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Magnesium with Vitamin B6

4.8
★ ★ ★ ★ ★
(24122 ratings)
Vitamin B6 25 mg
Magnesium 400 mg
Product Image
Score76
A low-cost magnesium and B6 formula with a substantial label amount. Poorly absorbed magnesium oxide and cumulative B6 risk reduce its suitability for long-term use.
How scoring works
Tablet
Quantity:100 Tablet(s) • (33 servings)
Goals:
General Health
Energy
Stress Relief
Fitness
Heart Health
Sleep Support
Cardiovascular Support
Bone Health

Score 76

A low-cost magnesium and B6 formula with a substantial label amount. Poorly absorbed magnesium oxide and cumulative B6 risk reduce its suitability for long-term use.
How scoring works

Also available as

1 option
250 servings B6 25 mg, Magnesium 400 mg • 250 Tablet(s) • 83 servings $14.67 ($0.17 per serving)
$8.24($0.24 per serving)
Vitacost
$ 8.25
Pure Formulas
$ 8.24
Daily Vita
$ 9.07
iHerb
$ 8.24
Walmart
$ 10.95
Report prices

Analysis

The 400 mg magnesium serving supports normal muscle, nerve, bone, and energy functions, while vitamin B6 adds a metabolic cofactor. Both amounts are clearly disclosed.

Magnesium oxide is inexpensive but less absorbable than citrate, glycinate, or taurate and is more likely to loosen stools. Pyridoxine hydrochloride is also less direct than active P-5-P.

The three-tablet serving may fill a nutrient gap but is not optimized for sleep, stress, productivity, or cardiovascular use. Long-term daily exposure to 25 mg vitamin B6 deserves particular caution when other supplements also contain B6.

Who is it for
  • Adults seeking inexpensive magnesium
  • Users who can tolerate magnesium oxide
  • People tracking total vitamin B6 intake
Best for
  • Basic magnesium intake
  • Short-term nutrient-gap support
  • Bowel-motility support when tolerated

Pros

  • Clearly disclosed amounts
  • Substantial magnesium serving
  • Simple two-active formula
  • Low serving cost

Cons

  • Low-absorption magnesium oxide
  • Three tablets per serving
  • Pyridoxine rather than P-5-P
  • Narrow goal coverage

Warnings

  • Magnesium oxide at 400 mg may cause diarrhea or abdominal cramping.
  • Long-term daily vitamin B6 at 25 mg may contribute to tingling, numbness, or other nerve symptoms.
  • Stacking this product with other magnesium or B6 supplements increases the tolerance and cumulative-exposure concerns.

Nutrient quality

68 High impact

Magnesium oxide absorbs poorly, and pyridoxine requires metabolic activation. The magnesium and vitamin B6 amounts are substantial despite the weak mineral form.

.

Ingredient transparency

81 Highest impact

All meaningful active amounts are clearly disclosed. The supplied data does not include a complete inactive ingredient list.

.

Customer satisfaction

73 High impact

The aggregate satisfaction measure is supported by adequate volume. Missing feedback themes leave recurring complaints and purpose fit uncertain.

.

Value for money

82 Highest impact

The price is reasonable for the formula quality and dose. Each serving provides good cost efficiency.

.
Report analysis

Goals

General Health
General Health
Impact
Highest effect
A Goal FitB- Strength of SupportC+ CoverageA- Formula Quality
Magnesium · 400 mg

Magnesium and vitamin B6 support foundational metabolic, muscle, and nerve functions with fully disclosed amounts. The magnesium amount falls within the collection's preferred range, and vitamin B6 gives the pair a reasonable formulation rationale.

Magnesium oxide has low absorption, so the strong label amount may not translate into equally strong systemic delivery. Daily vitamin B6 is also well above routine nutritional needs, which makes prolonged continuous use a practical point of caution.

Study evidence
Magnesium Supportive 114 studies
Energy
Energy
Impact
High effect
A- Goal FitB Strength of SupportC CoverageA Formula Quality
Magnesium · 400 mg

Magnesium and vitamin B6 provide complementary cofactors for cellular energy metabolism and nerve function. Both are present at substantial disclosed amounts.

