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Oxy-Cleanse

4.3
★ ★ ★ ★ ★
(736 ratings)
Magnesium 346 mg
Product Image
Score64
A targeted bowel-cleansing formula whose hydroxide base is more useful for short-term regularity than daily magnesium support.
How scoring works
Capsule
Quantity:75 Capsule(s) • (37 servings)
Goals:
Digestive Health
General Health
Testosterone Support

Score 64

A targeted bowel-cleansing formula whose hydroxide base is more useful for short-term regularity than daily magnesium support.
How scoring works
$23.19($0.62 per serving)
iHerb
$ 23.19
Vitacost
$ 23.19
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Analysis

Magnesium hydroxide is most relevant for occasional constipation rather than dependable systemic magnesium support. The substantial amount is paired with vitamin C, which can also influence bowel tolerance at higher intakes.

Sodium bicarbonate may affect stomach acidity, but the supplied amount does not turn the product into broad digestive support. Bioflavonoids are listed without details that establish a clear practical contribution.

The formula is costly for its narrow purpose and should be viewed as a targeted bowel product. Repeated strong laxative effects can lead to cramping and fluid loss.

Who is it for
  • Adults seeking occasional bowel support
  • People who specifically want magnesium hydroxide
  • Short-term users who can monitor tolerance
Best for
  • Occasional constipation support
  • Short-term bowel regularity
  • Users prioritizing an osmotic effect

Pros

  • Substantial magnesium hydroxide amount
  • Focused digestive-use rationale
  • Includes a disclosed vitamin C amount

Cons

  • Poor fit for systemic magnesium repletion
  • High serving cost
  • Added ingredients provide limited broader digestive coverage

Warnings

  • Magnesium hydroxide may cause diarrhea or abdominal cramping
  • Repeated laxative use can disturb fluid and electrolyte balance
  • Impaired kidney function increases magnesium accumulation risk

Nutrient quality

52 Moderate impact

Magnesium hydroxide with vitamin C and bioflavonoids provides the main quality signal, while a substantial magnesium amount shapes likely usefulness. Absorption, tolerability, and the formula's focus determine the main trade-off.

Ingredient transparency

85 Highest impact

Active amounts are clearly disclosed, and no proprietary blend hides the total formula. Specific ingredient names make the core actives reasonably easy to assess.

Customer satisfaction

77 High impact

The high average rating is supported by moderate review volume. No specific review comments are supplied, so repeated complaints and purpose alignment cannot be confirmed directly.

Value for money

39 Lower impact

Value is weak for the form quality and disclosed amount. The focused formula includes additions with limited value, while category competitiveness depends on absorption quality.

Report analysis

Goals

Digestive Health
Impact
High effect
B+ Goal FitA- Strength of SupportC- CoverageB- Formula Quality
Magnesium · 346 mg

Magnesium hydroxide provides a direct osmotic laxative effect and can support short-term constipation relief. Sodium bicarbonate may buffer stomach acid, while vitamin C and bioflavonoids add limited digestive value.

The formula is more likely to provoke bowel evacuation than provide broad gut health. The 346 mg magnesium hydroxide amount may cause diarrhea, cramping, and electrolyte imbalance, especially with kidney impairment or repeated use.

Study evidence
Magnesium Supportive 50 studies
General Health
Impact
High effect
B- Goal FitC+ Strength of SupportC CoverageB- Formula Quality
Magnesium · 346 mgVitamin C · 150 mg

Vitamin C and magnesium provide foundational nutrient support, but magnesium hydroxide is poorly absorbed for systemic use. The disclosed magnesium amount is substantial and may act more strongly in the digestive tract than as a daily mineral supplement.

Coverage extends to antioxidant and mineral needs without becoming overly complex. The 346 mg magnesium hydroxide serving may cause loose stools or cramping in sensitive users.

Study evidence
Magnesium Supportive 114 studies
Vitamin C Supportive 56 studies
Testosterone Support
Impact
High effect
B Goal FitC- Strength of SupportD+ CoverageA- Formula Quality
Magnesium · 346 mg

Magnesium provides a relevant route to testosterone support. The disclosed amount appears meaningful for that focused role.

The formula remains narrow rather than comprehensive. Oxy-Cleanse is best viewed as targeted support rather than proof of a clinical benefit.

Study evidence
Magnesium Disputed 5 studies
Energy
Impact
Moderate effect
B Goal FitD+ Strength of SupportD CoverageB- Formula Quality
Magnesium · 346 mg

Magnesium is required for ATP-producing enzymes, but magnesium hydroxide is poorly suited to systemic replenishment. The 346 mg amount is clear and substantial on paper, while vitamin C and bioflavonoids add limited related support.

Magnesium hydroxide is more likely to act in the digestive tract and may cause loose stools or cramping in sensitive users. Low absorption leaves the product weak for sustained energy despite a seemingly adequate elemental amount.

Study evidence
Magnesium Supportive 4 studies
Cardiovascular Support
Impact
Moderate effect
B Goal FitD Strength of SupportD CoverageC- Formula Quality
Magnesium · 346 mgVitamin C · 150 mg

Magnesium supports vascular relaxation, normal rhythm, and blood-pressure regulation. The 346 mg amount is substantial, but magnesium hydroxide is poorly suited to systemic mineral support.

