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Vitamin K2 100 mcg

4.5
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(239 ratings)
Vitamin K 100 mcg
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Score79
A well-dosed MK-7 softgel with focused delivery and clear labeling, missing only premium source detail and complementary nutrients.
How scoring works
Softgel
Quantity:30 Softgel(s) • (30 servings)
Goals:
Bone Health
General Health
Heart Health
Anti-Aging
Cardiovascular Support

Score 79

A well-dosed MK-7 softgel with focused delivery and clear labeling, missing only premium source detail and complementary nutrients.
How scoring works
$15.52($0.51 per serving)
Vitacost
$ 18.69
Walmart
$ 15.52
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Analysis

MK-7 is the long-lasting vitamin K2 form most suited to simple daily use. The clearly stated amount supports calcium-handling proteins involved in bone and arterial maintenance.

Softgel delivery fits a fat-soluble nutrient and improves practical absorption confidence. The label does not identify a branded or all-trans source, and no vitamin D is included.

The product fits adults wanting a focused one-ingredient K2 supplement without added minerals. It should be viewed as a calcium-regulation cofactor rather than complete bone or cardiovascular support.

Who is it for
  • Adults seeking daily MK-7
  • People who prefer softgels
  • Users building a separate bone-support routine
Best for
  • Vitamin K-dependent calcium handling
  • Bone-protein activation
  • Focused arterial-health support

Pros

  • Preferred MK-7 form
  • Practical daily amount
  • Softgel suits fat-soluble absorption

Cons

  • No branded or all-trans source claim
  • No vitamin D companion
  • Narrow single-pathway formula

Warnings

  • MK-7 can oppose warfarin and related vitamin K antagonist medicines
  • Keep vitamin K intake consistent if a prescriber approves use
  • Do not assume it supplies calcium, magnesium, or vitamin D needed elsewhere in a bone routine

Nutrient quality

94 Highest impact

Menaquinone-7 is a well-regarded, long-acting vitamin K2 form, and the vitamin K2 amount is meaningful for routine standalone support. The amount is not unnecessarily aggressive for a focused vitamin K2 supplement, while the single-active formula is not padded with low-value ingredients.

Ingredient transparency

84 Highest impact

Specific amounts are listed for every supplied active ingredient. No proprietary blend hides active doses, while capsule, softgel, or tablet excipients are not included in the supplied details.

Customer satisfaction

66 High impact

The supplied aggregate satisfaction metric is favorable, and the feedback volume offers some support but is less robust than heavily reviewed alternatives. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money

65 High impact

A focused formula and well-regarded vitamin K2 form support good value. Each serving provides a meaningful active amount with little burden, while the formula avoids unnecessary active extras.

Report analysis

Goals

Bone Health
Impact
Highest effect
A Goal FitA+ Strength of SupportC CoverageA Formula Quality
Vitamin K · 100 mcg

MK-7 supports activation of proteins that bind calcium into the bone matrix. The preferred long-lasting form and clearly stated amount provide strong depth for mineral placement.

The formula is focused but does not supply calcium, magnesium, vitamin D, or protein-matrix material. MK-7 can reduce the effect of warfarin-type anticoagulants, so people using those medicines need consistent intake planned with their prescriber.

Study evidence
Vitamin K Supportive 78 studies
General Health
Impact
Highest effect
A- Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Vitamin K · 100 mcg

Vitamin K2 is supplied as MK-7 at a useful amount in a softgel suited to a fat-soluble nutrient. The formula supports calcium handling and skeletal health through a focused, clearly disclosed active.

The absence of vitamin D means it does not provide the commonly paired nutrient within the same formula, though a single-ingredient design can still be appropriate. MK-7 can counteract warfarin and related vitamin K antagonist medicines, so people using that drug class need clinician-guided consistency.

Study evidence
Vitamin K Supportive 34 studies
Heart Health
Impact
Highest effect
A- Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Vitamin K · 100 mcg

Vitamin K2 as MK-7 is strongly aligned with healthy calcium handling and arterial support. Human evidence is promising for vascular markers, though it does not establish broad cardiovascular protection by itself.

The 100 mcg amount is within a practical daily range and the softgel suits a fat-soluble vitamin. People taking warfarin or other vitamin K antagonist medicines should keep vitamin K intake consistent and follow their prescriber’s guidance.

Study evidence
Vitamin K Mixed 62 studies
Anti-Aging
Impact
Highest effect
B+ Goal FitA Strength of SupportD+ CoverageA Formula Quality
Vitamin K · 100 mcg

Vitamin K2 as MK-7 supports bone mineral placement and vitamin K-dependent proteins involved in vascular flexibility. That calcium-management pathway is relevant to healthy aging, though clinical longevity outcomes are less established than the mechanism.

The focused MK-7 formula provides strong depth without unrelated ingredients. Vitamin K can counteract warfarin and other vitamin K antagonist medicines, so users of those drugs need clinician-guided intake.

Study evidence
Vitamin K Supportive 27 studies
Cardiovascular Support
Impact
High effect
B- Goal FitA+ Strength of SupportD+ CoverageA Formula Quality
Vitamin K · 100 mcg

Vitamin K2 as MK-7 supports activation of proteins involved in keeping calcium out of arterial tissue. The 100 mcg amount is well aligned with focused daily K2 use.

The softgel format suits this fat-soluble vitamin, although no branded source or all-trans purity claim is provided. MK-7 can counteract vitamin K antagonist medicines such as warfarin, so users of those drugs need prescriber-guided consistency.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin K2 (Menaquinone-7)
100 mcg
Gluten Free Adults 18–50
Report overview
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

A clearly labeled MK-7 dose falls within the preferred daily range. The softgel format supports delivery of this fat-soluble vitamin, although no branded or all-trans source claim is provided. Its mid-range serving cost offers sound value for a focused K2 supplement.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  3. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  4. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  5. Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis.
    Chen HG; Sheng LT; Zhang YB; Cao AL; Lai YW; Kunutsor SK; Jiang L; Pan A · European journal of nutrition · 2020
    Meta-analysis222,592 participants21 studies pooledCardiovascular Support forVitamin K
  6. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.
    van den Heuvel EG; van Schoor NM; Lips P; Magdeleyns EJ; Deeg DJ; Vermeer C; den Heijer M · Maturitas · 2014
    Cohort study577 participantsCardiovascular Support forVitamin K
  7. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  8. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  9. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  10. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  11. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  12. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  13. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  14. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  15. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  16. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  17. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  18. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  19. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  20. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  21. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  22. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  23. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  24. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K