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Glycine Powder

Metabolic Maintenance
4.8
★ ★ ★ ★ ★
(267 ratings)
Glycine 1000 mg
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Score85
A simple glycine powder offers excellent dosing flexibility and serving count, with raw-material verification as its main gap.
How scoring works
Quantity:200 Gram(s) • (200 servings)
Goals:
Detoxification
Anti-Inflammatory Support

Score 85

A simple glycine powder offers excellent dosing flexibility and serving count, with raw-material verification as its main gap.
How scoring works
$35.00($0.17 per serving)
iHerb
$ 35.00
Pure Formulas
$ 35.00
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Analysis

The powder supplies 1 g of glycine as a single ingredient. Powder delivery makes it easier to adjust upward than low-dose capsules when a larger amount is appropriate.

Glycine supports glycination and glutathione production, while its anti-inflammatory role is indirect and less established than targeted ingredients. The listed serving remains below common multi-gram use and lacks a premium purity designation.

Two hundred servings provide excellent flexibility and long-term practicality. The product fits users who value dose control and do not mind measuring powder.

Who is it for
  • Adults who prefer adjustable glycine powder
  • Users seeking glutathione and glycination support
  • People planning multi-gram use
Best for
  • Flexible glycine dosing
  • Detoxification-pathway support
  • Long-term powder use

Pros

  • Single-ingredient powder
  • Provides 1,000 mg per listed serving
  • Two hundred servings
  • Easy to adjust toward multi-gram intake

Cons

  • Listed serving is below common multi-gram use
  • Requires measuring powder
  • No purity grade
  • No independent certification

Warnings

  • Increase toward multi-gram intake only within label directions because larger servings may cause nausea or loose stool.
  • Measure the powder carefully rather than estimating the serving.
  • People with significant kidney or liver disease should review concentrated amino-acid use with their clinician.

Nutrient quality

88 Highest impact

Free-form glycine powder gives the formula reasonable ingredient quality. Dose uncertainty or limited delivery detail prevents a confident quality assessment.

Ingredient transparency

90 Highest impact

Important active details are incomplete or internally inconsistent. Practical use and inactive ingredients are described clearly.

Customer satisfaction

66 High impact

The aggregate rating is strong but the review volume limits confidence. No review excerpts are supplied to assess repeated complaints or purpose-specific experiences.

Value for money

89 Highest impact

Formula quality provides fair value for the category. Serving value is reasonable, with trade-offs in delivery or disclosure.

Report analysis

Goals

Detoxification
Impact
High effect
B+ Goal FitC+ Strength of SupportC+ CoverageA+ Formula Quality
Glycine · 1000 mg

Glycine supports glutathione production and is used directly in Phase II glycination. The pure powder clearly provides a meaningful amount without unrelated ingredients.

The serving offers focused support but may require multiple servings when a multi-gram intake is desired. It also leaves bile flow, methylation, mineral cofactors, and intestinal elimination unaddressed.

Study evidence
Glycine Supportive 5 studies
Anti-Inflammatory Support
Impact
High effect
C- Goal FitB- Strength of SupportD CoverageA+ Formula Quality
Glycine · 1000 mg

The 1000 mg glycine serving offers a plausible immunomodulatory pathway and a fully disclosed single-ingredient formula. Free-form powder also makes it practical to adjust the amount if a larger serving is desired.

Evidence for direct anti-inflammatory benefits in humans is less established than for fish oil or curcumin. The serving reaches only a modest supplemental amount, and no purity grade or source certification is stated.

Study evidence
Glycine Supportive 7 studies

Ingredients

IngredientAmount per serving
Glycine
1000 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Glycine · 1000 mg OverallScore68
D- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA- Value

The free-form powder makes glycine easy to measure and increase toward the amount commonly used for sleep support. The stated serving provides 1,000 mg, which is useful but below the established 3,000 mg sleep dose. The label is simple and transparent, while the missing purity grade or source certification limits confidence in raw-material quality.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
    Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
    Cohort study42 participantsDetoxification forGlycine
  2. Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
    Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
    Non-randomized trial21 participantsDetoxification forGlycine
  3. Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
    Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
    Methods validation study74 participantsDetoxification forGlycine
  4. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.
    Cruz M; Maldonado-Bernal C; Mondragón-Gonzalez R; Sanchez-Barrera R; Wacher NH; Carvajal-Sandoval G; Kumate J · Journal of endocrinological investigation · 2009
    Randomized trial74 participantsAnti-Inflammatory Support forGlycine
  5. Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.
    Vargas MH; Del-Razo-Rodríguez R; López-García A; Lezana-Fernández JL; Chávez J; Furuya MEY; Marín-Santana JC · BMC pulmonary medicine · 2018
    Randomized trial13 participantsAnti-Inflammatory Support forGlycine
  6. Clinical, inflammatory and microbiological outcomes of full-mouth scaling with adjunctive glycine powder air-polishing: A randomized trial.
    Zhang W; Wang W; Chu C; Jing J; Yao NA; Sun Q; Li S · Journal of clinical periodontology · 2021
    Randomized trial41 participantsAnti-Inflammatory Support forGlycine
  7. Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing.
    Guo X; Bai H; Lu X; Guo J; Qi Y; Huo X; Li S · Clinical oral investigations · 2026
    Randomized trial80 participantsAnti-Inflammatory Support forGlycine
  8. Long-term Implant Maintenance: A Systematic Review of Home and Professional Care Strategies in Supportive Implant Therapy.
    Araújo TG; Moreira CS; Neme RA; Luan H; Bertolini M · Brazilian dental journal · 2024
    Systematic review13 studies pooledAnti-Inflammatory Support forGlycine
  9. Analysis of the factors influencing the occurrence of peri-implantitis in patients with implant-supported restoration and study on the maintenance effect of subgingival sandblasting.
    Pan T; Meng W; Zhang M; Xie Y; Chen Z; Zhou M; Yin L; Xie H · BMC oral health · 2026
    Randomized trial198 participantsAnti-Inflammatory Support forGlycine
  10. Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
    Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
    Single-arm trial19 participantsDetoxification forGlycine
  11. The treatment of isovaleric acidemia with glycine supplement
    M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
    Non-randomized trial2 participantsDetoxification forGlycine