Vitamin C and bioflavonoids add antioxidant support without correcting the weak magnesium form. Magnesium hydroxide at this amount may cause loose stools or abdominal cramping in sensitive users.

Study evidence
Magnesium Supportive 123 studies
Vitamin C Supportive 101 studies
Stress Relief
Impact
Moderate effect
C Goal FitC Strength of SupportF CoverageD Formula Quality
Magnesium · 346 mgVitamin C · 150 mg

Magnesium has a plausible stress-support role, but magnesium hydroxide is poorly suited to systemic nervous-system support. Much of the substantial label amount may remain in the digestive tract.

Vitamin C and bioflavonoids do not compensate for the weak magnesium form or add a clear calming pathway. Magnesium hydroxide at this amount may act as a laxative and cause loose stools or cramping.

Study evidence
Magnesium Supportive 13 studies
Vitamin C Supportive 11 studies
Heart Health
Impact
Moderate effect
D+ Goal FitD Strength of SupportD CoverageC- Formula Quality
Magnesium · 346 mg

Magnesium is relevant to vascular tone and heart rhythm, but magnesium hydroxide is poorly suited to systemic support. The listed amount looks substantial while the low-absorption form limits its likely contribution.

Vitamin C and bioflavonoids add antioxidant context without creating broad, well-dosed cardiovascular coverage. Magnesium hydroxide at this amount may cause loose stools or cramping in sensitive users.

Study evidence
Magnesium Supportive 158 studies

Ingredients

IngredientAmount per serving
Sodium (Sodium Bicarbonate)
50 mg
Vitamin C (Ascorbic Acid)
150 mg
Magnesium (Magnesium Hydroxide)
346 mg
Bioflavonoid Complex
50 mg
Gluten Free Adults 18–50 Vegan Vegetarian
Report overview
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

Magnesium hydroxide is poorly suited to systemic magnesium support despite a clear therapeutic-range amount. The formula is more likely to act in the digestive tract, and 346 mg may cause loose stools or cramping in sensitive users. Its above-median serving cost represents weak value for this low-absorption form.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  2. Hospital-Acquired Dysmagnesemia and In-Hospital Mortality.
    Cheungpasitporn W; Thongprayoon C; Chewcharat A; Petnak T; Mao MA; Davis PW; Bathini T; Vallabhajosyula S; Qureshi F; Erickson SB · Medical sciences (Basel, Switzerland) · 2024
    Cohort study26,020 participantsGeneral Health forMagnesium
  3. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  4. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  5. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  6. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  7. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  8. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  9. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  10. Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.
    Rozemeijer S; Hemilä H; van Baaren M; de Man AME · BMC cardiovascular disorders · 2023
    Meta-analysis872 participants7 studies pooledCardiovascular Support forVitamin C
  11. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
    Taddei S; Virdis A; Ghiadoni L; Magagna A; Salvetti A · Circulation · 1998
    Clinical trial49 participantsCardiovascular Support forVitamin C
  12. Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study.
    Boonthongkaew C; Tong-Un T; Kanpetta Y; Chaungchot N; Leelayuwat C; Leelayuwat N · The Chinese journal of physiology · 2021
    Randomized trial24 participantsCardiovascular Support forVitamin C
  13. Vascular benefits of vitamin C supplementation against fine particulate air pollution in healthy adults: A double-blind randomised crossover trial.
    Ren J; Liang J; Wang J; Yin B; Zhang F; Li X; Zhu S; Tian H; Cui Q; Song J; Liu G; Ling W; Ma Y · Ecotoxicology and environmental safety · 2022
    Randomized trial58 participantsCardiovascular Support forVitamin C
  14. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes.
    Mullan BA; Young IS; Fee H; McCance DR · Hypertension (Dallas, Tex. : 1979) · 2003
    Randomized trial30 participantsCardiovascular Support forVitamin C
  15. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  16. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  17. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  18. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  19. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  20. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  21. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  22. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  23. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  24. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  25. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  26. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  27. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  28. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  29. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  30. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  31. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  32. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  33. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  34. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  35. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  36. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  37. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  38. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  39. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  40. Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress.
    Beglaryan N; Hakobyan G; Nazaretyan E · Stress and health : journal of the International Society for the Investigation of Stress · 2024
    Randomized trial69 participantsStress Relief forVitamin C
  41. Effect of Vitamin C on adrenal suppression by etomidate induction in patients undergoing cardiac surgery: A randomized controlled trial.
    Das D; Sen C; Goswami A · Annals of cardiac anaesthesia · 2017
    Randomized trial78 participantsStress Relief forVitamin C
  42. The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review.
    McCabe D; Lisy K; Lockwood C; Colbeck M · JBI database of systematic reviews and implementation reports · 2018
    Systematic review14 studies pooledStress Relief forVitamin C
  43. Exercise-induced oxidative stress before and after vitamin C supplementation.
    Alessio HM; Goldfarb AH; Cao G · International journal of sport nutrition · 1997
    Clinical trialStress Relief forVitamin C
  44. Effects of Oral Vitamin C Supplementation on Anxiety in Students: A Double-Blind, Randomized, Placebo-Controlled Trial.
    de Oliveira IJ; de Souza VV; Motta V; Da-Silva SL · Pakistan journal of biological sciences : PJBS · 2015
    Randomized trial42 participantsStress Relief forVitamin C
  45. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  46. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  47. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  48. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  49. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium