Product Image

Extra Strength Hair Skin & Nails Argan Oil Infused

Nature's Bounty Optimal Solutions
4.7
★ ★ ★ ★ ★
(169 ratings)
Biotin 5000 mcg
Manganese 5 mg
Vitamin A 5000 IU
PABA 10 mg
Niacin 25 mg
Vitamin D 800 IU
Iron 3 mg
Product Image
Score67
High-dose biotin, vitamin C, zinc, vitamin D3, and hyaluronic acid form a coherent beauty-nutrient base. Collagen, horsetail, argan oil, PABA, choline, and alpha-lipoic acid are too lightly dosed to contribute much beyond the vitamin-mineral core.
How scoring works
Quantity:250 Softgel(s) • (83 servings)
Goals:
Nail Health
Hair Health
Skin Health

Score 67

High-dose biotin, vitamin C, zinc, vitamin D3, and hyaluronic acid form a coherent beauty-nutrient base. Collagen, horsetail, argan oil, PABA, choline, and alpha-lipoic acid are too lightly dosed to contribute much beyond the vitamin-mineral core.
How scoring works

Also available as

1 option
150 servings 3 Softgel(s) • 150 Softgel(s) • 50 servings $11.40 ($0.22 per serving)
$24.99($0.30 per serving)
Walmart
$ 24.99
Report prices

Analysis

High-dose biotin, vitamin C, zinc, vitamin D3, and hyaluronic acid form a coherent beauty-nutrient base. The softgel format and clearly stated core amounts support practical daily use across hair, skin, and nail goals.

Collagen, horsetail, argan oil, PABA, choline, and alpha-lipoic acid are too lightly dosed to contribute much beyond the vitamin-mineral core. It suits users who want a long-supply biotin formula, but not those seeking a substantial collagen or botanical product.

The 5,000 mcg biotin amount can distort several common laboratory tests. The larger bottle improves convenience and serving value despite the formula padding.

Who is it for
  • Adults seeking hair, skin, and nail nutrient support
  • People who prefer a long-supply softgel bottle
  • Users who want high-dose biotin with zinc and vitamin C
Best for
  • High-biotin beauty support
  • Long-term softgel convenience
  • Combining micronutrients with hyaluronic acid

Pros

  • Provides 5,000 mcg of disclosed biotin
  • Includes vitamin C, zinc, vitamin D3, and hyaluronic acid
  • Offers a long 83-serving supply

Cons

  • Collagen is limited to 50 mg
  • Argan oil and horsetail are present in very small amounts
  • Several minor additions add label length more than functional depth

Warnings

  • The 5,000 mcg biotin dose can distort thyroid, hormone, and cardiac troponin test results; disclose use before blood testing.
  • Preformed vitamin A from retinyl palmitate warrants care when stacking other retinol-containing supplements, especially during pregnancy.
  • The 5 mg manganese amount adds to intake from food and other supplements, so repeated stacking is unnecessary.

Nutrient quality

62 Moderate impact

Vitamin D3, natural vitamin E, and several gluconate minerals are useful forms, though folic acid and cyanocobalamin are less preferred, and biotin is substantial, but collagen, horsetail, choline, selenium, and several specialty ingredients are modest. The very high biotin amount may interfere with some thyroid, hormone, and cardiac laboratory tests, while several low-dose additions lengthen the formula without adding much likely benefit.

Ingredient transparency

76 High impact

Specific amounts are listed for the active vitamins, minerals, and specialty ingredients. No proprietary blend hides the amounts of key active ingredients, while excipients and softgel materials are not included in the supplied label details.

Customer satisfaction

67 High impact

The supplied aggregate satisfaction metric is strong, and the feedback volume is adequate for a reasonably stable aggregate metric. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money

61 Moderate impact

The useful biotin and broad nutrient base partly support the cost, but many specialty ingredients are lightly dosed. Each serving offers broad coverage, though the meaningful contribution is concentrated in a few nutrients, while low-dose oils, herbs, and structural ingredients add limited practical value.

Report analysis

Goals

Nail Health
Nail Health
Impact
High effect
A- Goal FitB Strength of SupportB- CoverageC+ Formula Quality
Collagen · 50 mgBiotin · 5000 mcgHorsetail · 3 mg

A high-potency biotin serving provides the clearest nail-focused active, with zinc and B vitamins adding nutritional support. The blend also includes collagen and horsetail, but both are too small to contribute much structural material.

Most actives have exact amounts and the softgel format is practical. The biotin amount can interfere with some thyroid, hormone, and cardiac troponin blood tests, so users should disclose it before laboratory testing.

Study evidence
Biotin Supportive 8 studies
Collagen Supportive 4 studies
Horsetail Not classified

No linked studies yet.

Zinc No effect 1 study
Hair Health
Hair Health
Impact
High effect
B Goal FitC+ Strength of SupportB CoverageB Formula Quality
Biotin · 5000 mcgVitamin D · 800 IUZinc · 7.5 mgIron · 3 mgVitamin C · 60 mgCollagen · 50 mg

D-biotin at 5,000 mcg, zinc, iron, vitamin D3, hyaluronic acid, argan oil, and trace collagen create a broad beauty formula. Collagen at 50 mg, iron at 3 mg, horsetail at 3 mg, and argan oil at 25 mg are too small for strong structural depth.

The product covers several hair-related pathways but relies heavily on biotin as its only high-dose headline active. High-dose biotin may distort thyroid, hormone, or cardiac troponin blood tests, so it should be disclosed before laboratory testing.

Study evidence
Biotin Supportive 4 studies
Collagen Supportive 3 studies
Horsetail Not classified

No linked studies yet.

Iron Disputed 25 studies
Vitamin D Disputed 34 studies
Zinc Supportive 22 studies
Skin Health
Skin Health
Impact
High effect
B Goal FitC+ Strength of SupportB CoverageB Formula Quality
Hyaluronic Acid · 30 mgZinc · 7.5 mgVitamin C · 60 mgCollagen · 50 mgSelenium · 12.5 mcgVitamin E · 15 IU

Vitamin A, zinc, vitamin C, hyaluronic acid, and hydrolyzed collagen cover turnover, repair, hydration, and structure. Hyaluronic acid and collagen are present below stronger oral skin-support targets, limiting the likely visible contribution.

The softgel supports fat-soluble vitamin absorption, but several headline actives are lightly dosed. The 5,000 mcg biotin amount can distort thyroid, hormone, or cardiac troponin blood tests and should be disclosed before laboratory testing.

Study evidence
Biotin Supportive 10 studies
Collagen Supportive 62 studies
Vitamin A Supportive 106 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies

Ingredients

IngredientAmount per serving
Calories
15 Calorie(s)
Total Fat
1 Gram(s)
Vitamin A (Retinyl Palmitate)
 5000 IU
Vitamin C (Ascorbic Acid)
 60 mg
Vitamin D (Cholecalciferol, Vitamin D3)
 800 IU
Vitamin E (D-Alpha-Tocopheryl Acetate)
 15 IU
Thiamine (Thiamine Mononitrate, Vitamin B1)
 5 mg
Riboflavin (Vitamin B2)
 5 mg
Niacin (Niacinamide)
 25 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 5 mg
Folic Acid
200 mcg
Vitamin B12 (Cyanocobalamin)
 8 mcg
Biotin (D-Biotin)
 5000 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 15 mg
Iron (Ferrous Gluconate)
 3 mg
Zinc (Zinc Gluconate)
 7.5 mg
Selenium (Selenium Yeast)
 12.5 mcg
Manganese (Manganese Gluconate)
 5 mg
Argan Oil
25 mg
PABA
10 mg
Choline Bitartrate
10 mg
Alpha Lipoic Acid
10 mg
Horsetail
3 mg
hydrolyzed Collagen
50 mg
Hyaluronic Acid (Sodium Hyaluronate)
 30 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Biotin (D-Biotin) · 5000 mcg OverallScore92
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value

Extra Strength Hair Skin & Nails Argan Oil Infused specifies d-Biotin, while its softgel format has no listed artificial color or sweetener. The exact 5000 mcg amount is in the high-potency hair and nail range. The 5000 mcg dose may distort some thyroid, hormone, or cardiac troponin blood tests, so it should be disclosed before laboratory testing.

View ingredientView products
Manganese (Manganese Gluconate) · 5 mg OverallScore88
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Manganese gluconate offers good solubility and absorption as an organic salt. The elemental amount is well aligned with targeted support and remains below the upper intake limit. The serving cost compares favorably with the collection median.

View ingredientView products
Vitamin A (Retinyl Palmitate) · 5000 IU OverallScore78
C- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

Retinyl palmitate supplies a clear 5,000 IU amount but offers no carotenoid-based regulation. The rapid-release softgel and argan oil create a favorable lipid environment for absorption. Its broader beauty-support formula keeps the value fair despite only moderate vitamin A efficiency.

View ingredientView products
Loading alternative details
68 Performance

Hair Vitamins

SugarBearHair
A potentially better match in selected areas comes from 5,000 mcg of biotin with vitamin D3, vitamin C, zinc citrate, and pantothenic acid. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 25 mg of argan oil, the ingredient focus is directly aligned with hair and nail support, although the supporting nutrient amounts are modest and high-dose biotin can distort some laboratory tests.
71 Performance

Extra Strength Hair Skin & Nails

Spring Valley
A potentially better match in selected areas comes from 5,000 mcg of D-biotin with 2,000 IU of vitamin D3, 90 mg of vitamin C, zinc, and 60 mg of collagen. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 25 mg of argan oil, the beauty-support core is broader while staying relatively economical, although collagen, hyaluronic acid, horsetail, and oils are still modest and the high biotin amount can affect laboratory tests.
55 Performance

Enzyme Nutrition Multi-Vitamin Two Daily

Enzymedica
A potentially better match in selected areas comes from vitamin D3, natural mixed vitamin E, beta-carotene, folate, and a broad vitamin-and-mineral base. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 25 mg of argan oil, the natural vitamin E forms and broad coverage improve several nutrient-quality details, although enzyme, probiotic, ATP, and botanical entries lack measurable amounts.
72 Budget

One Daily Women's Adult Gummy

Equate
A lower serving cost comes with vitamin D, vitamin E, folic acid, biotin, calcium, and zinc in a women’s adult gummy. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 25 mg of argan oil, it provides broad basic coverage without the original formula’s very high biotin exposure, although many forms are unspecified and mineral amounts are light.
73 Budget

Muti Vitamin Raspberry Flavor

Yum-V's Complete
A lower serving cost comes with vitamin D3, vitamin C, folic acid, biotin, and several B vitamins in an adult gummy. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 25 mg of argan oil, it supplies basic adult nutrient coverage without extremely high biotin, although synthetic vitamin E, basic B-vitamin forms, and very little choline limit formulation depth.
75 Budget

Flintstones Complete

Bayer
A lower serving cost comes with beta-carotene, vitamin C, vitamin D, iron, zinc, and broad basic vitamin coverage. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 25 mg of argan oil, it supplies a wide maintenance base at low serving cost, although the child-focused amounts and many unspecified forms do not match every adult.
70 Value

Hair Skin & Nails

Nature's Bounty Optimal Solutions
A useful quality-to-cost balance comes from 3,000 mcg of biotin with vitamin D3, vitamin C, zinc, 50 mg of collagen, and 30 mg of inositol. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 25 mg of argan oil, the targeted beauty formula remains economical and lowers biotin exposure relative to the extra-strength version, although collagen and horsetail are too lightly dosed to add much structural support.
75 Value

Multi Adult Gummies

Nature Made
A useful quality-to-cost balance comes from vitamin D3, vitamin C, folic acid, biotin, and zinc in an adult gummy. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 25 mg of argan oil, it provides inexpensive broad vitamin coverage in a simpler serving, although mineral coverage is thin and several nutrient forms are basic.
78 Value

Children's Chewable

Thompson
A useful quality-to-cost balance comes from vitamin D3, natural-form vitamin E, beta-carotene, iron, and clearly named minerals. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 25 mg of argan oil, the formula offers broad maintenance coverage with several useful forms, although it is designed for children and calcium, magnesium, and zinc are lightly dosed.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsSkin Health Hair Health Nail Health forBiotin
  2. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
    Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
    Non-randomized trial60 participantsSkin Health forBiotin
  3. Interventions for infantile seborrhoeic dermatitis (including cradle cap).
    Victoire A; Magin P; Coughlan J; van Driel ML · The Cochrane database of systematic reviews · 2019
    Systematic review35 participants2 studies pooledSkin Health forBiotin
  4. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  5. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  6. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsSkin Health Hair Health forBiotin
  7. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
    Narrative reviewNail Health forBiotin
  8. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
    Other32 participantsNail Health forBiotin
  9. Brittle nails: response to daily biotin supplementation.
    Hochman LG; Scher RK; Meyerson MS · Cutis · 1993
    Case series35 participantsNail Health forBiotin
  10. Nail Supplements: When, How, and Why?
    Zaraa I; Richert B · Skin appendage disorders · 2026
    Narrative reviewNail Health forBiotin Nail Health forCollagen
  11. Brittle nails.
    Iorizzo M; Pazzaglia M; M Piraccini B; Tullo S; Tosti A · Journal of cosmetic dermatology · 2009
    Narrative reviewNail Health forBiotin
  12. Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis.
    Alsaati AA; Kaliyadan F; Alsaadoun D; Alzakry LM; Alzabadin RA; Hakami TH; Rubaian NFB · Indian dermatology online journal · 2025
    Meta-analysisHair Health forVitamin D
  13. Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis.
    Lee S; Kim BJ; Lee CH; Lee WS · Journal of the European Academy of Dermatology and Venereology : JEADV · 2018
    Meta-analysis2,039 participants14 studies pooledHair Health forVitamin D
  14. Estimated serum vitamin D status, vitamin D intake, and risk of incident alopecia areata among US women.
    Thompson JM; Li T; Park MK; Qureshi AA; Cho E · Archives of dermatological research · 2017
    Cohort study55,929 participantsHair Health forVitamin D
  15. 25-hydroxyvitamin D status in patients with alopecia areata.
    Erpolat S; Sarifakioglu E; Ayyildiz A · Postepy dermatologii i alergologii · 2022
    Case-control study73 participantsHair Health forVitamin D
  16. Vitamins for the Management of Nail Disease: A Literature Review.
    Curtis KL; Lipner SR · Skin appendage disorders · 2025
    Narrative reviewNail Health forVitamin D
  17. Recommendations for the definition, evaluation, and treatment of nail psoriasis in adult patients with no or mild skin psoriasis: A dermatologist and nail expert group consensus.
    Rigopoulos D; Baran R; Chiheb S; Daniel CR; Di Chiacchio N; Gregoriou S; Grover C; Haneke E; Iorizzo M; Pasch M; Piraccini BM; Rich P; Richert B; Rompoti N; Rubin AI; Singal A; Starace M; Tosti A; Triantafyllopoulou I; Zaiac M · Journal of the American Academy of Dermatology · 2019
    Guideline / consensusNail Health forVitamin D
  18. Nail psoriasis: clinical presentation and best practice recommendations.
    Edwards F; de Berker D · Drugs · 2010
    Narrative reviewNail Health forVitamin D
  19. Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.
    Hwang S; Won J; Kim S; Kang W; Park M · Journal of medicinal food · 2026
    Randomized trial114 participantsHair Health forCollagen
  20. Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
    Duangjai A; Srivilai J; Nangola S; Amornlerdpison D · Clinics and practice · 2025
    Randomized trialHair Health forCollagen
  21. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
    Biełach-Bazyluk A; Jurga M; Flisiak I; Zbroch E · Nutrients · 2026
    Narrative reviewHair Health forCollagen
  22. The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.
    Davidovici B; Drutin Y; Ben-Tov A; Mimouni D; Wohl Y · Journal of personalized medicine · 2026
    Case-control study100,203 participantsHair Health forIron
  23. Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis.
    Treister-Goltzman Y; Yarza S; Peleg R · Skin appendage disorders · 2022
    Meta-analysis10,029 participants36 studies pooledHair Health forIron
  24. Comparative Analysis of Postoperative Hair Loss and Micronutrient Deficiencies After One-Anastomosis Gastric Bypass Versus Sleeve Gastrectomy.
    Chinisaz F; Maleki T; Najjari K; Miratashi Yazdi SA · Obesity surgery · 2026
    Cohort study261 participantsHair Health forIron
  25. Assessment of Serum Ferritin Levels in Female Patients With Telogen Effluvium.
    Thamotharan N; Harikumar MV; Sundaram M; Swaminathan A; Rangarajan S · Cureus · 2026
    Cross-sectional study100 participantsHair Health forIron
  26. Diagnosis and treatment of female alopecia: Focusing on the iron deficiency-related alopecia.
    Lin CS; Chan LY; Wang JH; Chang CH · Tzu chi medical journal · 2023
    Cohort study155 participantsHair Health forIron
  27. Intralesional vitamin D3 in treatment of alopecia areata: A randomized controlled clinical trial.
    Rashad AF; Elgamal E; Fouda I · Journal of cosmetic dermatology · 2022
    Randomized trial60 participantsHair Health forVitamin D
  28. Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial.
    El Taieb MA; Hegazy EM; Ibrahim HM; Osman AB; Abualhamd M · Archives of dermatological research · 2020
    Randomized trial60 participantsHair Health forVitamin D
  29. Serum 25 hydroxyvitamin D in non-scarring alopecia: A systematic review and meta-analysis.
    Chen Y; Dong X; Wang Y; Li Y; Xiong L; Li L · Journal of cosmetic dermatology · 2024
    Meta-analysis10,670 participants23 studies pooledHair Health forVitamin D
  30. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  31. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  32. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  33. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  34. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  35. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
    Randomized trial50 participantsNail Health forBiotin
  36. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forBiotin Nail Health forZinc
  37. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails.
    Hexsel D; Zague V; Schunck M; Siega C; Camozzato FO; Oesser S · Journal of cosmetic dermatology · 2018
    Single-arm trial25 participantsNail Health forCollagen
  38. Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trial.
    Vleminckx S; Virgilio N; Asserin J; Prawitt J; Silva CIF · Journal of cosmetic dermatology · 2024
    Randomized trial85 participantsNail Health forCollagen
  39. Expanding the COL7A1 mutation database: novel and recurrent mutations and unusual genotype-phenotype constellations in 41 patients with dystrophic epidermolysis bullosa.
    Kern JS; Kohlhase J; Bruckner-Tuderman L; Has C · The Journal of investigative dermatology · 2006
    Observational study41 participantsNail Health forCollagen
  40. Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
    Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
    Non-randomized trial25 participantsSkin Health forBiotin
  41. Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
    Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
    Case series4 participantsSkin Health forBiotin
  42. Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
    Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
    Meta-analysis967 participants14 studies pooledSkin Health forCollagen
  43. Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
    Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
    Meta-analysis646 participants10 studies pooledSkin Health forCollagen
  44. Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
    Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
    Randomized trial100 participantsSkin Health forCollagen
  45. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
    Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
    Randomized trial64 participantsSkin Health forCollagen
  46. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
    de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
    Meta-analysis1,125 participants19 studies pooledSkin Health forCollagen
  47. Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
    Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
    Meta-analysis471 participants6 studies pooledSkin Health forVitamin A
  48. Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
    Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
    Randomized trial120 participantsSkin Health forVitamin A
  49. Antiaging action of retinol: from molecular to clinical.
    Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
    Randomized trial48 participantsSkin Health forVitamin A
  50. An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
    Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
    Narrative reviewSkin Health forVitamin A
  51. Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
    Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
    Randomized trialSkin Health forVitamin A
  52. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  53. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  54. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  55. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  56. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  57. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  58. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  59. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forVitamin E Skin Health forZinc
  60. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  61. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E
  62. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  63. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  64. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  65. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc