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B Complex

INNATE Response Formulas
4.8
★ ★ ★ ★ ★
(654 ratings)
Niacin 45 mg
Thiamin 9 mg
Vitamin B5 45 mg
Riboflavin 9 mg
Product Image
Score76
A moderate B complex with some food-derived sources and a sensible B6 amount. Basic B12, unclear folate, and middling value keep it from standing out.
How scoring works
Quantity:90 Tablet(s) • (90 servings)
Goals:
Energy
Metabolism Boost

Score 76

A moderate B complex with some food-derived sources and a sensible B6 amount. Basic B12, unclear folate, and middling value keep it from standing out.
How scoring works

Also available as

1 option
180 servings B5 45 mg, B1 9 mg +2 more • 180 Tablet(s) • 180 servings $77.99 ($0.43 per serving)
$33.74($0.37 per serving)
Amazon
$ 40.99
iHerb
$ 33.74
Vitacost
$ 44.99
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Analysis

The formula combines standard vitamin sources with nutrients derived from brown rice and S. cerevisiae. Thiamine, niacinamide, B6, folate, B12, biotin, and pantothenic acid provide broad coverage without extreme B6 dosing.

Food-derived sourcing does not automatically mean the active chemical forms are better. Cyanocobalamin remains a basic B12 choice, folate form is not disclosed, and the 9 mg riboflavin amount is moderate.

A single tablet is practical and the 10 mg B6 amount is easier to justify than a B-50 formula. It suits users who value mixed food-derived sourcing, though the premium is difficult to justify on form quality alone.

Who is it for
  • Adults who prefer food-derived nutrient sources
  • People seeking moderate rather than extreme B6
  • Users wanting one-tablet convenience
Best for
  • Moderate daily B-vitamin coverage
  • Food-derived B-vitamin sourcing
  • Routine energy-metabolism support

Pros

  • Uses brown-rice and yeast-derived sources
  • Keeps vitamin B6 at 10 mg
  • Provides a complete B-vitamin base
  • Requires one tablet per serving

Cons

  • Uses cyanocobalamin
  • Folate form is not stated
  • Riboflavin is modest
  • Value is limited for the disclosed forms

Warnings

  • S. cerevisiae-derived ingredients make the product unsuitable for people with a true yeast allergy.
  • The 45 mg niacinamide amount may cause stomach upset in sensitive users.

Nutrient quality

80 High impact

Food-derived carriers add context, but pyridoxine hydrochloride and cyanocobalamin remain conventional forms. The listed amounts are generally measured, though niacin is relatively high.

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Ingredient transparency

86 Highest impact

Specific amounts are supplied for every listed active ingredient. No proprietary blend hides the listed doses.

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Customer satisfaction

70 High impact

The supplied aggregate rating is very strong. No complaint themes or purpose-specific experience details are supplied.

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Value for money

62 Moderate impact

Quality or dose limitations weaken the premium position. The kale addition is secondary but does not dominate the formula.

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Report analysis

Goals

Energy
Essential Energy Nutrients
Energy
Impact
High effect
A- Goal FitB- Strength of SupportB- CoverageB+ Formula Quality
Vitamin B5 · 45 mgRiboflavin · 9 mgThiamin · 9 mgVitamin B12 · 50 mcg

The B-complex supports several coenzymes needed to convert carbohydrate, fat, and protein into usable energy. Its effects are most relevant when intake or status is inadequate.

Amounts are above basic daily needs but below the high targets specified for several energy collections. Riboflavin form is vague, B12 uses cyanocobalamin, and duplicate yeast-source listings add complexity.

Study evidence
Riboflavin Mixed 6 studies
Metabolism Boost
Metabolic B-Vitamins
Metabolism Boost
Impact
Moderate effect
D- Goal FitD Strength of SupportD CoverageB Formula Quality
Biotin · 30 mcgNiacin · 45 mgVitamin B12 · 50 mcgRiboflavin · 9 mgThiamin · 9 mgVitamin B5 · 45 mgVitamin B6 · 10 mg

The B vitamins support normal energy metabolism but do not directly raise metabolic rate. Moderate amounts make the formula more suitable for nutritional coverage than targeted thermogenesis or insulin support.

Several forms are clearly named, though riboflavin and part of the niacin supply remain imprecise. The focused B-complex design is coherent but covers only cellular cofactor needs.

Study evidence
Niacin Supportive 17 studies
Riboflavin Mixed 5 studies
Thiamin Supportive 11 studies
Vitamin B5 Supportive 12 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine HCl)
 9 mg
Riboflavin (organic Brown Rice)
 9 mg
Niacin (Niacinamide, S. cerevisiae)
 45 mg
Vitamin B6 (Pyridoxine Hydrochloride, S. cerevisiae)
 10 mg
Folate
400 mcg DFE
Vitamin B12 (Cyanocobalamin)
 50 mcg
Biotin (Brown Rice)
 30 mcg
Pantothenic Acid (Calcium D-Pantothenate)
 45 mg
Kale
125 NP
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
Niacin (Niacinamide, S. cerevisiae) · 45 mg OverallScore67
B- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyC Value

The B-complex provides 45 mg of niacin, including clearly identified niacinamide, within a suitable multivitamin range. A standard tablet with no release technology offers fewer delivery advantages, and the yeast-derived portion does not identify its precise chemical form. The broad B-vitamin profile supports fair value, although the cost is higher than a basic niacin supplement.

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Thiamin (Thiamine HCl) · 9 mg OverallScore56
B- Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyD- Value

The serving supplies 9 mg of thiamin as thiamine hydrochloride within a B-complex. The amount is low for a targeted metabolism or neurological-support use. Cost efficiency is weak when normalized to the thiamin amount.

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Vitamin B5 (Calcium D-Pantothenate) · 45 mg OverallScore56
B Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyF Value

The standard calcium D-pantothenate form is well suited for dependable B5 delivery. At 45 mg, the serving supports routine intake but offers less potency than products aimed at intensive metabolic or skin support. Its cost per equivalent dose is high, and missing excipient details leave formulation purity uncertain.

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Loading alternative details
77 Performance

Vitamin B Complex

California Gold Nutrition
<p>Riboflavin 5-phosphate, P-5-P, and a named folate form improve on the original pyridoxine and cyanocobalamin-heavy profile. Duplicate label entries make some totals unclear, and vitamin B6 may still be high for sustained use.</p>
70 Performance

Coenzymate B Complex Peppermint

Source Naturals
<p>Flavin mononucleotide, P-5-P, hydroxocobalamin, and methylcobalamin provide more active forms than the original formula. Folic acid and ambiguous duplicate totals remain limitations, while serving value is less favorable.</p>
76 Performance

Megasorb B-Complex '50'

Solgar
<p>Riboflavin 5-phosphate, P-5-P, and pantethine provide more active forms than the original conventional vitamin B6 and B12 profile. The much higher vitamin B6 amount makes this a targeted high-potency option rather than an easy routine replacement.</p>
80 Budget

Super Vitamin B-Complex

Spring Valley
<p>Broad B-vitamin coverage plus vitamin C comes at a much lower serving cost, and the 2 mg vitamin B6 amount is more restrained than the original. Missing chemical forms limit quality assessment, while the high thiamine amount adds little likely benefit for most users.</p>
80 Budget

B-Complex plus Vitamin C

21st Century
<p>Vitamin C and six core B vitamins provide focused metabolic coverage at a lower serving cost, with a more moderate vitamin B6 amount than the original. Missing folate, vitamin B12, and biotin make the formula less complete.</p>
71 Budget

B 50 Complex

Thompson
<p>A broad B-complex provides folate, vitamin B12, biotin, and pantothenic acid at a lower serving cost. Conventional forms, an undisclosed base blend, and 50 mg of vitamin B6 make it less balanced than the original for routine use.</p>
81 Value

Super B-Complex

Nature Made
<p>Broad B-vitamin coverage, added vitamin C, and a restrained 2 mg vitamin B6 amount create a practical quality-to-cost balance. The forms remain conventional, but the serving value is markedly stronger than the original.</p>
78 Value

B-50 Complex

21st Century
<p>A complete core B profile provides folate, vitamin B12, biotin, and pantothenic acid at a much lower serving cost. Conventional forms and 50 mg of pyridoxine are meaningful trade-offs compared with the original moderate-dose design.</p>
73 Value

B-50 Gels

Carlson
<p>A full B-complex and long supply improve serving value while preserving the main energy-metabolism nutrients. The softgel uses conventional forms and raises vitamin B6 to 50 mg, so lower cost does not remove the long-term-use caution.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults.
    Dhir S; Tarasenko M; Napoli E; Giulivi C · Frontiers in psychiatry · 2026
    Narrative reviewMetabolism Boost forThiamin
  2. Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials.
    Nakanishi N; Abe Y; Matsuo M; Tampo A; Yamada K; Hatakeyama J; Yoshida M; Yamamoto R; Higashibeppu N; Nakamura K; Kotani J · Clinical nutrition (Edinburgh, Scotland) · 2024
    Meta-analysis3,494 participants35 studies pooledMetabolism Boost forThiamin
  3. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  4. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  5. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  6. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.
    González-Domínguez R; Castellano-Escuder P; Lefèvre-Arbogast S; Low DY; Du Preez A; Ruigrok SR; Lee H; Helmer C; Pallàs M; Urpi-Sarda M; Sánchez-Pla A; Korosi A; Lucassen PJ; Aigner L; Manach C; Thuret S; Samieri C; Andres-Lacueva C · Alzheimer's research & therapy · 2022
    Observational studyMetabolism Boost forVitamin B5
  7. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  8. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  9. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  10. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  11. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Boost forRiboflavin
  12. Niacin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Boost forNiacin
  13. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans.
    Fangmann D; Theismann EM; Türk K; Schulte DM; Relling I; Hartmann K; Keppler JK; Knipp JR; Rehman A; Heinsen FA; Franke A; Lenk L; Freitag-Wolf S; Appel E; Gorb S; Brenner C; Seegert D; Waetzig GH; Rosenstiel P; Schreiber S; Schwarz K; Laudes M · Diabetes care · 2018
    Clinical trialMetabolism Boost forNiacin
  14. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.
    Christen S; Redeuil K; Goulet L; Giner MP; Breton I; Rota R; Frézal A; Nazari A; Van den Abbeele P; Godin JP; Nutten S; Cuenoud B · Nature metabolism · 2026
    Randomized trial65 participantsMetabolism Boost forNiacin
  15. Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance.
    Linke A; Sonnabend M; Fasshauer M; Höllriegel R; Schuler G; Niebauer J; Stumvoll M; Blüher M · Atherosclerosis · 2009
    Randomized trial30 participantsMetabolism Boost forNiacin
  16. Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.
    Vaag A; Skött P; Damsbo P; Gall MA; Richter EA; Beck-Nielsen H · The Journal of clinical investigation · 1991
    Clinical trial12 participantsMetabolism Boost forNiacin
  17. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  18. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  19. Plasma vitamin profiles and their associations with metabolic health and mental wellbeing in midlife Asian women.
    Tan KML; Tint MT; Cabral RM; Lau R; Kee MZL; Garg V; De Iorio M; Tan SSL; Eriksson JG · Scientific reports · 2026
    Cohort study662 participantsMetabolism Boost forThiamin
  20. High-resolution plasma metabolomics and thiamine status in critically Ill adult patients.
    Gundogan K; Nellis MM; Ozer NT; Ergul SS; Sahin GG; Temel S; Yuksel RC; Teeny S; Alvarez JA; Sungur M; Jones DP; Ziegler TR · Metabolomics : Official journal of the Metabolomic Society · 2024
    Cross-sectional study76 participantsMetabolism Boost forThiamin
  21. Pathophysiology, prevention, and treatment of beriberi after gastric surgery.
    Wilson RB · Nutrition reviews · 2021
    Narrative reviewMetabolism Boost forThiamin
  22. Red blood cell transketolase activity and the effect of thiamine supplementation in patients with chronic liver disease.
    Rossouw JE; Labadarios D; Krasner N; Davis M; Williams R · Scandinavian journal of gastroenterology · 1978
    Single-arm trialMetabolism Boost forThiamin
  23. Exploring auxotrophy and engineering vitamin B6 prototrophy in the acetogen Clostridium sp. AWRP.
    Kwon SJ; Lee J; Lee HS · Applied and environmental microbiology · 2024
    Clinical trialMetabolism Boost forVitamin B5
  24. Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy.
    Spry C; van Schalkwyk DA; Strauss E; Saliba KJ · Infectious disorders drug targets · 2010
    Narrative reviewMetabolism Boost forVitamin B5
  25. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  26. Serum metabolites of hypertension among Chinese adolescents aged 12-17 years.
    Sun J; Ding W; Liu X; Zhao M; Xi B · Journal of human hypertension · 2022
    Other77 participantsMetabolism Boost forVitamin B5