Product Image

Bedtime Burn

Dr. Emil Nutrition
4.4
★ ★ ★ ★ ★
(79 ratings)
Theanine 125 mg
Melatonin 5 mg
Valerian 55 mg
Green Tea 200 mg
Tryptophan 60 mg
Product Image
Score59
A mixed sleep-and-weight formula led by melatonin, with unclear caffeine and lightly dosed calming extras.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Sleep Support

Score 59

A mixed sleep-and-weight formula led by melatonin, with unclear caffeine and lightly dosed calming extras.
How scoring works
$25.75($0.85 per serving)
iHerb
$ 25.75
Vitacost
$ 25.75
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Analysis

Melatonin is the clearest sleep active, supported by theanine, valerian, passionflower, and tryptophan. Several of those supporting amounts are modest, leaving melatonin to carry much of the nighttime effect.

Green-tea extract and white kidney bean fit the weight-management positioning, but neither creates a strong reason to take the product at bedtime. The caffeine content is not disclosed, so the extract could work against sleep in sensitive users.

The formula combines many goals without fully resolving their tension. It may suit users seeking a combined nighttime routine, but a simpler sleep product would be easier to assess.

Who is it for
  • Adults seeking a combined nighttime and weight-management product
  • Users who tolerate melatonin
  • People not sensitive to green-tea extracts
Best for
  • Sleep preparation
  • Nighttime routine support
  • Users wanting a combined formula

Pros

  • Includes melatonin and theanine
  • Discloses an EGCG amount
  • Combines several calming botanicals

Cons

  • Caffeine amount is not stated
  • Valerian and passionflower amounts are modest
  • Metabolic and sleep goals may conflict

Warnings

  • Melatonin and valerian may cause next-day drowsiness
  • Unknown caffeine content may disrupt sleep or cause palpitations
  • Green-tea extract may cause nausea, especially when taken without food

Nutrient quality

56 Moderate impact

Melatonin provides a clear sleep-active foundation. Underdosed calming herbs and potentially stimulating weight-management ingredients weaken coherence.

.

Ingredient transparency

73 High impact

Most active names and total amounts are visible. Repeated source entries and missing non-active ingredients reduce clarity.

.

Customer satisfaction

55 Moderate impact

The supplied average rating is mixed. No specific review comments were supplied, so repeated negative experiences cannot be assessed.

.

Value for money

45 Lower impact

Melatonin and green-tea extract provide some substance. Goal conflict and weak supporting doses limit category value.

.
Report analysis

Goals

Sleep Support
Sleep Support
Impact
High effect
B- Goal FitB Strength of SupportB- CoverageD Formula Quality
Melatonin · 5 mgTheanine · 125 mg

Melatonin and theanine directly support sleep timing and relaxation. Passionflower, valerian, and tryptophan are present only at modest amounts.

Green tea extract and weight-management ingredients dilute the bedtime purpose, and any residual caffeine would conflict with sleep. The higher melatonin amount may cause morning grogginess or vivid dreams in some users.

Study evidence
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Tryptophan Mixed 1 study
Valerian Supportive 31 studies
Brain Health
Brain Health
Impact
Moderate effect
C Goal FitC+ Strength of SupportD+ CoverageD+ Formula Quality
Vitamin D · 60 mcg

L-theanine and melatonin provide a plausible route to better sleep and calmer attention. Theanine is well dosed, but tryptophan and the calming botanicals are too modest to add much independent support.

Metabolic ingredients such as white kidney bean and green tea make the formula less focused on brain health. The melatonin amount is relatively high and may cause next-day grogginess in sensitive users.

Study evidence
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
Stress Relief
Stress Relief
Impact
Moderate effect
C+ Goal FitC Strength of SupportC CoverageD Formula Quality
Vitamin D · 60 mcgTryptophan · 60 mgTheanine · 125 mg

Theanine and melatonin provide the clearest stress-related sleep support. Green-tea EGCG and white kidney bean extract serve a separate weight-management purpose.

Tryptophan, valerian, and passionflower are too small to add much, while the melatonin amount may be more than many users need. Any residual caffeine in the green-tea extract could also work against the bedtime goal because caffeine content is not disclosed.

Study evidence
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Valerian Supportive 18 studies
Anti-Aging
Anti-Aging
Impact
Moderate effect
D+ Goal FitC Strength of SupportC CoverageD Formula Quality
Vitamin D · 60 mcgGreen Tea · 200 mg

Green tea extract supplies an antioxidant and metabolic link to healthy aging, while vitamin D adds foundational support. The rest of the formula is centered on nighttime weight management and sleep rather than a coherent longevity strategy.

The EGCG amount is stated, but caffeine content and broader extract standardization are unclear. Melatonin, valerian, and passionflower can add to drowsiness, so the combination is unsuitable before driving and may compound other sedatives.

Study evidence
Green Tea Supportive 9 studies
Melatonin Supportive 6 studies
Vitamin D Supportive 50 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
D Goal FitC+ Strength of SupportD+ CoverageD Formula Quality
Vitamin D · 60 mcgGreen Tea · 200 mgTheanine · 125 mg

L-theanine may support calm attention, but melatonin, valerian, passionflower, and tryptophan make the formula sedating. Green tea adds an antioxidant component without clear disclosure of caffeine or extract standardization.

The blend is better suited to bedtime than memory or daytime processing speed. Its sedating ingredients may impair driving and can compound the effects of other sedatives.

Study evidence
Green Tea Supportive 32 studies
Theanine Supportive 25 studies

Ingredients

IngredientAmount per serving
Vitamin D (Cholecalciferol)
 60 mcg
White Kidney bean extract
500 mg
Green Tea extract (EGCG, Polyphenols)
 200 mg
L-Theanine
125 mg
L-Tryptophan
60 mg
Passion Flower extract
55 mg
Valerian root powder
55 mg
Melatonin
5 mg
Gluten Free Adults 18–50 Vegan Women Vegetarian
Report overview
Theanine · 125 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Explicit L-theanine identity confirms the active isomer, but no branded source or purity testing is shown. The clearly disclosed amount falls within the optimal range for calm and focused support. The effective amount is paired with several sleep and metabolic actives, but theanine-specific cost is high.

View ingredientView products
Melatonin · 5 mg OverallScore51
F Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyC Value

The 5 mg amount is usable but higher than the range most aligned with natural circadian signaling. Capsule delivery offers standard absorption, but it does not provide sustained release. The high serving cost is partly supported by substantial theanine, botanical, and metabolic ingredients.

View ingredientView products
Valerian · 55 mg OverallScore48
C- Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyF Value

Raw root powder provides no concentration or standardization advantage. The 55 mg root amount is too low to contribute much beside the other ingredients. A token valerian amount makes the premium poor value for valerian-focused use.

View ingredientView products
Loading alternative details
76 Performance

Best-Rest Formula

Pure Encapsulations
<p>It is a stronger formulation match because branded L-theanine, active vitamin B6, substantial GABA, valerian, calming herbs, and conservative melatonin create a coherent sleep blend. Compared with the original’s higher-melatonin formula with green tea and small calming-herb amounts, botanical marker percentages are missing and the sedating combination should not be used before driving.</p>
79 Performance

Sleep Optimizer

Jarrow Formulas
<p>It is a stronger formulation match because valerian, tryptophan, GABA, calming herbs, and low-dose melatonin form a coherent sleep blend. Compared with the original’s higher-melatonin formula with green tea and small calming-herb amounts, ingredient-quality details are basic and the sedating combination may impair driving.</p>
75 Performance

Sleep & Stress Support

Solgar
<p>It is a stronger formulation match because a full L-theanine amount is paired with valerian, passionflower, hops, and vitamin B6. Compared with the original’s higher-melatonin formula with green tea and small calming-herb amounts, botanical standardization is incomplete and the calming combination may intensify alcohol or sedative medicines.</p>
85 Budget

3 a.m. Melatonin Fast Dissolve Lavender Vanilla

Natrol
<p>It is a more economical option because fast-dissolve melatonin is paired with a modest L-theanine amount for sleep onset. Compared with the original’s higher-melatonin formula with green tea and small calming-herb amounts, the formula has little depth beyond those two actives and may cause next-day drowsiness.</p>
71 Budget

Sleep Essentials

Swanson
<p>It is a more economical option because fully disclosed melatonin is paired with several supporting calming ingredients. Compared with the original’s higher-melatonin formula with green tea and small calming-herb amounts, most companion amounts are small, magnesium uses the oxide form, and stacked sedatives may cause next-day drowsiness.</p>
85 Budget

L-Theanine 100 mg

NOW
<p>It is a more economical option because 100 mg of L-theanine provides a simple option for calm attention. Compared with the original’s higher-melatonin formula with green tea and small calming-herb amounts, it omits caffeine and the green-tea catechin potency is not standardized, so it does not fully reproduce the original energy effect.</p>
73 Value

Restful Sleep Blackberry Zen

OLLY
<p>It offers a useful quality-to-cost balance because melatonin and a substantial L-theanine amount provide practical sleep-onset support. Compared with Bedtime Burn, the lightly dosed botanicals add little depth and immediate release may cause next-day drowsiness without supporting all-night maintenance.</p>
62 Value

Sleep tonight Melatonin Drops Cherry Flavored

Nature's Way
<p>It offers a useful quality-to-cost balance because a meaningful L-theanine amount is paired with liquid melatonin for relaxation and sleep onset. Compared with Bedtime Burn, the melatonin amount is less conservative and the tiny hidden herbal blend adds little assessable value.</p>
68 Value

Super Snooze Melatonin with Herbal Blend

Sundown Naturals
<p>It offers a useful quality-to-cost balance because melatonin is paired with fully disclosed herbs and minerals at a low recurring cost. Compared with Bedtime Burn, the melatonin amount is relatively assertive and the supporting ingredients use basic forms.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
    Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
    Randomized trial202 participantsSleep Support forValerian
  2. A systematic review of insomnia and complementary medicine.
    Sarris J; Byrne GJ · Sleep medicine reviews · 2011
    Systematic review20 studies pooledSleep Support forValerian
  3. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  4. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  5. Unintended consequences: college students' melatonin usage, sleep disturbance, and depressive symptoms.
    Peltz JS; Rogge R · Sleep and biological rhythms · 2025
    Cohort study331 participantsSleep Support forMelatonin
  6. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsSleep Support Brain Health Cognitive Support forTheanine
  7. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support forTheanine
  8. Green tea and coffee intake and risk of cognitive decline in older adults: the National Institute for Longevity Sciences, Longitudinal Study of Aging.
    Shirai Y; Kuriki K; Otsuka R; Kato Y; Nishita Y; Tange C; Tomida M; Imai T; Ando F; Shimokata H · Public health nutrition · 2021
    Cohort study1,305 participantsAnti-Aging forGreen Tea
  9. Associations of green tea, coffee, and soft drink consumption with longitudinal changes in leukocyte telomere length.
    Sohn I; Shin C; Baik I · Scientific reports · 2023
    Cohort study1,952 participantsAnti-Aging forGreen Tea
  10. Can teatime increase one's lifetime?
    Nakachi K; Eguchi H; Imai K · Ageing research reviews · 2003
    Cohort studyAnti-Aging forGreen Tea
  11. Influences of tea consumption on self-rated health and life satisfaction among older adults: Evidence from the CLHLS.
    Zou M; Sun C; Yang M; Li C; Wang S; Zheng D; Wang J; Yu L; Sun L; Wang Y; Chen H; Zeng Y · PsyCh journal · 2025
    Cohort study78,345 participantsAnti-Aging forGreen Tea
  12. Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin.
    Chiu AE; Chan JL; Kern DG; Kohler S; Rehmus WE; Kimball AB · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial40 participantsAnti-Aging forGreen Tea
  13. Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.
    Shang Y; Song N; He R; Wu M · Advances in nutrition (Bethesda, Md.) · 2024
    Meta-analysis2,617 participants20 studies pooledAnti-Aging forMelatonin
  14. Lipidomic and Instrumental Evaluation of a Melatonin-Based In & Out Strategy Versus Topical Treatment in Skin Aging: A Randomized Prospective Trial.
    Colombo F; Alfano S; Milani M · Metabolites · 2025
    Randomized trial39 participantsAnti-Aging forMelatonin
  15. Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age.
    Tsui KH; Li CJ; Lin LT · Reproductive biology and endocrinology : RB&E · 2024
    Cohort study161 participantsAnti-Aging forMelatonin
  16. Melatonin and healthy aging.
    Cardinali DP · Vitamins and hormones · 2021
    Narrative reviewAnti-Aging forMelatonin
  17. Clinical Studies Using Topical Melatonin.
    Greco G; Di Lorenzo R; Ricci L; Di Serio T; Vardaro E; Laneri S · International journal of molecular sciences · 2024
    Narrative reviewAnti-Aging forMelatonin
  18. Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.
    Pan Z; Zeng J; Chen Z; Chen S; Yang J; Li H; Wang S; Wang J; Li N; Gong Y; Liu M; Li C · The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Cohort study389,217 participantsAnti-Aging forVitamin D
  19. Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels.
    Schöttker B; Hagen L; Zhang Y; Gào X; Holleczek B; Gao X; Brenner H · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Cohort study9,940 participantsAnti-Aging forVitamin D
  20. Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study.
    Song S; Lim JY; Kim M; Won CW; Park HY · The journal of nutrition, health & aging · 2025
    Cohort study1,292 participantsAnti-Aging forVitamin D
  21. Vitamin D deficit is associated with accelerated brain aging in the general population.
    Terock J; Bonk S; Frenzel S; Wittfeld K; Garvert L; Hosten N; Nauck M; Völzke H; Van der Auwera S; Grabe HJ · Psychiatry research. Neuroimaging · 2022
    Cross-sectional study1,865 participantsAnti-Aging forVitamin D
  22. Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
    Zhao C; Tsapanou A; Manly J; Schupf N; Brickman AM; Gu Y · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort study1,759 participantsAnti-Aging forVitamin D