Magnesium oxide has low absorption despite the high labeled amount, which limits practical contribution. The vitamin B6 amount may contribute to nerve symptoms with prolonged daily use, and magnesium oxide may also cause loose stools.

Study evidence
Magnesium Supportive 4 studies
Stress Relief
Stress Relief
Impact
High effect
B- Goal FitC+ Strength of SupportB- CoverageA- Formula Quality
Magnesium · 400 mgVitamin B6 · 25 mg

Magnesium provides relevant foundational support for nervous-system regulation and may help with stress-related tension. The disclosed amount appears substantial enough to contribute meaningfully.

Magnesium oxide is clearly disclosed but has relatively weak absorption. Vitamin B6 adds a distinct metabolic support pathway alongside magnesium.

Study evidence
Magnesium Supportive 13 studies
Vitamin B6 Supportive 10 studies
Fitness
Fitness
Impact
High effect
A- Goal FitC Strength of SupportC- CoverageB Formula Quality
Magnesium · 400 mg

Magnesium and vitamin B6 support energy metabolism and normal nervous-system function. The 400 mg magnesium amount is substantial, but its oxide form has low systemic absorption.

Vitamin B6 is supplied at 25 mg, which is much more than basic nutritional needs. Long-term high B6 intake can cause tingling or numbness, so the formula is not ideal for unrestricted daily use.

Study evidence
Magnesium Disputed 29 studies
Heart Health
Heart Health
Impact
High effect
B- Goal FitC+ Strength of SupportC- CoverageB+ Formula Quality
Magnesium · 400 mgVitamin B6 · 25 mg

A 400 mg magnesium amount is relevant to heart rhythm and vascular tone, with vitamin B6 providing metabolic support. Magnesium oxide is the only disclosed mineral form, which limits absorption confidence and may be harder on digestion.

The focused combination does not cover lipids, cardiac energy, or homocysteine as broadly as a dedicated heart formula. The 25 mg pyridoxine amount also deserves attention when combined with other B6 supplements over long periods.

Study evidence
Magnesium Supportive 158 studies
Vitamin B6 Supportive 44 studies
Sleep Support
Sleep Support
Impact
High effect
B- Goal FitC Strength of SupportD+ CoverageA- Formula Quality
Magnesium · 400 mg

Magnesium and vitamin B6 provide a plausible relaxation-focused nutrient pair, with a substantial elemental magnesium amount. The exact quantities are clear, but magnesium oxide has low absorption and is not the preferred form for sleep.

The formula does not address circadian timing or mental overactivity through a separate calming active. The 400 mg magnesium oxide amount may cause diarrhea or abdominal discomfort, while repeated use alongside other high-B6 products may raise neuropathy risk.

Study evidence
Magnesium Supportive 23 studies
Vitamin B6 Disputed 7 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 25 mg
Magnesium (Magnesium Oxide)
 400 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Vegetarian
Report overview
Vitamin B6 (Pyridoxine Hydrochloride) · 25 mg OverallScore73
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

Pyridoxine hydrochloride supplies a well-placed B6 dose but lacks the active form and a disclosed riboflavin cofactor. Three tablets make the serving less convenient than one or two, though it stays below the stated pill-count penalty. Value is moderate for an inactive B6 product.

View ingredientView products
Magnesium (Magnesium Oxide) · 400 mg OverallScore54
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
+3

The elemental dose is clearly disclosed and falls within the preferred range. Vitamin B6 provides useful formulation support, but magnesium oxide has low absorption. The low serving cost partly offsets the weak mineral form.

View ingredientView products
Loading alternative details
79 Performance

Magnesium Taurate +

KAL
<p>Magnesium taurate and active P-5-P provide a well-dosed combination that covers both original nutrient groups. Compared with the original, taurate and active P-5-P improve magnesium and B6 form quality. The high supplemental magnesium and B6 amounts may affect tolerability with prolonged use.</p>
81 Performance

Ultra-Mag

Source Naturals
<p>Citrate, glycinate, malate, succinate, and taurinate provide broad organic magnesium-form diversity alongside vitamin B6. The organic magnesium blend improves form diversity versus an oxide-heavy formula and broadens the form options versus taurate alone. The label does not identify each magnesium form’s share, and prolonged use of the B6 amount may add nerve-related risk.</p>
79 Performance

P-5-P 50 mg

NOW
<p>Magnesium bisglycinate pairs with a moderate vitamin B6 amount in a compact formula. Bisglycinate improves magnesium form quality, while the lower B6 amount reduces but does not remove long-term dose concern. The ingredient entry does not confirm the B6 form, and the magnesium amount is far below the original products.</p>
83 Budget

Magnesium Citrate Pure Powder

Best Naturals
<p>Magnesium citrate supplies a useful amount in an adjustable and clearly labeled powder. Its lower serving cost makes it a more economical way to cover one part of the original combination. It omits vitamin B6, and citrate may loosen stools in sensitive users.</p>
85 Budget

Vitamin B6 25 mg

Solgar
<p>A focused vitamin B6 serving matches the original B6 amount without adding other active ingredients. Its lower serving cost makes it a more economical way to cover one part of the original combination. Pyridoxine is less direct than active P-5-P, and the product omits magnesium.</p>
84 Budget

P-5-P 50 mg

Nutricost
<p>Active P-5-P provides ready-to-use vitamin B6 in a simple capsule. Its lower serving cost makes it a more economical way to cover one part of the original combination. The high B6 amount may add nerve-related risk with prolonged daily use, and magnesium is absent.</p>
88 Value

Magnesium Bisglycinate Powder

NOW
<p>Magnesium bisglycinate provides a well-absorbed form at a practical amount in an adjustable powder. The lower serving cost and stronger single-nutrient form improve value, provided the missing nutrient is supplied elsewhere. It omits vitamin B6, so users seeking both nutrients would need a separate B6 source.</p>
89 Value

P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength

Swanson
<p>Active pyridoxal phosphate provides a meaningful vitamin B6 serving at a low serving cost. The lower serving cost and stronger single-nutrient form improve value, provided the missing nutrient is supplied elsewhere. It omits magnesium, and prolonged daily use of the substantial B6 amount may add nerve-related risk.</p>
85 Value

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate provides a premium chelated form and a useful elemental amount. The lower serving cost and stronger single-nutrient form improve value, provided the missing nutrient is supplied elsewhere. It is a magnesium-only powder, so it does not replace the original vitamin B6 component.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  2. The effect of magnesium supplementation on muscle fitness: a meta-analysis and systematic review.
    Wang R; Chen C; Liu W; Zhou T; Xun P; He K; Chen P · Magnesium research · 2018
    Meta-analysis542 participants14 studies pooledFitness forMagnesium
  3. Association between magnesium deficiency scores and hip bone health in adults: a population-based study.
    Li S; Chang W; Wu G; Wang K; Sun X; Sun H; Zhou J · Magnesium research · 2025
    Cross-sectional study13,259 participantsBone Health forMagnesium
  4. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  5. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  6. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD · The American journal of clinical nutrition · 2014
    Cohort study73,684 participantsBone Health forMagnesium
  7. Magnesium status and the physical performance of volleyball players: effects of magnesium supplementation.
    Setaro L; Santos-Silva PR; Nakano EY; Sales CH; Nunes N; Greve JM; Colli C · Journal of sports sciences · 2014
    Randomized trial25 participantsFitness forMagnesium
  8. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  9. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial.
    Kubota M; Ito K; Tomimoto K; Kanazaki M; Tsukiyama K; Kubota A; Kuroki H; Fujita M; Vandenplas Y · Nutrients · 2020
    Randomized trial60 participantsDigestive Health forMagnesium
  10. Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.
    Bomar MC; Ewell TR; Brown RL; Brown DM; Kwarteng BS; Abbotts KSS; Butterklee HM; Williams NNB; Wrigley SD; Walsh MA; Hamilton KL; Thomson DP; Weir TL; Bell C · Nutrients · 2025
    Randomized trial15 participantsFitness forMagnesium
  11. Dialysate Magnesium and Coronary Artery Calcification, Bone Mineral Density, and Cramping in Maintenance Hemodialysis: A Quasi-experimental Study.
    Srisuwarn P; Sethakarun S; Nongnuch A; Jongjirasiri S; Sritara C; Klyprayong P; Disthabanchong S · Kidney medicine · 2022
    Non-randomized trial40 participantsBone Health forMagnesium
  12. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsFitness Energy forMagnesium
  13. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  14. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  15. The effects of magnesium supplementation on exercise performance.
    Finstad EW; Newhouse IJ; Lukaski HC; Mcauliffe JE; Stewart CR · Medicine and science in sports and exercise · 2001
    Randomized trial32 participantsFitness forMagnesium
  16. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  17. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  18. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  19. Prospective association between dietary magnesium intake and physical performance in older women and men.
    Arias-Fernández L; Struijk EA; Caballero FF; Ortolá R; García-Esquinas E; Rodríguez-Artalejo F; Lopez-Garcia E; Lana A · European journal of nutrition · 2022
    Cohort study863 participantsFitness forMagnesium
  20. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation.
    Bu LN; Chang MH; Ni YH; Chen HL; Cheng CC · Pediatrics international : official journal of the Japan Pediatric Society · 2007
    Randomized trial45 participantsDigestive Health forMagnesium
  21. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects.
    Ryder KM; Shorr RI; Bush AJ; Kritchevsky SB; Harris T; Stone K; Cauley J; Tylavsky FA · Journal of the American Geriatrics Society · 2006
    Cross-sectional study2,038 participantsBone Health forMagnesium
  22. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  23. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsBone Health Fitness forMagnesium
  24. No Effect of Topical Application of a Commercial Magnesium Gel on Exercise Recovery in Active Individuals.
    Coates AM; Patel DV; Binet ER; Gibala MJ · International journal of sport nutrition and exercise metabolism · 2025
    Randomized trial35 participantsFitness forMagnesium
  25. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  26. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  27. Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
    van Dronkelaar C; Fultinga M; Hummel M; Kruizenga H; Weijs PJM; Tieland M · Journal of the American Medical Directors Association · 2023
    Systematic review45 studies pooledFitness forMagnesium
  28. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  29. Serum magnesium is associated with osteoporosis risk in postmenopausal women: a retrospective study and risk-prediction model.
    Shi D; Li X; Men N; Ren B; Ma Y; Wang L; Zhang Z; He K; Du X; Wang J · Frontiers in medicine · 2026
    Observational study496 participantsBone Health forMagnesium
  30. The effects of magnesium supplementation on exercise performance.
    Newhouse IJ; Finstad EW · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2000
    Systematic review12 studies pooledFitness forMagnesium
  31. Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial.
    Yoneda H; Tomita T; Kitano T; Morishita D; Kodani M; Nishii N; Sei H; Eda H; Sato T; Kawai M; Yokoyama Y; Igeta M; Okugawa T; Fukui H; Shinzaki S · Neurogastroenterology and motility · 2026
    Randomized trial40 participantsDigestive Health forMagnesium
  32. Associations of Dietary Intakes of Calcium, Magnesium, and Soy Isoflavones With Bone Fracture Risk in Men: A Prospective Study.
    Cui Y; Cai H; Zheng W; Shu XO · JBMR plus · 2026
    Cohort study61,025 participantsBone Health forMagnesium
  33. Does magnesium supplementation improve body composition and muscle strength in middle-aged overweight women? A double-blind, placebo-controlled, randomized clinical trial.
    Moslehi N; Vafa M; Sarrafzadeh J; Rahimi-Foroushani A · Biological trace element research · 2013
    Randomized trial74 participantsFitness forMagnesium
  34. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  35. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  36. The Effects of the AGE Inhibitor Pyridoxamine on Bone in Older Women With Type 2 Diabetes: A Randomized Clinical Trial.
    Brossfield AV; McMahon DJ; Fernando J; Omeragic B; Majeed R; Agarwal S; Sroga GE; Wang B; Vashishth D; Rubin MR · The Journal of clinical endocrinology and metabolism · 2025
    Randomized trial55 participantsBone Health forVitamin B6
  37. Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study.
    Dai Z; Wang R; Ang LW; Yuan JM; Koh WP · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Cohort study63,257 participantsBone Health forVitamin B6
  38. Hip fracture patients may be vitamin B6 deficient. Controlled study of serum pyridoxal-5'-phosphate.
    Reynolds TM; Marshall PD; Brain AM · Acta orthopaedica Scandinavica · 1993
    Case-control study103 participantsBone Health forVitamin B6
  39. Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls.
    Saito M; Fujii K; Marumo K · Calcified tissue international · 2006
    Case-control study50 participantsBone Health forVitamin B6
  40. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledBone Health forVitamin B6
  41. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  42. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  43. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  44. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  45. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  46. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  47. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  48. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  49. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  50. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  51. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  52. Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women.
    Welch AA; Kelaiditi E; Jennings A; Steves CJ; Spector TD; MacGregor A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Cross-sectional study2,570 participantsFitness forMagnesium
  53. Nutritional intake as a determinant of high-speed resistance and multicomponent training efficacy on strength in older women at risk of sarcopenia. A randomized clinical trial.
    Polo-Ferrero L; Recio-Rodriguez JI; González-Manzano S; Martín-Vallejo J; Barbero-Iglesias FJ; Montero-Errasquín B; Cruz-Jentoft AJ; Méndez-Sánchez R · Clinical nutrition (Edinburgh, Scotland) · 2025
    Randomized trial80 participantsFitness forMagnesium
  54. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  55. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  56. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  57. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  58. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  59. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  60. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  61. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  62. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forVitamin B6
  63. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  64. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  65. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  66. Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.
    Tao MH; Chuang SC; Wu IC; Chan HT; Cheng CW; Chen HL; Lee MM; Chang HY; Hsiung CA; Hsu CC · European journal of nutrition · 2024
    Cohort study5,663 participantsProductivity Boost forMagnesium
  67. Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients.
    Tu X; Qiu H; Lin S; He W; Huang G; Zhang X; Wu Y; He J · Neuropsychiatric disease and treatment · 2022
    Cohort study327 participantsProductivity Boost forMagnesium
  68. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
    Lopresti AL; Smith SJ · Frontiers in nutrition · 2026
    Randomized trial100 participantsProductivity Boost forMagnesium
  69. Hypomagnesemia and Acute Cognitive Decline in Older Adults: An Evaluation of Clinical Practice and Cognitive Outcomes at a National Health Service (NHS) Trust in England.
    Lai XN; Sadhwani V; Ng WM; Gani A · Cureus · 2025
    Cohort study667 participantsProductivity Boost forMagnesium
  70. Magnesium Depletion Score as a Novel Predictor of Cognitive Impairment: A Population-Based Cross-Sectional Study From NHANES.
    Chen M; Xue R; Zhang M; Zhang J; Zheng J; Ye D; Sun J · Journal of the American Medical Directors Association · 2025
    Cross-sectional study2,768 participantsProductivity Boost forMagnesium
  71. Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011-2014.
    Xu H; Wang S; Gao F; Li C · Neuropsychiatric disease and treatment · 2022
    Cross-sectional study2,421 participantsProductivity Boost forVitamin B6
  72. Effect of megavitamin treatment on mental performance and plasma vitamin B6 concentrations in mentally retarded young adults.
    Coburn SP; Schaltenbrand WE; Mahuren JD; Clausman RJ; Townsend D · The American journal of clinical nutrition · 1983
    Non-randomized trialProductivity Boost forVitamin B6
  73. Identifying Key Predictors of Cognitive Dysfunction in Older People Using Supervised Machine Learning Techniques: Observational Study.
    Rankin D; Black M; Flanagan B; Hughes CF; Moore A; Hoey L; Wallace J; Gill C; Carlin P; Molloy AM; Cunningham C; McNulty H · JMIR medical informatics · 2024
    Cohort studyProductivity Boost forVitamin B6
  74. Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression.
    Guligowska A; Pigłowska M; Fife E; Kostka J; Sołtysik BK; Kroc Ł; Kostka T · Clinical interventions in aging · 2017
    Case-control study49 participantsProductivity Boost forVitamin B6
  75. A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.
    Anlacan VM; Jamora RDG; Krattinger LF; De Longis E; Hartweg M; Steinmann M; Trovò L · Frontiers in nutrition · 2026
    Randomized trial44 participantsProductivity Boost forVitamin B6
  76. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  77. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  78. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  79. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  80. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  81. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  82. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  83. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  84. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  85. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  86. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  87. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  88. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  89. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  90. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium Stress Relief forVitamin B6
  91. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsStress Relief forVitamin B6
  92. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  93. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  94. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6
  95. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  96. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  97. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  98. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  99. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium