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Chelated Magnesium Glycinate 400 mg

4.8
★ ★ ★ ★ ★
(10399 ratings)
Magnesium 400 mg
Product Image
Score83
A strong, well-dosed bisglycinate option, tempered by a larger tablet serving and incomplete processing details.
How scoring works
Tablet
Quantity:90 Tablet(s) • (30 servings)
Goals:
Energy
General Health
Stress Relief
Cardiovascular Support
Heart Health
Testosterone Support
Fitness
Bone Health
Digestive Health

Score 83

A strong, well-dosed bisglycinate option, tempered by a larger tablet serving and incomplete processing details.
How scoring works

Also available as

1 option
180 servings Magnesium 400 mg • 180 Tablet(s) • 60 servings $29.99 ($0.49 per serving)
$18.19($0.60 per serving)
iHerb
$ 18.19
Pure Formulas
$ 18.19
Walmart
$ 18.19
Vitacost
$ 18.19
Report prices

Analysis

Bisglycinate is a useful choice for systemic magnesium support and is often gentler than citrate or oxide. The substantial amount suits adults whose diet does not provide enough magnesium.

The focused formula supports muscle, nerve, relaxation, and energy-related functions without unrelated actives. It does not address other nutrient gaps or disclose whether the chelate is fully reacted.

Three tablets per serving may be inconvenient, and the serving cost is above simpler forms. Even glycinate can loosen stools at a high supplemental amount.

Who is it for
  • Adults seeking well-absorbed magnesium
  • People who prefer glycinate over citrate or oxide
  • Users targeting muscle or relaxation support
Best for
  • Systemic magnesium repletion
  • Muscle and nerve function
  • Stress and relaxation support

Pros

  • Well-absorbed bisglycinate form
  • Substantial disclosed amount
  • Focused single-mineral formula

Cons

  • Three-tablet serving
  • Full excipients and chelation details are missing
  • Higher serving cost than basic magnesium forms

Warnings

  • The full serving may cause loose stools or abdominal discomfort
  • People sensitive to magnesium may need a smaller divided amount
  • Impaired kidney function can increase magnesium accumulation risk

Nutrient quality

86 Highest impact

Magnesium bisglycinate provides the main quality signal, while a substantial magnesium amount shapes likely usefulness. Absorption, tolerability, and the formula's focus determine the main trade-off.

Ingredient transparency

87 Highest impact

Active amounts are clearly disclosed, and no proprietary blend hides the total formula. Specific ingredient names make the core actives reasonably easy to assess.

Customer satisfaction

91 Highest impact

The high average rating is supported by substantial review volume. No specific review comments are supplied, so repeated complaints and purpose alignment cannot be confirmed directly.

Value for money

66 High impact

Value is weak for the form quality and disclosed amount. The focused formula avoids paying for token extras, while category competitiveness depends on absorption quality.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
A+ Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Magnesium · 400 mg

Magnesium bisglycinate supplies a foundational ATP cofactor in a well-absorbed chelated form. The 400 mg amount provides substantial targeted support for people with inadequate magnesium intake.

Coverage remains limited to magnesium-related metabolism, nerve activity, and muscle function. Three tablets are required, and no patented or fully reacted chelation standard is identified.

Study evidence
Magnesium Supportive 4 studies
General Health
General Health
Impact
Highest effect
A Goal FitA Strength of SupportC+ CoverageA+ Formula Quality
Magnesium · 400 mg

Magnesium bisglycinate provides a highly absorbable form at a clearly stated amount suited to foundational magnesium support. The formula may support normal muscle, nerve, and energy-related functions when additional magnesium is needed.

The single-ingredient design offers depth rather than broad nutritional coverage. No patented or fully reacted chelation standard is named, leaving some uncertainty about processing quality.

Study evidence
Magnesium Supportive 114 studies
Stress Relief
Stress Relief
Impact
Highest effect
A- Goal FitA+ Strength of SupportC+ CoverageA Formula Quality
Magnesium · 400 mg

Magnesium bisglycinate provides foundational nervous-system support and may help relaxation when magnesium status is low. The substantial amount and highly absorbable chelated form make the formula well aligned with stress support.

The focused design offers strong depth without unrelated ingredients, although it does not address adaptogen or amino-acid pathways. The full serving may cause loose stools or abdominal discomfort in sensitive users despite glycinate's generally good tolerance.

Study evidence
Magnesium Supportive 13 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
B+ Goal FitA+ Strength of SupportC- CoverageA+ Formula Quality
Magnesium · 400 mg

Magnesium bisglycinate provides focused support for vascular tone, normal rhythm, and electrolyte balance. The clearly stated 400 mg amount is therapeutically meaningful, and the chelated form generally absorbs well.

The label does not identify a patented or fully reacted chelation standard, so processing quality cannot be confirmed. The full supplemental amount may still cause loose stools in sensitive users, and impaired kidney function can increase magnesium accumulation risk.

Study evidence
Magnesium Supportive 123 studies
Heart Health
Heart Health
Impact
Highest effect
B- Goal FitA+ Strength of SupportC+ CoverageA Formula Quality
Magnesium · 400 mg

Magnesium bisglycinate provides a well-absorbed mineral form that supports normal heart rhythm and vascular relaxation. The disclosed amount is substantial and sits within the preferred therapeutic range.

The focused formula is easy to assess and avoids competing minerals. It does not cover lipid management, cardiac energy, or other cardiovascular pathways beyond magnesium.

Study evidence
Magnesium Supportive 158 studies
Testosterone Support
Testosterone Support
Impact
High effect
C+ Goal FitA Strength of SupportD+ CoverageA+ Formula Quality
Magnesium · 400 mg

A substantial amount of magnesium bisglycinate provides focused mineral support for normal endocrine function. Benefits for testosterone are most likely when magnesium intake or status is inadequate.

It delivers depth on one pathway rather than broad hormonal coverage. The full amount may still loosen stools in sensitive users despite the well-tolerated form.

Study evidence
Magnesium Disputed 5 studies

Ingredients

IngredientAmount per serving
Magnesium (Magnesium Bisglycinate)
 400 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Vegetarian
Report overview
Magnesium (Magnesium Bisglycinate) · 400 mg OverallScore74
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD+ Value
+1

Magnesium bisglycinate offers strong absorption and a clearly labeled therapeutic amount. The label does not identify a patented or fully reacted chelation standard. Its above-median serving cost is only partly justified by the premium form.

View ingredientView products
Loading alternative details
91 Performance

Krebs Magnesium Potassium Complex

Nature's Way
<p>Magnesium lysinate and malate provide favorable forms at a useful 250 mg amount, with 95 mg potassium citrate for broader mineral support. Compared with the original 400 mg amount from Magnesium Bisglycinate, the form disclosure is clearer and the dose is less aggressive for many users.</p>
88 Performance

Magnesium Bisglycinate Powder

NOW
<p>The pure powder provides 250 mg magnesium bisglycinate in a well-absorbed, adjustable form. Compared with the original 400 mg amount from Magnesium Bisglycinate, the single named form is easier to assess and may be gentler on digestion.</p>
85 Performance

Magnesium Bisglycinate Chelate

Healthy Origins
<p>The clean powder uses TRAACS magnesium bisglycinate at a practical 200 mg elemental amount. Compared with the original 400 mg amount from Magnesium Bisglycinate, it prioritizes absorption quality and moderate dosing, although it may provide less total magnesium.</p>
83 Budget

Magnesium Citrate Pure Powder

Best Naturals
<p>The lower-cost powder provides 210 mg magnesium citrate in an adjustable serving. Compared with the original 400 mg amount from Magnesium Bisglycinate, citrate is clearly identified and generally useful for routine repletion, though it may loosen stools.</p>
80 Budget

Magnesium Caps 500 mg

Life Extension
<p>The lower-cost blend supplies 500 mg magnesium across citrate, succinate, glycinate, and oxide sources. It offers a substantial amount for the cost, but oxide lowers average absorption quality and the high serving may cause diarrhea or cramping compared with the original 400 mg amount from Magnesium Bisglycinate.</p>
84 Budget

Potassium + Magnesium

Nutricost
<p>The lower-cost two-mineral formula supplies 210 mg magnesium citrate with 99 mg potassium citrate. It offers clear mineral forms and practical value, although its magnesium amount may be lower than the original 400 mg amount from Magnesium Bisglycinate.</p>
85 Value

Magnesium Bisglycinate 200 mg

Natural Factors
<p>The focused powder combines 200 mg magnesium bisglycinate with a moderate serving cost and a nonaggressive dose. Compared with the original 400 mg amount from Magnesium Bisglycinate, the clearly named form improves quality-to-cost balance while reducing the chance of dose-related digestive discomfort.</p>
85 Value

Cal/Mag 500 mg/250 mg

NaturesPlus
<p>The formula pairs 250 mg chelated magnesium with 500 mg chelated calcium in an economical serving. It adds useful bone-mineral breadth and clear forms compared with the original 400 mg amount from Magnesium Bisglycinate, though calcium may be unnecessary for users seeking magnesium alone.</p>
81 Value

Ultra-Mag

Source Naturals
<p>The broad blend supplies 400 mg magnesium from citrate, glycinate, malate, succinate, and taurinate forms at a favorable serving cost. Form diversity improves practical value compared with the original 400 mg amount from Magnesium Bisglycinate, while the high amount and 30 mg vitamin B6 may reduce suitability for long-term routine use.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  2. Hospital-Acquired Dysmagnesemia and In-Hospital Mortality.
    Cheungpasitporn W; Thongprayoon C; Chewcharat A; Petnak T; Mao MA; Davis PW; Bathini T; Vallabhajosyula S; Qureshi F; Erickson SB · Medical sciences (Basel, Switzerland) · 2024
    Cohort study26,020 participantsGeneral Health forMagnesium
  3. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  4. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  5. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  6. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  7. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  8. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  9. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  10. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  11. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  12. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  13. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  14. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  15. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  16. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  17. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  18. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  19. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy Fitness forMagnesium
  20. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  21. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  22. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsFitness forMagnesium
  23. Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women.
    Welch AA; Kelaiditi E; Jennings A; Steves CJ; Spector TD; MacGregor A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Cross-sectional study2,570 participantsFitness forMagnesium
  24. Nutritional intake as a determinant of high-speed resistance and multicomponent training efficacy on strength in older women at risk of sarcopenia. A randomized clinical trial.
    Polo-Ferrero L; Recio-Rodriguez JI; González-Manzano S; Martín-Vallejo J; Barbero-Iglesias FJ; Montero-Errasquín B; Cruz-Jentoft AJ; Méndez-Sánchez R · Clinical nutrition (Edinburgh, Scotland) · 2025
    Randomized trial80 participantsFitness forMagnesium
  25. Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
    van Dronkelaar C; Fultinga M; Hummel M; Kruizenga H; Weijs PJM; Tieland M · Journal of the American Medical Directors Association · 2023
    Systematic review45 studies pooledFitness forMagnesium
  26. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  27. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  28. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  29. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  30. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  31. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  32. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  33. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  34. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  35. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  36. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  37. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  38. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  39. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  40. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  41. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  42. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium