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B-50

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4.7
★ ★ ★ ★ ★
(3985 ratings)
PABA 50 mg
Niacin 50 mg
Vitamin B6 50 mg
Thiamin 50 mg
Riboflavin 50 mg
Choline 50 mg
Vitamin B5 50 mg
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Score77
Complete and economical B-vitamin coverage is offset by conventional forms and a 50 mg vitamin B6 dose that is too aggressive for routine long-term use.
How scoring works
Quantity:250 Tablet(s) • (250 servings)
Goals:
Energy
Metabolism Boost

Score 77

Complete and economical B-vitamin coverage is offset by conventional forms and a 50 mg vitamin B6 dose that is too aggressive for routine long-term use.
How scoring works
$25.50($0.10 per serving)
iHerb
$ 26.94
Daily Vita
$ 25.50
Vitacost
$ 28.83
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Analysis

Thiamine, riboflavin, niacinamide, vitamin B6, folate, vitamin B12, biotin, and pantothenic acid create broad support for normal energy metabolism. Most core B vitamins are supplied at 50 mg or a similarly high multiple of daily needs, so the formula is better described as high potency than balanced maintenance nutrition.

Pyridoxine hydrochloride and cyanocobalamin are conventional forms that require conversion before use. Choline at 50 mg is only a small addition, and PABA and inositol provide limited practical depth beside the main B vitamins.

Folate at 667 mcg DFE is clearly stated and provides substantial coverage. The simple serving and complete disclosure support ease of use, but the dose pattern is more aggressive than most adults need every day.

Who is it for
  • Adults seeking a high-potency B-complex for limited or clinician-directed use
  • People who value a simple once-daily serving
  • Users who have checked total vitamin B6 and folic acid intake from other products
Best for
  • Broad B-vitamin coverage
  • Supporting normal energy metabolism when intake is inadequate
  • Users prioritizing low serving cost over premium coenzyme forms

Pros

  • Includes all core B vitamins with stated amounts
  • Uses non-flushing niacinamide
  • Provides substantial thiamine, riboflavin, and pantothenic acid
  • Simple daily serving is easy to follow

Cons

  • 50 mg pyridoxine is unnecessarily high for a daily maintenance formula
  • Uses conventional cyanocobalamin and pyridoxine hydrochloride
  • Choline is modest at 50 mg
  • PABA and inositol add little to the core energy rationale

Warnings

  • Prolonged use of 50 mg vitamin B6 may cause tingling, numbness, or other nerve symptoms; stop use and seek advice if these occur.
  • Niacinamide at this amount may cause nausea or stomach discomfort in sensitive users.
  • PABA can interfere with sulfonamide antibiotics, so concurrent use should be reviewed with the prescriber.

Nutrient quality

73 High impact

The broad B-vitamin pattern provides substantial, focused coverage. Basic forms and an aggressive B6 amount reduce form quality and long-term balance.

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Ingredient transparency

71 High impact

Active amounts are broadly disclosed without a hidden blend. Repeated vitamin names, missing directions, and absent tablet excipients reduce full clarity.

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Customer satisfaction

71 High impact

The aggregate satisfaction signal is strong and supported by extensive volume. Missing review details prevent assessment of recurring complaints or purpose fit.

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Value for money

94 Highest impact

Broad dosing and a low serving cost provide excellent supply value. Basic forms and high B6 are the main trade-offs against gentler competitors.

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Goals

Energy
Impact
High effect
A- Goal FitB- Strength of SupportB- CoverageA Formula Quality
Vitamin B5 · 50 mgRiboflavin · 50 mgThiamin · 50 mgVitamin B12 · 50 mcg

A complete high-potency B-complex provides focused support for normal energy metabolism. Thiamin, riboflavin, niacin, vitamin B6, and B5 are all clearly quantified.

Vitamin B12 is below the goal threshold and uses cyanocobalamin rather than a bioactive form. The vitamin B6 amount is high enough that prolonged daily use may increase neuropathy risk.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Metabolism Boost
Impact
High effect
B- Goal FitB- Strength of SupportD+ CoverageA- Formula Quality
Biotin · 50 mcgNiacin · 50 mgVitamin B12 · 50 mcgRiboflavin · 50 mgThiamin · 50 mgVitamin B5 · 50 mgVitamin B6 · 50 mg

High-potency B vitamins provide a focused set of cofactors for normal cellular energy production. The formula is most relevant when low B-vitamin status is impairing energy metabolism.

No thyroid nutrient, chromium, thermogenic, carnitine, or substantial mitochondrial active broadens the effect. Long-term daily use of the supplied B6 amount may cause tingling, numbness, or other nerve symptoms.

Study evidence
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride, Vitamin B1)
50 mg
Riboflavin (Vitamin B2)
50 mg
Niacin (Niacinamide, Vitamin B3)
50 mg
Vitamin B6 (Pyridoxine Hydrochloride)
50 mg
Folate
667 mcg DFE
Vitamin B12 (Cyanocobalamin)
50 mcg
Biotin
50 mcg
Pantothenic Acid (Calcium Pantothenate)
50 mg
Choline (Choline Bitartrate)
50 mg
PABA
50 mg
Inositol
50 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
PABA · 50 mg OverallScore91
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA- Value

PABA is clearly named in a standard form, though no pharmaceutical-grade or high-purity claim is supplied, and the delivery format suits the dose. The clearly disclosed 50 mg amount suits a high-potency B-complex, and no targeted additives appear in the supplied ingredient data. PABA-specific cost efficiency is favorable within the broader formula.

B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

Niacinamide at 50 mg fits a general B-complex and avoids the typical nicotinic-acid flush concern. The tablet has no stated release technology, but the form and amount are clearly suited to routine multivitamin use. A long supply and low serving cost make it an efficient option for broad B-vitamin coverage.

D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The 50 mg B6 dose is useful, but pyridoxine hydrochloride is less metabolically ready than P-5-P. A substantial riboflavin amount supports conversion of the precursor.

One tablet provides a convenient B-complex serving at strong value. Excipients remain uncertain because the supplied product data omits other ingredients.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  2. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  3. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  4. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  5. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  6. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  7. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  8. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  9. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  10. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  11. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  12. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  13. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  14. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  15. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  16. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  17. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  18. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  19. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6