12 and folate coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  2. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  3. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  4. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  5. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  6. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  7. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  8. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  9. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  10. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  11. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  12. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  13. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  14. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  15. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  16. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  17. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  18. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  19. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  20. A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia.
    Draelos ZD; Jacobson EL; Kim H; Kim M; Jacobson MK · Journal of cosmetic dermatology · 2009
    Randomized trial60 participantsHair Health forNiacin
  21. Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia.
    Watanabe Y; Nagashima T; Hanzawa N; Ishino A; Nakazawa Y; Ogo M; Iwabuchi T; Tajima M · International journal of cosmetic science · 2016
    Randomized trial102 participantsHair Health forNiacin
  22. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  23. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  24. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  25. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  26. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  27. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  28. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  29. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  30. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  31. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  32. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsHeart Health forVitamin B12
  33. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  34. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  35. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  36. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsHeart Health forVitamin B6
  37. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  38. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  39. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  40. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  41. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  42. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  43. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  44. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6
  45. Influence of folic acid on postprandial endothelial dysfunction.
    Wilmink HW; Stroes ES; Erkelens WD; Gerritsen WB; Wever R; Banga JD; Rabelink TJ · Arteriosclerosis, thrombosis, and vascular biology · 2000
    Randomized trial20 participantsStress Relief forFolate
  46. The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial.
    Bahmani F; Karamali M; Shakeri H; Asemi Z · Clinical endocrinology · 2015
    Randomized trial69 participantsStress Relief forFolate
  47. Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials.
    Taylor MJ; Carney SM; Goodwin GM; Geddes JR · Journal of psychopharmacology (Oxford, England) · 2004
    Meta-analysis247 participants3 studies pooledStress Relief forFolate
  48. Depressive symptoms and associated factors among women preparing for pregnancy: a population-based study from the Seoul metropolitan preconception health management program.
    Lee HJ; Shin W; Han JY; Choi HZ; Kang J; Woo SY · BMC women's health · 2026
    Cross-sectional study14,004 participantsStress Relief forFolate
  49. Folate administration decreases oxidative status and blood pressure in postmenopausal women.
    Cagnacci A; Cannoletta M; Xholli A; Piacenti I; Palma F; Palmieri B · European journal of nutrition · 2016
    Randomized trial30 participantsStress Relief forFolate
  50. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forVitamin B6
  51. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsStress Relief forVitamin B6
  52. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  53. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  54. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6