  23. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  24. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  25. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  26. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  27. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  28. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  29. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support forTheanine
  30. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  31. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health forTheanine
  32. Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.
    de la Torre R; de Sola S; Hernandez G; Farré M; Pujol J; Rodriguez J; Espadaler JM; Langohr K; Cuenca-Royo A; Principe A; Xicota L; Janel N; Catuara-Solarz S; Sanchez-Benavides G; Bléhaut H; Dueñas-Espín I; Del Hoyo L; Benejam B; Blanco-Hinojo L; Videla S; Fitó M; Delabar JM; Dierssen M; TESDAD study group · The Lancet. Neurology · 2017
    Randomized trial87 participantsCognitive Support forGreen Tea
  33. Association between tea consumption and risk of cognitive disorders: A dose-response meta-analysis of observational studies.
    Liu X; Du X; Han G; Gao W · Oncotarget · 2018
    Meta-analysis48,435 participants17 studies pooledCognitive Support forGreen Tea
  34. Investigating the Impact of Tea Consumption on Cognitive Function and Exploring Tea-Genetic Interactions in Older Adults Aged 65-105 Years: Findings from the 2002-2018 CLHLS Data.
    Yu L; Yang M; Ye KX; Li C; Zou M; Wang J; Yuan X; Zheng D; Sun C; Zhang Y; Feng Q; Maier AB; Sun L; Feng L; Wang Y; Chen H; Zeng Y · The journal of prevention of Alzheimer's disease · 2024
    Cohort study76,270 participantsCognitive Support forGreen Tea
  35. Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline.
    Noguchi-Shinohara M; Yuki S; Dohmoto C; Ikeda Y; Samuraki M; Iwasa K; Yokogawa M; Asai K; Komai K; Nakamura H; Yamada M · PloS one · 2014
    Cohort study490 participantsCognitive Support forGreen Tea
  36. Green Tea Consumption and the Risk of Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study.
    Tomata Y; Sugiyama K; Kaiho Y; Honkura K; Watanabe T; Zhang S; Sugawara Y; Tsuji I · The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018
    Cohort study13,645 participantsCognitive Support forGreen Tea
  37. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  38. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support forTheanine
  39. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  40. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  41. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  42. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  43. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  44. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  45. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  46. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
    Clarinda N Sutanto, Wen Wei Loh, Jung Eun Kim · Nutrition Reviews · 2022
    Meta-analysis4 studies pooledSleep Support forTryptophan
  47. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsSleep Support Stress Relief forValerian
  48. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
    Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Randomized trial40 participantsSleep Support forValerian
  49. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
    Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
    Randomized trial40 participantsSleep Support forValerian
  50. Valerian for sleep: a systematic review and meta-analysis.
    Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
    Meta-analysis1,093 participants16 studies pooledSleep Support forValerian
  51. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
    Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
    Randomized trial202 participantsStress Relief forMelatonin
  52. Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
    Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
    Randomized trial90 participantsStress Relief forMelatonin
  53. Melatonin for pre- and postoperative anxiety in adults.
    Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
    Meta-analysis774 participants12 studies pooledStress Relief forMelatonin
  54. Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
    Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
    Meta-analysis441 participants5 studies pooledStress Relief forMelatonin
  55. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
    Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
    Randomized trial88 participantsStress Relief forMelatonin
  56. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  57. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsStress Relief forTheanine
  58. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsStress Relief forTheanine
  59. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forTheanine
  60. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
    Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
    Randomized trial54 participantsStress Relief forValerian
  61. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledStress Relief forValerian
  62. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
    Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
    Non-randomized trial54 participantsStress Relief forValerian
  63. Stress-induced insomnia treated with kava and valerian: singly and in combination.
    Wheatley D · Human psychopharmacology · 2019
    Single-arm trial24 participantsStress Relief forValerian